Fibrinogen Puns

(Title was meant to be "breakdown of")

https://labs.selfdecode.com/blog/high-fibrinogen/

Thought this was a good read with a few things to think about for those of us tryng to tackle the microclotting.

As the title reads, I am doing our 6 month instrument comparison study. Being a small lab, we don’t get a lot of the abnormally high/low samples we need to cover our reporting range. So I am using older samples, proficiency samples and whatever I can find to cover the range, but I’m still missing a couple. Since we are only testing result correlation between analyzers and not the capability of measuring in vivo, is it ok to spike or alter real samples to get abnormal results? If so, what could be done for coagulation testing for the 4 tests mentioned in the title?

Hello there! My mother (51 year old Female) who has no history of any medical conditions has been displaying increasing levels of Fibrinogen on her bloodtest. She has also been experiencing some chest pains. About a month ago, her blood results showed that she had 800 mg/dL on her Fibrinogen levels, this was accompanied by chest pain as well. Her GP seemed very concerned and asked her to go to the emergency room to get some tests done. She had a CT scan done to check for blood clots, and the doctor also performed a neurological exam. Everything seemed to be normal and she was sent home. Today she had another bloodtest done to check if the Fibrinogen levels decreased, but instead they increased up to 1000 mg/dL. The doctor called again and sounded concerned. She referred my mother to a blood specialist, but they will only be available from monday. I was wondering if someone here knows what could be causing such high Fibrinogen levels?

28 years old, female, Caucasian, 66kg last weighing, 162cm, no smoking, no recreational drugs, alcohol VERY rarely and only in very small portions because of my meds (like, a glass of very weak gin tonic in a month).

Meds: coaxil 3x12,5mg, ambien and diazepam as needed but fairly rarely, ibuprofen or celecoxib for back pain, also fairly rarely, esopramazole when taking ibuprofen, B12 and vitamin D supplement (due to veganism and a mutual hate relationship I have with the sun).

Existing medical issues: BPD and PTSD, chronic back pain, arthropathy, possibly arthritis but it was never confirmed nor specified which kind, allergies (cats, ambrosia, grass), gastritis on occasions.

Few months ago, I had a regular checkup with my gyneacologist, only blood so far because covid. My cholesterol came up just slightly elevated, which is a regular thing for me since I started hormonal BC (combination pill) 7 years ago, but I'm vegan so doctors mostly ignore it if all other tests are a-okay. However, this time my d-dimers came up high, 1.49 mg/L and fibrinogen was 4.62 g/L. My gyno took me off BC and told me to go to my GP, who sent me to a haematologist. Haematologist then sent me for another blood test 2 which happened 2 months after the first one. At that point I was off BC for at least 3 months. My d-dimers came up high again, 1.25 mg/L and so did fibrinogen 5,1, so even higher than before. So the haematologist had me tested for DVT the same day via doppler ultrasound and it came up okay, no DVT. She had nothing else to do and sent me back to my GP for further testing, but I haven't had time to see my GP yet.

I would like some guidance on where I could go next or what to expect in the future. I would also like y'alls opinion on how safe would resuming contraception be for me. I was planning on getting the implant at some point before this whole thing, because my cycle wreaks havoc on my body.

Feel free to ask about another blood test results, because I don't know what else could be relevant because docs only mentioned d-dimers as an issue so far. If I forgot anything else relevant, do tell.

Hey all! First time Post, and have a question! I found out I have heterozygous FVL when I had tests done in preparation for ICSI treatment a few years back. It was unfortunately unsuccessful, but only recently found the paperwork again, and also noticed that I was flagged as having a high Clauss Fibrinogen level. I was wondering is this related to the FVL or are they seperate issues?

Thanks in advance!

For those of us with persistent tachycardia even at rest, and don’t have POTS, this might be evidence that inflammation is contributing to the tachycardia?

I’m going to try to convince my doctor to prescribe a blood test for inflammatory markers. (Even though I “just have anxiety”!)

The more I read about endothelial damage and inflammation, the more I suspect is what’s going for for a lot of long haulers.

Link to the article in title: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280910/

Has anyone else noticed this? Can we get something different? 😭

I don't understand this card, including the post already on it a year ago. I thought that since fibrinolysis is when you cleave fibrin and fibrinogen, disorders of fibrinolysis would prevent this cleavage, therefore you'd have increased fibrinogen. Would love an explanation!

I'm in tech school, working through my clinicals, and I'm super confused on how I keep doing this mistake.

I've repeated this fibrinogen assay three times today, with all the same blood. And I keep getting a negative number! The non-incubated total solids is always higher than the incubated total solids. So when I multiply by a thousand, and then subtract the NTS by the ITS, it's negative which obviously is not correct.

I'm following the steps directly and using the correct formula. But something is a miss?? I'm not sure what in the world it could be - no one else in my clinic can figure out what I'm doing wrong either.

Thank you

Can someone please explain this card to me? I've just been memorizing it, but I keep getting it wrong and I want to understand so I can stop seeing this card. Any help would be appreciated!

https://imgur.com/a/uCkOgfx

So, I'm a bit confused about this card in the Heme/Onc Zanki deck:

Disorders of fibrinolysis are due to {{c1::plasmin}} overactivity, resulting in excessive cleavage of serum {{c2::fibrinogen}}

Shouldn't the c2 be fibrin, not fibrinogen, or does pathologically activated plasmin also cleave fibrinogen as well?