Introduced: Sponsor: Sen. James “Jim” Inhofe [R-OK]

This bill was referred to the Senate Committee on Environment and Public Works which will consider it before sending it to the Senate floor for consideration.

Sen. James “Jim” Inhofe [R-OK] is the chairman of the committee.

Govtrack.us Summary

Housekeeping:

• HOW TO SUPPORT: I know we are all facing unprecedented financial hardships right now. If you are in the position to support my work, I have a patreon, venmo, and a paypal set up. No pressure though, I will keep posting these pieces publicly no matter what - paywalls suck.

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#Haitian migrants

Images of Border Patrol agents on horseback riding down Haitian migrants at the southern border prompted national outrage, but little has been done to rectify the situation as advocates lose faith in Biden’s campaign promises.

Photographer Paul Ratje was on scene in the migrant camp in Del Rio, Texas, when Border Patrol stormed the area on September 19 (images). The mounted officers aggressively chased migrants across the Rio Grande river, wielding the horse reigns as apparent whips and—in at least one video—yelling offensive remarks at a group attempting to pick up their scattered belongings (video): “This is why your country’s shit, because you use your women for this!” one shouted, harkening back to Trump’s 2018 “shithole countries” comment.

The White House was quick to condemn the scene. "I don't have the full context. I can't imagine what context would make that appropriate...I don't think anyone seeing that footage would think it was acceptable or appropriate,” said White House spokeswoman Jen Psaki (clip).

Biden, for his part, promised the agents “will pay,” adding that their actions “send the wrong message around the world” and “at home” (clip). As far as we know, the agents were placed on administrative duties and an investigation is still ongoing.

The administration’s criticism of the Border Patrol’s methods misses the point that immigration and human rights advocates are arguing, however: Expulsions shouldn’t be occurring, even if done wit

Do your worst!

https://doi.org/10.1371/journal.ppat.1009495

Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi

Abstract

Trypanosoma cruzi, the parasite causing Chagas disease, is a digenetic flagellated protist that infects mammals (including humans) and reduviid insect vectors. Therefore, T. cruzi must colonize different niches in order to complete its life cycle in both hosts. This fact determines the need of adaptations to face challenging environmental cues. The primary environmental challenge, particularly in the insect stages, is poor nutrient availability. In this regard, it is well known that T. cruzi has a flexible metabolism able to rapidly switch from carbohydrates (mainly glucose) to amino acids (mostly proline) consumption. Also established has been the capability of T. cruzi to use glucose and amino acids to support the differentiation process occurring in the insect, from replicative non-infective epimastigotes to non-replicative infective metacyclic trypomastigotes. However, little is known about the possibilities of using externally available and internally stored fatty acids as resources to survive in nutrient-poor environments, and to sustain metacyclogenesis. In this study, we revisit the metabolic fate of fatty acid breakdown in T. cruzi. Herein, we show that during parasite proliferation, the glucose concentration in the medium can regulate the fatty acid metabolism. At the stationary phase, the parasites fully oxidize fatty acids. [U-14C]-palmitate can be taken up from the medium, leading to CO2 production. Additionally, we show that electrons are fed directly to oxidative phosphorylation, and acetyl-CoA is supplied to the tricarboxylic acid (TCA) cycle, which can be used to feed anabolic pathways such as the de novo biosynthesis of fatty acids. Finally, we show as well that the inhibition of fatty acids mobilization into the mitochondrion diminishes the survival to severe starvation, and impairs metacyclogenesis. Author summary: Trypanosoma cruzi is a protist parasite with a life cycle involving two types of hosts, a vertebrate one (which includes humans, causing Chagas disease) and an invertebrate one (kissing bugs, which vectorize the infection among mammals). In both hosts, the parasite faces environmental challenges such as sudden changes in the metabolic composition of the medium in which they develop, sever

Foreign Player Tracker

It really does, I swear!

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

They’re on standbi

Buenosdillas

Pilot on me!!

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

When I got home, they were still there.

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

I won't be doing that today!

You take away their little brooms

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

There hasn't been a post all year!

Why

It’s pronounced “Noel.”

After all his first name is No-vac

What, then, is Chinese rap?

Edit:

Notable mentions from the comments:

• Spanish/Swedish/Swiss/Serbian hits

• French/Finnish art

• Country/Canadian rap

• Chinese/Country/Canadian rock

• Turkish/Tunisian/Taiwanese rap

[Removed]

I'm surprised it hasn't decade.

There hasn't been a single post this year!

(Happy 2022 from New Zealand)

Nothing, it just waved

Bob

Just to clarify, 12345678

Introduced: Sponsor: Rep. André Carson [D-IN7]

This bill was referred to the House Committee on Transportation and Infrastructure which will consider it before sending it to the House floor for consideration.

Rep. André Carson [D-IN7] is a member of the committee.

Govtrack.us Summary

https://doi.org/10.1371/journal.pone.0248482

Enteral nutrition modulation with n-3 PUFAs directs microbiome and lipid metabolism in mice

Abstract

Nutritional support using exclusive enteral nutrition (EEN) has been studied as primary therapy for the management of liver diseases, Crohn’s disease, and cancers. EEN can also increase the number of beneficial microbiotas in the gut, improve bile acid and lipid metabolism, and decrease the number of harmful dietary micro-particles, possibly by influencing disease occurrence and increasing immunity. This study investigated the effects of EEN-n-3 polyunsaturated fatty acids (3PUFAs) (EEN-3PUFAs) on the gut microbiome, intestinal barrier, and lipid or bile acid metabolism in mice. Metagenomic sequencing technology was used to analyze the effects of EEN-3PUFAs on the composition of gut microbiome signatures. The contents of short-chain fatty acids (SCFAs) and bile acids in the feces and liver of the mice were assayed by gas chromatography and ultra-high-pressure liquid chromatography/high-resolution tandem mass spectrometry, respectively. The levels of lipopolysaccharide (LPS) and D-lactic acid in the blood were used to assess intestinal permeability. The results indicated that EEN-3PUFAs could improve the composition of gut microbiome signatures and increase the abundance of Barnesiella and Lactobacillus (genus), Porphyromonadaceae, and Bacteroidia (species), and Bacteroidetes (phylum) after EEN-3PUFAs initiation. In addition, EEN-3PUFAs induced the formation of SCFAs (mainly including acetic acid, propionic acid, and butyric acid) and increased the intestinal wall compared to the control group. In conclusion, EEN-3PUFAs modulate the alterations in gut microbiome signatures, enhanced intestinal barrier, and regulated the fatty acid composition and lipid metabolism shifts and the putative mechanisms underlying these effects.

Authors:

Joseph Blommer, Megan C. Fischer, Athena R. Olszewski, Rebeccah J. Katzenberger, Barry Ganetzky, David A. Wassarman, William H. Hoffman, Stephen A. Whelan, Norman Lee, Roaya S. Alqurashi, Audrey S. Yee, Taylor Malone, Sumaiah Alrubiaan, Mary W. Tam, Kai Wang, Rozena R. Nandedwalla, Wesley Field, Dalal Alkhelb, Katherine S. Given, Raghib Siddiqui, James D. Baleja, K. Eric Paulson, Amy S. Yee, Irene Tosi, Tatiana Art, François Boemer, Dominique-Marie Votion, Michael S. Davis, Hyun Sang Kim, Eun Tae Kim, Jun Sik Eom, You