Why do normally quiet sensory neurons start firing after nerve injury? What are the signalling molecules, receptors and ion channels involved? (University level answer)

I just wrote that it's because of :

-Large A-delta&c-fibre nociceptor activation causing a release of glutamate from Dorsal root ganglion cells to 2nd order neurones in the substantia gelatinosa of the spinal cord. This unsilences NMDA receptors and activates them causing a large ca2+ influx into 2nd order neurones. This triggers an intracellular signalling cascade e.g., MAPK pathway that activates gene transcription that promotes central sensitisation and nociceptive signalling.

-Spontaneous primary afferent discharge

There is a lowered activation threshold and receptive field size increases.

The prolonged increase in membrane excitability-caused by changes in threshold+activation kinetics of NMDAR+AMPAR strengthened excitatory synaptic inputs(changes in the trafficking of AMPAR to membrane&alterations in ion channels to increase inward currents+reduce outward currents-caused by gene expression changes&by production+trafficking of receptors,channels&downstream signalling pathways)+reduced inhibitory interneurone activity) causing a reduction in release or activity of gaba+glycine (disinhibition).

- Changes in expression& activity of caused by cytokines, growth factors (e.g., BDNF) etc. altering Nav1.3, Nav1.8, Nav1.9 expression and activity, this causes sub-threshold membrane potential oscillations and ectopic activity-as primary afferent neurones start firing spontaneously. Nav1.7-gain in function via mutation causes ectopic activity in c-fibres. Nav1.3 expressed in development but nerve injury causes adults to express it, it has fast gating kinetics which causes depolarising after potentials, contributing to pain

What are some other points I can make?

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πŸ“…︎ Jan 06 2022
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Frontier Fauna: The Frillbeak | blind, diminutive cousins of the Viperwolf. They travel in packs, and use their flap-like sensory receptors for both sight and in threat displays. v.redd.it/1yu3loshsb981
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πŸ“…︎ Jan 02 2022
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A platypus closes its eyes, nose, and ears when it dives in search of bottom-dwelling invertebrates relying solely on its bill which has super-sensory receptor cells that help the platypus detect movements and subtle electric fields produced by its prey. This sixth sense is called electroreception.
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πŸ‘€︎ u/KimCureAll
πŸ“…︎ Jun 28 2021
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Sensory receptors that I always lose free points in! My friend and I remember it this way, hope it helps! A Leo a day keeps loneliness away.
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πŸ‘€︎ u/leprakraken
πŸ“…︎ Jul 20 2021
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That freakish star on the star nosed mole has more than 25,000 minute sensory receptors
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πŸ‘€︎ u/nofomo2
πŸ“…︎ Apr 09 2021
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Free Nerve endings vs Sensory receptors?

Every time I come across this card, I think it's sensory receptors!! What's the difference between sensory receptors and free nerve endings?

https://preview.redd.it/zydbk9l2mhn61.png?width=856&format=png&auto=webp&s=c92d2d8722b37f163faa56970077b98b100cdc82

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πŸ‘€︎ u/Henna-ali
πŸ“…︎ Mar 17 2021
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Hearing, sense of taste, and sense of smell are all just tactile on different sensory receptor.
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πŸ‘€︎ u/balloon_80391
πŸ“…︎ Dec 25 2020
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The sonic particle wave blaster that puts images,sounds and affects in all sensory receptors using local devices. β€œphone tablets etc” by hacking works will now be used on target 1. THE MISSION CONTINUES
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πŸ‘€︎ u/RoyTamII
πŸ“…︎ Apr 03 2021
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The Types as Sensory Receptors

Nociceptor: INTJ, ISTJ, ESTJ

Nociceptors send pain signals to the central nervous system. In other words, they make your body say "NO!" so you can get away from danger or take care of something that is wrong with your body.

Thermoreceptor: ISTP, INTP, ENTP

Thermoreceptors are dedicated to sensing temperature changes. They quickly adapt to constant stimuli.

Mechanoreceptor: ESTP, ENFP, ENTJ

Mechanoreceptors detect touch, pressure, sound, and vibration from the external environment. A specialized mechanoreceptor called a proprioceptor senses the body in relation to the environment.

Chemoreceptor: ESFJ, ENFJ, INFJ

Chemoreceptors pick up chemicals from the environment to send certain signals to the brain. Thet detect smells, tastes, and changes in the pH of the blood.

Photoreceptor: ISFP, ESFP, ISFJ

Photoreceptors are located in the human retina and allow (most of) us to see the world in full color.

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πŸ“…︎ Nov 29 2020
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Sensory Receptors

Does anyone ever wonder if everyone else's senses are fundamentally different? Like... What if your red would be what you see when you see the color "green" through their eyes? What of sounds? Tastes? Thoughts?

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πŸ‘€︎ u/Tartarus-Vampire
πŸ“…︎ Dec 17 2020
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It is believed that elephants have more sensory receptors in the tip of nose than the tip of the peepee
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πŸ‘€︎ u/fukyoucancer
πŸ“…︎ Dec 30 2019
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Sensory homunculus used in science to show where touch receptors are located. images.app.goo.gl/YzgXdVe…
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πŸ‘€︎ u/rainbow_blobfish
πŸ“…︎ Jan 05 2021
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The histamine receptor H4 is functionally expressed on murine colonic sensory neurons and contributes to chronic visceral hypersensitivity (implications for IBS) youtube.com/watch?v=rPOge…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Apr 10 2020
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In need of a good way to remember the sensory receptors

Does anyone have a good mnemonic to remember what the functions of meisner, ruffini, pacinian, merkel's receptors...I really doubt we would need to be able to tell the difference, but I keep seeing them on my anki cards and can't remember which does which for the life of me haha. Thanks!!

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πŸ‘€︎ u/kronimus64
πŸ“…︎ Jul 29 2020
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I need to know...Im busy with work n' stuff however feel like Im slightly loosing it (in a balcony-less flat)...but my receptors are going crazy about nature and music. Anyone else feeling this compensatory sensory effect?
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πŸ‘€︎ u/bickering_fool
πŸ“…︎ Apr 17 2020
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Decades-old model of slow adaptation in auditory sensory receptors is not supported in mammals advances.sciencemag.org/c…
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πŸ‘€︎ u/TheBlackCat13
πŸ“…︎ Aug 16 2020
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Do you think there's a purpose to the Xenomorphs iconic elongated head? Does it house a large brain, perhaps extra sensory receptors, or something else entirely?
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πŸ‘€︎ u/Gak-Man
πŸ“…︎ May 07 2018
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Cicada Ocelli (singular Ocellus) are simple photo-receptors (light detecting organs). They consist of a single lens and several sensory cells. (Cicadoidea) 3172 x 2508 pixels. [OC] KY, USA.
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πŸ‘€︎ u/dreadredheadfae
πŸ“…︎ Jul 23 2020
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Cicada Ocelli (singular Ocellus) are simple photo-receptors (light detecting organs). They consist of a single lens and several sensory cells. (Cicadoidea) 3172 x 2508 pixels. [OC] KY, USA.
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πŸ‘€︎ u/dreadredheadfae
πŸ“…︎ Jul 23 2020
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We interact with the world using our 5 senses: touching , smelling , tasting, seeing and hearing. Maybe humans have not evolved a sensory receptor and are missing out on something huge.

Imagine if we didn't had a ability to touch and feel or if we had not developed the nose , we would have never known what it is like to smell the world around us. Imagine the world without ability to see if we didn't had eyes . Now how are we sure that we have it all. Maybe we missed out on some important sensory receptors and are not experiencing the world as it is in reality.

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πŸ“…︎ Nov 09 2019
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The histamine receptor H4 is functionally expressed on murine colonic sensory neurons and contributes to chronic visceral hypersensitivity (implications for IBS) youtube.com/watch?v=rPOge…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Apr 10 2020
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Question about the role of the sensory receptors compared to the sensory cortoces

I have two questions regarding the fact that each sensory receptor has its specific ion channels that open in response to a specific stimulus (for example, ion channel that opens when streching for somatosensation), and is (the receptor) connected to correspondent sensory cortex.

  1. Did our sensory system developed perfectly so that each ion channels in the sensory receptors are connecting to the corespondent sensory cortex? If not, can you elaborate and give examples?
  2. Theoretically, what would happen if they weren't corresponding? And specific, if for example, we had sound receptor that was connected to the visual cortex?
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πŸ‘€︎ u/idop11
πŸ“…︎ Jun 14 2020
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The histamine receptor H4 is functionally expressed on murine colonic sensory neurons and contributes to chronic visceral hypersensitivity (implications for IBS) youtube.com/watch?v=rPOge…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Apr 10 2020
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Dome pressure sensor receptors, which are unique to crocodilians, are sensory organs in the animal's face (and body for Nile crocs) that detect pressure, temperature, and chemical changes in the environment around them. Crocodilians use this information to orient their bodies toward potential prey. previouslife.lanevol.org/…
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πŸ‘€︎ u/FillsYourNiche
πŸ“…︎ Jan 21 2019
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Dome pressure sensor receptors, which are unique to crocodilians, are sensory organs in the animal's face (and body for Nile crocs) that detect pressure, temperature, and chemical changes in the environment around them. Crocodilians use this information to orient their bodies toward potential prey.
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πŸ‘€︎ u/FillsYourNiche
πŸ“…︎ Feb 13 2019
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Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity doi.org/10.1152/ajpgi.004…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Oct 09 2019
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Is it possible to interpret nerve signals from sensory receptors in the brain?

In stroke patients or similar cases where feeling is lost in parts of the body but mobility is somewhat recovered, the frame work for the peropheral nerves still function but the stimulus isn't being recognised by the brain due to the injury. Would it be feasible to create an artifical somatosensory cortex that interprets the signal for the brain or perhaps "rewire" the unaffect hemisphere to take on that role?

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πŸ‘€︎ u/GodonSpeed
πŸ“…︎ Jan 03 2019
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Dome pressure sensor receptors, which are unique to crocodilians, are sensory organs in the animal's face (and body for Nile crocs) that detect pressure, temperature, and chemical changes in the environment around them. Crocodilians use this information to orient their bodies toward potential prey.
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πŸ‘€︎ u/FillsYourNiche
πŸ“…︎ Jan 21 2019
🚨︎ report
Dome pressure sensor receptors, which are unique to crocodilians, are sensory organs in the animal's face (and body for Nile crocs) that detect pressure, temperature, and chemical changes in the environment around them. Crocodilians use this information to orient their bodies toward potential prey. previouslife.lanevol.org/…
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πŸ‘€︎ u/FillsYourNiche
πŸ“…︎ Jan 22 2019
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Sensory receptors

Are slowly adapting receptors better at signaling the length or the intensity of a stimulus? Thanks in advance!

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πŸ‘€︎ u/sunset1098
πŸ“…︎ Jul 26 2019
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Mnemonic sensory receptors

Any mnemonic for sensory receptors?

Pacinian, Ruffini...

Tks

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πŸ‘€︎ u/Pterigoide610
πŸ“…︎ Aug 17 2018
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