I've recently cut Magnesium Citrate from my stack (250mg) and I've noticed my thinking has become much faster and I have shorter bouts of brain fog/lethargy.
I decided to stop taking it for three days and then add it back on the third day in the afternoon. That afternoon, I became intensely sluggish and unable to form coherent thoughts or remember much detail.
I've tried various forms of magnesium over the past year including threonate, glycinate, citrate, oxide, and taurate. They all give the same negative side effects.
The only reason I discovered this now is that I ran out of magnesium and didn't restock in time so I had two whole days without magnesium supplementation.
I will add that I have been taking many other supplements in attempt to reduce brainfog and increase cognition however I really noticed huge changes when I stopped taking magnesium, much more than taking any other supplement.
I know for a fact that I do not get sufficient magnesium from my diet so magnesium is supposed to help yet it only hurts my cognition. Why is this?
Just like Magnesium deficiency takes time to manifest if you're eating poorly, it takes time to reverse it once you have it.
A human study found that 3 months of daily Magnesium supplementation are needed to significantly increase RBC (Red Blood Cell) Magnesium levels. The study used Magnesium Di-Malate (supplement form is usually Magnesium Mono-Malate, should be similar), and Vitamins B6, B9 and B12, as it is known B6 improves Magnesium absorption.
After 30 days, the participants had a 6% higher RBC Mg content. After 90 days, however, the participants had a 30% higher RBC Mg content, which is considered a significant increase. The 6% increase at 30 days could be beneficial as well, but it shows that restoring normal Magnesium stores in the body can take a long time.
Magnesium Malate is known to be well absorbed, but even with its good absorption, it can take as long as 3 months to fix a deficiency.
It seems like many people here decide that a certain Magnesium supplement is useless, after only a few weeks on it, and then switch to another one that they claim to find more effective. What might actually be happening, is that the multiple weeks of being on the first Magnesium supplement partially fixed the deficiency, making the second Magnesium supplement build on top of that, hence having more noticeable effects.
It was a cell fulfilling prophecy.
Manganese is said to be an essential trace mineral, required for the body in small amounts (RDA of 2.5mg) to function optimally. The body does not produce Manganese however it's stored in the in the liver, pancreas, bones, kidneys, and brain.
Animal food sources of manganese are lacking. Mussels are a great one but I think it's safe to assume that the Paleolithic were not always eating mussels on the regular. So, being a firm believer that the optimum human diet is/was completely (or 99%) carnivorous this leads me to two conclusions:
A) Manganese is not really essential and/or similar to vitamin C in that it's requirements drop dramatically in carnivorous diet and/or a almost completely void of carbohydrates
or
B) Manganese intake in the Paleolithic came from non-traditional food sources like consuming small amounts of dirt/soil or via drinking water
Sort of leaning towards a combination of the two. Anyone want to speculate with me? When I researched Boron before, another essential trace mineral, the answer lied in "B". Boron is commonly found in natural water springs as well as soil/dirt (and soil used to have a lot more Boron)
I mean it's safe to assume the Paleolithic consumed some amount of dirt right...they certainly didn't have plates to put the meat on! Also I'd imagine some dirt was consumed via drinking water. With an RDA as low as 2.5mg and Manganese capable of being stored by the body this is what I'm thinking. Thoughts?
Thanks.
Hi guys, I wanted to know if anyone has experienced or has any ideas on this. So basically I was taking a strong dose of ZMA every night before bed for about a year. I was also accidentally supplementing extra zinc, b6 and magnesium from my daily supplementation routine for some time without realising and this over a long period of supplementing for over a year, resulted an issue.
The reason I was doing this was because I was intent on becoming healthy and fit after having being a fat fuck for a long time. I was basically trying everything in the book. This was along with an excersise regime that I started, working out 4 or 5 days a week, mostly compound and bodyweight lifting with some cardio.
I made some great progress, gained a lot of strength and was looking better. Then, one day after working out I got shortness of breath. I thought wow, this is weird. Must've went too hard, maybe I injured my diaphragm? Weird. Anyway, moved on, didn't pay much heed. This issue started to come back after working out more and more frequently, until eventually, it was constant and even when I wasn't working out or doing any activity at all. I would be having breathing problems for weeks on end. Really struggling to breathe properly every day and at this point I stopped all working out because it would nearly make me pass out and I just had no strength at all anymore.
Doctor said it was a workout related injury and sent me on my way, they didn't probe more even after I asked for some tests (healthcare here can be quite bad, doctors see you for 5-10 minutes and that's that). So I waited, like the doctor said and there was no improvement after 3 weeks. I went back and the doctor said I must have exercise induced asthma. He asked a bunch of questions like, have you ever had issues with asthma before, did you ever have breathing issues as a child, did you ever experience problems excersising as a kid to which I answered no to all of them because I was actually a super hyperactive kid and had no issues like that. Still, he said, exercise induced asthma and gave me an inhaler and sent me on my way telling me to take it before working out. So I tried this and as expected, it didn't affect my breathing at all. I didn't feel any of the "widening" airways like it was supposed to do because I never felt like my airways were closed or it was "like breathing through a straw", that wasn't the issue. Frustrated, I went to do some private blood testing. That's when I saw some signs o
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Sometimes I, and probably a lot of you guys, end up seeing a post claiming that magnesium reduce withdraw or side effects of some drugs.
Most of what I saw there's no scientific paper linked, one had this linked, about NMDA role in drug tolerance.(google scholar said it was cited 228 times)
I always thought why, most times I searched "magnesium and x drug" x being modafinil, methylphenidate or adderall. I never found anything. But once I typed "magnesium in drug dependences" and found this, and google scholar said it was cited just 17 times.
" Abstract. Magnesium decreases the intensity of some drug-induced dependences (e.g. opiates, nicotine, cocaine, amphetamine, ethanol, etc.). The main mechanism involved is a decreasing activity of central glutamatergic synapses, especially those involved in the reward system. There are many particularities of action for each drug dependence. Apart from the effects during emerging dependence, magnesium ions administered only during the withdrawal syndrome decrease the intensity of clinical symptoms. In some cases, Mg2+ decreased the relapse and reinstatement of cocaine and amphetamine intake. Administered alone, in the absence of any abused drug, Mg2+ has moderate stimulatory effects on the reward system and reinforcement, without inducing dependence. The existent data stress a modulatory role of Mg2+ in some drug-induced dependences. Therapeutic administration of magnesium decreases nicotine dependence and cocaine/amphetamine self-administration. "
And for me at least, the most impressive part of the paper was in the final paragraph of the opiate subtitle:" Treatment using magnesium l-aspartate (732 mg/day) for 12 weeks decreases the frequency of relapse in heroin addicted patients treated with methadone. The urinary test was positive for 22.6% in the group of patients who received magnesium vs 46.4% in the placebo group [33]. "
I just want to put this paper into light, because by number of times it was cited, it does not looks much famous. I'm not specialist in any area of biology or health, just a bit skeptic, and also want if possible a specialist opinion on this paper.
TL:DR; I found a paper that claims magnesium does decrease dependence of some drugs.
HeHeHe OMg
There was a thread on here earlier this month where I mentioned I was switching from strictly supplementing magnesium glycinate to a combo of magnesium malate and glycinate and a redditor or two wanted me to follow up with an experience report, so here it is!
I've been taking magnesium glycinate for years, probably 7 or 8 years if I had to guess and I consider it one of my few essential supplements. Due to modern farming practices and soil depletion the magnesium content of our food (including meat) has a much lower magnesium content than it once did. If you supplement vitamin D3, as you probably should, your requirements for magnesium go up as well. Furthermore things like coffee consumption, alcohol consumption, environmental pollutants and stress also deplete magnesium. For these reasons I supplement.
Anyway, glycinate (Doctors Best brand) has always been my magnesium of choice and for most of those 7 or 8 years I took it at a dosage of 400mg, divided into two daily doses, 200mg in the morning and 200mg in the evening. A month or so ago I started to suspect my morning dose of glycinate was causing some brain fog and fatigue. Subtle enough that it took me awhile to notice this but prevalent enough that I started skipping my morning doses with good success. I still however wanted to hit ~400mg of magnesium daily and not take such a large dose of glycinate all at once in the evening; in comes magnesium malate.
15 days ago I started taking magnesium malate (NOW brand) in the morning/afternoon and glycinate in the evening. This knocked out the day time brain fog and fatigue the morning/afternoon dose of glycinate was giving me. It's hard to pin down for certain but I actually feel like the magnesium malate gives me a nice energy boost ta-boot! So anyway, that's my report. Two types of chelated magnesium are better than one and I highly recommend a combo of malate and glycinate as opposed to just glycinate alone.
TL;DR: Just read the last paragraph.
Also, why aren't phosphorous rich foods recommended at the end of an extended fast more often?
Hi Reddit, I am Kit Yates. I'm a senior lecturer in Mathematical Biology at the University of Bath. I'm here to dispel some rumours about my fascinating subject area and demonstrate how maths is becoming an increasingly important tool in our fight to understand biological processes in the real world.
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On a personal note I'm from Manchester, UK, so it's almost a pre-requisite that I love football (Manchester City) and Music (Oasis were my favourite band). I also have two young kids, so they keep me busy outside of work. My website for both research and pop maths is https://kityates.com/
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What?! Have we all been making substances contaminated with mag sulfate for decades whenever we dry ether solutions with MgSO4?
https://en.wikipedia.org/wiki/Magnesium_sulfate
I can't a find corroborating primary source.
My worst issue with this is that sodium sulfate is known to not be very good at drying diethyl ether.
Edit: I titled this wrong, its 1 g/100 mL which is more concerning. At 1 g/L I would be OK.
I was like OMg
- DOI/PMID/ISBN: 30829204
- [URL] :
Thank you!
