https://pubmed.ncbi.nlm.nih.gov/34837347/
Abstract:
>The psychopharmacological properties of the psychedelic drug lysergic acid diethylamide (LSD) have attracted the interest of several generations of scientists. Whilst further explorations involving novel LSD-type compounds are needed to assess their potential as medicinal drugs, the emergence of novel derivatives as recreational drugs has also been observed. 1-Valeroyl-LSD (also known as 1-valeryl-LSD, 1-pentanoyl-LSD, 1V-LSD, or "Valerie") is a new N1 -acylated LSD derivative that recently appeared on the online market and it could be viewed as a higher homolog of ALD-52, 1P-LSD, and 1B-LSD. The present study included the analytical characterization and involved various methods of mass spectrometry (MS), gas- and liquid chromatography (GC and LC), nuclear magnetic resonance spectroscopy (NMR), GC solid-state infrared (GC-sIR) analysis and Raman spectroscopy. The in vivo activity of 1V-LSD was assessed using the mouse head twitch response (HTR), a 5-HT2A -mediated head movement that serves as a behavioral proxy in rodents for human hallucinogenic effects. Similar to LSD and other psychedelic drugs, the HTR induced by 1V-LSD was dose-dependent and the median effective dose for 1V-LSD was 373 nmol/kg, which was about a third of the potency of LSD (ED50 = 132.8 nmol/kg). Lysergamides containing the N1 -substituent typically act as weak partial agonists at the 5-HT2A receptor and are believed to serve as prodrugs for LSD. 1V-LSD is also likely to be hydrolyzed to LSD and serve as a prodrug, but studies to assess the biotransformation and receptor pharmacology of 1V-LSD should be performed to fully elucidate its mechanism-of-action.
Just came out yesterday so no full text available on sci-hub yet. Anyone have a source for it?
What have your experiences been like with 1V-LSD in comparison to the other LSD prodrugs?
Welcome back,
For the second challenge we are gonna remix a track from our season 1 winner u/Monarch_Techno.
As the winner of our first reworx challenge, he has been kind enough to provide us with some stems from his challenge winning track: LYSERGIC ACID DIETHYLAMIDE! Huge shout out to him!
The Stems
You can have a listen to the original track over here
The stems to the track can be found over here
Rules:
- Any plagiarism or cheating will result in a permanent ban from these challenges.
- If you are willing to compete in these challenges. Try to take time and give some feedback to other contestants as well. In the and this is all fun and games but producers really appreciate feedback above anything else.
- Deadline: Friday 5 November, 23.59 CEST
- HAVE FUN!
Well Germany banned all dissos and psychs that were available on the RC market yesterday and now a reptiloid told me that 1V-LSD will start shipping at the end of the month. Has anyone heard of this chemical before or has any (un)educated guesses about it? Excited to hear what y'all think
I’m having a rendez-vous with Alice
And she’s taking me to Wonderland
Where we’ll spend the evening in the palace
Of a crazy queen who loves to command.
I’ve got front row seats at a tennis match
Between Tweedledee and Tweedledum;
With the caterpillar I’ll smoke a batch
Of mushrooms to treat my chronic boredom.
Munch on the tea leaves of the mad hatter
It thrashes your head like cookie batter.
Look at the turtle with the head of a calf
Watch it stretch out its neck like a giraffe.
When the grinning cat pounds logic’s hammer
Don’t dare speak the truth and watch your grammar.
I'm also curious to know, how the process in the context of legality too, logistically speaking, well prior to this Lysergimide being illegal ofc, how do research chemical labs in europe generally source controlled precursors?, is it done legally with licenses by the government?, is there a regulated market in the EU for ergot and well for precursors to Lysergimides? PS: I'm not asking for sources, just curious on the process.
