Abbott recently announced its upcoming consumer biowearable device that will track a series of indicators linked to metabolic health - glucose, ketones and lactate. They also mentioned tracking alcohol levels as well.

Abbott has also created Freestyle Libre which is a continuous glucose monitor. The Lingo sensors are still under development and not intended for medical use.

“Diabetes was our first priority, and we wanted to get it right, so we focused intently on it,” said CEO Robert Ford. “Now that we have the evidence and the expertise that comes from 3.5 million users, we’re going to take it to the next level. We’re going to translate a wide range of biometric signals: glucose, ketones, lactate and alcohol.”

“This will be like having a window into your body,” said Ford. “It’s science that you will be able to access any time so you can understand what your body is telling you and what it needs. Our vision is that Lingo will go far beyond today’s wearables for consumers to help you proactively manage your health, nutrition and athletic performance [1].”

They expect their first Lingo product, Lingo Keto, to be available in Europe later this year.

Source: https://abbott.mediaroom.com/2022-01-06-Abbott-Announces-Future-of-Biowearables-at-Consumer-Electronics-Show

You can also checkout their youtube video showcasing the product and features: https://www.youtube.com/watch?v=6Lfmn49I5Sk

Hello! I’m curious about this. What happens when you eat, let’s say 1000 calories, over your calorie goal or typical calorie intake.

The way with a high carb diet there’d be hyperinsulinemia chillin for a while, does overeating with keto cause extra ketones to float around to manage all the extra fat/nutrients?

Or is there also an insulin spike with too much energy consumption on keto, regardless of macros?

Ultimately I know that within keto it’s also about calories so I’m curious the mechanism for how weight gain happens if insulin is very low.

Thanks!

I haven’t been on top of making sure I eat enough lately and as someone in college it can kinda just go by the wayside. Tonight I’ve been feeling extra thirsty with a dry mouth and tested my ketones which were 0.6mmol according to the meter. This should be fine right? I’ve been diagnosed for less than a year at this point so I don’t know exactly what levels to look out for and when I might just be overthinking things

Hi all,

Wondering if someone can give me some input. I’ve had three instances in the past 8 days where my sugar has spiked to over 14mmol between 3am and 6am; the rise starting around 3am. My libre wakes me up with a high glucose alarm, and I check blood ketones and they are between 0.8-1.2mmol. I change my pump site, dose, and I come down quickly.

But like what the hell!! 3 bad overnight sites at the same time within about a week? This is terrible luck, or is something else happening? For the record I know it could very well just be three bad sites, or me laying on it funny in a certain position. I’m assuming it’s this and it is the obvious answer.

But my concern is something else medically happening. Can I just become randomly insulin resistant for a period of time on some days and not others? Is my body being super weird with a new issue in the early morning??

Other nights/mornings I’m perfectly fine and in target, wake up and my sugar is 5.7mmol, so I don’t adjust the basal or I’ll go low.

Just wondering if someone has experienced the same thing, other than bad sites. This disease is so fun :))))))

Hi. I’m fairly new to this woe and it’s going ok I think ! Was very interested in the 20g carb post…. However my q is what ketone tests do you use? I’ve been consistently on / under 30g (and 1400 cals)but testing using Seba Nutrition KETO test strips always produce a negative result.I bought two boxes off Amazon so have tried both & have same results.. bit gutted. Any thoughts or recommendations for another brand or, are there other indications that you are in ketosis? I’m definitely not as hungry…..

I recently posted about my stupid keto rash that is ruining my life right now and for a while I thought it was dairy but it has returned again without me eating dairy.

I had an idea that maybe if I add some exogenous ketones I can see if the rash gets worse and maybe I can determine if it is the actual ketones I am reacting to?

Would this even be worthwhile? I really don't know anything about exogenous ketones or if they behave the same way as ketones produced naturally. Just getting a bit desperate :(

When a Type 1 Diabetic attempts to follow an extremely low carb diet they would have to take close to no insulin or else they would risk facing repeated low blood sugar levels which then would force them to eat carbohydrates to raise, making the diet no longer low carb. When insulin levels are cut too far down from a low carb diet, why doesn’t ketoacidosis occur? Do Type 1 Diabetics on keto produce more ketones because of this? And if so, does that mean that they can shred excess fat at a more effective rate than someone without the disease?

I’ve recently started Keto and am loving everything about it - the weight loss, no sugar cravings, never hungry and feel better all together. But just curious, what DOES happen to that 20g of net carbs if the body is using ketones instead? I guess it doesn’t really matter, but my logical mind just wants to know. Haven’t seen anyone say anything about it before.

Warning! Not peer reviewed!

https://www.biorxiv.org/content/10.1101/2022.01.04.474961v1

Summary

Short-term fasting is beneficial for the regeneration of multiple tissue types. However, the effects of fasting on muscle regeneration are largely unknown. Here we report that fasting slows muscle repair both immediately after the conclusion of fasting as well as after multiple days of refeeding. We show that ketosis, either endogenously produced during fasting or a ketogenic diet, or exogenously administered, promotes a deep quiescent state in muscle stem cells (MuSCs). Although deep quiescent MuSCs are less poised to activate, slowing muscle regeneration, they have markedly improved survival when facing sources of cellular stress. Further, we show that ketone bodies, specifically β-hydroxybutyrate, directly promote MuSC deep quiescence via a non-metabolic mechanism. We show that β-hydroxybutyrate functions as an HDAC inhibitor within MuSCs leading to acetylation and activation of an HDAC1 target protein p53. Finally, we demonstrate that p53 activation contributes to the deep quiescence and enhanced resilience observed during fasting.

Authors:

Daniel I. Benjamin, Pieter Both, Joel S. Benjamin, Christopher W. Nutter, Jenna H. Tan, Jengmin Kang, Leo A. Machado, Julian D. D. Klein, Antoine de Morree, Soochi Kim, Ling Liu, Hunter Dulay, Ludovica Feraboli, Sharon M Louie, Daniel K Nomura, Thomas A. Rando

I've been on keto for about 8 months. I'm usually between 0.5-1.0 bhb levels. Maybe 1.5 after a long run.

However, the morning after I drink, I always get 2.5-3.0 on the blood test, which seems crazy to me. I blew 4.65 into my breathalyzer.

It's 11 hours since I stopped drinking, so there's definitely no alcohol in my system, so thats not corrupting the tests.

My blood sugar was pretty high last night so when I got up this morning I checked my ketones and it says trace. The on call doctor is not returning my call, and I feel like a hospital wouldn't take me seriously since my blood sugar is fine now. Do I just drink a bunch of water?

Has anyone used ketones with their keto diet? I've got some questions if you wouldn't mind answering! Much appreciation in advance!

I'm looking on Amazon and I've run across ketologic they seem rather inexpensive and their flavors seem intriguing enough. I'm not looking to spend an arm and a leg so has anyone tried it? Are they worth it?

Is this a supplement to take in place of a meal?

How much am I supposed to drink? Am I supposed to do once per day or with every 8oz of water that I drink? Is drinking ketones even worth it?

So I started feeling very badly, felt like I needed to throw up, dry mouth peeing a lot. So I tested my ketones and they are moderate level. But my BG has been 100% in range for the last 4 days. Should I go to the ER or wait it out and see what happens?

im using these https://www.walmart.com/ip/ReliOn-Ketone-Test-Strips-50-Count/33574014?athbdg=L1600

and they are in mg/dl but most sites measure ketosis in mmol/l

but I find different sites using different measurements. which is accurate??

http://www.scymed.com/en/smnxtb/tbcbgpr1.htm - uses mg/dl * .17212 (ex. 40mg/dl = 6.88 mmol/l)

https://complainingaboutfood.wordpress.com/2019/04/05/ketone-conversion-from-mg-dl-to-mmol-l/ - has it listed as 40 mg/dL = 3.9182 mmol/L . and explains it as such: Also, if you test at “MODERATE” “40mg/dL” you have a very high risk of DKA and should get medical help immediately. ---- is this true?

Started a zerocarb diet due as I'm trying to fix a few health problems. It's great not having to worry about my blood sugars spiking and crashing all the time but I am slightly concerned about my raised blood ketone level of 1.4 mmol/L.

I have good control of my blood sugars with a hba1c always under 6.5 and I really want to carry on with this diet. Do I run the risk of going into diabetic ketoacidosis?

Hello all, I am currently positive & have been keeping an eye on my ketones, they haven't gone above small the past few days. This morning at 9am they were small & my sugar was hovering just below 200. I've just tested again and my sugar shot up to 314 with large ketones. I tried to reach out to my endo but to my surprise(since i've never had to use it) they have no emergency line. I'm wondering if anyone has dealt with something similar, or if advice could be offered. I would really rather not go to the hospital if at all possible.

edit: thank you all! sugar is back under control & the worst of the illness is over.

Uhh…. If it isn’t one thing… it says 1+ ketones detected in my urinalysis yesterday. Can someone explain what this means? :(

https://doi.org/10.1123/ijsnem.2021-0280

https://pubmed.ncbi.nlm.nih.gov/35042186

Abstract

There has been much consideration over whether exogenous ketone bodies have the capacity to enhance exercise performance through mechanisms such as altered substrate metabolism, accelerated recovery, or neurocognitive improvements. This systematic review aimed to determine the effects of both ketone precursors and monoesters on endurance exercise performance. A systematic search was conducted in PubMed, SPORTDiscus, and CINAHL for randomized controlled trials investigating endurance performance outcomes in response to ingestion of a ketone supplement compared to a nutritive or nonnutritive control in humans. A meta-analysis was performed to determine the standardized mean difference between interventions using a random-effects model. Hedge's g and 95% confidence intervals (CI) were reported. The search yielded 569 articles, of which eight were included in this review (80 participants, 77 men and three women). When comparing endurance performance among all studies, no significant differences were found between ketone and control trials (Hedges g = 0.136, 95% CI [-0.195, 0.467], p = .419). Subanalyses based on type of endurance tests showed no significant differences in time to exhaustion (Hedge's g = -0.002, 95% CI [-0.312, 0.308], p = .989) or time trial (Hedge's g = 0.057, 95% CI [-0.282, 0.395], p = .744) values. Based on these findings, exogenous ketone precursors and monoesters do not exert significant improvements on endurance exercise performance. While all studies reported an increase in blood ketone concentrations after ingestion, ketone monoesters appear to be more effective at raising concentrations than precursors.

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Open Access: False

Authors:

• Emma Brooks
• Gilles Lamothe
• Taniya S. Nagpal
• Pascal Imbeault
• Kristi Adamo
• Jameel Kara
• Éric Doucet

I've read that via reductive amination and eschweiler-clark you can alkylate an amine OR ammonia directly by reacting it with with an aldehyde or a ketone to produce an imine that can be reduced to an amine, and this will result in a primary amine, and not a mixture of primary/secondary/tertiary amines. For example here and here both claim you can do this to ammonia directly.

For example, say I would like to make n-methylisopropylamine. First I could react acetone with ammonia and reduce the imine to pure isopropylamine, not a mixture. Then I can react this primary amine with formaldehyde and reduce the imine to pure n-methylisopropylamine, not a mixture.

However, if you google "react ammonia and acetone" some people say that this will give some complicated pyrimidine compound. Other people say it will give hexamine. Others say it results in the expected imine.

I ran into some interesting threads on sciencemadness about this. However 90% of the threads are people just making personal attacks on each other, screaming that it will result in hexamine, or that it will result in the pyrimidine, or that it will result in the imine, or that it will result in a mixture of primary/secondary/tertiary you cannot control easily. I did see one or two people who said that the result depends on ph, temperature, time, and molar excess but didn't elaborate too much.

I have a few questions. The first is, why is there any debate over this? Ammonia and acetone are very common chemcials. Has no one really reacted them together in different conditions and published the results? I would assume that of course this has already been done. But if it has, why doesn't any website I go to bother to include all the various factors and possible results?

The second question, does anyone here have experience with or know how to produce an amine from ammonia and a ketone/aldehyde? What specific factors like ph, temp, time, and molar excess are needed to result in the imine? What factors will instead result in hexamine? What factors will instead result in the pyrimidine?

The third question, the sources that claim you can make the imine from ammonia say that it will always result in the primary amine and that there will be no weird secondary reactions where the imine starts reacting with the aldehyde/ketone to result in a mixtu

I’m doing keto for a neurological disorder. I’m strict keto but can’t get about 1.5 ketones with diet alone. Anyone use exogenous ketones? Do they work? Are they worth it? Also if they do work, how long do they increase ketones for? Aka, how often would I have to take them to keep my ketones elevated? Let’s say my goal is 3.0 for example

I’m not a new diabetic, but I’ve never really been informed on what ketones are, how to test for them, what they do and why they’re bad to have in your urine or blood. Can someone inform me please?

Have any of you experienced ketones in your urine? Is this normal? My urine has a meat/weird smell and signs of ketones.

Hello, 27 year old with almost a 5 year history of T1.

I have gained lots of weight over the course of 3 years and I decided to take measures to lower my weight by going on a low carb high protein and fat diet also limiting calories to 1600-1800 at most, along with light to moderate daily exercise (more heavier on the weekends). I am averaging at 70-120 grams of carbs daily. I've also been drinking lots of water, approximately 2 liters daily or more.

I recently tested my ketones with over the counter testing strips and found my ketones to be moderate to high.

Am I at risk for DKA? If so what can I do to prevent it?

Does anyone have any additional YouTube videos of websites to help with conversion questions? Ex: Show how ____ is converted to ____. I'm very weak in organic chemistry and I'm finding it really hard to understand how to solve these questions. Do we just byheart as many answers as possible?

Thanks

Hey guys, so I’ve been an avid keto-doer on and off for about the last 2 years or so and it never fails to amaze me with what it does to my body. So I convinced my mom to do this and she’s been going very strong and sticking to it religiously for about 9 or 10 weeks now, probably lost about 15 pounds (most of it was water weight, I believe). But, it has begun to stall. Now I know sometimes that happens with keto so I wasn’t too concerned but the 15 lbs in 10 weeks seemed still way too slow for keto, especially compared to mine.

So I bought a ketone meter. I measured her ketones and they were at a measly 0.3. I was so disappointed. I don’t know how could this be possible and that’s why I’m looking for help so we could modify her diet somehow.

Here are the facts:

58 year old woman 203 to 188 lbs currently She has kept under the 20 net carbs limit religiously ever since she started. Her diet consists of a lot of vegetable including lettuce, cabbage, tomatoes, cucumbers, olives, radishes, broccoli, asparagus, green beans, okra. Most of these she eats pretty much daily, especially the first 5 or 6, but always small portions as to stay under 20 net carbs.She eats strawberries and blueberries. Ham and cheese, flour tortillas that are carb balance (4 net carbs each, I eat them all the time too) She also eats every type of meat but not very big portions, definitely doesn’t overeat proteins. Very rarely she eats some keto treats like atkins bars but it’s not often at all. Lastly 0 net carb gelatins. No medical history

Please help!

Wanted to test a 5 gal batch or mead 10lbs honey 5lbs raspberry jam and 1lb or frozen raspberries and hit it with some Voss kviek came home from work and the whole house just reeks of yeasty raspberry ketone to the point it almost got a bit chemical/paint like but I'm not worried, just the Voss doing its thing and was just an observation. I've never had this much smell from a batch and im super excited to see how it turns out as it smells wonderful just a bit strong ATM.

https://doi.org/10.14283/jpad.2022.3

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults ≥ 55 Years Old. A Study Protocol for a Double-Blinded Randomized Controlled Clinical Trial

Abstract

Background Ketone bodies have been proposed as an “energy rescue” for the Alzheimer’s disease (AD) brain, which underutilizes glucose. Prior research has shown that oral ketone monoester (KME) safely induces robust ketosis in humans and has demonstrated cognitive-enhancing and pathology-reducing properties in animal models of AD. However, human evidence that KME may enhance brain ketone metabolism, improve cognitive performance and engage AD pathogenic cascades is scarce. Objectives To investigate the effects of ketone monoester (KME) on brain metabolism, cognitive performance and AD pathogenic cascades in cognitively normal older adults with metabolic syndrome and therefore at higher risk for AD. DESIGN: Double-blinded randomized placebo-controlled clinical trial. Setting Clinical Unit of the National Institute on Aging, Baltimore, US. Participants Fifty cognitively intact adults ≥ 55 years old, with metabolic syndrome. Intervention Drinks containing 25 g of KME or isocaloric placebo consumed three times daily for 28 days. Outcomes Primary: concentration of beta-hydroxybutyrate (BHB) in precuneus measured with Magnetic Resonance Spectroscopy (MRS). Exploratory: plasma and urine BHB, multiple brain and muscle metabolites detected with MRS, cognition assessed with the PACC and NIH toolbox, biomarkers of AD and metabolic mediators in plasma extracellular vesicles, and stool microbiome. Discussion This is the first study to investigate the AD-biomarker and cognitive effects of KME in humans. Ketone monoester is safe, tolerable, induces robust ketosis, and animal studies indicate that it can modify AD pathology. By conducting a study of KME in a population at risk for AD, we hope to bridge the existing gap between pre-clinical evidence and the potential for brain-metabolic, pro-cognitive, and anti-Alzheimer’s effects in humans.

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Open Access: False (not always correct)

Authors: K.I. Avgerinos - R.J. Mullins - J.M. Egan - D. Kapogiannis

Additional links: None found

27F

I think the ketones are from not eating enough everyday. I was quarantining for a while so it was hard to get food. I also want to preface that I was on my period when I took the blood test and urine test.

blood test and urine test

Doing Keto 20:4. Any advice on ketone levels? I'm doing this along side my partner and it'll be one week tomorrow. I feel fine except for a little light headedness when I wake up in the mornings, so bought a test kit. Both of us registered at 8.0 in our urine test.