Hello all, I had seen someone recommend on here the use of the calcifediol form of vitamin D supplements in order to reduce the side effects found with the other forms of vitamin D. Is there anyone here who uses it? What is your experience (any side effects, effectiveness)?

For those who are wondering what calcifediol is, it is what's formed in the next step of the process by the liver in metabolizing the usual cholecalciferol-D3 into the active form that the body uses (further steps are required to reach the end product). The user I saw recommending it said that one could avoid requiring the use of magnesium for side effects since it is not needed to metabolize it. According to Wikipedia, " Calcifediol may have advantages over cholecalciferol for the correction of vitamin D deficiency states.[4] A review of the results of nine randomized control trials which compared oral doses of both, found that calcifediol was 3.2-fold more potent than cholecalciferol.[4] Calcifediol is better absorbed from the intestine and has greater affinity for the vitamin-D-binding protein, both of which increase its bioavailability.[18] Orally administered calcifediol has a much shorter half-life with faster elimination.[18] These properties may be beneficial in people with intestinal malabsorption, obesity, or treated with certain other medications.[18] "

I found a calcifediol product on Amazon and will be receiving it in a few days and will leave a report on how the experience goes. With regular vitamin D3, I get extreme anxiety and insomnia, magnesium supplementation helps somewhat, but then I get other side effects from the magnesium. I have a diagnosed vitamin D deficiency so I am really hoping I can tolerate this form better than the others!

This is going to be a rather wordy post on why Vitamin D in its various forms is:

• An effective treatment mechanism for covid-19
• Predictive of outcomes (severity) of covid-19
• Able to lower cases and reduce mortality across populations

A more specific tl;dr is at the bottom.

I've written this post as a more "academic" vent, since I am extremely frustrated with the clear double standards held by every major academic and governmental institution regarding covid-19 treatment and prevention. Major institutions are desperately focused on NPIs like lockdowns, mask mandates, or movement restrictions while simultaneously sitting on their hands when it comes to even such a safe intervention as Vitamin D. Early treatment or better yet preventative measures that target the disease are obviously better than the late treatment we have seen in hospitals around the world. In this case, any sort of prevention and even early (post-testing or post-positivity) treatment has been systemically rejected or ignored, while we see NPIs pushed as some apparently infallible intervention. I have come to view it as an equivalent to abstinence-only sex ed: they'll only teach you how not to have covid.

I live in Australia but have used US sources for my discussion of the evidence double standard, since they are quite jarring to read. Frankly, Australian institutions have been far lazier than their US counterparts (somehow) and have not even looked at Vitamin D as far as I can tell.

Although many treatments have been proposed, many of them have far more significant criticisms in terms of legitimacy and efficacy than Vitamin D. Whereas we see criticisms of somewhat popular drugs that are proposed for treatment such as ivermectin or fluvoxamine in a general lack of high-quality supporting evidence (I would tend to disagree, but I digress) such criticisms are not valid for Vitamin D. Even so, I will only be citing publications in Q1 sources for this post. For anyone not familiar with academic rankings, a Q1 source is one which is in the top 25% of publications overall, and I'll use scimagojr for this. Although I am not one to completely discount articles from sources that are not Q1 journals, limiting the sources in this post to Q1 only makes the work by comparison much harder to critique in a lazy manner that you typically see.

Meta-Analysis and Reviews

I will briefly mention some very high-quality meta-analysis/review articles that have been

Do your worst!

I'm surprised it hasn't decade.

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

Buenosdillas

They’re on standbi

Pilot on me!!

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

When I got home, they were still there.

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

I won't be doing that today!

You take away their little brooms

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

There hasn't been a post all year!

[Removed]

Why

It’s pronounced “Noel.”

After all his first name is No-vac

What, then, is Chinese rap?

Edit:

Notable mentions from the comments:

• Spanish/Swedish/Swiss/Serbian hits

• French/Finnish art

• Country/Canadian rap

• Chinese/Country/Canadian rock

• Turkish/Tunisian/Taiwanese rap

There hasn't been a single post this year!

(Happy 2022 from New Zealand)

Nothing, it just waved

Bob

So that I could frequently say, "I am going to walk 5 miles now."

Edit: My most popular post on Reddit! 😀 Thank you for the awards.

Just to clarify, 12345678

Me grabbing a soda from my (what I thought was) half full 12pk...

Notices there's only 2;

Me: "Awe man... This is a damn bird box!" Her: "What the hell does that mean?!" Me: (Pulls both cans out & shows them to her) "It's only got Toucans."

I'm not ashamed to admit the look on her face was glorious.

I was just sitting there doing nothing.

“BOOM”?!

free

"That's what they're fighting about."

Because his Visa didn’t work.

Because the audience only responds in a low ha