Alpha Blockers Puns

I am curious as I read a lot about the dangers of abrupt discontinuation of beta blockers, but never that much about alpha agonist (e.g clonidine) or alpha blocker (prazosin) withdrawals.

From what I understood, agonism of beta receptors has a direct effect on cardiac output, but not much on vasodilation and vasoconstriction. Yet alpha agonists target the body’s autoreceptors that are triggered in case of excessive catecholamines. I also read that beta and alpha receptors each respond to adrenaline or noradrenaline (specific to each receptor type).

Which class of drugs, in theory, would be more dangerous to stop abruptly? And why?

Does anyone have any experience or information on using psychedelics while taking alpha blockers for treating prostate issues? Cannot find any info online.

I am three weeks into Silodosin and I swear my symptoms are worse. Supposedly it takes months to work, but that sounds dubious.

Is this the wrong medication for our condition?

Just curious to see who has tried alpha blockers and whether they experienced any positive or negative effects? I tried to get some from my urologist but he suggested trying Valium suppositories first to relax the pelvic floor. These have helped some but still don’t seem as effective at relaxing the muscles in the front of the pelvic floor as they do the back side.

TNF alpha blockers are strong anti-inflammatory drugs which are used for different inflammatory diseases like arthritis.I'm wondering has anybody used these drugs for chronic epididymitis?

has anyone here tried alpha blockers in particular Silodosin? any success? side-effects?

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Has anybody ever experienced any bad sides from alpha blockers or am I losing it? I was on Aflusozin successfully for about 2-3 weeks for frequent urination and it helped. Then out of the blue I started experiencing weird mild ache in my coccyx area, tingling sensations in my buttocks area, legs and arms and general leg fatigue. I decided to stop the medication until my uro visit on the 27th. Not sure if it is sides or a cpps issue at this point. I'm also worried about being on antibiotics a few months ago for 42 days when apparently it wasn't bacterial and perhaps somehow it harmed the body.

I stretch a ton, exercise daily. Sometimes I get the feeling that it's all in my head, but then I start feeling like shit. These last few months have been hell for me. I think I've been to the doctor's office more times in the last 4 months than my 35 years combined. I know many of you have been going through this much longer. It just sucks because I felt like I was starting to get better and then, out of the blue, more health issues.

PS. Blood tests were all fine.

My dr prescribed it since the tramadol didn’t help my PE, there is also a chance it helps with my shrinkage and ED I’m hoping. Anyone have good or bad experiences?

25M 5'11 180 lbs no health issue. I been prescribed Silodosin (Rapaflo) to fix my premature ejaculation . whenever I'm on it I feel a weird sensation that is hard to describe ,definiitly not a good one , like if there is something in my head preventing me from feeling good and kinda sick.

Will taking it everyday make that side effect dissepear?

I’ve burning in perineum and penis urethra after bowel movements.

It’s most probably hypertonic pelvic floor, but I’m wondering if the use of alpha-blockers could relax the muscles and consequently ease burning and pain.

Can anyone share their experience with Alpha blockers? Specifically, how long it takes to work? I started Alfluzosin 10mg, a few days ago. On the first night, obviously had crazy side effects, tachycardia, dizziness, fatigue, stuffy nose, but at the same time, immediate relief in urinary urgency and hard flaccid; hallelujah! Now on day three, negative side effects have mostly subsided, as have the initial positives unfortunately. Does it take a while to build up in your system after that initial surge or something? Or is it possible i should try a different one?

I know NSAID’s can be bad but used the search bar and didn’t see anything about alpha blockers.

I am 10 months post flox and about 98-99% recovered and don’t wanna make matters worse again.

Over the years there have been stories of people with paruresis getting some relief (or not) by utilizing alpha blockers, along side following a program of exposure therapy and practice. For some it’s seemed to help reduce the time needed to start a stream. I would be curious to take the informal poll here to get some input.

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My Urologist prescribed Doxazosin Alpha-Blockers as a possible treatment against my symptoms of Prostatitis. He told me that there is a chance that it could help, it helped some of his patients, but others had no luck with it.
I wonder now, has anyone of you had success treating Prostatitis (or CPPS) with Alpha Blockers?
After reading through the possible side-effects (doctor also told me that at the beginning of taking it the side-effects can be quite strong), I am very sceptical of taking them. I really want to get rid of this, but to me it just doesn't sound too promising.

Hello there,

I would like to know what would happen if you take a stimulant (Noradrenaline and dopamine inhibitor), Beta blocker and alpha blocker all at the same time? Blocking both a1 and a2 receptors + b1 and b2 receptors. Where would these elevated neurotransmiters go if receptors are blocked? I'm asking because I got prescribed ritalin for adhd and antipsychotics for sleep issues which block a2 and a1 receptors. I also have a hypertension beacause of which my cardiologist wants to prescribe me a beta blocker.

Edit: Will speak to doctor about this for sure just wanna know more toughts on this if possible please. Thx.

I just found a Step 1 AnKing card with the following text:

{{c2::α}}-adrenergic antagonists cause K+ to shift {{c1::into}} cells, causing {{c1::hypokalemia}}

Likewise, there is a card claiming that alpha agonists cause hyperkalemia. Can anyone verify this information? To my knowledge, beta agonists/antagonists have been well documented to cause hypo/hyperkalemia, but I cannot find an outside source that reports the opposite effect with alpha receptors.

I know stimulants aren't good for the heart long term but do they cause any horrible reactions or anything with beta/alpha blockers? I read about one person who OD'd on cocaine and propranolol but people are saying that's just a myth perpetuated by an anecdote.

And I'm still guy what gives???

Doxazosin

Prazosin

Terazosin

•Tamsulosin(flomax)

Am I getting that right ? There was a uworld concept about this I guess but didn’t take notes unfortunately

I’m currently on propanolol and midodrine for my pots. While propanolol has improved my symptoms it has also come with unwanted side effects. I notice at 10mg 2-3 times a day it has caused me insomnia, weight gain, tiredness and some depression. Small reductions in dose just to try to mitigate the affects just result in my tachycardia being uncontrolled. I’ve been wanting to try ivabradine so I was wondering if anyone has experience with this med. if so, has it been more effective than a beta or alpha blocker?

I've been battling more acute symptoms of Prostatitis/maybe BPH for about 6 months now. I've had battles on an off through the years, but nothing that has lasted this long. My urologist prescribed alpha blockers and PT. I have been doing the PT, many yoga, icing and heat sessions, and really trying to take the alpha blockers, but they make me so tired and dizzy it's hard to stay on them. I'm an active early 40's year old male and feel like my blood pressure is dropping pretty significantly from the alfuzosin.

My question is has anyone had relief by taking alpha blockers like flomax or alfuzosin? This med knocks me out more than any I have ever taken, and I wonder how long I may need to be on this and if there are any alternatives out there that would be a little more tolerable?

Thanks!

Here is a good read about anyone who's worried about taking beta blockers with your favourite amphetamines. This also applies to coke as well as mdma, even caffeine since they all stimulate your alpha receptors.

There are studies embedded as the post goes that look further into it and it's genuinely worth a read. Even Alexander Shulgin was promoting use of propranolol at 10-20mg doses before taking mdma as in to reduce the potential side effects of his substance.

Direct link to amphetamine related study for the lazy people

"The use of butyrophenone and later-generation antipsychotics, benzodiazepines, and β-blockers is recommended based on existing evidence."

Stay safe