high tumor necrosis factor

hi everyone! i had a cytokine panel done that recently showed high tumor necrosis factor. i was wondering if anyone else has found this and treated it? possibly with tumor necrosis factor inhibitors, or other?

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πŸ‘€︎ u/dylpickledude
πŸ“…︎ Jun 06 2021
🚨︎ report
[Article] Tumor necrosis factor: function, release and clearance

success, thank you reddit

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πŸ‘€︎ u/ManBearPigDad
πŸ“…︎ May 24 2021
🚨︎ report
Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine

* ALWAYS CONSULT A DOCTOR BEFORE STARTING A PHARMACOLOGICAL CARE PROTOCOL

Venlafaxine, a serotonin and norepinephrine reuptake inhibitor antidepressant, appears to be able to provide relief to patients with NDPH by suppressing TNFa

I quote:

"NDPH is a disorder with multiple associate triggers including surgical procedure, stressful life event, and viral infection. Interestingly, the only clue to a common mechanism appears to be an increase in the inflammatory cytokine TNF-Ξ±.4 This increase in TNF-Ξ± is localized specifically to the CSF and is not present within blood serum.Prior reports have shown Venlafaxine to reduce TNF-Ξ± production within microglial cells in vitro following lipopolysaccharides stimulation as well as in sera of MDD patients.In addition, Venlafaxine binds to the 5-HT2A receptor which has been shown to cross talk with tumor necrosis factor receptor 1 (TNFR1) inhibiting its signaling.7,8Normally, TNF-Ξ± binds to TNFR1 recruiting tumor necrosis factor receptor type 1- associated death domain protein (TRADD) and Receptor-interacting serine.threonine-protein kinase (RIPK). This causes phosphorylation and degradation of IΞΊBΞ± allowing for NF-ΞΊB nuclear translocation and activity driving inflammation.8 The 5-HT2A receptor binds to serotonin/Venlafaxine leading to a G-protein-coupled pathway.8 Protein Kinase C, downstream of G-protein, inhibits phosphorylation and degradation of IΞΊBΞ± preventing NF-ΞΊB nuclear translocation and activity. We hypothesize that this inhibition of TNF-Ξ± by Venlafaxine is driving amelioration. "

A twenty-one-old patient, with more than six years suffering NDPH due to, in his own words, a series of highly stressful events, managed to eliminate the pain after six months with the administration of venfalaxine

" the patient was administered 37.5 mg of Venlafaxine and instructed to incrementally increase dosage by 37.5 mg every week if no adverse side effects occurred. We found that a dosage of 300 mg resulted in a predictable attenuation of headache pain with the average pain score decreasing to a 3. After 3 months of treatment, we tried to see if removal of Venlafaxine would allow for retention of improvement. Following a 3 week washout, there was a rise in headache pain back to baseline along with accompanying symptoms. Readministration and titration of Venlafaxine once again ameliorated symptoms. Interestingly, 6 more months of Venlafaxine treatment resulted in resolution of pain. "

" We did not measure TNF-Ξ± withi

... keep reading on reddit ➑

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πŸ‘€︎ u/K8L21
πŸ“…︎ May 09 2021
🚨︎ report
[ARTICLE] Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.
  • PMID: 8393046

  • URL

Thanks in advance!

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πŸ‘€︎ u/faux_larmes
πŸ“…︎ Mar 14 2021
🚨︎ report
Expansion of CD4 T Lymphocytes Expressing Interleukin 17 and Tumor Necrosis Factor in Patients with Major Depressive Disorder mdpi.com/2075-4426/11/3/2…
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πŸ‘€︎ u/HearTomorrow
πŸ“…︎ Mar 23 2021
🚨︎ report
Modulating inflammation through the neutralization of Interleukin-6 and tumor necrosis factor-Ξ± by biofunctionalized nanoparticles sciencedirect.com/science…
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πŸ‘€︎ u/HearTomorrow
πŸ“…︎ Feb 11 2021
🚨︎ report
Study is first to identify potential therapeutic targets for COVID-19. Scientists found that six molecules were uniquely elevated in COVID-19 ICU patients (tumor necrosis factor, granzyme B, heat shock protein 70, interleukin-18, interferon-gamma-inducible protein 10 and elastase 2). lawsonresearch.ca/study-f…
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πŸ‘€︎ u/Wagamaga
πŸ“…︎ Jun 25 2020
🚨︎ report
Study is first to identify potential therapeutic targets for COVID-19. Scientists found that six molecules were uniquely elevated in COVID-19 ICU patients (tumor necrosis factor, granzyme B, heat shock protein 70, interleukin-18, interferon-gamma-inducible protein 10 and elastase 2). lawsonresearch.ca/study-f…
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πŸ‘€︎ u/Wagamaga
πŸ“…︎ Jun 25 2020
🚨︎ report
Study Correlating Tumor Necrosis Factor Alpha with Recurrent Apthous Ulcers

"Statistically significant difference in the level of salivary TNF-Ξ± between the RAS and TUs subjects as well as controls suggests the significant contribution of TNF-Ξ± in pathogenesis of RAS."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365135/#b4-eor-52-3-157

Just read this study info and thought I'd share. I'd heard TNF-a had been linked to recurrent cankers, but this is the first study I've seen about it.

If you're a medical professional/researcher/biologist/etc., you may know more about this stuff than me, so feel free to jump in.

My layperson's understanding of TNF-a is that it's part of the immune system that goes out looking to destroy potentially damaged cells, therefore preventing those cells from spreading and royally messing things up with tumors or cancer or whatnot. So then TNF-a comes onto the scene like a super trigger-happy assassin and destroys so many cells that--voila--a canker sore appears.

My understanding from what I read in the study is that subjects with RAS (recurrent apthous ulcers--canker sores) had statistically significant levels of TNF-a in their saliva as compared to subjects without RAS. It looks like people with RAS even had higher TNF-a levels than folks without RAS who happened to have a random trauma-induced sore. (I didn't catch whether they did the saliva readings while sores were active or not.)

So of course this is only one study, but basically it looks like TNF-a is truly potentially linked with recurring canker sores.

Maybe TNF-a blockers will be a useful treatment?

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πŸ‘€︎ u/CankerLass
πŸ“…︎ Aug 14 2019
🚨︎ report
Garlic Supplementation Reduces Circulating C-reactive Protein, Tumor Necrosis Factor, and Interleukin-6 in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials (Mofrad et al., 2019) academic.oup.com/jn/artic…
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πŸ‘€︎ u/dreiter
πŸ“…︎ Apr 15 2019
🚨︎ report
Tumor necrosis factor alpha (TNF-a) inhibition, can anyone attest to what works well?

Just form what I have read, it seems like ginkgo and stinging nettle are good for stopping, and possibly reversing this, but can anyone here attest to what may work better, or which works better? Im not sure how these two would compare, but any help would be good. It seems also that TNF is also agrivated by certain foods such as bread heated past 248 F, and potato chips. I can remember the link, but if anyone knows people please help me.

Update, I found it here.

https://selfhacked.com/2014/10/20/interleukin-6/

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πŸ‘€︎ u/needstechhelp7
πŸ“…︎ Mar 07 2017
🚨︎ report
Abstract: Periodontal condition of patients with autoimmune diseases and the effect of anti-tumor necrosis factor-Ξ± therapy. "Patients with AI diseases have higher periodontal indices and higher TNF-Ξ± levels in GCF than H controls. Anti-TNF-Ξ± treatment appears to reverse this phenomenon." ncbi.nlm.nih.gov/pubmed/2…
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πŸ“…︎ Dec 09 2018
🚨︎ report
Strawberries decrease circulating levels of tumor necrosis factor and lipid peroxides in obese adults with knee osteoarthritis (2018) ncbi.nlm.nih.gov/pubmed/3…
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πŸ‘€︎ u/TheReviewNinja
πŸ“…︎ Nov 03 2018
🚨︎ report
[J] [Mental Health: Biomarkers] [Brain Zapping: Biomarkers] Interleukin-6, omega 3 and tumor necrosis factor are common neuroinflammation biomarkers of radio wave sickness, brain zapping, traumatic brain injury and depression.

Inflammation as a Predictive Biomarker for Response to Omega-3 Fatty Acids in Major Depressive Disorder: A Proof of Concept Study (2016)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581883/

>baseline biomarker data (IL-1ra, IL-6, hs-CRP, leptin, adiponectin),

IL-6 is interleukin-6. Brain zapping can induce brain inflammation and mild traumatic brain injury (mTBI). Elevated interleukin-6 and omega 3 deficiency are common biomarkers of depression, radio wave sickness, mild traumatic brain injury (mTBI) and TIs who are attacked by DEW.

https://www.reddit.com/r/Electromagnetics/comments/4t5zhw/wiki_inflammation_interleukin/

>subjects with any β€œhigh” inflammation improved more on EPA than placebo (ES=βˆ’0.39) or DHA (ES=βˆ’0.60) and less on DHA than placebo (ES=+0.21); furthermore, EPA-placebo separation increased with increasing numbers of markers of high inflammation

Omega 3 is accepted treatment for mTBI. Patients with TBI have a high rate of suicide. Possibly, brain zapping uses up omega 3 thereby causing an omega 3 deficiency which could induce depression and suicide.

[WIKI] Diet: Essential fatty acids: DHA and EPA

https://www.reddit.com/r/Electromagnetics/comments/3tddzu/wiki_diet/

Genova Labs offers fatty acid tests. Medical insurance pays for the tests.

https://www.gdx.net/product/essential-metabolic-fatty-acids-analysis-nutritional-test-blood

https://www.gdx.net/product/fatty-acids-profile-nutritional-test-blood

If deficient in omega 3, eat an epi-paleo diet and supplement with cod liver oil and DHA eggs.

[WIKI] Diet: Paleo and Epi-Paleo

https://www.reddit.com/r/Electromagnetics/comments/3tddzu/wiki_diet/

Tumor necrosis factor-a is a biomarker of depression, radio wave sickness, brain zapping and alzheimer's disease.

Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-Ξ± (TNF-Ξ±) in Major Depressive Disorder: A Systematic Review (2016)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881555/

[WIKI] Inflammation: Tumor Necrosis Factor-Ξ± (TNF-Ξ±)

https://www.reddit.com/r/Electromagnetics/comments/5zujcc/wiki_inflammation_tumor_necrosis_factor%CE%B1_tnf%CE%B1/

[J] [Brain Zapping] The combined effect of brain zapping and continuous wave lasering of lumbar spine or hip during sleep.

https://www.reddit.com/r/TargetedEnergyWeapons/comments/7d9fvc/j_brain_zapping_the_combined_effect_of_brain/

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πŸ“…︎ Nov 16 2017
🚨︎ report
Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration pnas.org/content/early/20…
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πŸ‘€︎ u/burtzev
πŸ“…︎ Oct 11 2016
🚨︎ report
Born today : December 29th - Bruce Beutler, MD, Immunologist, Geneticist, Nobel Laureate, for "their discoveries concerning the activation of innate immunity", "was the first to isolate mouse tumor necrosis factor-alpha (TNF)", "invented recombinant molecules expressly designed to neutralize TNF" en.wikipedia.org/wiki/Bru…
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πŸ‘€︎ u/spike77wbs
πŸ“…︎ Dec 29 2017
🚨︎ report
Bananas and Tumor Necrosis Factor

A Japanese study has shown yet another great thing about bananas: they stimulate one's immune system to produce Tumor Necrosis Factor.

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πŸ‘€︎ u/urdude
πŸ“…︎ Jul 23 2012
🚨︎ report
(5-HT)2A antagonist(A.K.A. Classic psychedelic drugs) reduce tumor necrosis factor alpha related inflammation. m.jpet.aspetjournals.org/…
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πŸ‘€︎ u/electricdog
πŸ“…︎ Feb 22 2015
🚨︎ report

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