Tumor necrosis factor superfamily Puns

hi everyone! i had a cytokine panel done that recently showed high tumor necrosis factor. i was wondering if anyone else has found this and treated it? possibly with tumor necrosis factor inhibitors, or other?

Tumor necrosis factor alpha (TNF-α) inhibitor is known to be elevated significantly in the cerebral spinal fluid of patient suffering from new daily persistent headache (NDPH), and chronic migraine sufferers.

Effexor is one such inhibitor.

Has anyone been prescribed Effexor for this purpose and how has it worked out?

Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine

success, thank you reddit

• DOI: 10.1615/CritRevImmunol.v37.i2-6.50
• [URL] http://www.dl.begellhouse.com/journals/2ff21abf44b19838,069604365dd5c794,2ffe033e0f62a3c6.html
• Sci-hub did not seem to have this and my institution did not have access.

• PMID: 8393046

• URL

Thanks in advance!

"Statistically significant difference in the level of salivary TNF-α between the RAS and TUs subjects as well as controls suggests the significant contribution of TNF-α in pathogenesis of RAS."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365135/#b4-eor-52-3-157

Just read this study info and thought I'd share. I'd heard TNF-a had been linked to recurrent cankers, but this is the first study I've seen about it.

If you're a medical professional/researcher/biologist/etc., you may know more about this stuff than me, so feel free to jump in.

My layperson's understanding of TNF-a is that it's part of the immune system that goes out looking to destroy potentially damaged cells, therefore preventing those cells from spreading and royally messing things up with tumors or cancer or whatnot. So then TNF-a comes onto the scene like a super trigger-happy assassin and destroys so many cells that--voila--a canker sore appears.

My understanding from what I read in the study is that subjects with RAS (recurrent apthous ulcers--canker sores) had statistically significant levels of TNF-a in their saliva as compared to subjects without RAS. It looks like people with RAS even had higher TNF-a levels than folks without RAS who happened to have a random trauma-induced sore. (I didn't catch whether they did the saliva readings while sores were active or not.)

So of course this is only one study, but basically it looks like TNF-a is truly potentially linked with recurring canker sores.

Maybe TNF-a blockers will be a useful treatment?

Just form what I have read, it seems like ginkgo and stinging nettle are good for stopping, and possibly reversing this, but can anyone here attest to what may work better, or which works better? Im not sure how these two would compare, but any help would be good. It seems also that TNF is also agrivated by certain foods such as bread heated past 248 F, and potato chips. I can remember the link, but if anyone knows people please help me.

Update, I found it here.

https://selfhacked.com/2014/10/20/interleukin-6/

Inflammation as a Predictive Biomarker for Response to Omega-3 Fatty Acids in Major Depressive Disorder: A Proof of Concept Study (2016)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581883/

>baseline biomarker data (IL-1ra, IL-6, hs-CRP, leptin, adiponectin),

IL-6 is interleukin-6. Brain zapping can induce brain inflammation and mild traumatic brain injury (mTBI). Elevated interleukin-6 and omega 3 deficiency are common biomarkers of depression, radio wave sickness, mild traumatic brain injury (mTBI) and TIs who are attacked by DEW.

https://www.reddit.com/r/Electromagnetics/comments/4t5zhw/wiki_inflammation_interleukin/

>subjects with any “high” inflammation improved more on EPA than placebo (ES=−0.39) or DHA (ES=−0.60) and less on DHA than placebo (ES=+0.21); furthermore, EPA-placebo separation increased with increasing numbers of markers of high inflammation

Omega 3 is accepted treatment for mTBI. Patients with TBI have a high rate of suicide. Possibly, brain zapping uses up omega 3 thereby causing an omega 3 deficiency which could induce depression and suicide.

[WIKI] Diet: Essential fatty acids: DHA and EPA

https://www.reddit.com/r/Electromagnetics/comments/3tddzu/wiki_diet/

Genova Labs offers fatty acid tests. Medical insurance pays for the tests.

https://www.gdx.net/product/essential-metabolic-fatty-acids-analysis-nutritional-test-blood

https://www.gdx.net/product/fatty-acids-profile-nutritional-test-blood

If deficient in omega 3, eat an epi-paleo diet and supplement with cod liver oil and DHA eggs.

[WIKI] Diet: Paleo and Epi-Paleo

https://www.reddit.com/r/Electromagnetics/comments/3tddzu/wiki_diet/

Tumor necrosis factor-a is a biomarker of depression, radio wave sickness, brain zapping and alzheimer's disease.

Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review (2016)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881555/

[WIKI] Inflammation: Tumor Necrosis Factor-α (TNF-α)

https://www.reddit.com/r/Electromagnetics/comments/5zujcc/wiki_inflammation_tumor_necrosis_factor%CE%B1_tnf%CE%B1/

[J] [Brain Zapping] The combined effect of brain zapping and continuous wave lasering of lumbar spine or hip during sleep.

https://www.reddit.com/r/TargetedEnergyWeapons/comments/7d9fvc/j_brain_zapping_the_combined_effect_of_brain/