I have been diagnosed with “benign joint hypermobility”. Am HLA B27 positive (which I know doesn’t mean much necessarily). RA negative, have had high non specific inflammatory blood markers in the past.
Also have taken ciprofloxacin in the past (years ago).
X rays of spine and other joints did NOT show inflammation. Hence an OA diagnosis (based on knee and toe arthritis seen on x ray and bone scan)
Recently got Achilles tendinopathy- best ultrasound place in my area said it was chronic and degenerative. Also have plantar fasciitis.
Couple of weeks ago started having pain in fingertip (DIP) joints on my left hand - index to pinky.
Every major joint - have had tendonitis. Random effusions.
Does this sound like OA or maybe Psa, or like fluoroquinolone side effects?
I don’t think I have psoriasis. I know some small % of people with psa don’t have psoriasis immediately but if I’m not textbook, not sure a doc would want to go there.
Have seen rheumatologists… as soon as they find out I don’t have RA they don’t care and send me to my GP or a sports med. sports med says it’s weird that you have so many injuries, must be systematic.
The Achilles tendinosis is quite scary and disabling as it is. How bad can it get from here? If there’s any kind of treatment, I’ll be thrilled.
Oh also x rays of feet showed extra accessory bones or old fractures, they couldn’t tell. Maybe there’s some genetic problem?
Author: /u/sp4cerat
Usually the side effects are rare, but i believe if the dose is higher, everybody will suffer. especally if combined with cortison. Usually you dont get just one side effect but many combined
If so, what helped, what hurt, what didn't matter?
Thanks
Hello all, First of all as to why i joined this nice community is to learn about how to MD. I've tried LSD tabs before 150iu and 200iu which blasted me to space before including truffles once as well.
However, i also want to learn from here and raise awareness from my part about an antibiotic called Ciprofloxacin.
Prior to June 21st 2021 i was playing basketball, hitting the gym 3x a week, enjoying life. I was a pothead at nights and enjoyed some molly once every 6/7 months at a party.
However come June i had a burning sensation while peeing so i , as anyone would, went to the doctor and got prescribed Cipro for 6 days. I google the side effects and it showed simple ones as nausea , irritability, fatigue. After my 3rd pill, all hell broke loose, tendon pain, muscle soreness, insomnia for 2 months, nerve burning sensation which sent me to hell. It never occurred to me a medication would do this but as i researched more and more, found out that there are 3 FDA black box warnings , and countless horror stories of people bring disabled by it.
Doctors are clueless , I went to 10 doctors and only 1 knew of the side effects. Its prescribed like candy all around the world and most doctors ignore the guidelines set by the FDA and EMA.
Its been 7 months of torment , pain and hell. I couldn't even smoke weed anymore as it flared my pains and threw me into a panic attack which never ever happened to me prior to taking this poison (i would smoke 10 joints a day and wouldn't phase me). I have recovered to some extent but others are left permanently damaged by this so called antibiotic. I don't even know why doctors prescribe it for mild infection, suspected infections, and non-bacterial ones. There is even a subreddit for those affected by this poison called r/floxies
In any case , i just want to raise awarness about taking Fluoroquinolones which Cipro belongs to and there are others as well like Levofloxacin, Oflofloxacin, Moxifloxacin etc... and btw if you have taken it before with no issue then the next time might as well damage you as it can be cumulative.
Now that is aside, im trying to treat my depression from all of this with microdosing lsd , as shr
... keep reading on reddit ➡Unfortunately a significant number of urologists and GPs are still happy to empirically prescribe floroquinolone class antibiotics like Ciprofloxacin, Levofloxacin, and Moxifloxacin with no identified pathogen - based only on an assumption. Let me be clear, this is not best practice and is highly discouraged by the FDA and EMA guidelines due to the risk of severe and potentially permanent side effects in up to 2% of people who use them. It's also not in line with American Urological Association best practice for prostatitis/CPPS treatment.
FDA and EU guidelines.
There is good reason that the mod team recommends running EPS cultures (and/or PCR for STI pathogens) before popping pills with multiple safety warnings, to mitigate risk to yourself. We genuinely want you to be safe. Identify, then treat. The culture will tell you what antibiotic the strain of bacteria is most susceptible to: that's the one you would take.
If you are already taking these drugs and your doctor did not find a bacteria: Of course, ALWAYS speak to your doctor about medication start/stopping. The caveat being that doctors don't always follow best practice or downplay the risks and wave a dismissive hand. Feel free to present this:
"FDA determined that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options." - https://www.fda.gov/news-events/press-announcements/fda-updates-warnings-fluoroquinolone-antibiotics-risks-mental-health-and-low-blood-sugar-adverse
"Restrictions on the use of fluoroquinolone antibiotics will mean that they should not be used:
-
to treat infections that might get better without treatment or are not severe (such as throat infections);
-
to treat non-bacterial infections, e.g. non-bacterial (chronic) prostatitis;
-
for preventing traveller’s diarrhoea or recurring lower urinary tract infections (urine infections that do not extend beyond the bladder);
-
to treat mild or moderate bacterial infections unless other antibacterial med
As many of you know, antibiotics like cipro and levaquin target ALL bacteria within the gut microbiome and the flora within our stomach. I've read conflicting reports that say our microbiomes restore after 4 weeks, some say after 6 months, and some say that after quinolones that our microbiomes never fully restore.
Does anyone have more information on this? I'm currently two months out and am trying to determine how my gut microbiome recovery is looking.
There are more than 85 drugs that interact with grapefruit ^1
Here is an incomplete list of medications that interact with grapefruit^2 :
- aliskiren (Tekturna) - also apple juice, orange juice
- alprazolam (Xanax)
- amiodarone (Pacerone)
- atorvastatin (Lipitor)
- carbamazepine (Tegretol)
- cilostazol (Pletal)
- citalopram (Celexa)
- clarithromycin (Biaxin)
- cyclosporine (Gengraf, Neoral)
- colchicine
- dronedarone (Multaq)
- erythromycin (E.E.S., Eryped)
- escitalopram (Lexapro
- felodipine (Plendil)
- fentanyl
- fentanyl transdermal system (Duragesic Skin Patch)
- fexofenadine (Allegra)
- flibanserin (Addyi)
- indinavir (Crixivan)
- loratadine (Claritin)
- losartan (Cozaar)
- lovastatin
- nilotinib (Tasigna)
- naloxegol (Movantik)
- palbociclib (Ibrance)
- pazopanib (Votrient)
- pimozide (Orap)
- ranolazine (Ranexa)
- saquinavir (Invirase, Fortovase)
- sildenafil (Revatio, Viagra)
- simvastatin (Zocor)
- tadalafil (Adcirca, Cialis)
- vardenafil (Levitra, Staxyn)
- verapamil (Calan, Calan SR)
- warfarin
Grapefruit generally changes how these drugs are metabolized, and can alter how much medication is entering your bloodstream. It has the ability to increase or decrease the dose you’re receiving, which can cause the medication to lose efficacy or intensify side effects.
Drugs like statin cholesterol drugs, calcium channel blockers, immunosuppressants, and SSRIs may be affected by grapefruit.
In some cases, this interaction can severely damage kidneys or lead to depressed breathing, both of which can lead to life-threatening conditions.
If you take any medications, you can check to see if there are any other food or drug interactions that may affect your dose. Generally, pharmacists and general practitioners can also tell you if there are certain foods or OTC medicines you should avoid while taking certain medications.
Other interactions to note^3 :
- Sudafed and other nasal decongestants can increase your heart rate and shouldn’t be mixed with any beta blockers, blood pressure medications, or ADHD medications
- ACE Inhibitors-Potassium Supplements
- ACE Inhibitors-Spironolactone
- Digoxin-Amiodarone
- Digoxin-Verapamil
- Theophylline-Quinolones
- Warfarin-Macrolides
- Warfarin-NSAIDs
- Warfar
Right, so I’m going to get a lot of hate from this post, not because they can sufficiently debate the science but because they have ego attachments to alternative and “natural” methods and want to believe it works even when the reality and studies don’t back that up. Those who have an open mind, don’t have ego attachments and are willing to look at things objectively will receive great value from this post. I am not selling anything nor associated with any doctor I’m doing this because god tells me to do this.
I suffered from chronic prostatitis and Epididymitis for over 2 years, it all started from unprotected sex, there is No doubt about this.
Backflow (bacteria passing back into the prostate and other urogenital areas) is the cause of male UTS (urinary tract symptoms) include the more common ones prostatitis Epididymitis.
This condition ruined me, physically and mentally. Mentally due to the fact I could not find a cure, my sex drive was ruined and doctors refused to help me because all my bacteria test results came back negative.
Me being a man, I decided to stop feeling sorry for myself and take action and solve this with my own hands, I started researching like crazy.
It was during this intense research of bacteria I discovered the female Urinary tract community, and noticed they were huge followers of a professor called James Malone Lee from London and Dr Stewart Bundrick from Louisiana.
This was huge, I looked into their research and things were finally falling into place I was incredibly happy. Here were hundreds of female and male UTI sufferers who although didn’t all have prostatitis had the same issue of receiving negative culture results from their tests and therefore not receiving treatment.
It turns out traditional culture testing, is totally unreliable as the infection when chronic is nearly always embedded onto tissue wall (in our case our prostate tissue) and therefore is not seen in urine or semen samples.
The other thing they had in common with me is they were often prescribed short term antibiotics which would initially help but they’d come off them and the symptoms would return, that’s because embedded infections take Months to get rid of, they hide behind biofilm and when you don’t take an antibiotic for long enough, the bacteria hiding behind biofilm (sleepers) come out and take the vacant spaces of the bacteria that had been killed and multiply again, so you’re back to wheee you started.
The solution is long term
... keep reading on reddit ➡Antibiotics are drugs that can treat bacterial infections. Our bodies contain healthy bacteria that live in a specific location, like on our skin and in our colon. When this bacteria moves to another part of the body, like in a urinary tract infection, or if we come into contact with bacteria that is not normally present in our bodies, like in the case of food poisoning cause, this results in a bacterial infection that causes unwanted symptoms and must be treated with antibiotics before we can start feeling better.
For many people, the first thought that arises on being prescribed an antibiotic is whether it is penicillin. Penicillin was discovered more than 90 years ago by Alexander Fleming in 1928. Fleming, a Scottish scientist, accidentally found that a ‘fluffy white’ substance that changed color throughout the course of a few days contaminated a plate of bacteria that he was growing in the laboratory. This fluffy white mass was identified to be a mold (Penicillium notatum) that was capable of killing the bacteria that he was growing. Further research with penicillin showed that it could kill a group of bacteria called ‘gram-positive’ organisms. These include infections caused by bacterial species Streptococcus or Staphylococcus. While Fleming only spent a few years studying this revolutionary new discovery, it was rapidly picked up by others and by the 1940s, patients were successfully being treated with penicillin to clear them from bacterial infections caused by gram-positive organisms. It is estimated that penicillin was instrumental in drastically reducing the number of deaths due to infections and amputations during World-War II. Today, the penicillins include more than five sub-groups and over fifteen antibiotics, and they are among the most widely used antibiotics in the world for bacterial infections.
https://preview.redd.it/xeqcs3kftq981.jpg?width=700&format=pjpg&auto=webp&s=461353f9051a8d8d33496ac83e2b75d7c1dcf12b
Penicillin was originally used to describe the drug benzylpenicillin, or Penicillin G. Now, it is used to describe a group of antibiotics that all contain a chemical beta-lactam ring structure with many natural and synthetic derivatives of the original penicillin available. One of the most commonly prescribed penicillin-type antibiotics is Amoxicillin (also known as the brand Moxatag, Amoxil or Augmentin when combined with another beta-lactamase inhibitor clavunalate potassium). Other common penicillin-typ
... keep reading on reddit ➡Hi guys, been following along for quite a while. This one is a long one but thought I'd share my experience after finally receiving a negative test. Might be easiest in 'short' dot format. (Mid 20s Male, gay, Melbourne, Australia)
-Symptoms started Early July after a short fling with casual partner. Inflammation of urethra, itchiness, discharge in morning and lightly throughout day, burning urination, "tingles/zings" in the urethra constantly throughout the day.
-Visited MSHC (Melbourne Sexual Health Clinic) Let me start by saying I have a huge sense of gratitude to be able to access this clinic, as all prescribed drugs here are free and access to leading doctors and researchers is available, I definitely understand my privilege here.
-Tested for STDs and Prescribed 7 days Doxycycline 100mg 2x daily.
-Returned Positive MG test, returned to clinic 7 days later after doxys, prescribed Moxifloxacin 5 days, 400mg 1x daily. On the second day I started experiencing a reaction to the drugs, sharp pins and needles in my hands and feet, couldn't walk correctly, couldn't return to work that weekend. Stopped course immediately. Had to visit an external doctor who could only say to wait and see what happens, that the effect shouldn't last more than 48 hours. A couple of days of intense anxiety there, luckily the symptoms did fade. I must have built up a reaction to Moxi somehow, as I had taken a course about two years prior and was completely fine, and it got rid of my MG back then too.
-Symptoms disappear for around 10 days. Returned to the clinic when they re-emerge, and due to my reaction to quinolones, my next option was a combination of Pristinamycin 1g 3x Daily and Doxycycline 100mg 2x daily for 10 days. Pristinamycin is restricted here in Australia and so the doctor had to fill out a bunch of special forms, starting to feel like I'm a science experiment here.
-Symptoms never really disappear on Pris/Doxy and kick back up 10 days after last pill. A few different consults with different doctors at the clinic have me now just on Doxycycline for the rest of August as there was some thought that perhaps these symptoms are a result of scar tissue/residual symptoms, and as they would like me to wait for a two week grace period for a true test of cure. The next step is discussed, should I try Minocycline, which may have the same effect of Doxy, or move up a step to Lefamulin. Given I was starting to get disheartened, I opted for the Lefamulin as the
... keep reading on reddit ➡I'm going to try and keep this short and sweet since I know this will undoubtedly be a controversial post. Normally I would post this in another prostatitis related sub but as many know, I was banned by a MOD who has a long history of banning people and removing any and all references to successful bacterial prostatitis treatment so he can funnel suffering patients to his website that he profits from. I won't be mentioning the sub or mod by name because the Mods here will lock my post.
Some background info about me: Over the last 4 years I've had several bouts of bacterial prostatitis and have been treated to complete cure multiple times. I have seen multiple Physicians, Urologist, Physical therapists, and recently an Infectious disease specialist. I've taken many antibiotics at the request of my physicians, some have worked some have not. Over the years, I suffered from both CPPS & bacterial prostatitis. The foremost responding to PT and the latter to antibiotics.
Here is my most recent story: (I have linked all my test results as well)
5/29 - Unprotected exposure
6/7 - Nocturia, urgency, bladder discomfort - These symptoms intensified over the month of June prompting me to request a microgenDX test.
6/25 - Microgen Positive E. faecalis -
6/25 - Negative Kaiser Urine Culture
7/1 - 7/12 - Treated with amoxicillin - Saw some symptom improvement, but missed some doses. Ultimately treatment failed and E. Faecalis & above mentioned symptoms slowly came back. Not Sexually active during this time.
7/30 - Positive Microgen E. Faecalis again - Around this time, my symptoms were intensifying quickly, worse than the initial onset on 6/7. Burning with urination, waking up multiple times to pee, Perineal pain, urgency, frequency, weak stream etc.
8/5 - 8/13 Nitrofurantoin 2x day 100mg 10 days (I stupidly do 8 fearing the side effects) - Wow Nitrofurantoin works incredibly fast. Day 2 my symptoms were lightening up. By day 8 I was feeling much better but still had very light symptoms, I assumed it was residual inflammation.
8/26 - Negative Kaiser Urine Culture
8/26 - Postive Microgen E. Faecalis yet again - At this point I am still having light symptoms, I always retest until I am in the clear. I am very disheartened to find out the results are positive again. I ask my Uro for 14 days nitrofurantoin thi
... keep reading on reddit ➡Right, so I’m going to get a lot of hate from this post, not because they can sufficiently debate the science but because they have ego attachments to alternative and “natural” methods and want to believe it works even when the reality and studies don’t back that up. Those who have an open mind, don’t have ego attachments and are willing to look at things objectively will receive great value from this post. I am not selling anything nor associated with any doctor I’m doing this because god tells me to do this.
I suffered from chronic prostatitis and Epididymitis for over 2 years, it all started from unprotected sex, there is No doubt about this.
Backflow (bacteria passing back into the prostate and other urogenital areas) is the cause of male UTS (urinary tract symptoms) include the more common ones prostatitis Epididymitis.
This condition ruined me, physically and mentally. Mentally due to the fact I could not find a cure and doctors refused to help me because all my bacteria test results came back negative.
Me being a man, I decided to stop feeling sorry for myself and take action and solve this with my own hands, I started researching like crazy.
It was during this intense research of bacteria I discovered the female Urinary tract community, and noticed they were huge followers of a professor called James Malone Lee from London and Dr Stewart Bundrick from Louisiana.
This was huge, I looked into their research and things were finally falling into place I was incredibly happy. Here were hundreds of female and male UTI sufferers who although didn’t all have prostatitis had the same issue of receiving negative culture results from their tests and therefore not receiving treatment.
It turns out traditional culture testing, is totally unreliable as the infection when chronic is nearly always embedded onto tissue wall (in our case our prostate tissue) and therefore is not seen in urine or semen samples.
The other thing they had in common with me is they were often prescribed short term antibiotics which would initially help but they’d come off them and the symptoms would return, that’s because embedded infections take Months to get rid of, they hide behind biofilm and when you don’t take an antibiotic for long enough, the bacteria hiding behind biofilm (sleepers) come out and take the vacant spaces of the bacteria that had been killed and multiply again, so you’re back to wheee you started.
The solution is long term high dose antibiotics for
... keep reading on reddit ➡