- pramiracetam and aniracetam inhibit prolyl endopeptidase and alter enzyme activity in the brain. slowing the destruction of neurotransmitters, etc. https://www.ncbi.nlm.nih.gov/pubmed/3330562 ( Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect.)
- Prolyl oligopeptidase affects glutamatergic, GABAergic, and cholinergic neurotransmission systems https://www.ncbi.nlm.nih.gov/pubmed/18253937 (Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters.)
- inhibition of prolyl oligopeptidase causes significant changes in the peptidome https://www.ncbi.nlm.nih.gov/pubmed/22546504 ( Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney. )
- Moreover, POP was highly colocalized with IP3R1 in hippocampal CA1 pyramidal cells . In these cells, IP3 has been associated with long-term potentiation (LTP), an important phenomenon in memory and learning. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728128/ ( Issues About the Physiological Functions of Prolyl Oligopeptidase Based on Its Discordant Spatial Association With Substrates and Inconsistencies Among mRNA, Protein Levels, and Enzymatic Activity )
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
Buenosdillas
They’re on standbi
Pilot on me!!
This study (1) investigated the molecular mechanisms underlying Bacopa Monnieri's effects on memory enhancement. Researchers used Bacomind, which is an extract of bacopa monnieri standardized to 40% bacosides. The most popular brand on this subreddit is NootropicsDepot's Bacognize or Synapsa brands, both of which were advertised as containing
12.6% Bacopa Gycosides, and 59% Bacosides, respectively. There are several chemical constituents responsible for bacopa's effects. Some of which being bacosides and alkaloids, including nicotine. More on this can be found under 'Chemical Constituents' in this study (2). Differences in bacosides and other alkaloids may cause differences in effects between batches and brands.
Numerous anecdotes (3,4,5,6) have reported lethargy, anhedonia, and decreased motivation. After three weeks of supplementing Bacognize Synapsa myself, I was forced to stop because of intense lethargy unaffected by amphetamine or caffeine.
Researchers found that Bacomind inhibited three enzymes; catechol-o-methyltransferase (COMT), prolyl endopeptidase (PEP), and Poly (ADP-ribose) polymerase (PARP). Bacomind also produced an antagonistic effect on two serotonin receptors: 5-HT2A, and 5-HT6.
Catechol-o-methyl-transferase is an enzyme responsible for breaking down catecholamines, most notably dopamine, norepinephrine, and epinephrine. In theory, inhibiting this enzyme should provide an increase in energy by increasing levels of catecholamines. PEP has a high concentration in the brain and the ability to cleave neuropeptides, which makes it an attractive target for neurological drug treatment (7). Paradoxically, it was first discovered in the human uterus as an oxytocin degrading enzyme. I am unsure of how/if this enzyme's inhibition plays a role in bacopa's effects on energy levels. PARPs are a family of enzymes that play an important
... keep reading on reddit ➡
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
Nothing, he was gladiator.
When I got home, they were still there.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
I won't be doing that today!
[Removed]
This morning, my 4 year old daughter.
Daughter: I'm hungry
Me: nerves building, smile widening
Me: Hi hungry, I'm dad.
She had no idea what was going on but I finally did it.
Thank you all for listening.
You take away their little brooms
There hasn't been a post all year!
It’s pronounced “Noel.”
After all his first name is No-vac
What, then, is Chinese rap?
Edit:
Notable mentions from the comments:
-
Spanish/Swedish/Swiss/Serbian hits
-
French/Finnish art
-
Country/Canadian rap
-
Chinese/Country/Canadian rock
-
Turkish/Tunisian/Taiwanese rap
There hasn't been a single post this year!
(Happy 2022 from New Zealand)
Nothing, it just waved
Him: I can explain everything!
(It's his best joke yet I think)
Bob
Just to clarify, 12345678
So that I could frequently say, "I am going to walk 5 miles now."
Edit: My most popular post on Reddit! 😀 Thank you for the awards.
Me grabbing a soda from my (what I thought was) half full 12pk...
Notices there's only 2;
Me: "Awe man... This is a damn bird box!" Her: "What the hell does that mean?!" Me: (Pulls both cans out & shows them to her) "It's only got Toucans."
I'm not ashamed to admit the look on her face was glorious.
I was just sitting there doing nothing.
“BOOM”?!
