Nucleic acid analogue Puns

Artificial Nucleic Acid Analogue Substitutes, or ANAAS as they are known, or colloquially Pineapples due to the Latin and Germanic similarity linguistically, they have multiple uses, such as:

• As a tool to detect particular sequences
• As a tool with resistance to RNA hydrolysis
• As a tool for another purpose, such as sequencing
• Naturally occurring, such as in tRNA
• Investigation of the mechanisms used by enzyme, such as an enzyme inhibitor
• Investigation of possible scenarios of the origin of life
• Investigation of the structural features of nucleic acids
• Investigation of the possible alternatives to the natural system in synthetic biology

Nucleic acid analogues are compounds which are structurally similar to naturally occurring RNA and DNA, used in medicine and in molecular biology research. An analogue may have any specification of these altered. Examples include universal bases, which can pair with all four canon bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix). Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.

This could potentially pave the way into developing lab grown animals, lifeforms and possible even humans. The potential is unlimited, we merely have to open our eyes to the wonders that Nano-Afrika can bring us.

I can recogonize them if shown them, but I have been really struggling to draw them out precisely. Like I know I can draw out the rough features and I know how to differentiate between them.

Weibo forwarding: Auntie said that her stomach hurts at 7pm on January 1, 2022. When it was delivered, it was already over 8pm, but she was not allowed to enter at the door. It was delayed until more than 10pm, saying that the nucleic acid exceeded For 4 hours, my aunt sat at the door for a while. It was not because of the delay for so long that it caused heavy bleeding. I saw the video sent by my uncle. My aunt was sitting on a chair with her hands supporting her body very hard. The blood ran down the chair and pants, and the blood on the floor was sent to the operating room. As a result, the 8-month-old child suffered a miscarriage because of the delay in treatment, and the 8-month-old child was stillborn because of the time delay. No more heartbeat! Originally, I was thinking about telling this story on other platforms. I actually saw a screenshot of the host’s story told by my friend in Moments just now. I read the comments and found that I was not alone in this hospital. This kind of thing, I just cry!

Important updates to this post including that a clinical trial was based on "misreported data" and the fact #Exicure CEO David Giljohann, one of the developers of the #SphericalNucleicAcids in Chad Mirkin's group is "separating" from the company.

https://raphazlab.wordpress.com/2021/11/22/allegations-of-research-improprieties-at-spherical-nucleic-acids-company-exicure/

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Nucleic acids are chemically modified to fine-tune their properties for biological function. Chemical tools for selective tagging of base modifications enables new approaches; the photosensitizers riboflavin and anthraquinone were previously proposed to oxidize N6-methyladenine (m6A) or 5-methylcytosine (5mdC) selectively. Herein, riboflavin, anthraquinone, or Rose Bengal were allowed to react with the canonical nucleosides dA, dC, dG, and dT, and the modified bases 5mdC, m6A, 8-oxoguanine (dOG), and 8-oxoadenine (dOA) to rank their reactivities. The nucleoside studies reveal that dOG is the most reactive and that the native nucleoside dG is higher or similar in reactivity to 5mdC or m6A; competition in both single- and double-stranded DNA of dG vs. 5mdC or 6mdA for oxidant confirmed that dG is favorably oxidized. Thus, photosensitizers are promiscuous nucleic acid oxidants with poor chemoselectivity that will negatively impact attempts at targeted oxidation of modified nucleotides in cells.

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