https://preview.redd.it/52zxdr8emv481.png?width=764&format=png&auto=webp&s=1cec018c4c279bb70d51100fcb151df2fee9a5c9
It isn't mentioned in the syllabus I saw in CBSE's website, but all the youtube channels don't mention it being deleted :(? They all continue to teach it even though it isn't there! Why?
Biological alkylation is highly selective, yet it depends on complex leaving groups. Now, promiscuous and engineered enzymes achieve selective enzymatic alkylation using simple haloalkanes.
Abstract
Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst‐controlled pyrazole alkylation by a cyclic two‐enzyme cascade. In this enzymatic system, a promiscuous enzyme uses haloalkanes as precursors to generate non‐natural analogs of the common cosubstrate S‐adenosyl‐l‐methionine. A second engineered enzyme transfers the alkyl group in highly selective C−N bond formations to the pyrazole substrate. The cosubstrate is recycled and only used in catalytic amounts. Key is a computational enzyme‐library design tool that converted a promiscuous methyltransferase into a small enzyme family of pyrazole‐alkylating enzymes in one round of mutagenesis and screening. With this enzymatic system, pyrazole alkylation (methylation, ethylation, propylation) was achieved with unprecedented regioselectivity (>99 %), regiodivergence, and in a first example on preparative scale.
https://ift.tt/39Zt3iM
What’s the product of the alcohol from haloalkane? Would it be a halide or would it be sodium halide?
I have a textbook which appears to contradict itself.
In one instance: a nucleophilic substitution requires aqueous solvent at room temperature.
In another instance: a nucleophilic substitution reaction requires ethanolic solvent at hot temperature.
If someone could clear this up for me I’d be greatly appreciative.
Organic co‐crystal engineering has emerged as a promising method to make multifunctional materials. Here, we report that the marriage of macrocyclic chemistry and co‐crystal engineering provides a smart strategy to build vapochromic materials. The macrocycle co‐crystals (MCCs) have been constructed by π‐electron rich pillar[5]arene (P5) and an electron‐deficient pyromellitic diimide derivative (PDI) on a ten‐gram scale. MCCs of P5‐PDI are in red color due to the formation of charge‐transfer (CT) complex. After removing the solvent, a white crystalline solid with a new structure (P5‐PDIα) is yielded, which exhibits selective vapochromic responses to volatile organic compounds (VOCs) of haloalkanes, accompanied by color changes from white to red or orange. Powder and single crystal X‐ray diffraction analyses reveal that the color changes are attributed to the vapor‐triggered solid‐state structural transformation to form CT co‐crystals. In particular, coating films of P5 and PDI on glass also showed a visible vapochromic behavior with good reversibility.
https://ift.tt/3goAtMh
This is purely academic and for my own knowledge, I will not be doing any experiments with methyl mercury
In Module 12 of my chemistry course it briefly mentions organic compounds containing halogens, and teaches how to name haloalkanes and halogenated cycloalkanes. Does this means haloalkenes do not exist? The Google couldn't give me a straight answer to yes or no so im asking u guys. Is it possible for an alkene to replace a hydrogen atom with a halogen, the way alkanes do, or do halogens prefer to form haloalkanes through an alkene addition reaction?
Just clarifying because Wikipedia does not mention alkenes or haloalkanes and begins with cations at the top then carboxylic acids
oh god he and his lab partner have airpods in oh god oh fuck...
Let’s say you have a strong small base reacted with a tertiary haloalkane, what would be the minor product of this reaction? I believe the major product would be E2. I know SN2 would have trouble since it’s a tertiary, but usually SN2 and E2 go together.
For example C2H5Cl + NaOH -> C2H5OH + NaCl (Chloroethane) (Sodium Hydroxide) (Ethanol) (Sodium Chloride) and reverse it so that you can use EtOH and NaCl to make the haloalkane?
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
Because she wanted to see the task manager.
Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst‐controlled pyrazole alkylation by a cyclic two enzyme cascade. In this enzymatic system, a promiscuous enzyme uses haloalkanes as precursors to generate non‐natural analogs of the common cosubstrate S‐adenosyl‐ l ‐methionine. A second engineered enzyme transfers the alkyl group in highly selective C – N bond formations to the pyrazole substrate. The cosubstrate is recycled and only used in catalytic amounts. Key is a computational enzyme library design tool that converted a promiscuous methyltransferase into a small enzyme family of pyrazole alkylating enzymes in one round of mutagenesis and screening. With this enzymatic system, pyrazole alkylation (methylation, ethylation, propylation) was achieved with unprecedented regioselectivity (>99%), regiodivergence and in a first example on preparative scale.
https://ift.tt/39Zt3iM
A smart strategy to build functional materials was designed through the marriage of macrocyclic chemistry and co‐crystal engineering. The resulting macrocycle co‐crystals (MCCs), P5‐PDIα exhibit selective vapochromic responses to volatile organic compounds of haloalkanes, accompanied by color changes from white to red or orange and vapor‐triggered solid‐state structural transformation to form charge‐transfer co‐crystals.
Abstract
Organic co‐crystal engineering is a promising method to make multifunctional materials. Here, the marriage of macrocyclic chemistry and co‐crystal engineering provides a smart strategy to build vapochromic materials. The macrocycle co‐crystals (MCCs) were constructed from π‐electron rich pillar[5]arene (P5) and an electron‐deficient pyromellitic diimide derivative (PDI) on a 10 g scale. MCCs of P5‐PDI are in red owing to the formation of a charge‐transfer (CT) complex. After solvent removal, a white crystalline solid with a new structure (P5‐PDIα) is yielded, which exhibits selective vapochromic responses to volatile organic compounds (VOCs) of haloalkanes, accompanied by color changes from white to red or orange. Powder and single‐crystal X‐ray diffraction analyses reveal that the color changes are attributed to the vapor‐triggered solid‐state structural transformation to form CT co‐crystals. Coating films of P5 and PDI on glass showed a visible vapochromic behavior with good reversibility.
https://ift.tt/3goAtMh
A smart strategy to build functional materials was designed through the marriage of macrocyclic chemistry and co‐crystal engineering. The resulting macrocycle co‐crystals (MCCs), P5‐PDIα exhibit selective vapochromic responses to volatile organic compounds of haloalkanes, accompanied by color changes from white to red or orange and vapor‐triggered solid‐state structural transformation to form charge‐transfer co‐crystals.
Abstract
Organic co‐crystal engineering is a promising method to make multifunctional materials. Here, the marriage of macrocyclic chemistry and co‐crystal engineering provides a smart strategy to build vapochromic materials. The macrocycle co‐crystals (MCCs) were constructed from π‐electron rich pillar[5]arene (P5) and an electron‐deficient pyromellitic diimide derivative (PDI) on a 10 g scale. MCCs of P5‐PDI are in red owing to the formation of a charge‐transfer (CT) complex. After solvent removal, a white crystalline solid with a new structure (P5‐PDIα) is yielded, which exhibits selective vapochromic responses to volatile organic compounds (VOCs) of haloalkanes, accompanied by color changes from white to red or orange. Powder and single‐crystal X‐ray diffraction analyses reveal that the color changes are attributed to the vapor‐triggered solid‐state structural transformation to form CT co‐crystals. Coating films of P5 and PDI on glass showed a visible vapochromic behavior with good reversibility.
https://ift.tt/3goAtMh
This is purely academic and for my own knowledge, I will not be doing any experiments with methyl mercury
