According to Sketchy, Acetylcholinesterase Inhibitor Toxicity leads to flaccid paralysis. But, wouldn't that be spastic paralysis because if there's a lot of Acetylcholinesterase Inhibitors, there would be a lot of ACh left and this constantly activate the receptors at the NMJ?

?

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πŸ“…︎ Jan 12 2022
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DebunkThis: Oral polio vaccines heavily correlated with Non-Polio Acute Flaccid Paralysis (NPAFP) in India

https://www.scidev.net/asia-pacific/news/oral-polio-drops-linked-to-paralysis-in-india/

The news articles lists a study that finds that the flaccid paralysis was unusually high when vaccines were being given in india

"A previous study of data from 2000 to 2010 has detailed the NPAFP rate in a state correlated with the pulse polio rounds conducted there, and the strongest correlation with the NPAFP rate was found when the number of doses from the previous 4 years were used."

They however admit that this doesn't prove a causal relationship

"However, a simple association being found with regression analysis does not prove a causal relationship."

However what they found odd was that the paralysis rates went down as the vaccine rounds went down

NPAFP rate correlated with the OPV pulse polio rounds in that year (R = 0.46; p < 0.001), and the NPAFP rate started to decrease from 2012 when the number of pulse polio rounds had decreased. NPAFP rates in the states of Uttar Pradesh (UP) and Bihar were the highest in the country. Looking at the high-NPAFP states of UP and Bihar, we found that the correlation coefficient was strongest when doses used over 5 years was considered (R = 0.76; p < 0.001). The response to the reduction in OPV rounds (de-challenging) adds credence to the assumption that OPV was responsible for the change in the NPAFP rate. Now that India has been polio-free for over 6 years, we propose that we may be able to reduce NPAFP by further reducing pulse polio rounds

My thoughts: I honestly think that there is a possible causation here since vaccine rounds went up, the NFAFP also went up and went down as the rounds went down. However at the same time though, we have to take in account that correlation doesn't equal causation (especially when other factors haven't been ruled out).

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πŸ‘€︎ u/themaxedgamer
πŸ“…︎ Sep 23 2021
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Flaccid wallets for some sweet Botulinum toxin >>> Flaccid paralysis
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πŸ‘€︎ u/doc_martini
πŸ“…︎ Aug 12 2021
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How does succinylcholine cause flaccid paralysis?

I dont get it at all. If the muscle stays depolarized then the calcium is in the cytoplasm. Assuming there is enough ATP why does the muscle stop contracting? Please help I’m a med student and it makes me so annoyed when I cant understand a concept.

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πŸ‘€︎ u/Flufington
πŸ“…︎ Jun 06 2021
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Anking - Acetylcholinesterase inhibitor poisoning causes flaccid paralysis

Hi all, just ran into a card in Anking: Acetylcholinesterase inhibitor poisoning causes flaccid paralysis due to NMJ nicotinic ACh receptor overactivation

Does someone know why the paralysis is flaccid? I assume with so much Ach activating the skeletal muscles, you would be hypertonic.

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πŸ‘€︎ u/crzaznboi
πŸ“…︎ Aug 01 2020
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[Meme] Flaccid Paralysis
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πŸ‘€︎ u/nightswatchman
πŸ“…︎ Oct 22 2020
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Oral Polio Vaccine correlation to acute flaccid paralysis

Hello everyone, with COVID-19 and lockdown happening a lot of conspiracy theories are now circling. Well I am not here to discuss these but rather to discuss an article from India about the Polio vaccination program. So I was shown a video from an anti-vaxxer (doesn't matter who) who was talking about the polio campaign and mentioning and interesting article from the "International Journal of Environmental Research and Public Health": https://dx.doi.org/10.3390%2Fijerph15081755

(the numbers were wrongfully interpreted during the video but the article itself is quite interesting)

So there seems to be quite a high correlation of the rounds of polio vaccination and acute flaccid paralysis. The article shows that the incidence of acute flaccid paralysis in children who have received the polio vaccination has increased significantly. The risk rises additionally with each round of vaccination received. The numbers used were official numbers from the WHO statistics. So what I am wondering is why there was so little resonance concerning that article even though there seems to be a significant correlation.

DISCLAIMER: I am still a med student and might have yet the full oversight. But I am happy for everyone who is proficient in that topic.

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πŸ‘€︎ u/medrat23
πŸ“…︎ May 15 2020
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[UWorld ID: 11793] Flaccid Paralysis after Vertebral Subluxation

If a patient has a vertebral subluxation after intubation, wouldn't we expect LMN symptoms at the level of the lesion and then UMN (spastic paralysis) below?

Why does compression of the spinal cord cause flaccid paralysis acutely?

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πŸ“…︎ Apr 10 2020
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CDC has provided an update that from January 1 to September 30, 2016, a total of 89 people in 33 states across the US were confirmed to have acute flaccid myelitis (AFM), with most cases being children with spinal cord paralysis similar to polio, with no known cause or treatment. cdc.gov/acute-flaccid-mye…
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πŸ‘€︎ u/mvea
πŸ“…︎ Nov 05 2016
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Spastic vs. Flaccid Paralysis?

I was under the impression that spastic paralysis is when a muscle is getting depolarized too much and flaccid paralysis when depolarization is not occuring. Is this correct?

My logic above doesn't seem to hold up for this card below. My thinking is that because you have more ACh, more depolarization is occuring so it should be spastic paralysis

https://preview.redd.it/dx92mtyc06u31.png?width=1261&format=png&auto=webp&s=0d8cacdc90e0850e16bba29bd01db3152e2db982

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πŸ‘€︎ u/IAm1Spartan
πŸ“…︎ Oct 22 2019
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Atropine doesn't reverse flaccid paralysis?

I understand that atropine is an anti-muscarinic drug. Is the reason atropine doesn't reverse flaccid paralysis because nicotinic receptors will still be stimulated by Ach? So techincally, atropine mitigates flaccid paralysis?

https://preview.redd.it/5khzh1q08pa31.png?width=747&format=png&auto=webp&s=aa864a88c5f58b9c47c4c8ef79c9798c60d45137

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πŸ‘€︎ u/IAm1Spartan
πŸ“…︎ Jul 16 2019
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Acute flaccid paralysis: Health chiefs investigate mystery rise of rare polio-like illness leaving children paralysed across England - Experts usually expect fewer than 10 cases of condition that causes weakness or floppiness of limbs, but 28 seen so far in 2018 - and more than half since September independent.co.uk/news/he…
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πŸ‘€︎ u/ManiaforBeatles
πŸ“…︎ Dec 19 2018
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Rare viral sequelae on uptick in WA state and the US with potential paralysis and now a fatality. Acute flaccid myelitis thought to be due in part to enterovirus D68. komonews.com/news/local/6…
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πŸ‘€︎ u/NW_thoughtful
πŸ“…︎ Oct 31 2016
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Machine learning helps to hunt down the cause of a paralysing illness - The disease, called acute flaccid myelitis (AFM), causes limb weakness and paralysis in kids that resembles the symptoms of polio. nature.com/articles/d4158…
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πŸ‘€︎ u/mvea
πŸ“…︎ Dec 07 2018
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The Brazilian Wandering Spider's venom not only kills, but can cause paralysis and asphyxiation, but worst of all, it causes "priapism". This is when an erect penis cannot return to a flaccid start and is known to be extremely painful. en.wikipedia.org/wiki/Bra…
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πŸ‘€︎ u/fog1234
πŸ“…︎ Apr 21 2016
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Botulism causes flaccid paralysis while tetanus causes extreme muscle contraction. What happens if you become infected with both simultaneously?

With my limited undergraduate biology courses, I understand how the toxin responsible for tetanus prevents the release of GABA (neurotransmitter that causes relaxation) without GABA the muscles can't relax. While, botulinum toxin prevents the action of snare proteins that are responsible for the release of acetylcholine into the neuromuscular junction to signal muscle contraction (no snare proteins no contraction i.e. flaccid paralysis). My question is what actually happens to the body? Is one more potent than the other? Do they both act differently on different tissue types?

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πŸ‘€︎ u/BinaryPeach
πŸ“…︎ Dec 24 2015
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What Is Acute Flaccid Myelitis? This Mysterious Polio-Like Paralysis Was Diagnosed In 6 Children. buzzfeednews.com/article/…
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πŸ‘€︎ u/stitch-witchery
πŸ“…︎ Oct 13 2018
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@NBCNews: The CDC has identified 127 suspected cases of acute flaccid myelitis, or AFM, a rare disease blamed for polio-like paralysis in a growing number of children. https://t.co/4llUUr6D2O mobile.twitter.com/NBCNew…
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πŸ‘€︎ u/-en-
πŸ“…︎ Oct 17 2018
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@NBCNews: The CDC has identified 127 suspected cases of acute flaccid myelitis, or AFM, a rare disease blamed for polio-like paralysis in a growing number of children. https://t.co/AgHsT9cvIh mobile.twitter.com/NBCNew…
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πŸ‘€︎ u/-en-
πŸ“…︎ Oct 17 2018
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@ABC: 62 cases of acute flaccid myelitis, a rare condition that affects the spinal cord and can cause partial paralysis, confirmed across 22 states in the U.S., according to the CDC. https://t.co/zhGEKoRGkm mobile.twitter.com/ABC/st…
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πŸ‘€︎ u/-en-
πŸ“…︎ Oct 17 2018
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How does succinylcholine cause flaccid paralysis?

I dont get it at all. If the muscle stays depolarized then the calcium is in the cytoplasm. Assuming there is enough ATP why does the muscle stop contracting? Please help I’m a med student and it makes me so annoyed when I cant understand a concept.

πŸ‘︎ 5
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πŸ‘€︎ u/Flufington
πŸ“…︎ Jun 06 2021
🚨︎ report
How does succinylcholine cause flaccid paralysis?

I dont get it at all. If the muscle stays depolarized then the calcium is in the cytoplasm. Assuming there is enough ATP why does the muscle stop contracting? Please help I’m a med student and it makes me so annoyed when I cant understand a concept.

πŸ‘︎ 5
πŸ’¬︎
πŸ‘€︎ u/Flufington
πŸ“…︎ Jun 06 2021
🚨︎ report

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