Quadruplex Puns

hello, enjoy this talon quadrakill, D2 EUNE

https://reddit.com/link/rf9l2e/video/ias67qmub9581/player

Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c10745

Denise Liano, Souroprobho Chowdhury, and Marco Di Antonio

https://ift.tt/3EnTn2w

Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c06200

Kai-Bo Wang, Jonathan Dickerhoff, and Danzhou Yang

https://ift.tt/2WqVgeb

A PtII compound was synthesized and adaptively bound G-quadruplex DNA through kinetic control. The solution structure of the complex was solved. It was further proved that the compound can target G-quadruplex in living cells, repress VEGF expression in cancer cells and inhibit blood vessels growth in zebrafish.

Abstract

G-quadruplexes (G4s) are prevalent in oncogenes and are potential antitumor drug targets. However, binding selectivity of compounds to G4s still faces challenges. Herein, we report a platinum(II) complex (Pt1), whose affinity to G4-DNA is activated by adaptive binding and selectivity controlled by binding kinetics. The resolved structure of Pt1/VEGF-G4 (a promoter G4) shows that Pt1 matches 3′-G-tetrad of VEGF-G4 through Cl−-dissociation and loop rearrangement of VEGF-G4. Binding rate constants are determined by coordination bond breakage/formation, correlating fully with affinities. The selective rate-determining binding step, Cl−-dissociation upon G4-binding, is 2–3 orders of magnitude higher than dsDNA. Pt1 potently targets G4 in living cells, effectively represses VEGF expression, and inhibits vascular growth in zebrafish. We show adaptive G4-binding activation and controlled by kinetics, providing a complementary design principle for compounds targeting G4 or similar biomolecules.

https://ift.tt/3dQjT9O

I was considering on buying a quadruple as a first home with my partner. Let’s say that our loan qualifies us to a SFR for $645,000. And we want to buy a quadruplex that’s selling for $1,000,000. Would my loan amount change if I decide to buy a quadruplex instead? Because the remaining units rent can be used to offset the mortgage? And also, do I get taxed on the rent I collect from the tenants, since that would be used to pay the mortgage? Sorry in advance everyone because I have no idea how this works..