talon quadruplex

hello, enjoy this talon quadrakill, D2 EUNE

https://reddit.com/link/rf9l2e/video/ias67qmub9581/player

πŸ‘︎ 15
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πŸ‘€︎ u/TtvLolb1n0
πŸ“…︎ Dec 13 2021
🚨︎ report
Cooler/Z broly/black T.O.D requested by QuadrupleX_ v.redd.it/dwnm0klxakj71
πŸ‘︎ 219
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πŸ‘€︎ u/TheComboDrop
πŸ“…︎ Aug 25 2021
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BEHOLD, the Quadruplex and Quintuplex! youtube.com/watch?v=8ZdM-…
πŸ‘︎ 2
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πŸ‘€︎ u/Pensyfan19
πŸ“…︎ Nov 15 2021
🚨︎ report
[ASAP] Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures

Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c10745

Denise Liano, Souroprobho Chowdhury, and Marco Di Antonio

https://ift.tt/3EnTn2w

πŸ‘︎ 5
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πŸ‘€︎ u/TomisMeMyselfandI
πŸ“…︎ Dec 02 2021
🚨︎ report
Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation mdpi.com/2673-6284/10/4/2…
πŸ‘︎ 16
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πŸ‘€︎ u/Moro18
πŸ“…︎ Oct 04 2021
🚨︎ report
BEHOLD, the Quadruplex and Quintuplex! youtube.com/watch?v=8ZdM-…
πŸ‘︎ 20
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πŸ‘€︎ u/Pensyfan19
πŸ“…︎ Nov 15 2021
🚨︎ report
[ASAP] Solution Structure of Ternary Complex of Berberine Bound to a dGMP–Fill-In Vacancy G-Quadruplex Formed in the PDGFR-Ξ² Promoter

Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c06200

Kai-Bo Wang, Jonathan Dickerhoff, and Danzhou Yang

https://ift.tt/2WqVgeb

πŸ‘︎ 5
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πŸ‘€︎ u/TomisMeMyselfandI
πŸ“…︎ Sep 30 2021
🚨︎ report
Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation mdpi.com/2673-6284/10/4/2…
πŸ‘︎ 2
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πŸ‘€︎ u/Moro18
πŸ“…︎ Oct 04 2021
🚨︎ report
Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation mdpi.com/2673-6284/10/4/2…
πŸ‘︎ 11
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πŸ‘€︎ u/Moro18
πŸ“…︎ Oct 04 2021
🚨︎ report
G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 12
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 13 2021
🚨︎ report
IJMS | Free Full-Text | G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 2
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 11 2021
🚨︎ report
IJMS | Free Full-Text | G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 18
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 11 2021
🚨︎ report
Selectivity and Targeting of G‐Quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics

A PtII compound was synthesized and adaptively bound G-quadruplex DNA through kinetic control. The solution structure of the complex was solved. It was further proved that the compound can target G-quadruplex in living cells, repress VEGF expression in cancer cells and inhibit blood vessels growth in zebrafish.

Abstract

G-quadruplexes (G4s) are prevalent in oncogenes and are potential antitumor drug targets. However, binding selectivity of compounds to G4s still faces challenges. Herein, we report a platinum(II) complex (Pt1), whose affinity to G4-DNA is activated by adaptive binding and selectivity controlled by binding kinetics. The resolved structure of Pt1/VEGF-G4 (a promoter G4) shows that Pt1 matches 3β€²-G-tetrad of VEGF-G4 through Clβˆ’-dissociation and loop rearrangement of VEGF-G4. Binding rate constants are determined by coordination bond breakage/formation, correlating fully with affinities. The selective rate-determining binding step, Clβˆ’-dissociation upon G4-binding, is 2–3 orders of magnitude higher than dsDNA. Pt1 potently targets G4 in living cells, effectively represses VEGF expression, and inhibits vascular growth in zebrafish. We show adaptive G4-binding activation and controlled by kinetics, providing a complementary design principle for compounds targeting G4 or similar biomolecules.

https://ift.tt/3dQjT9O

πŸ‘︎ 2
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πŸ‘€︎ u/TomisMeMyselfandI
πŸ“…︎ Jun 02 2021
🚨︎ report
Interesting research article (July 2021): G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 3
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 14 2021
🚨︎ report
What are the full logistics of buying a quadruplex as a first home to live in, while renting out the remaining units?

I was considering on buying a quadruple as a first home with my partner. Let’s say that our loan qualifies us to a SFR for $645,000. And we want to buy a quadruplex that’s selling for $1,000,000. Would my loan amount change if I decide to buy a quadruplex instead? Because the remaining units rent can be used to offset the mortgage? And also, do I get taxed on the rent I collect from the tenants, since that would be used to pay the mortgage? Sorry in advance everyone because I have no idea how this works..

πŸ‘︎ 25
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πŸ‘€︎ u/jqucla
πŸ“…︎ Jan 27 2021
🚨︎ report
New interesting article: "G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story" mdpi.com/1422-0067/22/14/…
πŸ‘︎ 6
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 14 2021
🚨︎ report
G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 2
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 14 2021
🚨︎ report
A new paradigm in virology: Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection. sciencedirect.com/science…
πŸ‘︎ 5
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πŸ‘€︎ u/Moro18
πŸ“…︎ Apr 17 2021
🚨︎ report
G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 2
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 12 2021
🚨︎ report
Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences mdpi.com/1422-0067/22/7/3…
πŸ‘︎ 38
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πŸ‘€︎ u/Moro18
πŸ“…︎ Mar 28 2021
🚨︎ report
G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story mdpi.com/1422-0067/22/14/…
πŸ‘︎ 2
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 14 2021
🚨︎ report
IJMS | Free Full-Text | G-Quadruplex in Gene Encoding Large Subunit of Plan mdpi.com/1422-0067/22/14/…
πŸ‘︎ 8
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πŸ‘€︎ u/Moro18
πŸ“…︎ Jul 10 2021
🚨︎ report

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