Pramipexole Puns

Hi there, tnx for reading this, i could use some advice, would appriciate it very much. What do you think, could Pramipexole or 9mbc or something else help, considering all the stuff i tried. Looking for help with anhedonia+emotional numbnes and depression with lack of libido?

Here is quick list of some things i tried: Wellbutrine made depression and anxiaty worse, i could only take it for less then a week, it feelt like chemical depression, very dirty, darkness everywhere feel. Modafinil, vyvanse and ritalin increased anxiaty and focus (translate: staring like your favourite local drug addict into nothing) but no other benefit. Eglonil was a fun one few years ago, made me squirt milk, stopped taking it, my prolactin level is in upper normal range now, but still have few drops of milk producing daily, not enough to put in coffee tho. Ssri, venlafaxine, cimbalta, kvetiapin, seroquel, methyl-bcomplex, bremelanotide, don't help, nor NALT, dlphenylalanine and bunch of other nootropics. I dont feel any effect from them. NSI partialy helped for speach with aniracetam. Above 20 mg makes my thoughts go way to fast. Tho its possible aniracetam slowely worsenes depression, not sure about it yet.. 5htp gives me anxiety even in small doses, which makes me think i have enough of serotonin in my brain, yey... Magnesium glycanate makes me depressed with lack of energy, other forms of magnesium don't. One pill of Aripripazole made me severely loss energy levels, i couldnt move much for few days. Aripripazole is partial agonist of D2, 5HT1A, 5HT2C and D4 as well i think, and is 5HT2 antagonist. This little shit was like i went back to MDD.

Memantine helped with energy level and brain fog when i was in severe depression, you know the one where you cant get out of bed, but it doesnt help for anhedonia. I guess memantine helped becouse glutamate excitoxicity. Cagarette or two make my head hurt, my guess is because acetylcholine, becouse choline help to lower that headacke. I excercise regulary, blood, suger, everything is fine. Am not taking anything for over year and a half, just occasionaly some racetams, omega etc.. What do you think?

Instead of getting better , everything is worse . I take 0.18 prami and 6mg Zoloft per day . Both are very low but I have very bad side effects . Head pressure , headache, insomnia. Also genital numbness, Ed , delayed orgasm and zero libido came back . At least before I could get an erection with porn and cum within normal time . Wtf is going on guys ? Is this normal ? When does libido and spontaneous erection start ? Shall I stop or continue?

I am researching my RLS before I suggest to my psych.I found two possible treatments for my nighttime RLS. Gabapentin and Pramipexole.

The following is my analyses for both.

Gabapentin seems to help with RLS,Neuropathy and also sleep.It can be used for upto 6 weeks to not get dependent on it.

Pramipexole seems to be a superior option for RLS.But the sideeffects seem to be compulsiveness towards certain behaviour.

My question/postulation is this.Can I use gabapentin for 6 weeks and then use pramipexole(0.125mg) till signs of hypersexuality,excessive spendin/ gambling surface.

On the face of it,it seems like a good idea but I am not sure as I am not aware of what is actually happening in the body.

Any advise would be much aporeciated.

Hi All

I have some mild restless leg syndrome from mirtazapine, but that's not my main issue. I'm interested in pramipexole as an antidepressant for dopamine dysfunction (which I think was caused by covid affecting my neurological system).

Has anyone here got experience with it? What dosage did you take? What side effects did it cause? Did you notice any change in mood?

(Although pramipexole is used for parkinsons and restless leg syndrome, it's used for treatment resistant depression sometimes. But it's hard to find others who have taken it for this)

Thanks in advance..

I thankfully got some relieve from RLS with some emergency pramipexole and my neupro patch arrived right after. Last night I took the pramipexole. The restless legs disappeared instantly. However I did not sleep well, insomnia! Was a relief not to have as much pain and discomfort but alas it’s come back because of the lack of sleep. About to try the patch but wanted to see if anyone else gets insomnia from Dopamine Agonists and has any tips for me to help get a better nights sleep? I tried gabapentin at night and it helped the slew and the RLS but when it wore off on the am anxiety followed and it’s slowed me down with fatigue. Also made me depressed after a while. Hoping the insomnia goes away on the DA as they definitely work!

Can I use pramipexole with the Emsam patch?

Can pramipexole (mirapex) be added to tranylcypromine?

This is a dopamine receptor agonist.

If so, how long can it be taken and in what dose?

I need help asap...I have been using it for 6 days but no improvement 😨😨

Hi! Anyone taking Pramipexole experience too much dizziness, altered vision in the mornings?

So, has anyone here taken long or short term dopamine agonists? In particular, I am interested in pramipexole. Describe its effect and effect on anhedonia, and the effects of taking it or other dopamine agonists.

Well hello people... Taking Pramipexole doses sublingually for 1.5 months to eliminate anhedonia...

Now i decreased my dose and want to start Selegiline oral 5/10mg in a day....

So is it safe to start selegiline after pramipexole?? How many days should pass to start taking selegiline after prami? How is recomended?

There one man says that's they don't interact and i can take them together also ;)

For anyone who has tried pramipexole, what were the effects?

Even if it didn’t “work”, what did it do?

Has anyone here tried Pramipexole? Ibudilast? I have been using it since Dec 2019 at different doses and found it very helpful. Over time, I required less and less. I have spoken to one other user who has received great benefits from Ibudilast in restoring his cognition. If the following is somewhat correct, these wont "cure" your hppd. But they could help. There are several (if not dozens) of subtypes of hppd probably so a one size fits all is not going to happen. I'm not currently able to differentiate between people's subjective reported experiences and the different types (if someone knows more about this plz dm me). All I know is some people can have their remit completely with a single drug and others require a much more complex route for stopping symptoms and treating what cant be healed overnight.

My logic on this: This is just a theory of one part of one subset of HPPD. If it helps you, it likely will not help with visuals. It is meant to help with emotions. Also, I talk of toxcicity but it could also be, for you, just extreme overstimulation/d

1. Psilocybin upregulates SV2A --> decreased gaba --> increased excitatory activity at AMPA receptors --> possible immediate kaboom of receptors
2. If not immediate then psilocybin causes large increase and then temporary 50% decrease in 5ht2a receptor density --> disregulated neuro immune function --> tnf-a spikes -->decreases gaba a --> il-1b levels further disregulating ampar surface expression --> AMPA excitotoxcicity.
3. TNF causes astrocyte and microglial dysfunction furthering destruction and chaos
4. Pramipexole not only normalizes the surface functioning of AMPA receptors but also protects the brain from further insult via increasing reactive oxygen species, glutathione peroxidase, parkin, and α-synuclein (α-syn)
   1. it also "reduced cell apoptosis and promoted cell autophagy"
5. Ibudilast: IBD attenuated astroglial reactivity and increased glial cell-derived neurotrophic factor (GDNF) production in the striatum. Moreover, IBD reduced TNF-α, IL-6, and IL-1β expression.

The goal is to normalize the glutamate functioning via the pramipexole and to reduce the negative and cascading effects of the neuro-immune system.

Dosage: Pramipexole 1-4 mg daily. Start titration at .25mg daily; Ibudilast 10-30mg daily. Start at 10mg and work upwards comfortably.

.

"Our results showed that PPX 1 mg/kg prevented EAE development, abolishing EAE signs by blocking neuroinflammato

I'm coming off opiates, and the only thing that always get's me every time is the severe RLS I get; I can deal with every other symptom.

I've heard Requip is amazing for treating RLS brought on by withdrawals... I can't get this, but I can get a Pramipexole prescription - which basically does the same thing apparently. It's a dopamine agonist.

I know withdrawal from Prami or Requip can itself cause RLS - among other symptoms. My question is: has anyone used one of these meds for RLS during withdrawals? How long did you use it for, and did you find that you had any rebound symptoms when you stopped the medication?

If it's safe for me to take one of these for the 1st 1.5 weeks at a low dose, I absolutely will.

I was planning to microdose (1/6 of a 100 to 150ug tab) today but I took 0.250mg of pramipexole (sifrol) last night because of my RLS acting up and making it hard to sleep. is it ok for me to still microdose today? would they interact at all? thanks ! love you guys xx

Well hello people... I'm fighting with anhedonia and currently i'm choose to fight with this shit taking Pramipexole (Dopaminergic) sublingually...

Tried many SSRis SnRis and Atypicals before prescribed by doc...

So what's ur recomendations when take this med ??? In the morning on empty stomach or when?

Why it's not discussed here? I think this one is the strongest libido/sex booster med I've tried. 0.25-0.5mg is enough to get into horny trap that you're not able to escape until you're dry. Believe me, it gets you obsessed af. The downsides are sleepiness and slight nausea, but that may be countered by slow titration (don't take more than 0.25mg in your first day and titrate up no more than 0.125mg for each day)

Well hello people... Started taking Pramipexole (Dopaminergic) to cure and eliminate fully my anhedonia...

So i'm interested if any diet required while taking Dopaminergic med? Maybe i'll avoid rich tyrosine food like cheese?

What u know about this please comment...

Hello my fellow empties,

Long-term trauma has caused wiring changes and rendered me totally unfunctional, in spite of hella therapy, around 26 different medication trials, TMS, and ECT. Someone on here posted that mirapex got them out of anhedonia.

I looked into it, and there are several studies demonstrating some effectiveness. Here's an overview with some context, stats, and links to the studies. That site noted that "Severe anhedonia, lack of motivation, inability to initiate behaviours, and unreactive mood are predictors of response."

Has anyone here tried it out?

View Poll

Well hello people... Tried many meds to cure anhedonia... It's time to try pramipexole sublingually...

Need advice who knows and who taked...

So At what time of day is recomended to take pramipexole ? In the morning at empty stomach?

I have depression that almost certainly is rooted in dysfunctional dopaminergic processing (anhedonia, emotional blunting, low motivation, cognitive difficulties, zero libido). Taking tyrosine, phenylalanine, and other standard vitamins, minerals and amino acids hasn't really helped. In the past I have taken Adderall and Ritalin and my depression vanished almost 100% while the drugs were working. Pramipexole and 9-Me-BC both seem promising but I'm nervous about tinkering with my dopamine receptors.

tl;dr – Mirapex/Pramipexole worked awesomely on my anhedonia after living in hell for 3 months. Still working after 3 weeks and will give updates and answer questions.

I am a person prone to depressive episodes. As a result I have been on Lexapro (10mg) for years. About 2 years ago, I weaned off and felt fine. Six months after that, I had an episode that was pretty bad but standard depression. Lexapro didn’t kick it, but Lexapro plus .5 Rexulti just made it go away like nothing ever happened. Rexulti was a miracle.

Then comes Covid. I was fine for the first couple of months. Then at the end of May I had three incredibly stressful life events happen at once. Result was severe anhedonia that came on over a period of about a month. Could barely eat, nothing gave me pleasure. I could not read for pleasure or even watch TV. It was like living in a grey box with nothing but the feeling of despair of being trapped in that hell. I have never experienced anything like it, and would not wish it on any human being.

Psychiatrist tried Vibryd (couldn’t tolerate), increasing Rexulti (also could not tolerate due to akathisia), citilopram, atomoxetine, lithium, lamotrigine, mirtazapine, ketamine IV round. Nothing worked. Started a course of dTMS, but during it found the Fawcett paper and asked doctor to put me on Mirapex. He was game. Started at .25 2 times a day and no result. After 4 days increased to .5/.5 – Curtain completely lifted. A total fucking miracle. I increased to .75/.75 and have stuck there for the last 2 weeks. Working great with no side effects.

Note, when this happened I was in a course of dTMS. I was feeling no benefit, and the impact from the Mirapex was obvious and rapid. Even TMS psychiatrist acknowledged it was Mirapex. I still am going to complete the course as only 2 weeks to go.

Another note, during the 3 months of misery the doc gave me Modafinil. At 200mg it gave me some relief, but I built a tolerance in about 10 days. After that increased to 400, and again gave relief over 10 days. In each case diminished over time, and eventually disappeared.

In any event, ask me anything.

Hi, pls let me know if Bupropion is not working to help in minimizing sexual dysfunction cause by SSRIs. Can I ask my psych to try Pramipexole on me? And is this med okay for long term use? I am a male, 31 yo.

Blessings to all the members of this sub. My mom has a really rare condition of Parkinson's and Multiple Sclerosis. She was diagnosed with MS 40 year ago and then with Parkinson 10 year ago. She has been taking pramipexole for the last 10 years. Three months ago we took her to a new neurologist (we recently move to South Florida) who recommended to gradually eliminate the pramipexole because most of the syptoms she was displaying (muscle spasm, involuntary muscles movement, extreme drowsiness, insomnia, etc) could be attributed to the pramipexole. The neurologist told us her body was intoxicated with the medication and we should try leaving it out of her regular treatment. We were really happy to hear that because we have lost hopes thinking all those symptoms were due to a MS relapse.

Fast forward three months later, she has been having a horrible time since she left the pramipexole. She is having these daily episodes were she is unable to even move her tongue properly accompanied with a terrible migraine and muscles spasm. On the bright side, the involuntary movement has stopped completely. I increased her dose of Carbidopa/Levodopa and that seems to alleviate some of the symptoms.

I know this may be a case of Pramipexole withdrawal but i am unsure if she should keep grinding through the pain until she gets better or if this has been a terrible mistake on our end. I asked the neurologist and her response was: "it looks like withdrawal symptoms, but if she wants it she should start taking pramipexole again" i was really dissatisfied with that response and decided to take her to a different specialist. The new neurologist told us "thats the price you are paying for leaving the pramipexole" and also "there is another treatment that can help but it is extremely expensive and don't think your insurance will cover it. Besides, it will only improve her condition a 10% it is not worth it going broke for only 10%" at the end he recommended us to start taking pramipexole again.

I am really disappointed, angry, and hopeless because of both specialist responses, and i really do not know what is the right step to take. I do not want her to start taking pramipexole again, specially because she has been enduring so much expecting to eventually get better, but also, i don't want her to keep suffering for something that may never happen.

I am searching for a third opinion but if someone else has had any experience with pramipexole withdrawal i would love to read

So hello people... I'm thinking to start Taking Pramipexole to cure my Anhedonia caused by lifely stress and pain.... Also want to talk doctor about this but before doc i want ur suggestions... How i'll take my dose ? For example if my dose will be 0.250mg i'll take 0.125mg at morning and second dose before bedtime? Or take it fully in the morning or what? Also interested it can cause sleep problems? What if i'll take Melatonin Before sleep ?

I need help asap...I have been using it for 6 days but no improvement 😨😨...3mg