A list of puns related to "Microbiota"
If you have not read part 1 of gut microbiota theory then this post will not make sense. You can find it here: https://www.reddit.com/r/PSSD/comments/q03uci/gut_microbiota_theory_how_i_finally_cured_my_pssd/
As many of you know, despite being cured from PSSD for a few months now, I still dedicate much of my time towards helping people with PSSD and researching the gut connection. I believe that I now have a (nearly) complete etiology of PSSD, hence the reason for this post. To start, I want to establish the connection between PSSD/PAS/PFS, CFS (chronic fatigue syndrome), and Covid Longhaul. If you have not heard of CFS or Covid Longhaul, I encourage you to look into them. These conditions are identical to PSSD/PAS/PFS; the symptoms are the exact same (with the exception of those who do not experience brain fog or fatigue - I'll explain this discrepancy later). If you have any doubt about this, please go onto the corresponding subreddits for these conditions and read peopleβs stories, I can guarantee they will ring a bell. I began looking into CFS when my PSSD fatigue was getting bad and that was the first time I noticed all the similarities (however many other researchers have noticed these similarities as well). After I had cured myself by treating my SIBO, I began to notice that SIBO also has a very high prevalence in the CFS community. Sure enough, I had even found cases and stories of people curing their CFS after a corrective mechanism to the gut (change in diet, fmt, probiotics, etc). I doubt many of you know what Covid Longhaul is, but it is essentially a CFS/PSSD-type state that people can go into AFTER getting covid. Just like with CFS and PSSD, some recover and their symptoms go away and some donβt recover at all. It is common knowledge that viruses (such as covid) are capable of altering the gut microbiome so this is another clue that points to Covid Longhaul being a gut issue. You already know (from my previous post) that SSRIs can alter the gut microbiome and leave it with reduced diversity. If you do not know what the MMC (migrating motor complex) is, look into it. It is the muscle mechanism that the gut uses to digest food and move bacteria and fungi out of the small intestine. Gut motility describes the ability of the MMC to perform its job. There are many different factors that affect gut
... keep reading on reddit β‘Eubiosis is the condition where the "good" bacterias and "bad" ones are in equilibrium. Literature says probiotics (lactobacillum, bifidobacteria, eubacteria etc) have beneficial effects on our health and therefore we should promote their growth, expecially in the colon. But why the goal isn't an intestinal flora only made by probiotics? Why to maintain health we need pathogens?
I know thereβs all this hype going around about PSSD being linked to gut problems and a lot of people claim to have been cured or at least benefitted from antibiotics. I recently found out that a whole bunch of antibiotics can actually cause neurotoxicity, which is really a red flag when it comes to this theory. I had anhedonia for a year prior to taking the SSRI, and I had always figured that I developed it naturally. When I learned this information about antibiotics, I remembered that a few months before the anhedonia started, I took an antibiotic. Looked back at my medical records, turns out it wasnβt months, it was barely a week before the anhedonia. And the particular antibiotic I was given causes neurotoxicity.
So what do you guys think about this? Knowing that antibiotics can fuck up your brain chemistry, do you think this could be the reason some people here benefit from them?
^
A synthetic emulsifier has been shown to alter the types of bacteria in our gut, leading to inflammation.
https://www.sciencedaily.com/releases/2021/11/211130130223.htm
The lead researcher made a video about it too: https://www.youtube.com/watch?v=0o6F1A6moT8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861737/
Fasting is increasingly popular to manage metabolic and inflammatory diseases. Despite the role that the human gut microbiota plays in health and diseases, little is known about its composition and functional capacity during prolonged fasting when the external nutrient supply is reduced or suppressed. We analysed the effects of a 10-d periodic fasting on the faecal microbiota of fifteen healthy men. Participants fasted according to the peer-reviewed Buchinger fasting guidelines, which involve a daily energy intake of about 1046 kJ (250 kcal) and an enema every 2 d. Serum biochemistry confirmed the metabolic switch from carbohydrates to fatty acids and ketones. Emotional and physical well-being were enhanced. Faecal 16S rRNA gene amplicon sequencing showed that fasting caused a decrease in the abundance of bacteria known to degrade dietary polysaccharides such as Lachnospiraceae and Ruminococcaceae. There was a concomitant increase in Bacteroidetes and Proteobacteria (Escherichia coli and Bilophila wadsworthia), known to use host-derived energy substrates. Changes in taxa abundance were associated with serum glucose and faecal branched-chain amino acids (BCAA), suggesting that fasting-induced changes in the gut microbiota are associated with host energy metabolism. These effects were reversed after 3 months. SCFA levels were unchanged at the end of the fasting. We also monitored intestinal permeability and inflammatory status. IL-6, IL-10, interferon Ξ³ and TNFΞ± levels increased when food was reintroduced, suggesting a reactivation of the postprandial immune response. We suggest that changes in the gut microbiota are part of the physiological adaptations to a 10-d periodic fasting, potentially influencing its beneficial health effects.
My first thought is to maybe not mess with "improving" what the keto diet does for the gut.
>Conclusions
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>Multiple studies have shown the beneficial effects of a ketogenic diet on metabolic
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>health and reduced seizure activities. These effects are likely, at least in part, mediated via
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>the gut microbiota. However, in all domains, large clinical trials are lacking incorporating a
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>ketogenic diet, gut microbiota, and metabolic health. To date, most evidence comes from
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>rodent research and small clinical trials. Clinical trials and prospective cohorts are needed
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>to elucidate the mediating role of the gut microbiota in the beneficial metabolic effects of a
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>ketogenic diet. This will give rise to potentially altering the gut microbiota prior/during a
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>ketogenic diet using pre-, pro-, or synbiotics which can improve the effectiveness of the
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>ketogenic diet.
The Role of the Gut Microbiota on the Beneficial Effects of Ketogenic Diets (PDF)
Attaye, I., van Oppenraaij, S., Warmbrunn, M. V., & Nieuwdorp, M. (2022). The Role of the Gut Microbiota on the Beneficial Effects of Ketogenic Diets. Nutrients, 14(1), 191. https://doi.org/10.3390/nu14010191
Conclusions
The above-mentioned studies indicate that several age-related physical and physiological aspects of health in laboratory animals and even humans have been improved significantly after the supplementation of Lactobacillus strains either alone or in combinations. These aspects include enhancing the ageing-gut microbiota, improvements in host antioxidation system (production of antioxidant enzymes and regulation of gene expression), enhancements of immune system, minimizing the abnormalities related to brain ageing through the gut-brain axis (anxiety and memory loss), and inhibition of both internal and external factors that contribute to skin ageing. Emerging studies at the cellular and molecular level reveal that Lactobacillus can increase the resistance of cells, tissues, and organs to ageing and age-related disorders. Although previous studies have shown promising effects regarding the role of Lactobacillus, large-scale randomized, placebo-controlled, double-blind clinical trials are still needed to elucidate their substantial role in ageing and age-related problems in humans. The selection of appropriate strain, their optimal dose, method of administration, and duration of treatment period are yet to be confirmed. Progressive research suggests that in the future, probiotic Lactobacillus may be used as an alternative treatment to conventional therapy by modulating the gut microbiota and host immune system.
Hi everyone, I bought 99.86% pure methylene blue containing 1ppm of lead and 2ppm of arsenic. I was enthusiastic about the studies read on pubmed about the mitochondrial restorative abilities, antidepressant activity (maoi), neuropathic pain, nootropic activity, arthritic pain of methylene blue. in these studies they talk about excellent results, zero side effects, even at a high dosage (100mg per day). I have a scale that weighs up to the third decimal place (1mg minimum) I am taking it for a couple of days at 1mg, but I am not experiencing any positive effects, on the contrary ... increase of lethargy and reduction of strength and energy and strong difficulties digestive, with burps, acid regurgitation, headache even if i drink water. at this point I think that being a powerful antibacterial, methylene blue destroyed my intestinal bacterial flora, also because after I stopped it and started taking lactic ferments, my stomach was regularized. do you also encounter these problems? do i have to reduce the dose again? but how do you measure micrograms? how do you say it is a panacea even at 100mg a day if it kills all your intestinal flora? since it stains every surface it comes into contact with and does not go away even with bleach or ammonia, is it logical to think that even inside our stomach or body there are stains? are they harmless? Maybe this low energy and lethargy is caused also by its maoi effect, so by the serotonin increase ?
This seems... not good. https://www.sciencedaily.com/releases/2021/11/211130130223.htm
>The team performed a randomized controlled-feeding study in healthy volunteers. Participants, housed at the study site, consumed an additive-free diet or an identical diet supplemented with carboxymethylcellulose (CMC). Because the diseases CMC promotes in mice take years to arise in humans, the researchers focused here on intestinal bacteria and metabolites. They found that CMC consumption changed the make-up of bacteria populating the colon, reducing select species. Furthermore, fecal samples from CMC-treated participants displayed a stark depletion of beneficial metabolites that are thought to normally maintain a healthy colon.
Carboxymethylcellulose (CMC), also known as cellulose gum, is in a lot of food, even gum. It's basically wood chips. https://foodadditives.net/thickeners/cellulose-gum/
This study has shown that Finasteride alters the gut microbiome in persons who suffer from persistent Post-Finasteride Syndrome symptoms, suggesting a potentially new and novel approach to treating these unwanted symptoms
I want to start by discrediting my previous theory about what PSSD is. I originally stated that I believed PSSD to be the result of low dopamine caused by serotonin receptor downregulation in the brain. In my journey, Iβve discovered many holes in this theory and with my most recent discovery, I think it is safe to toss this theory out the window. However, it is still very relevant to the true cause of PSSD and I will make this connection at the end of this very long post.
In my journey, Iβve tried many things that did not work. Iβve tried 5HT1A antagonists (CBG), with no improvement. Iβve tried Inositol, with significant improvement, but nevertheless, upon discontinuation, my symptoms all slowly came back. Iβve tried a high dose testosterone cycle (despite testing at normal T levels), which yielded only slight improvement.
My fatigue and brain fog, which came with the PSSD, were seriously interfering with my job and so I decided to go to the doctor in the hopes of getting a lot of bloodwork done. My bloodwork came back completely normal, except that my vitamin B12 and D levels were low (not crazy low, but low). I asked my doctor what can cause this and she said that a large portion of the population has trouble absorbing these vitamins but oftentimes it is the result of overgrowth of bad bacteria in the intestine, known as SIBO. I told her that I have been experiencing occasional gut discomfort and bloating, and that Iβve had a history with IBS. That was enough for her to suggest a hydrogen/methane breath test (the test for SIBO). Sure enough, the test came back positive and so she referred me to a GI doctor to treat my SIBO.
At first, I doubted any connection between my SIBO and PSSD as a whole. I began looking at the r/SIBO subreddit to see what kinds of symptoms people experience, and found symptoms very similar to what Iβve been experiencing: fatigue, brain fog, gut/stomach discomfort, bloating, anxiety, even sexual dysfunction (low libido, ED, etc). I still wasnβt convinced this had anything to do with PSSD but I kept doing research. I discovered that ONE CAN HAVE SIBO BUT STILL EXPERIENCE NO GI SYMPTOMS. This is commonly referred to as silent sibo. DO NOT BE FOOLED BY THE SIBO SYMPTOM LISTS YOU ARE PRESENTED WITH ON GOOGLE. When talking with my SIBO specialist, he said that nearly β to Β½ the patients he sees have some kind of sexual impairment, yet there is next to no mention of this in the symptoms lists youβll find online. I did rese
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