Title title title title title title title title title title also like tell me the reason why I should
Edit: I got covid before and I didn't really feel anything? Just a cold I guess. At least for me.
What mechanism immunologically speaking, causes people to be asymptomatic COVID-19 carriers? Is it that the innate immune system is more capable of controlling the infection very early in certain individuals?
I've asked my immunology professor and a few other medical professionals and they have all stated that it is not yet clear. I was curious if anyone has a better answer for me :) Thanks!
Stamets has talked about the difference of sterile cultures of mushrooms versus ones found out in the wild.
Basically, if you have a sterile mushroom / mycelial culture, it is what is known as "immunologically naive". It has not had to deal with all of the things that try and attack/digest / consume out in the wild.
What I am wondering is for those of you who have tried both homegrown and wild collected versions of the same species: have you noticed any difference at length with MD'ing one or the other?
This is the best tl;dr I could make, original reduced by 94%. (I'm a bot)
> Here, we report that unadjuvanted seasonal influenza vaccination via intratumoral, but not intramuscular, injection converts "Cold" tumors to hot, generates systemic CD8+ T cell-mediated antitumor immunity, and sensitizes resistant tumors to checkpoint blockade.
> To increase response rates to immunotherapy, innovative solutions are needed to convert cold tumor microenvironments to hot by increasing infiltration of inflammatory immune cells that can serve as targets for immunotherapies in tumors devoid of immune infiltration and can overcome local immunosuppression in tumors infiltrated by regulatory cells.
> A similar systemic outcome was observed in the 4T1 model of metastatic triple-negative breast cancer, where both primary tumor growth and lung metastases were reduced after intratumoral injection of hiFLU only into the primary tumor, suggesting that intratumoral hiFLU positive antitumor outcomes are not limited to skin cancers or to nonmetastatic tumors.
> Our study proposes that intratumoral injection of an unadjuvanted seasonal influenza vaccine reduces tumor growth by converting immunologically inactive cold tumors to immune-infiltrated hot tumors, by augmenting DCs and tumor antigen-specific CD8+ T cells within the tumor microenvironment.
> Specifically, our study shows that intratumoral seasonal influenza vaccination 1) can reduce tumors on its own, 2) improves outcomes in the context of tumors that respond to PD-L1 therapy, 3) can reduce tumors even when they are resistant to PD-L1 blockade, and 4) in combination with PD-L1 blockade results in drastic reductions in tumor growth.
> For tumor challenge experiments, B6 and NSG mice were anesthetized with isoflurane and administered 100,000 to 150,000 B16-F10 melanoma cells via i.v. or intradermal injection and BALB/c mice were anesthetized with isoflurane and administered 100,000 to 150,000 4T1 triple-negative breast cancer cells in the mammary fat pad. B16-F10 and 4T1 cancer cell lines were cultured in Dulbecco's Modified Eagle Medium, 10% fatal bovine serum, 100 units/mL penicillin, 100 mg/mL streptomycin, and 0.29 mg/mL glutamine prior to harvesting for tumor injection.
Summary Source | [FAQ](http://autotldr.io/ "42317
... keep reading on reddit ➡Went for my monthly haircut last Sunday at supercuts (PhD stipend...). Only one hairdresser was available at the time, the same one that had cut my hair the last two times. We had a bit of small talk but it was a very quiet and fast haircut, no hot towel or mirror to check the back of my head at the end. I tipped my usual 25% and went to lab. I get home at night and look myself in the mirror and there are noticeable length differences just above the ears, next day I finally figure out how to look at the back of my head and notice the whole back looks awful and I have a rogue patch of hair hanging from my neck. I think to myself it was just a one time thing, but then I started to remember that the same hairdresser was very cold/rushed with me the previous 2 times (also no hot towel or mirror), and also remembered that the first time I saw her she was the only hairdresser not wearing a mask and also she seemed taken aback with my "I work in immunology research" answer after she asked what I do for a living. She also complained about "hispanics and their new year's firecrackers" (I'm from southamerica) to me, so I start to make a few assumptions about this person...
TL;DR: Don't tell your masks-less hairdresser in Texas that you work in immunology
Hey guys,
I'm looking to transition into biotech from my academic postdoc but I'm not sure where or when to start. I've been working in science for ~11 years but only in academia. I've been in my current position for about 1.5 years and think I've made significant contributions to the lab, but haven't published any research yet (it's a lot of long studies, in vivo work). I'm funded by a fellowship until mid-2023 and am paid ~10% above NIH guidelines. I'd like to stay in cancer immunology translational/clinical research.
I'm considering these areas:
- San Diego
- Boston
- New York
But have no idea what kind of salary or benefits to ask for, what companies I should seek out or avoid, or even what position/title I should look for. Is there a preference for bigger or smaller pharma companies? When should I start looking to leave? I like my boss and want to help finish up the work but I'm also eager to move on.
I'd really appreciate your help with this, I don't feel comfortable talking about it at work for obvious reasons so I'm at a loss for who else to ask for advice. Thank you so much.
As an IR I have forgotten a lot of the immunology I once learned. One of the arguments against a 4th COVID vaccine is that it might lead to a diminished immune response. Can someone smarter than me explain?
"We expect our vaccine candidate for prevention of genital herpes to proceed to human trials by summer 2022. We are now working on a vaccine as treatment for genital herpes that will reduce the frequency of outbreaks for people already infected. We are also evaluating whether we can develop a vaccine to prevent and treat oral herpes."
https://www.med.upenn.edu/apps/faculty/index.php/g20001882/p2712
Read a lot about it but couldn't find an answer or a more proper subreddit to ask this, so hoping this doesn't get deleted.
For clarity: can a fever be THE causing factor behind the human body winning an immunologic battle against an infection that would otherwise cause death or other permanent type of harm without the help of medical treatment?
I know the question is very specific and it might be hard to find someone who knows the answer.
If you provide a positive answer please specify against which pathogens does a fever actually enable a turning of the tides if you can.
