The most statistically-powerful study on autism to date has confirmed that the disorder is strongly heritable. The analysis found that over 80% of autism risk is associated with inherited genetic factors. jamanetwork.com/journals/…
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πŸ‘€︎ u/Lightfiend
πŸ“…︎ Jul 19 2019
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Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm tandfonline.com/doi/full/…
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πŸ“…︎ Aug 28 2019
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They meta-analyze whether race or ethnicity moderate the heritability of intelligence in the US; find moderate to high heritabilities that do not substantially differ by race or ethnicity bipartisanalliance.com/20…
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πŸ‘€︎ u/jordiwmata
πŸ“…︎ Nov 28 2019
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The heritability of self-control: A meta-analysis sciencedirect.com/science…
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πŸ‘€︎ u/mddtsk
πŸ“…︎ Jan 20 2020
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What is the Heritability of Planeswalker Sparks?

Post-mending, I know that Sparks appear at random in sentient creatures. Is there any evidence that Sparks are heritable? i.e. are children of walkers more likely to be walkers? Are children of two walkers guaranteed to be walkers?

I know of various examples of walkers having 'normal' children with a non-walker - Teferi's daughter springs to mind. However granted the extreme rarity of Sparks, this doesn't necessarily rule out that those children still had a better chance of getting a Spark.

I do not know of any examples of walkers having walker children/parents.

I do not know of any examples of two walkers having children of either tendency.

Can you help me out? Failing definitive answers, any speculation-fueling evidence one way or the other?

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πŸ‘€︎ u/ArchmageAries
πŸ“…︎ Sep 25 2019
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[Book] Genetics of Psychological Well-Being: The role of heritability and genetics in positive psychology

Pluess, Michael, ed. Genetics of Psychological Well-Being. Oxford University Press, 2015.

  • ISBN-13: 978-0199686674

  • ISBN-10: 019968667X

  • DOI: 10.1093/acprof:oso/9780199686674.001.0001

  • OCLC: 917215407

  • URL

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πŸ‘€︎ u/Epidemon
πŸ“…︎ Nov 10 2019
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Using heritability estimate as a measure of equal opportunity?

In his new book, Blueprint, behavioral geneticist Robert Plomin claim that you can use estimates of heritability as an indicator of equal opportunity and meritocracy within a society at a given point in time.

As everyone might not be familiar with the concept of heritability, some premises and context is needed (hope I don't miss something). Heritability does not simply equal "that which is passed down genetically". Rather, heritability is defined as the amount of variation in a phenotypic trait between individuals that can be attributed to inherited genetic differences between individuals. As such, when you reduce variation in genetics, environmental differences explain more of the variance (a good example is the trait of having two feet: this is a human universal and surely passed down genetically, but with almost no genetic variance due to its universality. Therefore, heritability is almost zero, and differences between people can be explained by environmental differences such as accidents). Similarly, when you reduce the variation in environmental conditions, heritability increases. For example, if there's large variations between those whose environmental circumstances allow them to get food on the table and those who can't, the heritability of height will decrease. If height no longer depend as much on whatever environment you happen to have been born in, but everyone is instead well fed, more of the variance can be explained by those who have a genetic propensity to grow tall. (This also means that a heritability estimate is specific to a specific population at a specific point in time. Change the circumstances and the estimate changes.)

Plomin suggest we can apply the same logic to things like educational attainment. Educational attainment shows substantial heritability (and is highly correlated with intelligence, also highly heritable), so removing environmental barriers would allow those with talent and interest to climb the socio-economic ladder and prosper in a society with equal opportunity and where there is selection for talent. And as he mentions, the heritability of educational attainment increased substantially in Norway during the post-war period where more and more people got access to education regardless of their circumstances. Current day Norway shows substantial heritability for educational

... keep reading on reddit ➑

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πŸ‘€︎ u/EvolutionaryPsych
πŸ“…︎ Jan 04 2019
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Large study reveals PTSD has strong genetic component like other psychiatric disorders - "Genetic data from 200,000 people reveals the heritability of post-traumatic stress disorder is similar to that of depression and other forms of mental illness" eurekalert.org/pub_releas…
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πŸ‘€︎ u/Lightfiend
πŸ“…︎ Oct 08 2019
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The Murray Fallacy and the Heritability of Bias

I wanted to share with this group some research I have done on the meaning of heritability metrics and how a number of people have misused them over the years. In relation to Sam, this is in the context of his discussion with Charles Murray, where this mistake was made widely and repeatedly.

The Murray Fallacy and the Heritability of Bias

I discuss in some detail the mathematics of heritability, it’s semantics, and how the misinterpretation of it causes mistaken assertions of futility in the face of ugly social constructs like bias.

I thought it important to share with this group in order to correct what are some very dangerous misunderstandings spread on Harris’ show to a community who are curious about the science.

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πŸ“…︎ Jul 30 2018
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"Estimating heritability and genetic correlations from large health datasets in the absence of genetic data", Jia et al 2019 nature.com/articles/s4146…
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πŸ‘€︎ u/gwern
πŸ“…︎ Dec 03 2019
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Estimating heritability and genetic correlations from large health datasets in the absence of genetic data nature.com/articles/s4146…
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πŸ‘€︎ u/TrannyPornO
πŸ“…︎ Dec 04 2019
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Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability nature.com/articles/s4146…
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πŸ‘€︎ u/enilkcals
πŸ“…︎ Dec 11 2018
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What's the heritability of ASD like in your family?`

I'm asking this for largely selfish reasons - my partner also has a pretty solid history of ASD in his family (not him but his father and grandfather).

We want kids, and we're planning to start the process of trying to get to a genetic counsellor, but we're contemplating whether it is responsible for us to even try to have children the biological way. I respect the right of all people to life, no matter where they are on the spectrum. But I would not handle it well if we produced someone who was nonverbal and could never be independent and we had to take care of them for the rest of our lives. I'm too emotionally frail for that (see: suspected ASD) and it wouldn't be fair to me, my partner or the kid.

So I'm terrified this means no bio kids for us...which has been making me really sad.

I know, I know, the logical answer is "just go see a genetic counsellor," and we will.

I guess I wanted to know if anyone is the product of ASD on two sides of the family? Or if anyone has good info on heritability of ASD (My reading basically comes up with: it's murky and poorly understood.)

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πŸ‘€︎ u/EmergencyBowler
πŸ“…︎ May 06 2018
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"Ultra-rare variants drive substantial cis-heritability of human gene expression", Hernandez et al 2019 biorxiv.org/content/10.11…
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πŸ‘€︎ u/gwern
πŸ“…︎ Sep 08 2019
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TIL at Stalin's time Soviet Union did not recognize Darwin's theory of evolution. Instead they recogized Lysenkoism. It belived in heritability of acquired characteristics. For example, the state of being leafless as a result of having been plucked could be inherited by that organism's descendants. en.wikipedia.org/wiki/Lys…
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πŸ‘€︎ u/wontbefound
πŸ“…︎ Mar 04 2018
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Statistical analysis of 400M people (family tree registrees of primarily Americans of European descent) suggests heritability of life span is below past estimates - seems less correlated with genetics than expected (previous results skewed by humans tendency to pick partners with similar traits) genetics.org/content/210/…
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πŸ‘€︎ u/stereomatch
πŸ“…︎ Nov 10 2018
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"Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model", Holland et al 2019 biorxiv.org/content/10.11…
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πŸ‘€︎ u/gwern
πŸ“…︎ Dec 16 2019
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The heritability of fertility makes world population stabilization unlikely in the foreseeable future sciencedirect.com/science…
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πŸ‘€︎ u/eleitl
πŸ“…︎ Jan 07 2019
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Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture nature.com/articles/s4158…
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πŸ‘€︎ u/TrannyPornO
πŸ“…︎ Jul 29 2019
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[OC] The Murray Fallacy and the Heritability of Bias – Nathan Harvey – Medium medium.com/@n.k.h.7390851…
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πŸ“…︎ Jul 19 2018
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The heritability of fertility makes world population stabilization unlikely sciencedirect.com/science…
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πŸ‘€︎ u/bprogramming
πŸ“…︎ Jul 05 2019
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Identification, Characterization, and Heritability of Murine Metastable Epialleles: Implications for Non-genetic Inheritance ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/TrannyPornO
πŸ“…︎ Mar 13 2019
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Dumb or smart asses? Donkey cognitive capabilities share the heritability and variation patterns of human cognitive capabilities escholarship.org/content/…
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πŸ‘€︎ u/gwern
πŸ“…︎ Sep 20 2019
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A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Areain Youth[85% heritability of total brain surface area] sci-hub.tw/10.1523/JNEURO…
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πŸ‘€︎ u/rayznack
πŸ“…︎ Jun 08 2019
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Little Evidence That Socioeconomic Status Modifies Heritability of Literacy and Numeracy in Australia onlinelibrary.wiley.com/d…
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πŸ‘€︎ u/TrannyPornO
πŸ“…︎ Mar 11 2019
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"Heritability of lifetime earnings", Hyytinen et al 2019 link.springer.com/article…
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πŸ‘€︎ u/gwern
πŸ“…︎ May 24 2019
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Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture biorxiv.org/content/10.11…
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πŸ‘€︎ u/TrannyPornO
πŸ“…︎ Jan 24 2019
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The extended genotype: the heritability of personality accounts for the heritability of recalled family environments in twins reared apart. ncbi.nlm.nih.gov/pubmed/1…
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πŸ‘€︎ u/TrannyPornO
πŸ“…︎ Jan 21 2019
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"Ancestry-specific polygenic scores and SNP heritability of 25(OH)D in African- and European-ancestry populations", Hatchell et al 2019 biorxiv.org/content/10.11…
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πŸ‘€︎ u/gwern
πŸ“…︎ Apr 05 2019
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