Hi everyone, I have a rather embarrassing question.
I am currently reading a paper which mentions "Haplotype switches" and I don't really know how I would explain that to others. I would be glad if someone could help me!
Hi All...
Beginner and learning about this. Have been doing some research on the mtdna full sequence, what the numbers means, etc. Been fun learning. My question is however, I just got the results from the mtdna full sequence and it of course told me my Haplotype, which is H3. Which I had known for years as I had the 23andme done. But when I have researched the h3, there are many subgroups and I was hoping the full sequence would tell me which specific subgroup I was apart of. But it just states H3. Is it not possible to find specific subgroup? Or does it take digging? Or am I just off in general about it. Im just part of H3, and if I was part of a subgroup it would be listed?
thanks
As the question says, I am trying to look for expertise in haplotype associations with right censored data. Where could I get help on this topic? I am at a loss.
Hi all! ELI5 request please 🙃 I am not an immunologist by any means and I’m way out of my depth here and would love some help. I am working with some mouse models and trying to understand further but keep digging myself into a more confused rabbit hole. I am trying to understand mouse haplotypes better. One of the mice I’m working with has h2kb and another is h2kd. Does this mean if i were to design primers targeted at k2kb (at a portion dissimilar from h2kd as I’m sure they’re quite homologous) that the mouse that is h2kd should not have any amplification? If the mouse is h2kd does that mean that the h2kb sequence should not exist anywhere in that mouse? There are multiple mutations that exist between these two mouse lines that serve to distinguish between the two lines but I’m just trying to understand if the h2kb mouse still has h2kd sequence existing somewhere in the germline or if it’s truly absent. I hope this question makes sense and I apologize if it’s a very dumb question.
Hi, Can anyone help me with the DNA searches? I want to filter the list to just the cousins with the same y Haplotype- is this possible? Non paternity events makes a surname search impossible. Hope this makes sense , many thanks
Hello people so I am ofc a Kohen, which is the Jewish priestly line that goes all the way back to Aaron though a patrilineal line so for example, my fathers, fathers, father.
But I got question because the things I found did not quite answer my question I’m under the impression any Jew with the J1 or J2 or J-p58 haplotypes are Kohen’s. But is that true? Or is it just one of them?
(For reference I have not got my kit back yet)
(Also for reference I’m a Kohen from both sides of my fathers fam)
(Also for reference my last name is not Cohen I have an oral tradition. For example on my great grandfathers Katuba I think it’s called or basically the tombstone it says “The Kohen” and it shows as such the hand symbol and in my Hebrew name has “Hakohen” at the end of it)
Hello, everyone! I’m currently reading a thesis paper on SNP genotype analysis using HMM. In the section that discusses the HMM structure, it is said that the HMM is “fully determined by the number of SNP loci n and a user-specified number of founders K (typically a small constant, we used K = 7 in our experiments).”
Now, I’m curious, what’s the basis for choosing the number of founders K? Also, once this constant is specified, are the K founders chosen at random from the reference panel? (assuming I understood it right that the “founders” are the individuals from the reference panel)
Thank you!
After the chromosomal fusion that gave us 23 chromosome gametes, there was a period of dicentrism, until one of the two centromeres failed and fertility returned to that founding line. But that failed centromere is still there on every #2, and it is completely non conserved, so that region is decaying dna.
I would expect that a study of the failed centromere, searching for changes across humanity, would at least give a date for the fusion event. Might give a full haplotype tree of human expansion since it happened.
