hi y’all, i’ve seen this on a few youtube channels awhile back but i’m wondering if anyone has any experience or advice for mini-doing glucagon?
this is something people do (from what i’ve seen) to treat lows in non emergency situations rather than just using glucagon for emergencies.
i am rarely hungry when i have lows and especially in the middle of the night, eating and going on the low to high yo-yo is a bitch. (i was low literally 3 different times last night)
i think mini dosing would make treating my lows much easier and manageable.
i’m wondering which glucagon people use for this? is it the vial kit that you reconstitute when ready to use? how long will that vial last?
any comments would be appreciated!
I had a bad low today; went down to 2.3mmol/L just before lunch. It was a bit scary because I had the shakes among other things and 1 1/2 cups of juice didn't budge my reading for a while. I just ate my lunch without bolusing and finally started to come back up. My daughter was working from home today, so I did ask her to come in and check on me during llunch.
I have no glucagon and no one on my medical team has ever mentioned it to ne, but after I was sufficiently recovered I called the diabetes educator at the hospital and asked if I can get a prescription when I go there on Monday to get my covid booster jab. They are going to organise the script for me, but I forgot to ask them the cost.
Is it subsidised via the NDSS or Medicare? I am on a low-income health card if that helps.
Why is calcium contraindicated in someone taking digoxin.
And during my inpatient psych clinical yesterday a psych patient made an alluding threat, “you’re a small women and you deal with a lot of big guys like me and you’re separated from your partner when we’re in the back transporting.”
Can I steal a firefighter for transport if a patient unsettles me in some way, like that one?
It was deeply unsettling the way he made a threat that didn’t sound like a threat if you weren’t paying attention.
what exactly is the difference in use of cortisol and glucagon? I know that glucagon is a peptide hormone that functions through interacting with GPCR's while cortisol is a steroid hormone that alters DNA transcription. I also know that the eventual end goal of the two is to increase blood glucose levels, my question is, when would one be used over another. I originally throught that glucagon increased blood glucose when fasting so it was slower while cortisol was associated with fight or flight so it was faster, but i saw an explanation somewhere that it is actually the opposite and Im now a little confused. Any help would be great
Our teen daughter has diabetes 1 and recently had her first major hypo attack. It was very scary but we managed to get her to drink some juice to get her blood sugar back up. But it was very close and we were lucky she could drink.
There are glucagon injections you can give to someone who is unable to swallow anything, but our doctor said that the pharmaceutical companies stopped selling them in China because of low demand. Does anyone know how to still get hold on them? Maybe even buy them abroad somehow? If needed her doctor can write a prescription (in Chinese or English or probably another language).
If anyone has any information then that would be extremely welcomed. We are very worried that it might happen again.
Edit : particularly glucose
Let's say a diabetic patient becomes hypoglycemic during exercise. Also, let's say this was because of the lingering effects of exogenous insulin and impaired ability to make endogenous glucose.
Regarding the second part, I know of two mechanisms that can lead to impaired endogenous glucose production—both involving glucagon-mediated gluconeogenesis and glycogenolysis:
- alpha-cell fatigue: alpha-cells somehow can't make enough glucagon.
- exogenous insulin suppressing glucagon release.
How can one differentiating between those two mechanisms in a clinical setting?
Looks like it's been out for a couple of years? I've not heard of it -Baqsimi - but I'm on my way to get some right now! baqsimi
I was raised with the idea that a diabetic and his Glucagon should never part, and as far as I know all my fellow Romanian diabetics get the same drilled into their skulls. I have several Glucagons stashed, one on me at all times and my partner also now has made it a habit of always carrying one on him, just in case I forget. But then I saw the other thread on what a diabetic should always have on them, and only two other people mentioned Glucagon.
It made me wonder: is this due to a cultural difference? Or do you guys have a reasoning for why you don't carry one? I have had to take it 3 times, when I got to 35 - the point where passing out is imminent. Forgive my brusque language, I am genuinely curious - how are you not scared of the potential of entering a coma?
Whenever I go out I always carry my glucagon in my pocket in the large plastic case it comes with. I would like something slimmer that can fit in my pocket to hold the needle and vial preferably side by side so the case doesn't stick out of my pocket. I think the best I've been able to find are some slim fountain pen cases but the dimensions are still slightly too small. Does anyone have any other suggestions?
After eight+ years of having t1d (I was diagnosed in my early 20s) I finally had a life-threatening low at home. My hubby knew what to do and injected me with glucagon as I was in and out of consciousness, and it brought it up as it’s supposed to. It only brought me to about 190 however, and then I started dropping again! Is this normal for glucagon? Is it only supposed to bring you up for a small amount of time? Thankfully I was conscious enough to dose sugar the second time around, but I was surprised it didn’t keep me in a safe range. Since it’s the first time we’ve had to use it I don’t know much! Info would be appreciated!
If so, what bags do you guys have/recommend? I’m trying to find a smaller alternative to what I have right now that can carry my boosts and glucagon. I have a dexcom and pump so I shouldn’t need to carry much else.
https://doi.org/10.2337/db21-0024
https://pubmed.ncbi.nlm.nih.gov/34702780
Abstract
Hyperglucagonemia is a common observation in both obesity and type 2 diabetes, and the etiology is primarily thought to be hypersecretion of glucagon. We investigated whether altered elimination kinetics of glucagon could contribute to the hyperglucagonemia in type 2 diabetes and obesity. Individuals with type 2 diabetes and preserved kidney function (8 with and 8 without obesity) and matched control individuals (8 with and 8 without obesity) were recruited. Each participant underwent a 1-hour glucagon infusion (4 ng/kg/min), achieving steady-state plasma glucagon concentrations, followed by a 1-hour wash-out period. Plasma levels, the metabolic clearance rate (MCR), half-life (T ½ ) and volume of distribution of glucagon were evaluated and a pharmacokinetic model was constructed. Glucagon MCR and volume of distribution were significantly higher in the type 2 diabetes group compared to the control group, while no significant differences between the groups were found in glucagon T ½ Individuals with obesity had neither a significantly decreased MCR, T ½ , nor volume of distribution of glucagon. In our pharmacokinetic model, glucagon MCR associated positively with fasting plasma glucose and negatively with body weight. In conclusion, our results suggest that impaired glucagon clearance is not a fundamental part of the hyperglucagonemia observed in obesity and type 2 diabetes.
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Open Access: True
Authors: Magnus F.G. Grøndahl - Asger Lund - Jonatan I. Bagger - Tonny S. Petersen - Nicolai J. Wewer Albrechtsen - Jens J. Holst - Tina Vilsbøll - Mikkel B. Christensen - Filip K. Knop -
Additional links:
So I get doc to write script for glucagon kit. This is something that we have had but realized they were very outdated so asked for a new one.
MedMu says that is strictly a Caremark issue and to talk to them.
Caremark rejected it, saying it needs a prior auth.
Back to doc. Doc sends prior auth, Caremark rejected, saying not covered. It is.
Back to medmu. They say they have no info on coverage (!) and need to talk to Caremark.
Call Caremark and they say I need doc to fax a medical necessity form to Caremark at special appeals fax number.
She also mentioned that when that is rejected I should call fir the “second appeal “ fax number.
Seriously! When do I get a lawyer involved?
The worldwide glucagon market was valued at US$ 461 Mn in 2019 and globally it is projected to reach US$ 837.0Mn in 2029 at a CAGR of 6.2% from 2020 to 2029.
https://preview.redd.it/5f6ro0yd51q71.jpg?width=3999&format=pjpg&auto=webp&s=9d514bf037d6dc533bd7c07fb602a475cc553fa4
I really don’t get why I have to pay out of pocket for basically sugar and a syringe They are about $600
Of course, narcan is free but sugar water is $600
I just received a letter that the Glucagon Kit by Eli Lilly with lot number D239382D is being recalled. It only affects this lot number. Contact 1-800-LILLYRX for return and replacement instructions. Hours of operation is M-F 9a.m.-7p.m. EST.
Glucagon production is triggered/stimulated in the pancreas by protein intake. What is it about the protein that triggers this hormones production? Is it not the protein itself but the breakdown of protein? I am really curious to know if its directly related to amino acids from protein or something else in the protein.
Hey guys 👋
So I'm newly diagnosed type 1 (3 months ago) and don't have an emergency glucagon injection kit. Is this something everyone should have or just for those that go low regularly?
Thanks
https://doi.org/10.1210/jendso/bvab118
https://pubmed.ncbi.nlm.nih.gov/34337278
Abstract
Context
Glucagon is produced and released from the pancreatic alpha-cell to regulate glucose levels during periods of fasting. The main target for glucagon action is the liver, where it activates gluconeogenesis and glycogen breakdown, however, glucagon is postulated to have other roles within the body.
Objective
We sought to identify the circulating metabolites that would serve as markers of glucagon action in humans.
Methods
In this study (NCT03139305), we performed a continuous 72-hour glucagon infusion in healthy individuals with overweight/obesity. Participants were randomized to receive glucagon 12.5 ng/kg/min (GCG 12.5), glucagon 25 ng/kg/min (GCG 25), or a placebo control. A comprehensive metabolomics analysis was then performed from plasma isolated at several time points during the infusion to identify markers of glucagon activity.
Results
Glucagon (GCG 12.5 and GCG 25) resulted in significant changes in the plasma metabolome as soon as 4 hours following infusion. Pathways involved in amino acid metabolism were among the most affected. Rapid and sustained reduction of a broad panel of amino acids was observed. Additionally, time-dependent changes in free fatty acids and diacylglycerol and triglyceride species were observed.
Conclusion
These results define a distinct signature of glucagon action that is broader than the known changes in glucose levels. In particular, the robust changes in amino acid levels may prove useful to monitor changes induced by glucagon in the context of additional glucagon-like peptide-1 or gastric inhibitory polypeptide treatment, as these agents also elicit changes in glucose levels.
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Open Access: True
Authors: Rick B Vega - Katie L Whytock - Johan Gassenhuber - Britta Goebel - Joachim Tillner - Inoncent Agueusop - Agnieszka D Truax - Gongxin Yu - Elvis Carnero - Nidhi Kapoor - Stephen Gardell - Lauren M Sparks - Steven R Smith -
Additional links:
https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvab118/38826537/bvab118.pdf
[https://www.ncbi.nlm.nih.gov/pmc/art
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