Comparison of cytotoxicity effects induced by four different types of nanoparticles in human corneal and conjunctival epithelial cells nature.com/articles/s4159…
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πŸ‘€︎ u/Levyyz
πŸ“…︎ Jan 11 2022
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Complement activation induces excessive T cell cytotoxicity in severe COVID-19 cell.com/cell/fulltext/S0…
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πŸ‘€︎ u/DoomDread
πŸ“…︎ Dec 29 2021
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Comparison of cytotoxicity effects induced by four different types of nanoparticles in human corneal and conjunctival epithelial cells nature.com/articles/s4159…
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πŸ‘€︎ u/Levyyz
πŸ“…︎ Jan 11 2022
🚨︎ report
2780 Deletion of CISH and TGFΞ²R2 in iPSC-Derived NK Cells Promotes High Cytotoxicity and Enhances In Vivo Tumor Killing

Off topic, but very interesting...

Editas Medicine
@editasmedΒ·12m
Check out our poster presentation at 6 p.m. today to learn about preclinical data on our iPSC NK (iNK) cell program! https://bit.ly/3HysYBd. #ASH21

"NK cells are typically isolated from either cord blood or peripheral blood of healthy donors, but recent advances with induced pluripotent stem cells (iPSCs) allows a nearly unlimited supply of iPSC-derived natural killer cells (iNK). In this study, we used CRISPR-Cas12a to generate edited iPSC lines that were differentiated into TGFΞ²R2-/-/CISH-/- double knockout (DKO) iNK cells."

________

In summary, we demonstrated that TGFΞ²R2-/-/CISH-/- DKO iPSCs differentiated into iNK cells have potent anti-tumor activity that is maintained after cryopreservation. Together, the increased overall effector function of TGFΞ²R2-/-/CISH-/- DKO human iNK cells support their development as a potent allogeneic cell-based medicine for cancer. This potential medicine is being investigated with other gene edits for future advancement to clinic.

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πŸ‘€︎ u/Streeker74
πŸ“…︎ Dec 12 2021
🚨︎ report
Anti-depressant, anti-oxidant, and cytotoxicity effect of Turkey Tail (Trametes versicolor) on the central nervous system. Research article (07-2021)

Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds

Evaluated was the anti-depressant, anti-oxidant, and cytotoxicity effect of Turkey Tail (Trametes versicolor) on the central nervous system (CNS). Alcohol (METV) and water extracts (AETV) were used in a mouse model.

The higher dose of METV (400 mg/kg) and the lower dose of AETV (200 mg/kg) showed a significant decrease in immobility time in the forced swimming test and an increased prolongation of sleep in the thiopental sodium-induced sleeping time test, respectively.

In contrast, a moderate finding was observed for the hole-board and rota-rod tests.

Additionally, a significant DPPH scavenging assay and a high toxicity effect in brine shrimp lethality assay were observed.

The conclusion is that Turkey Tail extracts could be an alternative source for CNS anti-depressant and anti-oxidant activity.

Full text is here

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πŸ‘€︎ u/Kostya93
πŸ“…︎ Nov 22 2021
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Cannabinoids pharmacological effects are beyond the palliative effects: CB2 cannabinoid receptor agonist induced cytotoxicity and apoptosis in human colorectal cancer cells (HT-29) pubmed.ncbi.nlm.nih.gov/3…
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πŸ‘€︎ u/lrrc49
πŸ“…︎ Oct 15 2021
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Vitamin B12 inhibits Ξ±-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity doi.org/10.1039/c8fo02471…
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πŸ‘€︎ u/chromoscience
πŸ“…︎ Sep 14 2021
🚨︎ report
What do you think of this article taking on the alleged fertility issues, wide biodistribution of spike protein, the cytotoxicity of spike protein and other allegations made by vaccine hesistant scientists and people?

Genuinely asking. I'm trying to look at both sides here before I make such a big decision!

https://medium.com/microbial-instincts/biodistribution-and-spike-protein-safety-of-mrna-vaccines-an-update-788fe58e39b9

Any opinion, advice, article, video is helpfull if you don't agree!

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πŸ‘€︎ u/Heyboy1996
πŸ“…︎ Aug 04 2021
🚨︎ report
Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/enterpriseF-love
πŸ“…︎ Oct 09 2021
🚨︎ report
Pokeweed Antiviral Protein: Its Cytotoxicity Mechanism and Applications in Plant Disease Resistance ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/t1rr2
πŸ“…︎ Oct 09 2021
🚨︎ report
11-Keto-boswellic acids are triterpenoids from genus Boswellia that exhibit anti-inflammatory and antitumor activity. A recent study discovered a novel 11-keto-boswellic acid with chemotaxonical potential and cytotoxicity against breast cancer cells in vitro and in vivo mdpi.com/1420-3049/26/2/3…
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πŸ“…︎ Aug 11 2021
🚨︎ report
Bret et al's claims of spike protein toxicity (cytotoxicity?)

is there scientific literature to back this? i find it hard to believe that Bret would go public announcing that the spike protein is cytotoxic without good reason to believe that. Normally he and Heather are very diligent about this stuff

but i'm not finding evidence

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πŸ“…︎ Jun 21 2021
🚨︎ report
Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials nature.com/articles/s4159…
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πŸ“…︎ Jul 18 2021
🚨︎ report
Complement activation induces excessive T cell cytotoxicity in severe COVID-19 medrxiv.org/content/10.11…
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πŸ‘€︎ u/smaskens
πŸ“…︎ Jun 11 2021
🚨︎ report
In conclusion, our study indicated that the cytotoxicity of e-cigarette was far less than conventional cigarette at equivalent nicotine content in BEAS-2B cells sciencedirect.com/science…
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πŸ‘€︎ u/krizval
πŸ“…︎ Jul 05 2021
🚨︎ report
Spike Protein Cytotoxicity? (Dr. Syed) youtube.com/watch?v=NsnDg…
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πŸ‘€︎ u/mastcell
πŸ“…︎ Jun 18 2021
🚨︎ report
Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials nature.com/articles/s4159…
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πŸ“…︎ Jul 18 2021
🚨︎ report
Cytotoxicity and Oxidative Stress Responses of Imidacloprid and *Glyphosate* in Human Prostate Epithelial WPM-Y.1 Cell Line ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/gh959489
πŸ“…︎ Jul 13 2021
🚨︎ report
Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials nature.com/articles/s4159…
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πŸ‘€︎ u/mightx
πŸ“…︎ Jul 07 2021
🚨︎ report
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity nature.com/articles/s4159…
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πŸ‘€︎ u/omicreo
πŸ“…︎ Feb 19 2021
🚨︎ report

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