I'm studying my section on cancer right now, and it made me wonder something.

If your cells lose contact inhibition it causes the excess cells and a tumor. And telomerase activity makes them essentially immortal by elongating the telomeres. So if the cells in an organism still have contact inhibition, but also had telomerase activity, could that organism theoretically be immortal?

I mean, aside from death by injury or other diseases.

So yes, in essence, how do multilayer cell structures come into existence if contact inhibition is always present? What is the difference between growing mono and multilayer cellular structures in culture? I'm sure there's an easy answer to this, I've just been unable to find it by googling. Thanks!

Mood Spoiler: >!Optimistic !<

Posts by u/CousinConundrum

First Post

I [27m] am confused about my feelings for my deceased wife’s cousin [20f]

My wife Julie and I were together for a total of 6 years. We met in college and things were always great. I loved her very much and she loved me. We got married and I took a position in the “big city” in the state we are from. She found a job helping to run a daycare and was thrilled. She loved children and everything that came with the job. It was her true calling and she was thrilled to have the opportunity. She was beautiful both inside and out and was the only girlfriend I have ever had. A little over a year ago, she was involved in a car wreck with a drunk driver and was killed. I was devastated, her family was devastated, my family was devastated it was just a terrible time in my life. We had just bought a house together and I was all alone.

Around the time we moved, her younger cousin started college in that same city where we lived. My wife and her cousin Cassie were very close and she was one of the bridesmaids at our wedding. I have always enjoyed her company as well. I met her when she was I think 16 and I was about 22 or 23. We instantly clicked like we were old friends. I don’t know if that says more about me and my maturity at the time, but we have always gotten along great. Over the years, Cassie would visit us; we’d all hang out and have a blast. In those visits, my wife would make jokes about how similar Cassie and I were. We shared the same sense of humor, shared the same interests, and watched the same shows. My wife even made jokes about how if she died, I should start dating Cassie. She wasn’t serious, and it was funny because, hell, I’m 7 years older than her and I truly loved my wife.

After my wife passed away, I started hanging out with Cassie a lot more because she was the only “family” I had near me at the time. We grieved together and our friendship has grown so much over this past year. She is always welcome in my house (she has a key) and we have been able to support one another emotionally. We were there for each other with my wife’s death and I was there when she broke up with her boyfriend. She has really become my best friend in this time, and I hers.

About a month ago, I got a call from Cassie asking if I could p

The brain illness in Canada is getting worse and is actually more serious than previously reported.

https://gizmodo.com/frightening-new-details-emerge-about-mystery-brain-illn-1848321759

>A possible cluster of a mysterious brain illness afflicting people in New Brunswick, Canada may be larger than officially reported, according to an investigation published by the Guardian earlier this week. As many as 150 people may have developed unexplained neurological symptoms dating back to 2013, including cases where people became sick after close contact with another victim. But it is not clear whether local health officials will conclude that any of these cases are truly connected, pending an upcoming report of theirs expected later this month.

Those are official figures. But turns out there is likely a lot more cases than that.

>According to the Guardian, however, there have been many more similar cases unofficially documented by doctors. Citing multiple sources, the Guardian reported that as many as 150 cases may be out there. In nine of these cases, a person developed symptoms following close contact with someone else similarly sick, often while caring for them. What’s more, younger people, who rarely develop these sorts of neurological symptoms, have been identified within and outside the official cluster.

Many people have suggest that the blue green alae toxin BMAA is to blame for this. So logically you would test the deceased for that toxin, right?

Well....

>The cases among close contacts suggest a common environmental factor. And there has been some speculation by experts that β-Methylamino-L-alanine (BMAA)—a toxin produced by blue-green algae—could be to blame. Some earlier research has shown that lobsters, a popular harvested food in the province, can potentially carry high levels of BMAA. But efforts by federal scientists to examine the brains of those deceased for BMAA, the Guardian reports, have so far not been allowed by the New Brunswick government, despite families themselves wanting the tests to be done.

They are literally stopping scientists from diagnosing this illness. Why? Possibly because it would have a devastating impact on the local fishing industry.

BMAA has been linked to both Parkinson's and Alzheimer's

>BMAA can cross the blood–brain barrier in rats. It takes longer to get into the brain than into other organs, but once there, it is trapped in proteins, forming a reservoir for slow release over time.

During the first few months in the life of the D, the sexual tension between Picard and Dr. Crusher was palpable. When they first came in contact on the D’s maiden voyage, we can see in their reactions that they each mistakenly thought they were mentally prepared for this moment—working with this person with whom they have a long, rich history—but they’re both clearly caught off guard by an instantaneous, visceral attraction to the other. During their next mission, in a fit of inebriated abandon they almost let their inhibitions completely go, but their sense of duty to the ship and its crew keep their heads just clear enough to prevent them from boldly going there.

This brings us to the moment that seals their fate. The tension has been building for months, but neither has made another move. Picard is intoxicated by his first holodeck experience, and he invites Crusher to join him. She interprets this invitation as a date, but Picard, oblivious, immediately mentions that he wants some nerd named Whalen to come too. Data invites himself, and Crusher’s dream of a romantic getaway turns into LARPing with the boys.

Nevertheless, she doesn’t let this get her down. Ever the optimist and confident in herself, she gets dolled up and is determined to make the best of it. When they finally meet in the holodeck, Picard is taken aback by her beauty. This turns out to be the make-or-break moment for their romantic relationship. They are both horny and sober, yet enchanted by their surroundings and each other. Crusher asks to go back to his (Dixon Hill’s) office, and Picard agrees. It is clear to us what will happen in that office, but apparently it is not clear to their other two companions. Whalen, the absolute dope, actually has the nerve to adjust his damn bow tie and asks, “Uh, captain, um, mind if I join you?” Crusher’s eyes tell the whole story here: I can’t believe this blockhead would step in here. Then Data says in his obnoxious period-specific impersonation, “Yeah, me too, boss. I’d love to take a gander.” And that is the nail in the coffin for Picard and Crusher’s romantic involvement: Data and Whalen obliviously third and fourth wheeling ended their chance at getting together. Whalen, of course, later gets shot in the room where Picard and Crusher had planned to explore strange new worlds together, and he awkwardly bleeds all over the place, totally killing the vibe.

After this, the mood and moment is never right again for Picard and Crusher during the

TL;DR - date last night got high. And super sick. I didn't know what to do. I came to reddit with"HEY STONERS DO NEED TO CALL 911?" It's all better now. And people kept asking for updates, so now there's a funny story below that you shouldn't read because this <IS> the /trees subreddit, and there is an 80% chance that you're too baked to put these words together.

To the other 20%, enjoy the ride.

DISCLAIMER I'm a part time comedian, so this is now just notes for how this is going to be a hilarious bit about dating when you're old and lonely.

Oh my God.

I'm on a date. At a girl's house. Right now. It's 10:25 PM on a Saturday night. It's a third or fourth date. The night to get lucky. This weekend is my last "weekend off" before 4 months of work hell and 18 hour days. Marijuana is legal where I live. She wanted to eat an edible to lower inhibitions for certain ... things ... you know. I don't know what the subreddit rules are. She got too high. She started crying. I tried to get her to lay down. She wouldn't. She says this is my fault. I asked her if she wanted me to leave. She said yes. I started packing up my bag. She said, "I'm going to be sick." Stood up, walked to the front door and projectile vomited everywhere. Floor, walls, into my shoes. Everywhere. Simultaneously went #1 and #2. I got her into the bathroom where she is now, and my instinct is to clean it up because I'm a gentleman, but I've never been to her house and I know where NOTHING is to clean with.

And I can't even follow her last directive and leave because -2 degrees here, the snow is deep, and I didn't bring a spare set of shoes with my bag. And I'm not ready to walk outside barefoot and abandon my $200 work steeltoes, because I CAME HERE AFTER WORK and she asked me to stay.

So I went into the bathroom and asked her if she wanted me to leave because my shoes are a wreck, and I'd like to clean them before I left, but I'd rather clean it all up before I leave if she still wants me to leave.

She's lying in the bathroom floor, wrecked. She's not coherent. I don't do drugs due to work, and I've never been around a high person. I'm caught between calling 911, and running barefoot to her neighbor's house to ask if they have any of her family or friends' contact information, because she told me that her family is all local and her brothers and sisters introduced her to edibles, so maybe one of them can come over and help. And I still want to clean, becaus

I don't have time to write this post so you'll have to deal with the pointers:

• People are too stupid for optics

  • Look up iseikonic &amp;amp;amp; atoric glasses
  • Look up multi-photon ray tracing
  • Look up the patent lockdown between Zeiss (Peripheral Vision, Wavefront Guidance), Hoya (Combined Custom Front+Back Surface Designs) & Shaw Lenses (Properly iseikonic glasses)

• People are too stupid for eyes &amp;amp;amp; physiology

  • look up wavefront aberrometers
  • Cycloplegia makes the eye relax into an unnaturally strong accommodation. This skews all test results by about 0.25-.5 diopters spherically.
  • http://journals.lww.com/optvissci/Abstract/2013/11000/Spherical_Aberration_and_the_Sign_of_Defocus.18.aspx
  • 'Nerd' frames cut off downward vision and peripheral vision
    • Peripheral vision is emotionally important (check out the research behind www.neuviewptsd.com)
    • Downwards fixation at center gaze triggers a vergence movement which triggers the accommodation reflex. You're not gonna have natural near vision. You're gonna have uncalibrated, coarsely grained accommodation movements at all distances. This messes up the natural, constant, & continous oscillation of accommodation
  • http://www.ingentaconnect.com/contentone/ist/ei/2016/00002016/00000016/art00048

• People are too stupid for statistics

  • Eye examines should use black on white, white on black, dark grey on light grey and light grey on dark grey images
  • Eye examines should use MAXIMALLY lit conditions, ZERO lit conditions, and three intermediate lighting conditions.
  • The examination distance in traditional eye examines is far too small. It was chosen arbitrarily. Look it up. Not kidding.
  • .0125 testing lenses are fucking available cheaply. Everyone uses .25.

• People are too stupid to follow procedures

  • Vertical eye height deviations are INCREDIBLY common. Take a pen. Or any cylindrical object with a visually SHARP edge. Hold it as far away from you as you can, precisely the middle of your nose (NOT in the middle of your field of view.). TILT IT TOWARDS YOU so it matches the angle of your nose. Focus & stare, with both eyes, on the sharp visual edge of your cylindrical object. Move it towards the TOP of your nose (not the tip) until it makes contact. Move it away again. Repeat this process a few times until you catch the double vision. Height difference? Height difference.
  • Traditional monocular

With no action on sanctions for almost 5 years, it is time for us to remove these obstacles to all of our prosperity.

• There has been no renewal of hostilities in Donbass - indeed they seek undependence, quite apart from Russia itself. We concede that we did supply some groups, particularly when it seemed likely the Ukraine government would fall in 2014; and antirussian sentiments were becoming lethal. But we have allowed the people of the region to stand on their own, and Russia can not rightly continue to be punished for an act of national self determination.
• The return of Crimea to Russia in turn was perhaps regrettable in its particular transferral; but the time for questioning whether the independent oblast wishes to be ruled by Ukraine from Kiev is over. Russia will continue to support Crimea as an autonomous oblast, and having - as a condition of sanction removal - us casting them out of our federation, is at this point without merit.
• The sanctions are now inhibiting our economic growth to such an extent that we must consider our position as supplier of natural gas to Europe. While our mutual friends China, Korea, India, Pakistan, and others, take steps to pay for gas services in ever increasing measures, supplying Europe is becoming increasingly infeasible while our banking sector remains hamstrung, and our utilities are squeezed. We note that you didnt sanction individuals and companies that you directly depend on. We must say that now your reticence to correct this short sighted measure, is impinging upon our ability to maintain services which you do depend on, to the detrimebt of all. If Europe will not take quick action, we will all be placed in further difficulty.

We call upon the EU to remove the sanctions remaining from 2014.

This is how I draft a manuscript, especially in mind of memoir, but can work just as well for fiction. So here we go :) We're gonna write a book.

THIS IS A PROCESS USED SPECIFICALLY FOR DRAFTING AS YOU GO ONE CHAPTER AT A TIME!

---

I. FIRST DRAFT

Keep in mind: Your first draft might always be a hunk of baloney. Just write, don't think too hard. There's nothing about a first draft that can be bad or a mess up because it's a first draft, that's just the nature of the first draft. Hey. You literally can't mess this up.

My advice: Always think a chapter ahead of what you're writing.

1. Paper Draft

>^(Start the draft on paper.) ^(Don't use lined paper when you're drafting a novel) ^((or short story. There may not be a study I can cite for this, but lined paper inhibits the limits of creativity. By not using lined paper, you can also use other pages in close proximity for drawing characters and settings, etc.)) ^(Use a pen.) ^(The boldness of a pen enhances confidence, and discourages the erasure of bad ideas. Go ahead with writing your draft until it feels like it's solid, and chapter X is "all there," with a beginning, middle, and a prospectively good place to stop the chapter. You know what I mean.)
>
>^(Edit: Writing by hand on paper is not accessible for every person. If you've been writing all of your first drafts on word, I'm in awe, because every time I try that, I will read it back and feel like it's just awful! Handwriting them was the solution to me feeling confident about first drafts, and if handwriting a first draft is accessible for you, I completely encourage it, but only based off of my own experiences.)

2. Electronic transfer

>^(Take a break from the pen and paper. Transfer your draft verbatim from the paper to a word processor. Try to transfer it verbatim, just get it to the word processor without thinking something needs to be substantially edited.) ^(It's important to just get it on there and not think about changing anything in respect of step 3: Thinking Ahead.)

3. Thinking Ahead

>^("3)**^(. Thinking Ahead)**^(" is in bold with a purpose. It's one of the secrets to writing out chapters to well-rounded and excellent completions, and in turn, it's one of the secrets to writing excellent books with connective, seamless chapters mindful to the rest of your manuscript. Thinking ahead, instead of one chapter at a time, is the secret to mindful writing with chapters that speak coherent

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

[first] [prev] [next]

Many species have wondered exactly what can stop Terran Descent Humanity. They feel sure that somewhere out there is something that can withstand the might of the Terran Descent Humanity's overwhelming strength, adaptability, and resilience.

There was a planet that could have. Everything about the planet, from the weather, to the microbes, to the flora and fauna, was designed to kill Terran Descent Humanity. Some of the creatures upon that planet even looked at the toxic stew of the human body and saw it as food.

I am sometimes asked what happened to that planet. What happened to those creatures?

The answer is simple: The Mantids Glassed it eight thousand years ago.

And Terran Descent Humanity, being humanity, recreated it in all of its lethal glory.

Behold: TerraSol. - Most High Great Super Secret Agent Ba'ahn Ya'ard, Lanaktallan espionage agent, TerraSol, 86th Century

People think of Terrans and only think of Terran Descent Humanity, the Clone Consortium, Digital Sentiences, and, of course, the cyborgs. People know that the humans were lonely, so they cloned themselves, created advanced digital sentiences in their image, and even journeyed out into the stars to find friends.

What they often forget is the Biological Artificial Sentience Systems. Most think it's simply genetically altered humans or humans reskinned into a new body.

They forget about one simple thing the humans did before even achieving superluminal flight.

The Uplift.

Behold: Humanity's Children. - General A'armo'o, the Atomic Hooves, Reflections upon War.

They lost us for over eight thousand years.

They did not forget us.

Just as we would never forget them. - CW3 Jack "Chief" Nuntru, The Scent of Memories Upon the WInd

Ralvex flexed his knees slightly as the striker set down. His armor felt light, almost like cloth, even though it weighed over five hundred kilos. It was heavy scout armor, with power assist, movement assist, light battlescreens, grav spike generation, and inertia dampeners.

It was just lighter than his thousand kilo heavy assault suit he had worn for the last three years of fighting on Genverall-3 against the Dwellerspawn and

The nurse asked the rabbit, “what is your blood type?”

“I am probably a type O” said the rabbit.

Summary: I (24M) have been having regular sex with my married neighbor(36F) for 6 months. Her husband is insisting that she has caught feelings for me and wants me to end it. I don’t know how to proceed because I like our arrangement a lot.

So here’s the story. It’s very long but I feel like it’s important to provide the context. I’m a 24 yr old guy. I live in a proper house that I have all to myself. The house belongs to my rich elder brother and he was kind enough to let me stay for a quarter of the rent that he would charge. I was happy about this because it’s close to my university and I like the house.

My neighbor, let’s call him Joe, is kind of an asshole. Even when my brother was staying there, he would always be complaining about something. No one on the street likes him. When I first moved in there, he was complaining that I had very bright Christmas decoration lights. I thought that was ridiculous because it was just normal decorations. On last new year’s eve, his wife, let’s call her Cindy(36 yr old), came around to my place and gave me some cookies and apologized for her husband’s behavior. This surprised me because she was very nice and very sweet and it was surprising that someone like her was married to someone like him. We just chatted for a while and I said that she didn’t have to apologize for his behavior and that the decorations would be removed in a few days anyways. That was the end of that.

Fast forward to a few months later, I ordered something on amazon. The package was supposed to be delivered to my home. I don’t know whether the delivery guy messed up the address or he thought it would be wise to leave it with the neighbor, but he left it at my neighbor’s doorstep. Joe, being the prick that he is, threw it in the trash. I was confused when I got an update saying that it was delivered but I couldn’t find the package. The next day, Cindy knocked on my door and explained what happened. To be honest, I was really angry and even though she was very apologetic, I just vented all my anger at her. She was upset that I yelled at her but she realized that I had a right to be angry and so she offered to pay for the cost of the item in the package. I told her it’s not about the money, it’s about decency. She left. The next day I felt bad for yelling at her for her husband’s behavior. I wanted to apologize to her when I found a note under my door from Cindy. The note said she was very sorry and had her cell phone number in it in case I wan

The doctor says it terminal.

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

Mentos

(I will see myself out)

Firm also agrees to implement significant improvements to its compliance controls

FOR IMMEDIATE RELEASE
2021-262

Washington D.C., Dec. 17, 2021 —

The Securities and Exchange Commission today announced charges against J.P. Morgan Securities LLC (JPMS), a broker-dealer subsidiary of JPMorgan Chase & Co., for widespread and longstanding failures by the firm and its employees to maintain and preserve written communications. JPMS admitted the facts set forth in the SEC’s order and acknowledged that its conduct violated the federal securities laws, and agreed to pay a $125 million penalty and implement robust improvements to its compliance policies and procedures to settle the matter.

“Since the 1930s, recordkeeping and books-and-records obligations have been an essential part of market integrity and a foundational component of the SEC’s ability to be an effective cop on the beat. As technology changes, it’s even more important that registrants ensure that their communications are appropriately recorded and are not conducted outside of official channels in order to avoid market oversight,” said SEC Chair Gary Gensler. “Unfortunately, in the past we’ve seen violations in the financial markets that were committed using unofficial communications channels, such as the foreign exchange scandal of 2013. Books-and-records obligations help the SEC conduct its important examinations and enforcement work. They build trust in our system. Ultimately, everybody should play by the same rules, and today’s charges signal that we will continue to hold market participants accountable for complying with our time-tested recordkeeping requirements.”

As described in the SEC’s order, JPMS admitted that from at least January 2018 through November 2020, its employees often communicated about securities business matters on their personal devices, using text messages, WhatsApp, and personal email accounts. None of these records were preserved by the firm as required by the federal securities laws. JPMS further admitted that these failures were firm-wide and that practices were not hidden within the firm. Indeed, supervisors, including managing directors and other senior supervisors – the very people responsible for implementing and ensuring compliance with JPMS’s policies and procedures – used their personal devices to communicate about the firm’s securities business.

JPMS received both subpoenas for documents and voluntary requests from SEC staff in numerous i

Do your worst!

How the hell am I suppose to know when it’s raining in Sweden?

Mathematical puns makes me number

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

They were cooked in Greece.

I was reading this article about the Stanford scientist studying UAP materials and really enjoyed the straight to the point perspectives by the professor.

However while reading it, he mentioned a certain Dr. Kit Green, and Vice links to this article. I am not a believer of what theSun posts but what gave this some credence for me:

1. The Stanford Professor Garry Nolan mentions Dr. Kit Green -- he was contracted by the DoD/Pentagon or a faction within it to study people who had come to contact with UAPs.
2. Vice links this particular article; there can be a few reasons:

• This is the most apprehensive article on the subject of Dr. Kit Green + the memo + video , all in one -- so it made it easier for the writer to show everything with one link
• I am guessing Vice interviewer checked with Professor Nolan and he said yes that summarizes well
• I don't know, the above two bullet points can be wrong, but I am taking the Vice article as well written, the Professor credulous, hence the Sun link = less salt

I read the article and in it there is a mention of the memo, the Sun article has two pages of it, but here is the full one.

• It's basically a summary of points by Dr. Kit Green from Eric Davis to Bigelow and cced Colm Kelleher (Colm is mentioned in the Vice article) + emails
• The summary goes deep into the professional thoughts of Dr. Kit Green re: the alien autopsy video
• Here is a link to the full autopsy video, I am sure all of you have seen this
• I had seen this as well and in my mind always dismissed it as fake, but never watched it to the end, where there are ibeams shown as well, which is crazy cool
• Basically Dr. Kit Green says that the video is legit
• You will find lots of debunking of it, but it seems it was done after the fact and the original guy that released it, Santilli, just stopped giving a two after years of harassment and went silent.

I also researched the areas that Dr. Green mentioned were missing in the brain, or different from human anatomy:

1. No Corpus Callosum -- This is an area that connects the two hemispheres of the brain. Lack of this in humans is known as **

The past few weeks I've started school again after Christmas and have been completely unable to get even a single assignment done; I've barely been able to get out of bed, and if I do manage, pretty much the furthest I make it is onto the couch to put on the tv and then not really pay attention to it.

I'm very aware that this is probably part of a depressive episode again, but it just feels really useless taking my adhd meds every day when it feels like it's making no difference and I'm still not able to function at all. Concerta was working well for me before, so I don't know if I maybe just need to work on getting the bipolar under control in order to be able to benefit from the concerta again, or if I should ask my psychiatrist about potentially increasing my concerta dosage?

It's causing me so much stress right now because there are so many things that I need to be able to get done asap (or really, get done several weeks ago), but instead I just spend the whole day exhausting myself by stressing about all of the things I'm supposed to be doing, while not actually doing any of them, and I don't know how to explain this problem because from the outside it just looks like I'm not trying. I can feel that people are getting extremely frustrated with me, and honestly so I am; it feels like I'm just watching myself self-sabotage without being able to fix it

I'm surprised it hasn't decade.