So if I take a drug that induces this enzyme, will it make me sober when drunk? Would it make it safe to drive?
Also, would it remove hangovers?
Jekathjenani Ratnakumaran & Namrata Verma In the world of chemistry, there are millions of enzymes, but in this lab the enzyme used is bovine alcohol dehydrogenase. This enzyme .
The combination of gold(I) and enzyme catalysis has been exhaustively analysed aiming to develop a two‐step concurrent approach. This strategy consists of a Meyer‐Schuster rearrangement of a series of easily available propargylic alcohols followed by the stereoselective bioreduction of the corresponding allylic ketone intermediates, providing optically pure β,β‐disubstituted allylic alcohols. Thus, the first concurrent cascade example involving the use of a gold N‐heterocyclic carbene and an enzyme is described, demonstrating the compatibility of both catalyst types in aqueous medium under very mild conditions. The combination of [1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene][bis(trifluoromethanesulfonyl)‐imide]gold(I) (IPrAuNTf 2 ) and a selective alcohol dehydrogenase (ADH‐A from Rhodococcus ruber , KRED‐P1‐A12 or KRED‐P3‐G09), has allowed the synthesis of a series of optically active ( E )‐4‐arylpent‐3‐en‐2‐ols in good isolated yields (65‐86%). The chemoenzymatic approach was also successfully extended to various 2‐hetarylpent‐3‐yn‐2‐ol, hexynol and butynol derivatives. Remarkably, the use of alcohol dehydrogenases of opposite selectivity has allowed the straightforward production of both allyl alcohol enantiomers (93‐>99% ee ) for a broad panel of substrates bearing different substitutions in the aromatic ring.
https://ift.tt/3tqPLH2
is reasonable aim to enzymatically transform alcohol in ketone and vice versa without nad/p?
Forgive my ignorance, I have no sort of biochemistry background. Just learned about these enzymes in an alcohol awareness training video. I know everyone's body is different. Is increasing their effectiveness even possible? I guess not drinking helps, haha.
Pretty much in the title. Why isn't it available as tablets or such?
Thanks. I have googled and have not found an answer. If you can provide a source that would be great https://www.chem.uwec.edu/Webpapers2001/clareymm/Pages/I/examp1.html
Im studying the structure and function of ADH enzymes, and what I don't understand is the differences between the three isozymes of class 1 ADHs. Do the genes for ADH1A, ADH1B and ADH1C code for three different protein subunits of one enzyme, or does it code for three separate enzymes that form dimers or function independently of one another?
Eleven men aged 28.1±5.0 y (mean±SD), who lived in a metabolic unit, participated in a controlled study of zinc (Zn) metabolism. It began with a 28 d equilibration period when dietary Zn was 10 mg/d, followed by dietary periods of 36 d each with 1, 2, 3, or 4 mg Zn/d presented in random order, and ended with a 36 d period when dietary Zn was 10 mg/d. Plasma Zn dropped to 4.0 μmol/L in one subject and was significantly lower for all subjects (11.2±2.8 μmol/L) during the 1 mg Zn/d dietary period than during the 10 mg Zn/d (13.6±0.9 μmol/L) period, P<0.0002. Serum alkaline phosphatase and testosterone followed a trend similar to that of Zn. Blood cell Zn was not significantly affected by dietary Zn. Apparent ethanol absorption, as evidenced by maximum serum ethanol concentration after a 0.5 g/k body weight dose and the time the maximum was reached, was not significantly (P>0.05) affected by dietary Zn. The rate of ethanol clearance from the blood, measured between 120 and 240 minutes, was significantly (P<0.03) affected by dietary Zn. The clearance rate (mmol/L/min) was greater during Zn repletion when 10 mg Zn/d was fed (0.046) than when 1 (0.040), 2 (0.036), 3 (0.041), or 4 (0.038) mg Zn/d were fed. Serum alcohol dehydrogenase activity was not significantly affected by dietary Zn at any of the measured time intervals. These data suggest that blood ethanol clearance is sensitive to short-term changes in dietary Zn intake.
Posted on ELI5 but got rejected because evolutionary topics "aren't ELI5 appropriate", so trying my luck here.
Here is the original post I made in ELI5:
Primary reasons I found online so far with some initial research[1][2] are:
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Women have less ADH (alcohol dehydrogenase) than men, but nothing explains why.
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Women have different body composition than men. Specifically, less water & more fat per unit mean less alcohol dilution & more alcohol retention respectively. But why?
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Women are generally smaller, and less body mass & blood volume are proportional to alcohol tolerance for both men and women.
*I am aware the above are ON AVERAGE, and obviously there are always exceptions.
My burning question that I can't find an answer to (on reddit or elsewhere) is WHY for reasons #1 and #2. Everything just states that women have less ADH and different body composition, but I want to know why women have less ADH and different body composition. I want deeper answers, but maybe this is reaching the threshold of our current knowledge, and we can only speculate on potential evolutionary answers to ADH (and other bodily) differences among different human populations including sex, race, etc.
The why for reason #3 is more intuitive I guess from a biology/human evolutionary perspective, but any additional insights are appreciated as well.
I'm hoping someone with more expert biology/medical knowledge can save the day.
[1] http://www.scientificamerican.com/article/enzyme-lack-lowers-womens/
[2] http://www.askdoctork.com/why-cant-women-drink-as-much-as-men-201602198893
I know enzymes are very expensive to make but regardless of cost, do you think this could work? It would have to be a mix of alcohol degydrogenase and acetaldehyde dehydrogenase to completely metabolize the alcohol and prevent toxic acetaldehyde levels. I guess it would have to be taken intravenously because the digestive system would break down the enzymes.
They could sell them in a vessel similar to an epi-pen or something. If you are drunk in a dangerous situation or need to drive home, just shoot it and be sober in a few minutes. Sans a massive headache I think it might be a good idea.
As in the same enzyme brakes ethanol, or do bacteria only make it as well and so on.
He is basically saying that alcohol can give cancer. Do you agree, askscience?
Jekathjenani Ratnakumaran & Namrata Verma In the world of chemistry, there are millions of enzymes, but in this lab the enzyme used is bovine alcohol dehydrogenase. This enzyme .
A concurrent process involving a gold N‐heterocyclic carbene (IPrAuNTf2) and an alcohol dehydrogenase is described for the first time. This cascade approach allows the development of a Meyer–Schuster rearrangement for the transformation of racemic propargylic alcohols, mostly with good selectivities towards the corresponding E‐allylic ketone intermediates, in aqueous medium, which are subsequently reduced to obtain the desired alcohol enantiomers with excellent optical purities.
Abstract
The combination of gold(I) and enzyme catalysis is used in a two‐step approach, including Meyer–Schuster rearrangement of a series of readily available propargylic alcohols followed by stereoselective bioreduction of the corresponding allylic ketone intermediates, to provide optically pure β,β‐disubstituted allylic alcohols. This cascade involves a gold N‐heterocyclic carbene and an enzyme, demonstrating the compatibility of both catalyst types in aqueous medium under mild reaction conditions. The combination of [1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene][bis(trifluoromethanesulfonyl)‐imide]gold(I) (IPrAuNTf2) and a selective alcohol dehydrogenase (ADH‐A from Rhodococcus ruber, KRED‐P1‐A12 or KRED‐P3‐G09) led to the synthesis of a series of optically active (E)‐4‐arylpent‐3‐en‐2‐ols in good yields (65–86 %). The approach was also extended to various 2‐hetarylpent‐3‐yn‐2‐ol, hexynol, and butynol derivatives. The use of alcohol dehydrogenases of opposite selectivity led to the production of both allyl alcohol enantiomers (93‐>99 % ee) for a broad panel of substrates.
https://ift.tt/3tqPLH2
If you didn't have this enzyme, would you actually die if you didn't consume alcohol?
