I reported on this paper with astounding results earlier and happy to report it has been through peer review with only a title change whilst retaining the classic line: "improvement of longevity is an eternal dream of human beings". The headline result was lifespan extension of 17.6% for female and 20.3% for male mice by injection of this undamaged mouse serum albumin.

Full title: Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice

rMSA = exogenous recombinant mouse serum albumin

https://www.mdpi.com/2218-273X/11/8/1191

M20, 145 pounds, 5ft10

My albumin was 5.2 and now is 4.8. I pee foamy and everything. I was wondering if this can be normal fluctuations?

Has anyone else experienced this with their T2?

I had a message today following my HbA1c results asking me to book an appointment regarding raised Serum Albumin levels.

My HbA1c has come down from 97mmol (in Sept when I was first diagnosed) to 44mmol - 6.2% (in Nov).

Docs appointment isn't until 14th Dec, so thought I'd check in to see if anyone else has experienced something similar?

The receptionist said my Serum Albumin level was slightly raised at 51 ?

https://doi.org/10.3389/fmed.2021.583093

https://pubmed.ncbi.nlm.nih.gov/34055818

Abstract

Background: Glycated hemoglobin (HbA1c) is commonly used in the diagnosis and evaluation of glycemic control in diabetes, and it may be influenced by several non-glycemic and glycemic factors, including albumin. This retrospective study investigated the influence of albumin on HbA1c and HbA1c-defined glycemic status.

Methods: The demographic, hematological, and biochemical data were collected for 11,922 patients undergoing routine physical examination. Univariate and multivariate linear regression analyses, stratified analyses and interaction analyses, and multiple logistic regression were conducted to identify the association between albumin and HbA1c in people with different glycemic status.

Results: HbA1c levels were inversely associated with serum albumin level (P < 0.0001) in all participants. Risk factors leading to the association included age > 45 years, high fasting plasma glucose (≥7.0 mmol/L), and anemia. The negative association between HbA1c and albumin was curved (P < 0.0001) and had a threshold effect in the HbA1c-defined diabetic population, the association was significantly stronger when the albumin level fell below 41.4 g/L (β: -0.31, 95% CI: -0.45 to -0.17,P < 0.0001). A 2 g/L increase in albumin reduced the odds of HbA1c-defined dysglycemia, diabetes, and poor glycemia control by 12% to 36%, after adjustment for all possible confounders.

Conclusions: HbA1c was inversely associated with albumin level in all participants, and the association was significantly stronger in people with diabetes (defined by HbA1c criteria). For diabetic patients with lower albumin level, there was an increased risk of an erroneous HbA1c-based identification and management of glycemic status.

------------------------------------------ Info ------------------------------------------

Open Access: True

Authors: Xiaojing Feng - Yanyi Yang - Siqi Zhuang - Yiyuan Fang - Yufeng Dai - Yaoyang Fu - Qian Hu - Qianqin Yuan - Haoneng Tang - Lingli Tang -

Additional links:

https://www.frontiersin.org/articles/10.3389/fmed.2021.583093/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149759

[https://www.researc

I have read that serum albumin decreases with age and this correlates with all-cause mortality^(1). I have also seen the synopsis of the studies regarding blood exchange and, more recently, blood plasma dilution (replacing blood serum with saline and albumin).^(2)

Can anyone point me towards data on the levels of other components of blood serum as we age? Specifically I'm interested in learning what displaces the albumin that we lose as we age? For example, if we have 44g/L of albumin in our blood serum and it drops to 40g/L in later years, what is taking the place of that 4g that is no longer present? I know that some of the research that follows from these studies is looking at lowering the levels of pro-inflammatory proteins, but what are good sources to learn more about these and other specific blood serum components and levels?

Hello, I am back! My situation has improved since my last post, but there’s developments since then.

My doctor in the UK had suspicions I might have coeliac disease due to my symptoms (persistent tiredness, especially after eating, general fatigue, joint pain, stomach pain, diarrhoea) - so I just got tested for it (in my home country as I couldn’t get it tested in the UK because of Covid-19). Test came back negative. So no coeliac, which is great, but it brings up further questions.

My ALT levels were abnormal for approximately 6 months without any possible explanation found (all tests for infections done, no sign; hence why we arrived at coeliac, which now is negative). My test results today, however, show that my ALT is normal.

However, my serum albumin keeps climbing (marked as too high in the tests), together with my RBC count, which is also climbing up.

My symptoms are more or less the same, except that my stomach pains have become less frequent and so has joint pain. I still experience a lot of fatigue.

I am currently using Wellbutrin 150mg as an antidepressant, as well as Concor 5mg for my tachycardia. I am taking supplements for my folic acid deficiency which was found in my previous tests, but the levels of folic acid now are back up to being normal.

Can anyone advice me, a 21 year old Northern European female, weighing in at around 50kg and at the height of 1.61, what could be causing the high albumin levels and high RBC count? It can’t be dehydration as I constantly drink water (which results in frequent urination). Frankly, I’m lost. I don’t know what could be wrong now because my ALT levels suddenly stabilised.

PS. previous test also showed increased amount of insulin (however, normal blood sugar levels) and increased insulin resistance levels too (HOMA, if I recall correctly).

Anyone know (or at least have a good link) to an explanation of what BSA is? I see it in a lot of passages, and I know it is often explained in the passage, but I think it would be good to have some background information on it so I feel more comfortable with it.