https://academic.oup.com/endo/advance-article/doi/10.1210/endocr/bqab118/6305268

When targeting the gut microbiome we all have the same few options:

1. Personalized diet (via elimination diet) & fasting.
2. Probiotic experimentation.
3. FMT.

Each of which are covered in this wiki: HumanMicrobiome.info

Here are some dietary modifications that were helpful for me.

For FMT, help push for high quality donor availability: https://old.reddit.com/r/fecaltransplant/comments/ax9vxe/another_letter_to_the_nih_and_fda_cancer_patients/ - https://archive.fo/I3wSb#selection-2007.56-2007.57

And/or help take things into our own hands: HumanMicrobes.org

Nearly everything you do/ingest (including exercise and sleep) will impact the gut microbiome though, so things like herbs/supplements are of course another thing that can be experimented with. But results will vary significantly from person to person.

Our data suggested that inflammation decreased NAD+ levels in GCs of PCOS patients, while supplementation of NR could restore NAD+ levels and alleviated mitochondrial dysfunction in GCs of PCOS patients.

https://academic.oup.com/biolreprod/advance-article-abstract/doi/10.1093/biolre/ioab078/6288483

https://academic.oup.com/humrep/article-abstract/10/8/1951/644774?redirectedFrom=PDF

So I've been diagnosed with PCOS for about 10 years. I've always had irregular periods and slight hirsutism, but everything got worse in my early 20s which is when I got diagnosed based on slightly elevated testosterone levels and oh so many follicles in my ovaries. Went on the BCP for 4/5 years which I quit last July, and still haven't had a period which pushed me to find the root of my PCOS.

I have done every test out there, and taken every recommended supplement. Based on this sub, I figured that I had to try keto and IF but I got miserable, lethargic and I lost a ton of weight. My only diet restriction at the moment is sugar.
For reference I am lean (have always been) and have a healthy lifestyle, and my main symptoms are extreme amenorrhoea (like 1 period per year pre-pill) and slight hirsutism.

I am sharing this in case anyone else is in the same boat as me. I know I am a minority in the PCOS group, but the article above really pinpoints the difference between the two main PCOS subgroups and I fit really well in the second, non-IR category. I am seeing my Gynecologist in 2 days to see where to go from here. My tests rule out IR, adrenal and inflammation, so I'm really quite lost at this stage, and I genuinely miss having a period...

Update: Thank you all for sharing your experiences 🥺🥺 It was heartwarming to see so many responses as PCOS is a condition that many do not know of and talked about 😕😕 All your experiences are definitely helpful to everyone and ladies know that you're not alone in this 😊🤗

https://pubmed.ncbi.nlm.nih.gov/33462940/

Ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese: A randomized, open-label, parallel-group, controlled pilot trial Jian Li et al. J Obstet Gynaecol Res. 2021. Show details

Full-text links Cite

Abstract

Aim: To evaluate the effect of a ketogenic diet (KD) in women with polycystic ovary syndrome (PCOS) and liver dysfunction who were obese.

Methods: Women with PCOS and liver dysfunction who were obese were enrolled in this prospective, open-label, parallel-group, controlled pilot trial, and randomly received KD (KD group) or conventional pharmacological treatment (Essentiale plus Yasmin, control group) in a 1:1 ratio for 12 weeks. The primary endpoint was the liver function markers. Secondary endpoints included the menstrual cycle, anthropometric characteristics, body composition, hormonal levels, and metabolic biomarkers.

Results: Of the 20 eligible participants enrolled, 18 participants completed the study. The KD group reported a significant reduction in anthropometric characteristics and body composition from baseline to week 12 (all p < 0.05). In addition, there were significant reductions in menstrual cycle, plasma estradiol, and progesterone levels in two groups (all p < 0.05), but no significant between-group difference was observed. KD significantly reduced the liver function markers compared with control group (p < 0.05). The signs of fatty liver disappeared in six out of seven fatty liver participants in KD group after 12 weeks of intervention, while only one of 10 fatty liver participants in control group disappeared.

Conclusions: In addition to improving the menstrual cycle, KD had the additional benefits of reducing blood glucose and body weight, improving liver function, and treating fatty liver compared to traditional pharmacological treatment in women with PCOS and liver dysfunction who were obese.

Keywords: fatty liver; ketogenic diet; liver dysfunction; obesity; polycystic ovary syndrome

I am a guy. I think this is the right subreddit to talk about an issue I have. I have been in a relationship with a girl for around 8months. And she is the best person I have ever met, she is sweet and caring and strong and bold and supportive. She pushes me to grow and I push her to grow and we both are very happy.

She has always told me about constant headaches and stomach pain. She also has irregular periods. I have always told her to go to a doctor but she just doesn't care/she tells me it will not last long. So recently after a lot of persuasion she went to the doctor and did a US scan and found out that she has PCOS.

Naturally I searched it on Google and found out that headache and irregular periods were it's symptoms. She also told me that there's no real cure for it. And she has to do regular exercise and not gain weight. Now I regularly go to the gym and maintain a good body, so I can help her out with that. But there are some effects that really scared me, infertility and high chance of diabetes and heart diseases. And I panicked, A LOT!. If she finds out about these, she is going to be sad and I don't want her to be sad.

We haven't talked about it very much, but we will very soon. And I don't know how to handle it. I want to make her happy and not worry about anything.

If there's anyone who has gone through the same, can you please tell me your experiences. Thank You!

I'm a 24 year old woman and recently went to my gynaecologist for a check up. I did an ultrasound down there and she said that my ovaries look like they have cysts (polycystic ovaries syndrome), but because I don't have any other symptoms (like irregular periods, excess body hair, acne or irregular weight changes) we needn't do anything about it. I am concerned though that if I leave this unchecked it will cause me problems in later life like cancer or infertility. Is the right approach there to leave this be or am I at risk of complications?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045520/pdf/12967_2020_Article_2277.pdf - full 11 page PDF

Efects of a ketogenic diet in overweight women with polycystic ovary syndrome

Antonio Paoli1,2* , Laura Mancin1,3, Maria Cristina Giacona4 , Antonino Bianco5 and Massimiliano Caprio6,7

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It is characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and the presence of polycystic ovaries. It is associated with an increased prevalence of metabolic syndrome, cardiovascular disease and type 2 diabetes. The onset of PCOS has been associated to several hereditary and environmental factors, but insulin resistance plays a key pathogenetic role. We sought to investigate the efects of a ketogenic diet (KD) on women of childbearing age with a diagnosis of PCOS.

Methods: Fourteen overweight women with diagnosis of PCOS underwent to a ketogenic Mediterranean diet with phyoextracts (KEMEPHY) for 12 week. Changes in body weight, body mass index (BMI), fat body mass (FBM), lean body mass (LBM), visceral adipose tissue (VAT), insulin, glucose, HOMA-IR, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TGs), total and free testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH); dehydroepiandrosterone sulfate (DHEAs), estradiol, progesterone, sex hormone binding globulin (SHBG) and Ferriman Gallwey score were evaluated.

Results: After 12 weeks, anthropometric and body composition measurements revealed a signifcant reduction of body weight (−9.43 kg), BMI (−3.35), FBM (8.29 kg) and VAT. There was a signifcant, slightly decrease of LBM. A signifcant decrease in glucose and insulin blood levels were observed, together with a signifcant improvement of HOMA-IR. A signifcant decrease of triglycerides, total cholesterol and LDL were observed along with a rise in HDL levels. The LH/FSH ratio, LH total and free testosterone, and DHEAS blood levels were also signifcantly reduced. Estradiol, progesterone and SHBG increased. The Ferriman Gallwey Score was slightly, although not signifcantly, reduced.

Conclusions: Our results suggest that a KD may be considered as a valuable non pharmacological treatment for PCOS. Longer treatment periods should be tested to verif

https://doi.org/10.2147/DMSO.S287936

https://pubmed.ncbi.nlm.nih.gov/33519218

Abstract

Objective

The aim of the present study was to investigate the possible correlation between the percentage of daily energy intake from fat (PEF) with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).

Methods

In this cross-sectional study, a total of 186 females with PCOS were screened. Daily dietary intake data were collected by a trained nutritionist using the 24-h dietary recall method over three consecutive days. A total of 111 subjects who had complete data were divided into two groups based on the percentage of daily energy intake from fat (PEF): the normal PEF (NPEF) group (PEF < 30%) and the high PEF (HPEF) group (PEF ≥ 30%). Pearson's correlation analysis and stepwise multivariate linear regression analysis were used to analyze the correlation of PEF with homeostasis model assessment of insulin resistance (HOMA-IR).

Results

The total prevalence rate of overweight/obesity was 80.2%. There were significant differences in waist circumference (WC), body mass index (BMI), fasting insulin, and HOMA-IR (P < 0.001) among the normal weight, the overweight, and the obese groups, but no significant differences were observed in total energy and dietary macronutrients intake in the three groups. The daily intake of fat and protein, fasting insulin, and HOMA-IR in the NPEF group were significantly higher than those in the HPEF group. Pearson's correlation analysis showed PEF in PCOS women was negatively correlated with BMI (r= -0.189, p=0.047) and HOMA-IR (log-transformed) (r= -0.217, p=0.022). Further, stepwise multivariate linear regression analysis showed PEF was negatively correlated with HOMA-IR (p<0.05).

Conclusion

The percentage of daily energy intake from fat is negatively correlated with IR in women with PCOS.

------------------------------------------ Info ------------------------------------------

Open Access: True

Authors: Xin Zheng - Yun Chen - Danyan Ma - Mulin Zhang - Yinxiang Huang - Meifeng Tong - Bing Yan - Shaowei Lin - Xiaohong Yan - Changqin Liu -

Additional links:

https://www.dovepress.com/getfile.php?fileID=65872

https://doi.org/10.2147/dmso.s287936

[https://www.ncbi.nlm.nih

How many people here have been diagnosed with PCOS? I’ve heard there’s a link between it and IC!

Bringing over from r/ketoscience

High-refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats - Oct 2020

📷r/ketoscience•Posted byu/dem0n0cracy7 hours ago

High-refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats - Oct 2020

PCOS Fertility XXKeto📷

https://pubmed.ncbi.nlm.nih.gov/32629074/

Toxicol Lett

. 2020 Oct 10;332:42-55. doi: 10.1016/j.toxlet.2020.07.002. Epub 2020 Jul 3.

High-refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats

Oscar M S Niño 1, Charles S da Costa 2, Karine M Torres 3, Jordana F Zanol 4, Leandro C Freitas-Lima 5, Leandro Miranda-Alves 6, Jones B Graceli 7Affiliations expand

• PMID: 32629074
• DOI: 10.1016/j.toxlet.2020.07.002

Abstract

Obesity is associated with several female reproductive complications, such

https://doi.org/10.1111/jog.14650

https://pubmed.ncbi.nlm.nih.gov/33462940

Abstract

AIM

To evaluate the effect of a ketogenic diet (KD) in women with polycystic ovary syndrome (PCOS) and liver dysfunction who were obese.

METHODS

Women with PCOS and liver dysfunction who were obese were enrolled in this prospective, open-label, parallel-group, controlled pilot trial, and randomly received KD (KD group) or conventional pharmacological treatment (Essentiale plus Yasmin, control group) in a 1:1 ratio for 12 weeks. The primary endpoint was the liver function markers. Secondary endpoints included the menstrual cycle, anthropometric characteristics, body composition, hormonal levels, and metabolic biomarkers.

RESULTS

Of the 20 eligible participants enrolled, 18 participants completed the study. The KD group reported a significant reduction in anthropometric characteristics and body composition from baseline to week 12 (all p < 0.05). In addition, there were significant reductions in menstrual cycle, plasma estradiol, and progesterone levels in two groups (all p < 0.05), but no significant between-group difference was observed. KD significantly reduced the liver function markers compared with control group (p < 0.05). The signs of fatty liver disappeared in six out of seven fatty liver participants in KD group after 12 weeks of intervention, while only one of 10 fatty liver participants in control group disappeared.

CONCLUSIONS

In addition to improving the menstrual cycle, KD had the additional benefits of reducing blood glucose and body weight, improving liver function, and treating fatty liver compared to traditional pharmacological treatment in women with PCOS and liver dysfunction who were obese.

------------------------------------------ Info ------------------------------------------

Open Access: False

Authors: Jian Li - Wen‐Pei Bai - Bo Jiang - Le‐Ran Bai - Bei Gu - Shu‐Xiang Yan - Fu‐Ying Li - Bin Huang -

Additional links: None found