A molecular view of a neuronal synapse highlighting the glutamate-carrying vesicle along with pre-and postsynaptic membranes with proteins relevant to transmitting and modulating of the neuronal signal [Sept 2021] / Author: Maria Voigt and PDB-101
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πŸ‘€︎ u/Kiraxes
πŸ“…︎ Dec 13 2021
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A molecular view of a neuronal synapse highlighting the glutamate-carrying vesicle along with pre-and postsynaptic membranes with proteins relevant to transmitting and modulating of the neuronal signal [Sept 2021] / Authors: Maria Voigt and PDB-101
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πŸ‘€︎ u/Kiraxes
πŸ“…︎ Dec 13 2021
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Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein pnas.org/content/119/1/e2…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Jan 01 2022
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Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling pnas.org/content/118/50/e…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Dec 11 2021
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Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein pnas.org/content/119/1/e2…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Jan 01 2022
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Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling pnas.org/content/118/50/e…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Dec 11 2021
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Does natural infection from coronaviruses produce neutralizing antibodies to envelope proteins and membrane proteins of the virus in addition to the spike protein?
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πŸ‘€︎ u/GebeTheArrow
πŸ“…︎ Jul 13 2021
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I recently learned COVID has a lipid membrane but I was taught in school that viruses are DNA or RNA packed inside a protein shell, so how many different virus physiologies are there and what exactly is COVID made out of?

As the title said, I was taught that viruses are a protein shell with a DNA packed in that inject their DNA (or RNA) into the host cell. Now I learn that some viruses actually have membranes and multiple membrane proteins, which is much more complex than the image I have in my mind. Now I'm wondering about how many different phenotypes of viruses there are, is it a binary thing, some are a protein shell and some are a membrane, or more of a spectrum? Do we know?

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πŸ‘€︎ u/bjos144
πŸ“…︎ Aug 06 2021
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Chinese Researchers Reveal Inner Nuclear Membrane Protein as Positive Regulator in Breast Cancer Metastasis
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πŸ‘€︎ u/Dr_Singularity
πŸ“…︎ Dec 08 2021
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Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant science.org/doi/10.1126/s…
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πŸ‘€︎ u/purplesugarwater
πŸ“…︎ Oct 26 2021
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Microdomain protein Nce102 is a local sensor of plasma membrane sphingolipid balance biorxiv.org/content/10.11…
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πŸ‘€︎ u/sburgess86
πŸ“…︎ Dec 09 2021
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I realized today that the reason I haven’t been able to blot for a specific protein is because ALL of the antibodies that recognize it only work on nitrocellulose membranes (recently started using) rather than PVDF (had been using for an embarrassing number of months before).
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πŸ‘€︎ u/GrouchoMarx1
πŸ“…︎ Oct 08 2021
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Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site dx.plos.org/10.1371/journ…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Nov 23 2021
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Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site dx.plos.org/10.1371/journ…
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πŸ‘€︎ u/MarcHerb
πŸ“…︎ Nov 23 2021
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Advice needed: What has better career options: membrane biochemistry or biochemistry of photoactive proteins + spectroscopy?

Basically I have to chose between two projects for my masters thesis in two different labs. The topics are quite different, but both very interesting.

Both labs are amazing smaller labs, with a great PI and coworkers that I would all consider friends. So basically I would love to do my thesis in either lab.

I have written my bachelors thesis about membrane proteins and have also done a lot of membrane stuff. The spectroscopy of photoactive proteins is definitively newer for me, but I feel like I already learned a lot during my current internship in that lab. Both PIs offered me to help me tailor a project to my goals and skills and in both cases it is not unlikely that there would be PhD position afterwards.

But I have realized that I donΒ΄t really have a solid long-term plan. I know that itΒ΄s not impossible to change your path again later, but since this is a hard decision for me anyway, I might as well consider the career options each project might lead to.

Any advice is welcome : )

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πŸ“…︎ Nov 05 2021
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Could a cell membrane consist of only proteins?

Title.

I started thinking about the minimum amount of things that a cell would need to survive. I know that proteins and nucleic acids are for the most part unavoidable, but amino acids could be used as a fuel source instead of carbohydrates which lead me to this question. I know that carbohydrates and lipids are involved in certain syntheses, but let's pretend that we are talking about the simplest possible organism here. I figured that hydrophilic amino acids could form beta sheets and interact with each other, but I don't know how well a cell could synthesize the proteins. There's also the obvious question of what happens when the cell divides. This might not be the right place to post it, but I feel like biochemists might have better answers, chemically speaking.

Sorry for the ramblings, but I was genuinely curious and couldn't find anything about it online, either in forums or in the literature.

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πŸ‘€︎ u/Krispy_Kolonel
πŸ“…︎ Oct 04 2021
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What is the exact carrier protein involved in the active transport of amino acids across villi membranes in the small intestine?

If there are multiple proteins involved for different amino acids list them with their respective amino acids. I appreciate any help/direction.

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πŸ“…︎ Oct 29 2021
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It has been a mystery why some people live a perfectly normal life until experiencing a potentially deadly cardiac episode. Researchers present a possible explanation in a microscopic modification of a protein in the cell membrane of heart cells, which causes a mutation to turn harmful. healthsciences.ku.dk/news…
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πŸ‘€︎ u/TX908
πŸ“…︎ Sep 04 2021
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