I've been having trouble with side effects from both allopurinol and febuxostat, so I did a little research on what other drugs are under development or already on the market. One in particular that caught my eye is topiroxostat (brand names: Topiloric, Uriadec).
From ScienceDirect:
>A novel, nonpurine, selective xanthine-oxidase inhibitor, topiroxostat bears dual inhibitory effects that combine the mechanisms of action of its predecessors. Similar to febuxostat, topiroxostat reduces uric acid production through chemical structure-based inhibition of xanthine oxidase. Akin to allopurinol, the drug covalently binds to, and inhibits, molybdenum-pterin, the active center of xanthine oxidase. Currently approved in Japan at doses ranging from 20 to 80 mg twice daily, topiroxostat 120 mg/day has been shown to be equivalent to allopurinol 200 mg in meeting serum urate target levels.17 Although the half-life of topiroxostat is reported to be 20 h, the agent may have additional, more persistent effects: studies suggest that once inhibited by topiroxostat, xanthine oxidase enzyme function never fully recovers even after disassociation of the drug-enzyme complex.18
>
>A 22-week randomized controlled trial analyzed the efficacy of topiroxostat versus placebo in patients with stage 3 chronic kidney disease. 90% of patients receiving topiroxostat (160 mg/day) achieved an serum urate (SU) target level of <6.0 mg/dL. Additionally, the percent decrease of SU in the topiroxostat group was 45.38%, compared with 0.08% in the placebo group. No serious adverse effects of topiroxostat were recognized when compared with placebo, but increases in liver enzyme elevations were more common in the intervention group.19
It does not appear that this is available in the U.S., and it's not clear to me that it's even widely used in Japan. It caught my eye nonetheless because it's apparently the only xanthine-oxidase inhibitor other than allopurinol and febuxostat that made it onto the market.
I would be very curious to know whether my body tolerates topiroxostat any better than it does allopurinol and febuxostat, but I guess I will never find out since it doesn't seem to be available here.
Does anyone else know anything about this drug, or others that are under development?
The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed. Organ indexes and serum biochemical indicators were measured in potassium oxonate-induced hyperuricemia mice.
Studies showed that TAIO had the strong inhibitory effect on XO activity, and its inhibition type was mixed and reversible. In vivo, TAIO decreased efficiently uric acid level, hepatic XO, serum blood urea nitrogen activities in hyperuricemia mice. Indicating that TAIO may ameliorate kidney damage and relieve inflammation in hyperuricemic mice, and had the inhibitory effect on XO activity. Furthermore, eight triterpenoids were identified by Ultra performance liquid chromatography electrospray quadrupole time of flight mass spectrometry.
These findings proved that triterpenoids from Inonotus obliquus would have potential biological characteristics and effect on controlling hyperuricemia and gout as an active supplement.
From :
- https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13932
so i have been wondering about a mix that could give a high similar to weed like lovely nutmeg, and i went to research about it so here is what i came up with black pepper has agonistic activity on TRPV1 receptors which has analgesic properties cause of the release of endocannabinoids like anandamide
black pepper also has a compound called guineensine which is a endocannabinoid reuptake inhibitor and dont forget it has terpenes like B-caryophyllene which bind to the CB receptors
red pepper on the other hand has TRPV1 activity which might mix well with the activity of black pepper
and vanilla which is also a agonist of the TRPV1
we could also add a little Kaempferol to the mix although im unsure from which herb, it has FAAH inhibiting activity
so here is my theory, i truly wonder if it could work and if someone could try i would be glad to hear their experience :) a a black pepper TRPV1a TRPV1 red peppera Kaempferol
i had one article about someone else theorizing about this but i cant find it, i will look harder but its late for me rn and im a bit sleepy i will be glad to talk about it in comments
This piece went live for a few hours at The Automatic Earth blog where it causes a sensation and then quickly went off-line.
Copy and paste this to your own local drive as it’s being taken down net-wide as fast as it appears
Fortunately a few archives were made, and here’s the text of the letter:
Hello,
My name is Spartacus, and I’ve had enough.
We have been forced to watch America and the Free World spin into inexorable decline due to a biowarfare attack. We, along with countless others, have been victimized and gaslit by propaganda and psychological warfare operations being conducted by an unelected, unaccountable Elite against the American people and our allies.
Our mental and physical health have suffered immensely over the course of the past year and a half. We have felt the sting of isolation, lockdown, masking, quarantines, and other completely nonsensical acts of healthcare theater that have done absolutely nothing to protect the health or wellbeing of the public from the ongoing COVID-19 pandemic.
Now, we are watching the medical establishment inject literal poison into millions of our fellow Americans without so much as a fight.
We have been told that we will be fired and denied our livelihoods if we refuse to vaccinate. This was the last straw.
We have spent thousands of hours analyzing leaked footage from Wuhan, scientific papers from primary sources, as well as the paper trails left by the medical establishment.
What we have discovered would shock anyone to their core.
First, we will summarize our findings, and then, we will explain them in detail. References will be placed at the end.
Summary:
COVID-19 is a blood and blood vessel disease. SARS-CoV-2 infects the lining of human blood vessels, causing them to leak into the lungs.
Current treatment protocols (e.g. invasive ventilation) are actively harmful to patients, accelerating oxidative stress and causing severe VILI (ventilator-induced lung injuries). The continued use of ventilators in the absence of any proven medical benefit constitutes mass murder.
Existing countermeasures are inadequate to slow the spread of what is an aerosolized and potentially wastewater-borne virus, and constitute a form of medical theater.
Various non-vaccine interventions have been suppressed by both the media and the medical establishment in favor of vaccines and expensive patented drugs.
The authorities have denied the usefulness of natur
... keep reading on reddit ➡
Hello everyone! I made a video on the connection between sulfur sensitivity and SIFO (Candida). The idea for this video came from Greg Nigh's book but I might have found a slight mistake in his book. I am no biochemist so I am open to being wrong but he talks about how the enzyme ALDH is molybdenum dependent and breaks down aldehydes and Candida creates aldehydes. I could not find any evidence that ALDH is molybdenum dependent but xanthine oxidase and aldehyde oxidase both break down aldehydes and require molybdenum. So in this video, I talk about how Candida might be holding you back if you have sulfur sensitivity as well as my experience with SIFO and requiring more molybdenum recently, even though my hydrogen sulfide SIBO is in remission
https://www.youtube.com/watch?v=0tyc9HMNVgU
What are your thoughts? Have you been able to reduce molybdenum usage by addressing presumed SIFO/Candida?
https://preview.redd.it/o8zpw82igki71.jpg?width=474&format=pjpg&auto=webp&s=a10d648e86dda3c5768914c63be69a83b49e4915
UPDATE: 11.03.2021 Since publication there has been a 11:74:1 reverse split. This gives the equivalent price of $1.96 on the date of publication. Current analyst coverage from eReaserch gives a $26 CAD price target equivalent to $20.97
Symbols CSE:$XRX.CA US OTC: $XRTX FRANKFURT: ANU1
Market Cap: 40.7 million USD (51.19m CAD)
Shares: 110,076,717 Issued
Options 6,700,000 at .26
Warrants 25,170,626 at .40
DISCLAIMER
-Before you read any further, I want you to understand what I look for in an investment; I invest in companies that appear undervalued, possess world changing technology and have a large potential catalyst upcoming. For it to make sense to me, the company must provide me with a large near-term upside and continued long-term growth. Basically, I am looking for penny stocks that should not be. Xortx fits these requirements, I am not a financial advisor, I am a mom and a professional firefighter, do your own DD. I believe that if you find the technology, the money will follow and that high quality research builds conviction. I write DDs on all of my long holds, they can be found on the subreddit named after me. I hold over 1 million shares of XORTX and I have no plans to sell them within the next two years. – PennyQueen
TLDR
Due the complex nature of this company and upcoming catalysts, even this TLDR will be long but I know most of you are not wanting to read 20 pages. Biotech is always complicated and this company has quite a few additional complications, including two uplistings, a reverse split, an IPO and a rapid Phase 3 trial for a treatment for COVID related Acute Kidney Disease.
Their main thesis is that high uric acid causes all sort of metabolic diseases and that lowering it can negate the harmful impacts, there are several studies which support this theory (linked at the bottom).
Xortx has reformulated and improved an FDA approved drug and is repurposing it for the treatment of kidney disease, diabetic nephropathy and acute kidney injury from COVID. They have received very broad patent protection covering ALL treatments which decrease serum uric acid to treat a huge list of metabolic conditions. This patent is much broader than is typically allowed and their greatest asset in my opinion.
Their acute kidney injury drug for COVID patients
... keep reading on reddit ➡Hello /r/Astrophotography! Welcome to another Object Of The Month contest!
This month's object Sh2-115 in Cygnus
Last month's winner was /u/xanthine_oxidase's Messier 17
What is the "Object of the Month Contest"?
The object of the month contest will hopefully promote discussion about astrophotography in the Subreddit. Each month there will be a new target chosen by the winner of last month's contest. Users participating should go out and image that target, and then share it here for all to see! On the last 3 days of the month, this thread will be replaced by a voting thread where anyone can vote on what image they think should win.
Why should I participate?
For the opportunity to WIN this month's object of the month! Winners will receive the OOTM Award (equivalent to a platinum award), a special winners flair, and your image can be added to the banner rotation at the top of the subreddit! You will also be able to choose the image of the month for the next month from a shortlist. (This is to ensure that it as a target that will be up at night this particular month, as well as ensure that there is a good mix between small and large objects).
How can I participate?
Firstly just submit your image to the Subreddit like normal. If you want to participate in the contest, leave a comment in this thread with the link to your post. On the last 3 days of the month, this thread will be replaced by a voting thread where anyone can vote on what image they think should win. When the voting thread is up no new posts will be allowed to enter into the contest. This allows for all posts submitted to receive an equal amount of time in the voting thread. Note: ONLY IMAGES CAPTURED IN THE LAST 6 MONTHS WILL BE ALLOWED TO ENTER. You can make multiple entries, as long as you are submitting images from different datasets.
What if I don't want to participate?
Posts will not be automatically entered into the contest. Only those who link their post as a comment in this thread will be entered.
[Here are the vote counts for last month's contest:](https://cdn.discordapp.com/attachments/247338197921693697/882506124253868132/un
... keep reading on reddit ➡[To update: 'Cacao is an MAOI', as probably a weak/insignificant one]
Introduction
- Tea/Lemon Tek could potentiate the effects as more of the prodrug psilocybin converts into the psychoactive psilocin. So more of the psilocin becomes bioavailable.
- This essentially means you are taking the same dose as you would do by ingesting the normal way but the effects would last over a shorter time-frame.
- So it is more advisable to start with a lower dose than planned with these methods.
- More details on how psilocybin metabolises to psilocin: FAQ/Tip 014: Why psilocybin mushrooms/truffles are more sedating than LSD (YMMV)?
- Also some may experience nausea due to the fibrous chitin which can be hard to digest.
- This could be partly due to low levels of chitin enzyme, chitinase. More details: 'The Chitin 🍄 Effect' in FAQ/Tip 002: Have nausea or an upset stomach? Then try 1.5g of ginger.
- Nausea is also a common symptom of the 'come-up' body load effects of macrodosing. So could be an indication that your microdose is too high and you are above your sub-threshold dose^([1]) (or as Paul Stamets more aptly described it as the intoxication dose.)
- Grinding the mushrooms/truffles into a fine powder increases the surface area which could also potentiate the effects - your stomach or one of the methods below requires less effort to convert the psilocybin, meaning a faster absorption rate.
- Some may also not like taste of mushrooms/truffles so these methods could help with that.
Tea ☕️
- Steeping chopped/ground mushrooms/truffles in tea should be fine but psilocybin/psilocin can degrade with heat.
- From the stickied comment of [Temperature stability of mushroom tryptamines from fungal homogenous powder](https://www.reddit.com/r/microdosing/comments/os7zym/research_da
I’ve read mixed reviews about gout and coffee. Aside from only drinking coffee does anyone have information about a cup of coffee followed with tons of water throughout the day?
XORTX THERAPEUTICS
Welcome to the wiki page for XORTX Therapeutics
created by u/BearTank with input from Dr. Allen Davidoff Ceo of XORTX Therapeutics
Subscribe and follow if you have found this information beneficial. Show some love!!
(information provided on this wiki page has been taken from the company website or online)
CSE Ticker – XRX
OTCQB Ticker – XRTXF
Frankfurt Ticker – ANU1
Company websitehttps://www.xortx.com/
About XORTX Therapeutics
XORTX Therapeutics Inc (XORTX) is a drug development company primarily focused on orphan disease indications which have a uric acid imbalance as well as metabolic syndrome, diabetes and diabetic nephropathy. XORTX possesses patents and patent applications that include US and Worldwide rights for the development of uric acid lowering agents for the treatment of Hypertension, Insulin Resistance, Diabetes, Metabolic Syndrome and Kidney Injury – large market opportunities.
Corporate Presentation
https://www.xortx.com/wp-content/uploads/Presentation-FactSheet/XORTX-InvestorPresentation.pdf
Fact Sheet
https://www.xortx.com/wp-content/uploads/Presentation-FactSheet/XORTX-ExecutiveSummary.pdf
Initiating Report by EResearch – August 17th 2020
https://www.xortx.com/wp-content/uploads/2020/08/E-Research-Initiating_Coverage-Aug17-20.pdf
From the Strategic Partnerships link on the website
https://www.xortx.com/business-development/
The Management Team
**Dr. **Allen W. Davidoff, phd - CEO
Dr. Allen Davidoff (16 years drug development experience) is the founder and CEO of XORTX. Allen has a broad range of clinical and regulatory experience and senior management experience in pharmaceutical R&D including two investigational new drug (“IND”) applications or supplemental IND’s, two phase I studies (four of which were multi-country), seven phase II studies, and one NDA. Prior to forming XORTX, Allen was the Chief Scientific Officer, VP Product Development and co-founder of Stem Cell Therapeutics Corp. (seven years) (Trillium TRIL:NASDAQ) and Senior Scientist and Head
... keep reading on reddit ➡I know Qi from tea is immensely subjective and there are tons of debates over all aspects of it. However, there are some common effects that I see people mention frequently and that I personally experience when drinking Sheng Puer:
- increase in body temperature
- increase in sweating (I usually become drenched)
- palpable increase in heart beat
- uplift in mood
- stronger mental stimulation than other teas or even coffee
- tendency to speak faster and think quicker
I used to take amphetamines for ADHD and these are exactly the same effects experienced from those medications. Coffee usually doesn't have these effects for me unless I have gone a very long time without it and then suddenly drink a lot.
Why would a certain type of tea have similar effects to Amphetamines? What chemicals are in sheng that could contribute to this? Usually caffeine by itself does not cause these effects. I do not get these effects from most other teas, so I doubt it has to do with theanine or polyphenols (the other common psychoactive chemicals in tea). Maybe other xanthines in tea contribute to this effect?
My own theory is that there could be some monoamine oxidase (MAO) inhibitors in sheng that synergize quite well with the caffeine.
I am uninterest in spiritual or metaphysical explanations, although I recognize that these could be meaningful to people.
On my second attack ever. On prednisone and indo which took 90 percent of pain away. Chugging water and cherry juice. Will be looking into allo. I’m on day 12!
I’m starting to freak out. Does the pain actually go away where I can fully flex my big toe and walk normal!?!
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.
THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB
Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"
I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual
So check out r/jokes for all types of jokes
r/unclejokes for dirty jokes
r/3amjokes for real weird and alot of OC
r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes
Punchline !
Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub
Edit 2: don't touch the thermostat
Do your worst!
How the hell am I suppose to know when it’s raining in Sweden?
Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.
But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.
We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.
They were cooked in Greece.
I'm surprised it hasn't decade.
He lost May
Now that I listen to albums, I hardly ever leave the house.
Don't you know a good pun is its own reword?
Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"
Then the other muffin says "AHH, TALKING MUFFIN!!!"
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
And now I’m cannelloni
Because she wanted to see the task manager.
But that’s comparing apples to oranges
I recently started needing more and more molybdenum and I was backsliding and regressing. I thought my hydrogen sulfide SIBO must be back but when I realized it wasn't, I went looking for more answers for why I might need gobs of molybdenum so I made a video on the connection between sulfur sensitivity and SIFO (Candida). The idea for this video came from Greg Nigh's book but I might have found a slight mistake in his book. I am no biochemist so I am open to being wrong but he talks about how the enzyme ALDH is molybdenum dependent and breaks down aldehydes and Candida creates aldehydes. I could not find any evidence that ALDH is molybdenum dependent but xanthine oxidase and aldehyde oxidase both break down aldehydes and require molybdenum. So in this video, I talk about how Candida might be holding you back if you have sulfur sensitivity as well as my experience with SIFO and requiring more molybdenum recently, even though my hydrogen sulfide SIBO is in remission
https://www.youtube.com/watch?v=0tyc9HMNVgU
Hello /r/Astrophotography! Welcome to another Object Of The Month contest!
This month's object NGC 6946 - The Fireworks Galaxy
Last month's winner was /u/xanthine_oxidase's LDN 673
(Contest was a tie between him and /u/nick027nd, decided by random number)
What is the "Object of the Month Contest"?
The object of the month contest will hopefully promote discussion about astrophotography in the Subreddit. Each month there will be a new target chosen by the winner of last month's contest. Users participating should go out and image that target, and then share it here for all to see! On the last 3 days of the month, this thread will be replaced by a voting thread where anyone can vote on what image they think should win.
Why should I participate?
For the opportunity to WIN this month's object of the month! Winners will receive the OOTM Award (equivalent to a platinum award), a special winners flair, and your image can be added to the banner rotation at the top of the subreddit! You will also be able to choose the image of the month for the next month from a shortlist. (This is to ensure that it as a target that will be up at night this particular month, as well as ensure that there is a good mix between small and large objects).
How can I participate?
Firstly just submit your image to the Subreddit like normal. If you want to participate in the contest, leave a comment in this thread with the link to your post. On the last 3 days of the month, this thread will be replaced by a voting thread where anyone can vote on what image they think should win. When the voting thread is up no new posts will be allowed to enter into the contest. This allows for all posts submitted to receive an equal amount of time in the voting thread. Note: ONLY IMAGES CAPTURED IN THE LAST 6 MONTHS WILL BE ALLOWED TO ENTER. You can make multiple entries, as long as you are submitting images from different datasets.
What if I don't want to participate?
Posts will not be automatically entered into the contest. Only those who link their post as a comment in this thread will be entered.
[Here are the vote counts
... keep reading on reddit ➡Hello /r/Astrophotography! Welcome to another Object Of The Month contest!
This month's object is Abell 21 - The Medusa Nebula
Last month's winner was /u/jimmythechicken1's NGC 2170
What is the "Object of the Month Contest"?
The object of the month contest will hopefully promote discussion about astrophotography in the Subreddit. Each month there will be a new target chosen by the winner of last month's contest. Users participating should go out and image that target, and then share it here for all to see! On the last 3 days of the month, this thread will be replaced by a voting thread where anyone can vote on what image they think should win.
Why should I participate?
For the opportunity to WIN this month's object of the month! Winners will receive the OOTM Award (equivalent to a platinum award), a special winners flair, and your image can be added to the banner rotation at the top of the subreddit! You will also be able to choose the image of the month for the next month from a shortlist. (This is to ensure that it as a target that will be up at night this particular month, as well as ensure that there is a good mix between small and large objects).
How can I participate?
Firstly just submit your image to the Subreddit like normal. If you want to participate in the contest, leave a comment in this thread with the link and your post will receive a special "Object Of The Month" flair. On the last 3 days of the month, this thread will be replaced by a voting thread where anyone can vote on what image they think should win. When the voting thread is up no new posts will be allowed to enter into the contest. This allows for all posts submitted to receive an equal amount of time in the voting thread. Note: ONLY IMAGES CAPTURED IN THE LAST 6 MONTHS WILL BE ALLOWED TO ENTER. You can make multiple entries, as long as you are submitting images from different datasets.
What if I don't want to participate?
Posts will not be automatically entered into the contest. Only those who link their post as a comment in this thread will be entered.
Here is a table with the final vote tally: (it sure was a close one!)
|User|Vote
... keep reading on reddit ➡
