Thiourea Puns

CHAPTER 3 METHODOLOGY This chapter explains briefly on the synthesis method of napthoyl-thiourea derivatives, experimental characterization techniques (CHNS, FTIR, UV-Vis, UV-F, 1H and 13C NMR, Singl.

The combination of transition metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral α‐aminonitriles and α‐aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active α‐functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable with the thiourea catalyst recycled and reused.

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Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04255

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Although acetalization is a fundamental transformation in organic synthesis, intermolecular asymmetric acetalization remains an unsolved problem. In this study, a thiourea–ammonium hybrid catalyst was revealed to promote the O‐alkylation of enols with a racemic γ‐chlorobutenolide via dynamic kinetic resolution to give chiral acetals with good enantioselectivity. The catalyst simultaneously activates both the nucleophile and electrophile in a multifunctional manner. This method was applied to the asymmetric synthesis of several strigolactones. DFT calculations suggest that hydrogen bonding interaction between the chlorine of γ‐chlorobutenolide and the Ts amide hydrogen of the catalyst, as well as other types of noncovalent catalyst‐substrate interactions are crucial for achieving high stereoselectivity.

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Hello all,

Was hoping someone could help with a question I’m having trouble finding an answer to. We are making a thiourea conjugate by reacting an aromatic isothiocyanate with a primary phenylamine. The reaction will be performed under dry, alkaline conditions however, the conjugate will eventually need to be reconstituted into an aqueous solution to be used for our studies. My question is - how stable can I expect this thiourea to be or will the thionyl bond slowly decompose into the corresponding carbonyl when sitting in an aqueous medium? If so, is there a straight forward scheme for converting a thiourea to urea?

Thanks for any help.

Was mentioned here under the header dissolution strategy: weakening hydrophobic interactions

Urea is highly polar but why does it disrupt hydrophobic interactions? Wouldn't urea hydrogen bond with other water molecules, leaving cellulose -OH groups alone?

Thanks for any response!

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12457

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doi:10.1684/ejd.2009.0723

[URL](http://www.john-libbey-eurotext.fr/medline.md… )

I recently posted about growing my own thiourea crystals for an a magnetic resonance study. I have changed my mind - "shitty" crystals worked up until now but at this point I could use a real sample. I'm looking for a potential collaborator/ sample maker for NQR studies in thiourea and compounds of interesting interest which contain thiourea/urea.

Summary:

I am a PhD student of physics working on NQR techniques for room temperature and very low frequencies, in both 14N and 35Cl.

The other day when I posted here I was in fact looking for 14N NQR in thiourea at room temperature and asked /r/chemistry about thiourea safety.

Apparently, NQR in SC(NH_2)_2 was has not been observed at temperatures higher than 230K. I wanted to use a polycrystalline sample to locate the pure NQR resonance.

I have a candidate signal now and wish to test whether it is in fact NQR. One way to do it is a zeeman study of a single crystal.

If you can grow the crystal, I should be able to have a result fairly quickly. Incidentally, there are many related compounds for which clear procedures for crystal growth exist that would likely exhibit NQR at frequencies near that of pure thiourea. Therefore, if you have an interest to characterize any thiourea containing substances (there are many - dichloro tetrakis thiourea nickel or NiCl_2 [SC(NH_2)_2)]_4 is one I am currently working on) send me a pm.

tl;dr: if you can grow a large thiourea crystal (~ cm), we can do some papers.

I wasn't sure if this belonged on /r/askscience or not, so let me know if it does.

I purchased this supertaster test kit and the results were that I could taste sodium benzoate and thiourea (they were very bitter), but not PTC. The test says that supertasters are people who can taste PTC, and that being able to taste sodium benzoate and/or thiourea makes you an even more sensitive supertaster. However, my configuration was not listed as a possible result (apparently everyone who tastes sodium benzoate and thiourea should be able to taste PTC). Sure enough, I contacted the company and they said that they had never heard of anyone receiving the results that I did, and that they couldn't say what it meant.

So, how is this possible? Thanks!

I am a physicist trying to use thiourea = SC(NH_2)_2 as a control sample for a magnetic resonance application. I've got some powdery sample from sigma Aldrich and want to fool around trying to crystallize it - just a bit - for the experiment.

I have seen complicated procedures for crystallizing thiourea and frankly I'm not interested in growing awesome crystals - shitty ones will do just fine. Therefore, my only holdup for trying a naive rock candy approach is whether or not thiourea is safe for me to mess with as I am obviously not a good chemist.

So the question is ... how can I find out if thiourea is safe for me to try and make shitty crystals with?

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

Do your worst!

I'm surprised it hasn't decade.

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

They’re on standbi

Buenosdillas

Pilot on me!!

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00335

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