Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions cell.com/neuron/fulltext/…
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πŸ‘€︎ u/paris_newyork
πŸ“…︎ Jan 19 2022
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Tachykinin NK2 antagonist for treatments of various disease states autonomicneuroscience.com…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Aug 09 2021
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Tachykinin neuropeptides might promote agression, fear, paranoia when released due to chronic social isolation.

I was listening to Andrew Huberman's Huberman lab podcast and there was a short segment that got me. He stated that there are (might be in humans) specific neuropeptides that are released on perceived lack of social connections/interaction. That in turn causes paranoia, fear and agression among possible other effects.

I found this study that states that this experiment was done in flies and mice (to confirm mammals having this mechanism).

I cannot really give any extra information about this, except that I looked back on my behaviour in the past months or so. It feels like I am incredibly paranoid and fearful at times when I did not recently interact with people who are already close to me.

I have to add that I might also be depressed. Going on a holiday with my family did not really elevate my mood or lack of motivation. However I feel a bit less like I am being ripped off, unequally dealt with or socially abandoned by other people.

I concluded that it might be essential for ya'll folks to be already having interacted, especially with people who you bond with, BEFORE you try to do it to people that are more like strangers to you. Maybe that is what a Wingman could do to certain people.

People who fear going out of their house might also consider whether they had personal (not through internet) interactions with any friends or relatives they like recently.

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πŸ‘€︎ u/mestermagyar
πŸ“…︎ Jul 04 2021
🚨︎ report
Gender-related differences of tachykinin NK 2 receptor expression and activity in human colonic smooth muscle pubmed.ncbi.nlm.nih.gov/3…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Aug 13 2020
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Tachykinin-1 in the central nervous system regulates adiposity in rodents. ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Apr 29 2015
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Tachykinin-1 in the central nervous system regulates adiposity in rodents. ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Apr 29 2015
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[Serious] How did you learn to be happy being alone, even if you're lonely?
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πŸ‘€︎ u/Givemeaupvotes
πŸ“…︎ Dec 26 2021
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SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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πŸ‘€︎ u/anywhereiroa
πŸ“…︎ Jan 15 2022
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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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What starts with a W and ends with a T

It really does, I swear!

πŸ‘︎ 6k
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πŸ‘€︎ u/PsychedeIic_Sheep
πŸ“…︎ Jan 13 2022
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Why did Karen press Ctrl+Shift+Delete?

Because she wanted to see the task manager.

πŸ‘︎ 11k
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πŸ‘€︎ u/Eoussama
πŸ“…︎ Jan 17 2022
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So 2 trees got arrested in the town I live...

Heard they've been doing some shady business.

πŸ‘︎ 7k
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πŸ‘€︎ u/K1ll47h3K1n9
πŸ“…︎ Jan 18 2022
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What is a a bisexual person doing when they’re not dating anybody?

They’re on standbi

πŸ‘︎ 11k
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πŸ‘€︎ u/Toby-the-Cactus
πŸ“…︎ Jan 12 2022
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What is the scariest tree?

BamBOO!

πŸ‘︎ 6k
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πŸ‘€︎ u/K1ll47h3K1n9
πŸ“…︎ Jan 18 2022
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Geddit? No? Only me?
πŸ‘︎ 6k
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πŸ‘€︎ u/shampy311
πŸ“…︎ Dec 28 2021
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I wanna hear your best airplane puns.

Pilot on me!!

πŸ‘︎ 3k
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πŸ‘€︎ u/Paulie_Felice
πŸ“…︎ Jan 07 2022
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E or ß?
πŸ‘︎ 9k
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πŸ‘€︎ u/Amazekam
πŸ“…︎ Jan 03 2022
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Which actor drives the least?

Christopher Walken

πŸ‘︎ 3k
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πŸ‘€︎ u/TR1771N
πŸ“…︎ Jan 18 2022
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What did Spartacus say when the lion ate his wife?

Nothing, he was gladiator.

πŸ‘︎ 9k
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πŸ‘€︎ u/rj104
πŸ“…︎ Jan 15 2022
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Pun intended.
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πŸ‘€︎ u/Sharmaji1301
πŸ“…︎ Jan 15 2022
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No spoilers
πŸ‘︎ 9k
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πŸ‘€︎ u/Onfour
πŸ“…︎ Jan 06 2022
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Covid problems
πŸ‘︎ 7k
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πŸ‘€︎ u/theincrediblebou
πŸ“…︎ Jan 12 2022
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These aren't dad jokes...

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

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πŸ‘€︎ u/Lance986
πŸ“…︎ Dec 15 2021
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Should we create an English word for the 'day after tomorrow'?

Or would that be too forward thinking?

πŸ‘︎ 2k
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πŸ‘€︎ u/afunkysquirrel
πŸ“…︎ Jan 19 2022
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Spi__
πŸ‘︎ 6k
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πŸ‘€︎ u/Fast_Echidna_8520
πŸ“…︎ Jan 11 2022
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What did 0 say to 8 ?

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

πŸ‘︎ 9k
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πŸ‘€︎ u/designjeevan
πŸ“…︎ Jan 03 2022
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I had a vasectomy because I didn’t want any kids.

When I got home, they were still there.

πŸ‘︎ 10k
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πŸ‘€︎ u/demotrek
πŸ“…︎ Jan 13 2022
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I dislike karma whores who make posts that imply it's their cake day, simply for upvotes.

I won't be doing that today!

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πŸ‘€︎ u/djcarves
πŸ“…︎ Dec 27 2021
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For Gotham
πŸ‘︎ 7k
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πŸ‘€︎ u/FreeHugsXD
πŸ“…︎ Jan 17 2022
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The Ancient Romans II
πŸ‘︎ 6k
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πŸ‘€︎ u/mordrathe
πŸ“…︎ Dec 29 2021
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I did it, I finally did it. After 4 years and 92 days I went from being a father, to a dad.

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

πŸ‘︎ 17k
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πŸ‘€︎ u/Sk2ec
πŸ“…︎ Jan 01 2022
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Where do you find a cow with no legs?

Where ever you left it πŸ€·β€β™€οΈπŸ€­

πŸ‘︎ 4k
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πŸ‘€︎ u/kitkatty0309
πŸ“…︎ Jan 16 2022
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I'd like to dedicate this joke to my wisdom teeth.

[Removed]

πŸ‘︎ 7k
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πŸ‘€︎ u/ThoughtPumP
πŸ“…︎ Jan 14 2022
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It this sub dead?

There hasn't been a post all year!

πŸ‘︎ 13k
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πŸ‘€︎ u/TheTreelo
πŸ“…︎ Jan 01 2022
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Naan-negotiable
πŸ‘︎ 5k
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πŸ‘€︎ u/sjmaeff
πŸ“…︎ Jan 16 2022
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How do you stop Canadian bacon from curling in your frying pan?

You take away their little brooms

πŸ‘︎ 6k
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πŸ‘€︎ u/Majorpain2006
πŸ“…︎ Jan 09 2022
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Remember that joke I told you about the chiropractor?

It was about a weak back.

πŸ‘︎ 6k
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πŸ‘€︎ u/tanglwyst
πŸ“…︎ Jan 16 2022
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School Was Clothed
πŸ‘︎ 5k
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πŸ‘€︎ u/Kennydoe
πŸ“…︎ Jan 08 2022
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Couch potato
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πŸ“…︎ Dec 31 2021
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Letting loose with these puns
πŸ‘︎ 6k
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πŸ“…︎ Jan 13 2022
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Baka!
πŸ‘︎ 5k
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πŸ‘€︎ u/ridi86
πŸ“…︎ Jan 09 2022
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My name is ABCDEFGHIJKMNOPQRSTUVWXYZ

It’s pronounced β€œNoel.”

πŸ‘︎ 14k
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πŸ‘€︎ u/beef_fried_rice
πŸ“…︎ Dec 25 2021
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All dad jokes are bad and here’s why

Why

πŸ‘︎ 7k
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πŸ‘€︎ u/LordCinko
πŸ“…︎ Jan 13 2022
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concrete πŸ—Ώ
πŸ‘︎ 5k
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πŸ‘€︎ u/Fast_Echidna_8520
πŸ“…︎ Jan 07 2022
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Why are people so surprised and angry about Djokovic being an anti-vaxxer?

After all his first name is No-vac

πŸ‘︎ 4k
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πŸ‘€︎ u/hangryman23
πŸ“…︎ Jan 06 2022
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