Good 3p news / verification re: interleukin 21 as an adjuvant (ino holds the patent to that)

https://www.biorxiv.org/content/10.1101/2022.01.21.476732v1

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πŸ‘€︎ u/ThugDonkey
πŸ“…︎ Jan 23 2022
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Upregulation of Interleukin-6 in HPV-Positive Breast Cancer Patients pubmed.ncbi.nlm.nih.gov/3…
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πŸ‘€︎ u/xdhpv
πŸ“…︎ Dec 28 2021
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Inhibition of Spinal Interleukin-33 Attenuates Peripheral Inflammation and Hyperalgesia in Experimental Arthritis link.springer.com/article…
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πŸ‘€︎ u/HearTomorrow
πŸ“…︎ Jan 27 2022
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A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19 | mBio journals.asm.org/doi/full…
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πŸ‘€︎ u/D-R-AZ
πŸ“…︎ Nov 23 2021
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Interpreting β€œanti‐inflammatory” cytokine responses to exercise: Focus on interleukin‐10 (Oct 2021) physoc.onlinelibrary.wile…
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Oct 18 2021
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Interleukin-10

IL-10 is the only anti-inflammatory interleukin that know of :) It inhibits the expression of molecules like IL-2 and TNF alpha which participate in inflammation. Selfhack has a page on it as well:

https://selfhack.com/blog/il-10/

Interestingly, type I regulatory T cells help create oral tolerance to food antigens like proteins by expressing IL-10. The induction of these helper cells from naive T cells is also aided by IL-10 I think increasing levels of IL-10 could help with our symptoms. The web page has a list of pros and cons of IL-10 and possible ways to control it.

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πŸ‘€︎ u/Tarragon83
πŸ“…︎ Oct 26 2021
🚨︎ report
Interleukin-1RA Mitigates SARS-CoV-2–Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice ahajournals.org/doi/10.11…
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πŸ‘€︎ u/Peeecee7896
πŸ“…︎ Oct 05 2021
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Lymes and resulting Interleukin tests

Hi! So I ( 35 F) got bit over the summer. Did my month of Doxy and hoped for the best. A month after doxy the symptoms returned.

Background: Over the past couple years I have been trying to figure out some of my auto inflammatory issues (pre lymes). I am also deficient in Mannose Lectin Binding ( body can't fight off bacteria as well as a normal person ). I happened to get tested for my inflammatory issues when the lymes symptoms popped up again and had increased interleukin levels . Of course now I don't know what is causing what

Has anyone gotten their interleukin/ inflammatory levels tested when they had lymes symptoms?

Thanks!

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πŸ‘€︎ u/HarleysDouble
πŸ“…︎ Sep 22 2021
🚨︎ report
What's the reason behind some interleukins having several isoforms in mammals?
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πŸ‘€︎ u/Bernard_Goldstein
πŸ“…︎ Nov 02 2021
🚨︎ report
Perceived Social Support-Giving Moderates the Association Between Social Relationships and Interleukin-6 sciencedirect.com/science…
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πŸ‘€︎ u/ksk1222
πŸ“…︎ Nov 11 2021
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Another supporting study for the DNA platform (interleukin is the key)

https://www.biorxiv.org/content/10.1101/2021.08.11.456014v2.full.pdf

What they showed is CD8 cell formation / genesis is IL2 dependent in meningitis. In other words, just as Inovio has proven with melanoma with β€œbricktell” (I believe that was the name of the company we did the trial with in 2019), DNA antigens in tandem with interleukin administration trigger potent and durable CD8 cellular activation. And putting 2 and 2 together it seems that every week a new study is coming out linking CD8 dysfunction to autoimmune disease and cancer severity in individuals.

It’s only a matter of time before the BP Dam comes crashing down and they are forced to accept what we already know.

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πŸ‘€︎ u/ThugDonkey
πŸ“…︎ Aug 17 2021
🚨︎ report
WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 who.int/news/item/06-07-2…
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πŸ‘€︎ u/jlovinn
πŸ“…︎ Jul 07 2021
🚨︎ report
Interleukin-2 Pathway Agonist Bempegaldesleukin Plus Nivolumab in the First-Line Treatment of Metastatic Melanoma ascopost.com/news/july-20…
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πŸ‘€︎ u/SoundBorn7572
πŸ“…︎ Aug 11 2021
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Chamber of Interleukins
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πŸ‘€︎ u/Gimme_dat_protein
πŸ“…︎ Apr 09 2021
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Confronting the controversy: Interleukin-6 and the COVID-19 cytokine storm syndrome erj.ersjournals.com/conte…
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πŸ‘€︎ u/kal31dic
πŸ“…︎ Aug 29 2021
🚨︎ report
Activation of colo‐rectal high‐threshold afferent nerves by Interleukin‐2 is tetrodotoxin‐sensitive and upregulated in a mouse model of chronic visceral hypersensitivity onlinelibrary.wiley.com/d…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Jun 28 2021
🚨︎ report
Add Interleukin-33 encoding to IL-12 encoding to the list of interleukins patented by inovio

Boring! I know, very boring. But highly significant to the platform as a whole. Specifically, Pennvax, 5401, and dMABs

https://uspto.report/patent/app/20210196818

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πŸ‘€︎ u/ThugDonkey
πŸ“…︎ Jul 02 2021
🚨︎ report
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms nature.com/articles/s1227…
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πŸ‘€︎ u/D-R-AZ
πŸ“…︎ Jul 24 2021
🚨︎ report
Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19 sciencedirect.com/science…
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πŸ‘€︎ u/allthejunkishere
πŸ“…︎ Jul 24 2021
🚨︎ report
Is Interleukin 2 pro or anti inflammatory?
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πŸ‘€︎ u/Big_Passion2652
πŸ“…︎ Jul 12 2021
🚨︎ report
Therapeutic Solutions International and Campbell Neurosciences Announce Preclinical Studies Showing Low Doses of FDA Cleared Immune Stimulant Interleukin-2 Reduces Inflammation Associated Depression in Animal Model prnewswire.com/news-relea…
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πŸ‘€︎ u/rrao11
πŸ“…︎ May 17 2021
🚨︎ report
Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19 ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/MadamePhantom
πŸ“…︎ Jun 07 2021
🚨︎ report

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