Regulatory T Cell Puns

I have been watching this anime recently, called "Cells at Work." It usually provides a well-detailed summary of certain parts of the human body and certain phases it can go through.

I decided to read the manga, and in a chapter, it describes the immune system fighting off a cancer cell. However, it also shows a Regulatory T-Cell "protecting" it by not allowing an NK Cell and other parts of the immune system to attack it.

I realize that cancer cells usually have different receptors than other cells, and trigger an immune response, but is it possible for a Regulatory T-Cell to not notice this difference and thus, protect the cancer cell?

Why is this cortical epithelial? Isn't negative selection in the medulla of the thymus?

*DOI/PMID/ISBN: https://doi.org/10.1111/tan.12822

• URL

doi: https://doi.org/10.2217/imt-2017-0017

URL https://www.futuremedicine.com/doi/pdfplus/10.2217/imt-2017-0017