Palmitic Acid Puns

PA has not been much discussed here and I've found little info online. This article from 2018 suggests it's the next best at increasing metabolism to stearic acid. My two local fish and chip shops both use sustainable palm oil so I'm thinking fish and chips could be back on the menu? http://commonsenseketogenics.com/what-fats-to-eat-to-increase-your-mitochondria-metabolic-rate/

their amount in it is often well below 50 %. A very significant amount is made up by oleic acid, only yielding an F/N of 0.457. If one considers that de-novo lipogenesis converts excess glucose into stearic and palmitic acid I think we would have a strong argument for a high-carb, low-fat diet.

(Side note: Depending on our stearoyl-CoA desaturase 1 (SCD-1) activity we would be converting some of the stearic into oleic acid. A hypothesis of mine is that SCD-1 is upregulated by cold, considering cold intolerance in SCD-1 knockout mice. The level of unsaturation of ingested fatty acids in general could be an evolutionarily conserved indicator of energy and temperature status of the environment, co-determining insulin sensitivity distribution between tissues. Note that salmon has very highly unsaturated lipids compared to a coconut or a cocoa bean.)

Am I missing something? What are your thoughts and ideas?

podcast switch to 45:10. They are speaking about Paul Saladino and saturated fats I want to share with you guys and first and foremost ask a question: why are there so many conspiracies about saturated fats, particularly in the fitness community, because I hear the similar claims all the time

It’s usually from the same source, 5016 NF, which is ~50% C16:0 and ~50% C18:0

Source: https://www.reddit.com/r/FoodNerds/comments/96hfjl/dietary_stearic_acid_regulates_mitochondria_in/e48gl76/

I bought some from Sigma Aldrich, 95% pure stearic acid, food grade. $70/kg.

Guys hi

What food source has highest stearic acid and lowest palmitic acid?

From foods i looked at all seem to be pretty high in palmitic acid, wonder if i am missing something.

https://www.ncbi.nlm.nih.gov/pubmed/31266188 ; https://sci-hub.tw/10.3390/molecules24132421

Li P1, Li L1, Zhang C2, Cheng X1, Zhang Y1, Guo Y1, Long M3, Yang S4, He J5.

Abstract

Ketosis is a nutritional metabolic disease in dairy cows, and researches indicated that ketonic cows always accompany reproductive problems. When ketosis occurs, the levels of non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHBA) in the blood increase significantly. Palmitic acid (PA) is a main component of saturated fatty acids composing NEFA. The aim of this study was to investigate whether high levels of PA and BHBA induce inflammatory responses and regulatory mechanisms in bovine endometrial cells (BEND). Using an enzyme-linked immunosorbent assay, quantitative real-time PCR, and western blotting, we evaluated oxidative stress, pro-inflammatory factors, and the nuclear factor (NF)-κB pathway in cultured BEND cells treated with different concentrations of PA, BHBA, pyrrolidinedithiocarbamate (PDTC, an NF-κB pathway inhibitor), and N-acetylcysteine (NAC, an antioxidant). The content of malondialdehyde was significantly higher, the content of glutathione was lower, and antioxidant activity-glutathione peroxidase, superoxide dismutase, catalase, and total antioxidant capacity-was lower in treated cells compared with control cells. PA- and BHBA-induced oxidative stress activated the NF-κB signaling pathway and upregulated

At least in 2016 he said so:

>I think palmitic acid would do exactly the same as stearic acid did for these mice. But who would risk their career with a finding like that?

http://high-fat-nutrition.blogspot.com/search/label/High%20fat%20fed%20mice%20on%20stearic%20acid

Can someone explain how a 16 carbon palmitate molecule produces 8 acetyl CoA in 7 cycles when only 1 acetyl CoA is produced per cycle? Does the last cycle produce 2 acetyl CoA?