Dietary palmitic acid (PA), found in palm oil, promotes metastasis in oral carcinomas and melanoma in mice (no such effect from oleic/linoleic acids). PA also exerts long-term effects on the genome, and tumour cells exposed to PA for a short time remained highly metastatic even after PA was removed. worldwidecancerresearch.o…
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πŸ‘€︎ u/Litvi
πŸ“…︎ Nov 11 2021
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Dietary palmitic acid promotes a prometastatic memory via Schwann cells nature.com/articles/s4158…
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πŸ‘€︎ u/LittleIsopod0
πŸ“…︎ Nov 17 2021
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Dietary palmitic acid promotes a prometastatic memory via Schwann cells (Nov 2021, mice) nature.com/articles/s4158…
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πŸ‘€︎ u/OOvifteen
πŸ“…︎ Nov 11 2021
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TIL despite the name, Palmitic acid is found in dairy products not because they feed cows palm oil supplements, rather it is a naturally occurring fatty acid found in animals and plants and even in human breast milk. theconversation.com/butte…
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πŸ‘€︎ u/ihatehappyendings
πŸ“…︎ Sep 23 2021
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Caffeine Promotes Conversion of Palmitic Acid to Palmitoleic Acid by Inducing Expression of fat-5 in Caenorhabditis elegans and scd1 in Mice - PubMed pubmed.ncbi.nlm.nih.gov/2…
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πŸ‘€︎ u/HicEstLeoSuperbus
πŸ“…︎ Aug 13 2021
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Dietary palmitic acid promotes a prometastatic memory via Schwann cells nature.com/articles/s4158…
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πŸ‘€︎ u/m3prx
πŸ“…︎ Nov 12 2021
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Saturated fatty acids other than LA and SA(caprylic, lauric, palmitic, butyric) youtube.com/watch?v=QTWPn…
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πŸ‘€︎ u/chaitanyathengdi
πŸ“…︎ Aug 14 2021
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Concentration-dependent change in hypothalamic neuronal transcriptome by the dietary fatty acids: oleic and palmitic acids biorxiv.org/content/10.11…
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πŸ‘€︎ u/sburgess86
πŸ“…︎ Aug 05 2021
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Palmitic Acid

PA has not been much discussed here and I've found little info online. This article from 2018 suggests it's the next best at increasing metabolism to stearic acid. My two local fish and chip shops both use sustainable palm oil so I'm thinking fish and chips could be back on the menu? http://commonsenseketogenics.com/what-fats-to-eat-to-increase-your-mitochondria-metabolic-rate/

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πŸ‘€︎ u/AliG-uk
πŸ“…︎ Feb 13 2021
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Effects of two consecutive mixed meals high in palmitic acid or stearic acid on 8-h postprandial lipemia & glycemia in healthy-weight & overweight men & postmenopausal women: A randomized controlled trial link.springer.com/article…
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πŸ‘€︎ u/Healthy_Fellow
πŸ“…︎ Mar 17 2021
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While stearic and palmitic acid, the two fatty acids with the highest F/N, are two prominent fatty acids in ruminant/dairy fat...

their amount in it is often well below 50 %. A very significant amount is made up by oleic acid, only yielding an F/N of 0.457. If one considers that de-novo lipogenesis converts excess glucose into stearic and palmitic acid I think we would have a strong argument for a high-carb, low-fat diet.

(Side note: Depending on our stearoyl-CoA desaturase 1 (SCD-1) activity we would be converting some of the stearic into oleic acid. A hypothesis of mine is that SCD-1 is upregulated by cold, considering cold intolerance in SCD-1 knockout mice. The level of unsaturation of ingested fatty acids in general could be an evolutionarily conserved indicator of energy and temperature status of the environment, co-determining insulin sensitivity distribution between tissues. Note that salmon has very highly unsaturated lipids compared to a coconut or a cocoa bean.)

Am I missing something? What are your thoughts and ideas?

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πŸ‘€︎ u/positiveDriver
πŸ“…︎ Sep 22 2020
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β€œPalmitic acid is neurotoxin” - the very confident statement of one of these gentlemen (begins from 45:10)

podcast switch to 45:10. They are speaking about Paul Saladino and saturated fats I want to share with you guys and first and foremost ask a question: why are there so many conspiracies about saturated fats, particularly in the fitness community, because I hear the similar claims all the time

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πŸ‘€︎ u/DrArseny
πŸ“…︎ Nov 18 2020
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Want to know the real cost of lipstick and lotion? An @AP investigation exposes rape, other abuses endured by female workers on plantations producing palm oil (named "Palmitic acid" in products ingredients), contained in nearly three out of four personal care products. apnews.com/article/plants…
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πŸ‘€︎ u/avivi_
πŸ“…︎ Nov 19 2020
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PSA: The stearic acid you buy online will likely be 50/50 stearic acid/palmitic acid

It’s usually from the same source, 5016 NF, which is ~50% C16:0 and ~50% C18:0

Source: https://www.reddit.com/r/FoodNerds/comments/96hfjl/dietary_stearic_acid_regulates_mitochondria_in/e48gl76/

I bought some from Sigma Aldrich, 95% pure stearic acid, food grade. $70/kg.

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πŸ‘€︎ u/virtuallynathan
πŸ“…︎ Dec 11 2019
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Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation pubmed.ncbi.nlm.nih.gov/3…
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πŸ‘€︎ u/hZ_e63_5344
πŸ“…︎ Oct 19 2020
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What food source has highest stearic acid and lowest palmitic acid?

Guys hi

What food source has highest stearic acid and lowest palmitic acid?

From foods i looked at all seem to be pretty high in palmitic acid, wonder if i am missing something.

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πŸ‘€︎ u/rtwyyn
πŸ“…︎ Jul 03 2020
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When it comes to saturated fat, the ingestion of stearic acid (C18:0), but not palmitic acid (C16:0), causes fusion of mitochondria within 3 hours in humans - This could explain part of the epidemiological differences, whereby C16:0 increases cardiovascular & cancer risk whereas C18:0 decreases both nature.com/articles/s4146…
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πŸ‘€︎ u/prpsc
πŸ“…︎ Aug 08 2018
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Palmitic oil raises serum phospholipids and cholesterol; stearic acid doesn't academic.oup.com/ajcn/art…
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πŸ‘€︎ u/BafangFan
πŸ“…︎ Dec 11 2019
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Palmitic Acid and Ξ²-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-ΞΊB Signaling - July 2019

https://www.ncbi.nlm.nih.gov/pubmed/31266188 ; https://sci-hub.tw/10.3390/molecules24132421

Li P1, Li L1, Zhang C2, Cheng X1, Zhang Y1, Guo Y1, Long M3, Yang S4, He J5.

Abstract

Ketosis is a nutritional metabolic disease in dairy cows, and researches indicated that ketonic cows always accompany reproductive problems. When ketosis occurs, the levels of non-esterified fatty acids (NEFAs) and Ξ²-hydroxybutyrate (BHBA) in the blood increase significantly. Palmitic acid (PA) is a main component of saturated fatty acids composing NEFA. The aim of this study was to investigate whether high levels of PA and BHBA induce inflammatory responses and regulatory mechanisms in bovine endometrial cells (BEND). Using an enzyme-linked immunosorbent assay, quantitative real-time PCR, and western blotting, we evaluated oxidative stress, pro-inflammatory factors, and the nuclear factor (NF)-ΞΊB pathway in cultured BEND cells treated with different concentrations of PA, BHBA, pyrrolidinedithiocarbamate (PDTC, an NF-ΞΊB pathway inhibitor), and N-acetylcysteine (NAC, an antioxidant). The content of malondialdehyde was significantly higher, the content of glutathione was lower, and antioxidant activity-glutathione peroxidase, superoxide dismutase, catalase, and total antioxidant capacity-was lower in treated cells compared with control cells. PA- and BHBA-induced oxidative stress activated the NF-ΞΊB signaling pathway and upregulated

... keep reading on reddit ➑

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πŸ‘€︎ u/Ricosss
πŸ“…︎ Jul 04 2019
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Hyperlipid Peter thinks palmitic acid would work the same as stearic

At least in 2016 he said so:

>I think palmitic acid would do exactly the same as stearic acid did for these mice. But who would risk their career with a finding like that?

http://high-fat-nutrition.blogspot.com/search/label/High%20fat%20fed%20mice%20on%20stearic%20acid

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πŸ‘€︎ u/ElHoser
πŸ“…︎ Dec 17 2019
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Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/BafangFan
πŸ“…︎ Dec 13 2019
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Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease cambridge.org/core/servic…
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πŸ‘€︎ u/tsarman
πŸ“…︎ Dec 12 2019
🚨︎ report
Mom: β€˜Hey sweetie, I sprinkled some aluminium salt on your naphthenic and palmitic acids. It smells amazing.’ Me: β€˜... I can hear their screams!!!’
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πŸ‘€︎ u/Gisus_K_Ryst
πŸ“…︎ Jun 25 2019
🚨︎ report
Palmitic and Stearic Acid metabolism and utilization (in the lactating cow) youtu.be/N-nVXbrPlqU
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πŸ‘€︎ u/BafangFan
πŸ“…︎ Dec 10 2019
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Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus. cell.com/trends/endocrino…
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πŸ‘€︎ u/jakbob
πŸ“…︎ Feb 26 2019
🚨︎ report
Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus cell.com/trends/endocrino…
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πŸ‘€︎ u/jakbob
πŸ“…︎ Apr 11 2018
🚨︎ report
TIL Modern Napalm actually contains no Napalm (NAphthenic and PALMitic acids). The original formula was too flammable and burned too quickly. Modern Napalm (or Napalm B) is the one that is used currently and gives off a characteristic smell. simple.wikipedia.org/wiki…
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πŸ‘€︎ u/Petal_Phile
πŸ“…︎ May 02 2016
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Beta Oxidation of Palmitic Acid

Can someone explain how a 16 carbon palmitate molecule produces 8 acetyl CoA in 7 cycles when only 1 acetyl CoA is produced per cycle? Does the last cycle produce 2 acetyl CoA?

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πŸ‘€︎ u/JSD1999
πŸ“…︎ Jan 19 2020
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Is there a good explanation as to why things sold as "Stearic acid" are actually only about 50% stearic acid and 50% palmitic acid? Is pure stearic acid unstable or something?
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πŸ‘€︎ u/stupidrobots
πŸ“…︎ Dec 17 2019
🚨︎ report

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