Most people with IMDS suffer from a loss of fat in the face, arms, legs, feet, and buttocks. Only the fat in the torso is spared, and in some people it accumulates in the lower abdomen. This fat loss and pattern of redistribution is a symptom of Acquired Generalized Lipodystrophy (AGL), which is a rare disease of which science does not yet have a complete understanding. The disease is defined by total generalized fat loss across the body, sometimes occurring basically overnight, and sometimes gradually over decades. In AGL, because of insulin resistance, fat gets stored in the liver, muscle and other organs (fatty liver seems to be common in IMDS). It is also associated with glomerulonephritis, a kidney disease.
AGL is often preceded by a flu-like illness, autoimmune hepatitis, lupus or other autoimmune diseases. Over time, the reduction in fat results in insulin resistance and leptin deficiency (which results in a huge increase in appetite, and worsened insulin resistance). The treatment for this disease is a synthetic form of leptin called Metreleptin, and anti-diabetic medications.
https://rarediseases.org/rare-diseases/acquired-lipodystrophy/
Two recent lipodystrophy studies have found antibodies to Perilipin-1 (a protein that coats lipid droplets within fat cells) in patients with AGL. Perilipin-1 (aka PLIN1) is a protein that protects fat cells from enzymes that the body produces to break down fat for energy. When antibodies attack PLIN1 this protection is removed, and the body is able to break down fat at a higher rate.
https://www.frontiersin.org/articles/10.3389/fimmu.2018.02142/full
https://www.medrxiv.org/content/10.1101/2021.09.24.21263657v1.full
I suspect that this disease is caused by molecular mimicry, where the immune system attacks a protein on the outside of a pathogen that "looks like" PLIN1. Effectively, the immune system is tricked into attacking our fat cells because they look like the pathogen. These antibodies are not actually produced to attack PLIN1 (so they maybe should not be strictly considered "autoantibodies"), but they happen to bind to it.
What pathogen could the body be attacking? The following is speculation because I am not a doctor or a scientist, but there seem to be two options:
An enveloped viru
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From what I understand, T cells have been selected for the inability to bind to host antigens during T cell selection prior to entering the periphery, so there shouldn’t be any T cells existing in the thymus that are able to recognise the pathogenic antigens (which are identical to the host’s). And so, the T cells won’t be able to attack the antigen-mimicking pathogens, not to mention the host himself. But obviously they do… why is that??
Long story condensed...(if you need the full story i will provide it) after 9 months of out of nowhere symptoms of pain on my entire left side, lymph nodes swollen, sudden severe weight loss and more....i went from dr to dr to specialist trying to get an answer. I finally got to an Immunologist/allergist who is the only one in my state that specializes in mast cell syndrome, disease, mastocytocis. And also specializes in drug interactions. Anyway tests were ran and they came back saying the following: My crp was 26.75 My esr: 35
And i showed that i had an antibody igg anti ige elevated
He said that this was an indication of a secondary mast cell activation caused by molecular mimicry.
Histamine levels normal Tryptase level normal
Every other thing was normal
So he says my mast cells are fine and they arent overly abundant so this is definitely not mastocytosis or a primary mast cell activation issue. That somewhere i got an infection, virus, etc and the igg thinks the anti ige slot on my mast cell is that virus, pathogen etc. So my mast cells are releasing mediators causing all my problems. Ok i get that. Ive been tested for autoimmune diseases. Not all of them. But everything comes back negative.
So basically im put on h1 h2 antihistamine, benadryl as needed last month and cromolyn sodium as of last week. Tried doxopene but decided to pause that to be sure the other meds arent making things worse. Next step is quercetin and high dose vitamin c ( all as purely made as possible) if that doesn't work then steroids and immunosuppressive meds.
I feel like we should be trying to uncover what caused this because so far ( and i know it's been a short time) nothing helps. Everything i eat causes internal swelling and nerve pain from head to toe. No anaphylaxis but minor swelling of the throat. Brain fog, blurry vision, migraines, skin burning, swollen lymph nodes. spine swelling and pain, swollen groin, joint pain, muscle spasms, sleep problems, borderline POTS. this all takes place only on my left side. Certain Smells give me huge migraies too. It hurts to bathe because products react with me as well. I keep trying more natural products but it's complicated.
I ended up in the hospital 2 weeks ago was given iv benadryl for nausea every 4 hours and every single symptom went away. I could still be triggered but reaction was mild. but i went from horrible constant pain all over that's been there since my son was born to zero. It lasted for 2 days. I
... keep reading on reddit ➡If they were working on a vaccine, maybe trying to kill two birds with one stone, the combo, chimeric type, and trying to make one size fits all?
Another!! Molecular Mimicry Between the Rabies Virus Glycoprotein and Human Immunodeficiency Virus-1 GP120: Cross-Reacting Antibodies Induced by Rabies Vaccination.
Same idea???? Anyone??
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
The nurse asked the rabbit, “what is your blood type?”
“I am probably a type O” said the rabbit.
The doctor says it terminal.
Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.
THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB
Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"
I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual
So check out r/jokes for all types of jokes
r/unclejokes for dirty jokes
r/3amjokes for real weird and alot of OC
r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes
Punchline !
Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub
Edit 2: don't touch the thermostat
Mentos
(I will see myself out)
Do your worst!
How the hell am I suppose to know when it’s raining in Sweden?
We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.
Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.
But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.
Long story condensed...(if you need the full story i will provide it) after 9 months of out of nowhere symptoms of pain on my entire left side, lymph nodes swollen, sudden severe weight loss and more....i went from dr to dr to specialist trying to get an answer. I finally got to an Immunologist/allergist who is the only one in my state that specializes in mast cell syndrome, disease, mastocytocis. And also specializes in drug interactions. Anyway tests were ran and they came back saying the following: My crp was 26.75 My esr: 35
And i showed that i had an antibody igg anti ige elevated
He said that this was an indication of a secondary mast cell activation caused by molecular mimicry.
Histamine levels normal Tryptase level normal
Every other thing was normal
So he says my mast cells are fine and they arent overly abundant so this is definitely not mastocytosis or a primary mast cell activation issue. That somewhere i got an infection, virus, etc and the igg thinks the anti ige slot on my mast cell is that virus, pathogen etc. So my mast cells are releasing mediators causing all my problems. Ok i get that. Ive been tested for autoimmune diseases. Not all of them. But everything comes back negative.
So basically im put on h1 h2 antihistamine, benadryl as needed last month and cromolyn sodium as of last week. Tried doxopene but decided to pause that to be sure the other meds arent making things worse. Next step is quercetin and high dose vitamin c ( all as purely made as possible) if that doesn't work then steroids and immunosuppressive meds.
I feel like we should be trying to uncover what caused this because so far ( and i know it's been a short time) nothing helps. Everything i eat causes internal swelling and nerve pain from head to toe. No anaphylaxis but minor swelling of the throat. Brain fog, blurry vision, migraines, skin burning, swollen lymph nodes. spine swelling and pain, swollen groin, joint pain, muscle spasms, sleep problems, borderline POTS. this all takes place only on my left side. Certain Smells give me huge migraies too. It hurts to bathe because products react with me as well. I keep trying more natural products but it's complicated.
I ended up in the hospital 2 weeks ago was given iv benadryl for nausea every 4 hours and every single symptom went away. I could still be triggered but reaction was mild. but i went from horrible constant pain all over that's been there since my son was born to zero. It lasted for 2 days. I
... keep reading on reddit ➡