https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320652/
In summary, the present study suggests that 5โday waterโonly fasting reduces metabolicโsyndrome and aging biomarkers. Waterโonly fasting upregulates Tregs to prevent or treat inflammationโrelated diseases, as well as potentially promote antiโaging by decreasing T3, insulin, IGFโ1, and significantly increasing ฮฒโhydroxybutyrate. The results of the present study are very promising as 5โday waterโonly fasting has many critical beneficial effects without toxicity. Because the present trial is carried out in specialized clinics, waterโonly fasting should be guided by clinical team and may not be applicable to general populations. Furthermore, participants who follow healthy diet may have better longโterm outcomes than participants with unhealthy diet. A future waterโonly fasting clinical trial will test the efficacy on obese patients.
https://doi.org/10.1002/ctm2.502
https://pubmed.ncbi.nlm.nih.gov/34459130
Dear Editor, Fasting is known to have many health benefits such as prolonging lifespan and suppression of tumorigenesis.1โ3 In the present study, we systematically evaluated the effects of water-only fasting on metabolic-syndrome and age-related risk markers in 45 normal-weight individuals. As shown, a 4.59 kg reduction in body weight, 9.85 cm reduction in waist circumference, and 1.64 kg/m2 reduction in body mass index (BMI) were observed during a 5-day water-only fast (Figures 1A-1C). After refeeding for 1 month (day 38), body weight, waist circumference, and BMI were still lower than the baseline level (Figures 1A-1C). Blood pressure (BP) significantly declined during water-only fasting with diastolic BP declining more than systolic BP and gradually both increased to the baseline level by 98 d (Figures 1D and 1E). Considering many fasting studies showed diastolic BP reduction did not exceed systolic BP reduction, future studies are needed on water-only fasting and BP reduction. Insulin dropped approximately 2.8-fold lower than the baseline level during water-only fasting (Figure 1F). Insulin-like growth factor 1 (IGF-1) decreased by a total of 26% during water-only fasting and decreased more in females than males (Figure 1G and Table S1). Future studies will address the sexual disparity of IGF-1 reduction during water-only fasting. The number of pan T cells, CD4 T cells, CD8 T cells, and B cells decreased during water-only fasting (Figures 1H-1K). In contrast, the frequency of Treg cells significantly increased during fasting and still exceeded the baseline level 3 months after refeeding (Figures 1L and 1M). This is an important benefit, since Treg cells have anti-inflammation effects.4 With regard to thyroid hormones, T4 increased rapidly during fasting, whereas T3 and TSH decreased (Figures 1N-1P). The decreased level of T3 during water-only fasting is of particularly importance since a low T3 level, without impairing thyroid function, is strongly associated with longevity.5,6 The present study suggested that water-only fasting for many parameters was similar to calorie restriction and a fasting-mimic diet.6โ9 Metabolomic profiling of serum and urine was preformed to investigate the underlying metabolic mechanisms of water-only fasting. Principal-component analysis (PC
... keep reading on reddit โกMy personal experience has been I get the lead like metallic rotten smell (telltale sign of ketosis) just 30 hrs into DF but take more than 3 days in WF.
Is this the case or am I just hallucinating my imaginary ketosis ?
Also, I've seen some people right on this forum itself questioning the phenomenon of metabolic water. Basically calling BS on the purported super benefits of DF. Whats the catch ?
https://preview.redd.it/keiq13x1kn541.jpg?width=533&format=pjpg&auto=webp&s=5af3b1e43f5f2dfb82ac4e3e74e204553c9b8730
Generally speaking. I know everyone is different.
I'm 325 lbs and have been fat-adapted since January/February. My glycogen levels are very low. I generally gain .2-.6 during the first 36 hours of a water fast because I have no water to expel.
I'm 12 hours into a soft dry fast. Trying for 24 hours this first time. Just curious how quickly the body goes from waiting for me to drink water to going and getting water itself.
I Soft Dry Fast for around 22.5-23 hrs a day, everyday.
Why is my urine significantly darker & more concentrated by the end of the the Dry Window, if my body "distills metabolic water" when I'm not drinking?
Thank you.
Here's the article preview (paywall)
(Some universities have access)
Highlights:
- They compared JAWBONE UP24, Fitbit Flex, Misfit Shine, EPSON PULSENCE PS-100, Garmin Vivofit, TANITA AM-160, OMRON CaloriScan HJA-403C, and Withings Pulse O2 (based on Japanese sales rankings).
- Beside the devices chosen by sales ranking, OMRON Active style Pro HJA-350IT, Panasonic Actimarker EW4800, SUZUKEN Lifecorder EX, and ActiGraph GT3X were also used in the research.
- n=19 patients
- Quote from the discussion: "Although further studies are required, the findings presented herein suggest that most wearable devices do not produce a valid measure of total energy expenditure."
- Compared to the measurments of the metabolic chamber, the three devices that deviated the least were the Panasonic Actimarker, the Epson Pulsense and the Tanita AM-160.
- The 3 devices that underestimated the energy expenditure the most were the Withings Pulse O2, Jawbone UP24, Garmin Vivofit.
- The 3 devices that overestimated the energy expenditure the most were the Fitbit Flex, Misfit Shine and both Omron devices.
Although it's not new that these types of devices are not very accurate, I found it interesting to see an actual scientific research done on the subject.
Discalimer: I've done short and long fasts, I'm not saying this without experience.
So, hi to everyone, i wanted to know about a particular type of fast: a sweating dry fast? If when we dry fast cells get the metabolic water, couldn't be more dehydrated make our cells accelerate the process? MMA fighters do a similar thing, with saunas etc, but they obviusly go too low on water so their body can't keep up with the fat breackdown. Now, if i sweat a fair amount of liquid, could i induce a deep dry fast state in a shorter amount of time? Anyone has tried this?
Doing this for personal developement, not for weight loss or because of a medical condition. Plus i just want to know how fast is the autophagy on a severe case of dehydration
Please share your experiences and thoughts
Thanks for reading
Inonotus obliquus (Chaga) has been traditionally used for treatment of metabolic diseases; however, the mechanism remains to be elucidated.
In this study, we found that the water-soluble melanin complex extracted from I. obliquus improved insulin sensitivity and reduced adiposity in high fat (HF)-fed obese mice.
These results suggest that the water-soluble melanin complex of I. obliquus exerts anti-hyperglycemic and beneficial lipid-metabolic effects, making it a candidate for promising anti-diabetic agent.
Melanins are water-soluble polyphenols with a high molecular weight. So that's something to look for on the label.
Note that these melanins are not present in cultivated biomass Chaga like Host Defense and Aloha Medicinals are selling. Easy to spot; those products are beige, whereas wild-harvested Chaga extracts are dark-brown, close to black. The color is due to the melanin content.
Trying to find the full paper now... here's the abstract.
