(Hey this is my first ever post and it's on mobile so forgive any errors) Are there any other survivors of a rare cancer called langerhans cell hastyocytosis? If so what's your story?
I'm 19 and barely know anything about this disease/illness. is there a chance that i will die from it anytime soon or in the far future? I'm sorry if this is a stupid question but I don't really know anything about this.
First Aid states that “caseating granulomas with central necrosis and Langerhans giant cell are characteristic of secondary tuberculosis“. However, doesn’t that also occur in primary tuberculosis in the form of a Ghon focus (isn‘t a Ghon focus a caseating Granuloma with central necrosis)?
First Aid says (somewhere) that macrophages in the skin become dendritic cells.
I remember getting a question *SPOILER but needed for the thread* on some NBME asking the origin of cells responsible for Langerhans cell histiocytosis, and the answer was dendritic cells.
Some googling taught me they are dendritic cells. Some said they're neither...
There is no discussion about this on reddit (as far as I searched), how come? am I missing something?
This card keeps popping up but I don't understand why the granuloma would be eosinophilic. Is this specific for pulmonary langerhans cell histiocytosis? Is the s100 stain "eosinophilic"?
The Q has been adopted.
A Q bank basically asked "which cell can HIV infect?" and the answer was "Langerhans cells".
I know HIV infects macrophages and T-cells via CCR5 and CXCR4. But, the explanation said HIV can also directly infect LCs... The explanation said "LC's are derived from dendritic cells and located in the epidermis (also referred to as macrophages of the skin and mucosa)." Other sources describe LCs the same way (like https://www.sciencedirect.com/topics/medicine-and-dentistry/langerhans-cell)
My Q's are:
- For Step1, are Langerhans cells considered dendritic cells or macrophages?
- Do Langerhans cells have CCR5?? if HIV can infect them and they're supposedly macrophages?
I'm reaching out here because I would like to talk to adults who are living with langerhans cell histiocytosis. It is the diagnosis my doctor is leaning towards but we are still waiting to get a bone biopsy to confirm. I'm curious to know what your symptoms are like, and your day to day life is like? Also if there was any major treatments you had to go through once you got your diagnosis. What I see the most online deals with children. Thanks in advanced.
Background: Langerhans cells histiocytosis (LCH) is a rare disease characterized by the uncontrolled proliferation of Langerhans cells (LCs). This study aimed to explore the clinic-epidemiological and pathological data of that disease in our population.
Methods: Sixteen patients were referred to the Dermatology and the Clinical Oncology & Nuclear Medicine Departments of our university during the 6 years from 2007 to 2012. Records data were retrospectively analyzed. Pathologic specimens and radiologic films were reassessed by consultants.
Results: Pediatric age and male sex predominated. The multifocal uni system (MUS) was the commonest presentation (50% of cases) while the multifocal multisystem (MMS) was found in 37.5% of cases including a case of Letterer-Siwe disease. Microscopic examination revealed dense infiltrate mainly of LCs with characteristic features and positive immunostaining for S100, CD1a and CD68. The treatment was heterogeneous. The follow-up time was well documented for 12 cases (mean=5 years). The prognosis was variable. Limitation of this study was the retrospective nature.
Conclusions: This case series showed the predominance of males, pediatric age, bone involvement and good treatment response. Diversity of system involvement necessitates a multidisciplinary approach. This diversity also could be a cause of underdiagnosis.
Please read full article : - www.journalaorj.com
Lot de Witte, Alexey Nabatov, Marjorie Pion, Donna Fluitsma, Marein A W P de Jong, Tanja de Gruijl, Vincent Piguet, Yvette van Kooyk & Teunis B H Geijtenbeek
http://www.nature.com/nm/journal/v13/n3/full/nm1541.html
I always thought langerhan cells were a type of dendritic cell, which I associate with neurons and cells of the nervous system. However, they are derived from monocytes?
Are these completely different things? My Kaplan book has Islet of Langerhans listed as pancreatic region which secretes glucagon, insulin, and somatostatin. While langerhans cells are macrophages in skin tissue. Is this right?
I found out I had a tumor in my right shoulder blade when I went in for an MRI thinking I tore my rotator cuff. They found the tumor inside the bone marrow and had to go into my back, cut through my shoulder muscle, and drill a hole into my bone with a 1/4 inch drill bit. Ima post a pic of the incision for proof. All just for the biopsy. Once they took the biopsy they filled the hole with literal side walk cement! I got the results today and have been reading everything on this disease. I had to get every bone in my body xrayed because there is usually more than one tumor. I'll find out if there is others this week a d hopefully get the one in my shoulder fully removed this month. Anyway im doing all this from my phone but ima answer any questions asap! Thanks!
Proof: http://imgur.com/a/ZY9n5
