Cadherins are a type of cell adhesion molecule that allow for intercellular binding through adherens junctions.
Desmosomes are intercellular binding junctions where you have intermediate filaments of the cytoskeletons of each adjacent cell attached to this desmosome that attaches the two cells together.
Are these just two types of ways cells can adhere? Are desmosomes attached *by* cadherins? (ie., is the protein that is responsible for the cell-to-cell linking within the desmosome actually cadherin?)
If so, do cadherins also act outside of desmosomes?
also, do hemidesmosomes (which connect cells to underlying connective tissue, rather than linking for example cells of the same type together) function the same way, withethe only difference being in the type of the cells being adhered?
Ty for any help - i am trying to get a sense of what's what with these cell adhesion molecules (so far I understand the other ones fairly well):
- integrins - 2 transmembrane domain proteins that attach to extracellular proteins
- immunoglobulin (Ig family) are antibodies that bind to antigens - the antibody is all protein with the variable and constant regions (and made up of light and heavy chains) - but the antigen can be anything really (?)
- selectins - bind to carbohydrate molecules on other cell surfaces (important for immune system. but not the same thing as immunoglobulin/antibodies
I saw this image in a lecture on the types of cell junction, but i dont understand what the difference between adherens junction and desmosomes is. I also dont know what the 'band of actin filaments' is, i thought the cytoskeleton was composed of tubulin microtubules, intermediate filaments and actin microfilaments? The lecture suggested that desmosomes and adherens junctions were the same thing but places online say they are different and that the adherens junction involves this band of actin filaments and desmosomes involve the intermediate filaments of the cytoskeleton.
Any help is appreciated, thanks!
https://preview.redd.it/xgc5l01zew341.png?width=766&format=png&auto=webp&s=ddae89f9f0461d1e0a9122af0b9101bb73002a08
I'm not really fully understanding their concept, would appreciate help!
desmosomes - provide strength by anchoring the cytoskeletons, specifically the intermediate filaments. important if there's mechanical stress. ex. skin, muscles
gap junctions - communication. protein channels called connexons. only ions and small stuff may passively go through. important for synchrony, like coordinated activity. Heart (Cardiac) and Smooth Muscle
tight junctions - prevent paracellular pathways. prevent water and other solutes from going in between cells. skin, GI tract
gap junction and tight junction are super clear and straight forward ,but i just cant tell the difference between those 2
Like his characteristics are they the same function as these compounds
And yes I've watched the show :p
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies π
It really does, I swear!
Theyβre on standbi
Pilot on me!!
Nothing, he was gladiator.
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
When I got home, they were still there.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
