Apixaban Puns

Apixaban is an anticoagulant drug used to treat thromboembolic disorders. I am trying to draw it using its IUPAC name, without reference to the structure.

Could somebody walk me through the steps they use to parse the IUPAC name to get to the right structure? i.e which and the bits of the name you are reading together to arrive at individual elements of the molecule.

Thanks.

For side effects

• pain in areas of body where there's no blood clot (eg blood clot in leg, but pain in abdomen)
• headache, brain fuzziness, etc..
• nausea, diarrhea
• anything else you guys want to bring up

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Hi,

I’ve been on Apixaban for little over a month now and everything is going well - had an unprovoked DVT in my right thigh.

Anyway I’ve noticed the past few days I’ve been getting a random tingling sensation, usually not in the one place but over my body.

Just wondering if this is a bizarre side effect to apixaban or if anyone else has experienced this?

Other than that I feel absolutely great! I’m able to walk around again and do everything i could do before… Minus the feeling of sudden doom I’ll end up with another DVT!

Meant to say it comes and goes it’s not persistent.

Just read the possible side effects… it’s there! Now I’m not an anxious mess lol

Thanks Nicole

I’ve been on Eliquis and I’m pretty confident it’s causing some GI issues. I wanted to hear if anyone else has soft stool (sometimes diarrhea) and mild abdominal pain while taking the drug.

1. The study will run for two years, with two groups, one on coumadin and the other on eliquis(there are roughly some 1000 participants, I believe).
2. Dosages of each drug will be monitored daily, with a monthly follow up and INR check for those on coumadin.
3. Vitals are monitored per each follow up and compared.
4. Participants are expected to self report any side effects experienced.

For those curious, I thought I'd provide some insights I've received from my brief time in the study, thus far.

1. As it stands, the primary motivation for this study is to ascertain the viability of an alternative anti-coagulant for patients with the On-X valve. As was expressed to me by my surgeon, there is an alarming rise in young patients in need of valve replacement opting for biological valves. This is due in no small part to coumadin and the restrictions it imposes, and the perceived difficulty in keeping one's INR under control. The hope is that by providing patients with a different blood thinner that does not require diet modification and INR testing, reoperations can be avoided by people opting for the more effective mechanical valve(namely On-X)
2. As I mentioned earlier, this study is specifically for patients with the On-X in the aortic valve position. The particular design of this valve, being comparatively state-of-the-art allows patients to reduce their INR to 1.5-2.0, as opposed to 2.0+ for other valves(though participants on coumadin in the study will be maintained at 2.0-3.0). It's believed the particular hemodynamics of the On-X make it a prime candidate for alternative anticoagulants. At this time, there is no information as to whether or not this is a possibility for other mechanical valves, unfortunately.
3. Eliquis, as opposed to coumadin(warfarin) is not a vitamin K antagonist but a direct Factor Xa inhibitor(it counteracts the blood clotting process to a degree directly), thus it does not require one to monitor their diet or monitor their INR. Presently, dosages have not been specified for this particular study, though generally eliquis is taken twice a day.
4. What limited interaction I've had with the research team has allowed me a few questions; Namely, when will this be approved? As it stands, there is no official projection. Medical studies are notoriously slow and FDA approval is a long process. As this study will span two years, it's expected that the most optimistic window will be that eliquis will be approved in five years if it conti

Is anyone else on this and is it a good blood thinner and do I take the tablets with food or is there anything else I should watch out for while taking it.