I suspect there will be only a very small handful of people interested in this-- but I certainly would have been! So I'm doing a lit review dump of some of what I've been collecting on ß2GP1 antibodies and infertility. Some of it generalizes to other antiphospholipid antibodies, some of it doesn't.

* * *

Abbreviated review of the research on beta2-glycoprotein 1 antibodies and infertility

There are many published reviews of the literature on antiphospholipid syndrome and pregnancy complications, but there are none, to my knowledge, on antiphospholipid antibodies ("APAs") and repeated implantation failure ("RIF")/unexplained infertility. Further, there are three qualifying antiphospholipid antibodies (lupus anticoagulant, anti-cardiolipin antibody, and beta2-glycoprotein antibody) and now two identified types of antiphospholipid syndrome (thrombotic and obstetric APS), which are frequently not disaggregated in review articles. I personally have only one of the antiphospholipid antibodies, and I have no history of thrombosis-- so I've been collecting lit that focuses on β2GP1 antibodies specifically wherever possible, and on mechanisms of implantation failure/infertility rather than on later pregnancy complications.

Background

>1. We know very little about APAs in women with RIF/unexplained infertility. APAs are associated with adverse outcomes in established pregnancy, but the vast majority of studies on APAs and pregnancy only recruit women who are 6-8≤ weeks pregnant. Issues with implantation/placentation have been hypothesized as mechanisms of later pregnancy complications in women with APS, but we know very little regarding whether APAs may also obstruct implantation entirely. Women are typically only tested for APAs if they are experiencing repeated pregnancy loss (RPL), so APA+ women with RIF/unexplained infertility are likely to be unobserved.
>
>2. β2GP1 antibodies are more prevalent in women with unexplained infertility & RIF than in fertile controls (Mahdian 2021), as are many other APAs (Coulam and Acacio 2012). (Those two studies aren't the strongest methodologically, but they're what currently exists on that question.)
>
>3. Obstetric and thrombotic APS are different disorders (e.g. [Morales et al. 2021](https://ard.bmj.com/conten

I keep hearing about AIP but get soooo overwhelmed looking through here and other sites. I don’t eat much so it should be simple or fairly easy for me. Does anyone know what book/website is simpler? As in maybe just gives specific items or snacks to buy that can easily be mixed up over and over again? A list I can add to over time? There’s sooooo much on the “no” list. I almost want to give up before I even start!

59 yr old female. Plavix, crestor, altace, indapamide. Anti phospholipid antibodies syndrome diagnosed 2000. multiple strokes, high blood pressure. No recreational drugs, no alcohol. Physically active.
I am wondering anyone on here could tell me if it is safe to get the vaccine since I have antiphospholipid antibodies syndrome.
I was not expecting to get the vaccine for a few weeks, but last night found out I am getting it on Tuesday. Monday is a holiday. I dont think I will be able to reach anyone for an answer before my appointment.

I cannot find any info about someone with APS and the vaccine.

I would appreciate any insight.
Thank you for your time.

Hi everyone - just wondering if anyone else has tested positive for antiphospholipid antibodies/had issues with clots?

I’ve recently been chasing around labs and symptoms and discovered I have hashimotos testing positive for thyroglobulin (581) and thyroperoxidase (358) antibodies.

In the process I also tested triple positive for antiphospholipid antibodies (LAC, and high positive cardiolipin and beta 2 IgG). Also tested positive for a bunch of other antibodies but anyway.

I’m seeing a hematologist and waiting on my 12 week recheck but started aspirin in mean time. Obviously this is all rather concerning and doctor seemed pretty shocked I haven’t had a clot and that I have two healthy children - but I had them 11 and 14 years ago.

Guess I’m just curious if anyone else has had this happen? perhaps its common? could the hashimotos either throwing these labs off... or more likely leading to an additional autoimmune disease - or do I have some hope these antibodies will magically disappear in next few weeks lol.

Thanks in advance! I’m still waiting on my appt with endocrinologist and that isn’t until the 16th so will obviously ask then... but considering my rheumatologist and hematologist seem to be thrown off by this we shall see lol.

Hi everyone. Earlier this year I had two miscarriages at 6weeks. I then got diagnosed with Antiphospholipid antibody syndrome (APS). I’ve been taking a daily baby aspirin since then and was told I would start injectable heparin when I became pregnant. Well I got a faint positive this morning! I’m waiting for my doctor to open so I can call.

Does anyone else have any experience with APS? I’m having a hard time finding stuff about it.

How did you find out you have it? I think some women find out during their childbearing years by suffering miscarriages or find out by having a massive PE out of the blue, like I did. How did you learn of yours?

Hey. This shit is exhausting.

Anyone out there have antiphospholipid antibody syndrome and/or mthfr mutation? I’m feeling so overwhelmed and sad thinking about trying again after our losses (most recent in 14th week of pregnancy) and would love and appreciate some connection. Positive stories, experiences with daily blood thinners injectables during pregnancy, things to be aware of that I probably haven’t thought about, etc.

I really feel like all of the odds are against us to even get pregnant (PCOS) and now I’m aware of all this extra bullshit that makes it feel like the odds will be against us to stay pregnant, if it ever happens again.

Hi All -

I've been diagnosed with lupus for around 10 years now. This year I will be 35 and my husband would like to start trying to have a child. Over a year ago I was taken off plaquinel because of it damaging my retina. ( Yes, I am the one person it happened to.) and generally feel well. I have been constantly been presenting with hi DNA antibodies and a low complement (for years), with all other blood work in the normal ranges. I have also been diagnosed with the A.A.S and am aware of the risk factors with pregnancy. Has anyone else had a pregnancy with that? Or tried and miscarried?

Would love to hear some experiences.

Thanks!

Age: 31 Sex: Female Height: 5’2” Race: Hispanic Duration of Complaint: 3 days Location on body: left neck to foot (worst in left shoulder, hip & toes) Diagnosed Medical Issues: antiphospholipid antibody syndrome, endometriosis Current medications: 81mg adult low dose aspirin daily No recreational drugs & non smoker

I was diagnosed with antiphospholipid antibody syndrome in January after some follow up bloodwork due to having my 4th miscarriage. I was informed that this blood disorder put me at higher risk for blood clots, DVTs, PEs, strokes, etc and is normally paired with other autoimmune diseases. I’m still waiting for a referral to a specialist for further testing on the autoimmunes. Starting 3 days ago, I woke up with pain,weakness & intermittent numbness down the left side of my body. The pain was mildly helped by ibuprofen & heat but not a lot. I’ve worked in the medical field for 5 years and see DVTs and strokes/TIAs frequently. The symptoms did not fully resemble either. There was no swelling or discoloration that we normally see with a DVT. There was numbness and weakness in my left side from the neck down but my vision, speech, balance, gross motor skills were unaffected. It’s more fine motor issues like grasping with my fingertips that I find hard. The pain is the worst in my shoulder & hip and in my foot when it goes tingly. Could this be symptoms of another autoimmune disease starting that my primary doc can handle or is this something more serious that I should go to the Urgent care or ER for?

So my wife has had APS since she was 16 she is now 23. Now she is going through prob the worse week ever, she's been hospitalized for over 2 weeks now and we lost our 18 week baby do to HELLP syndrome but now it's only gotten worse. My wife's body can't keep her platelets level stable nor get them back to normal. Averaging around the 10's and 20's for two weeks now. But yesterday was the worse. She slowly starting getting confusion to the point she didn't know who i was or where she was at. At the end of the day she couldn't speak, she had a mri today and found out she has tiny blood cloths in her brain. The hematologist said its CAPS (catastrophic Antiphospholipid antibody syndrome). I really don't know what to do right now, we are at a great hospital but just want some answer to know when my wife can talk and be normal again.

I got slightly high results on the Cardiolipins IGG (21) and IGM (16). They are repeating the tests in 3 months to see if it confirms it or not.

I also suffer from other auto-immune diseases such as vitiligo.

Since it is a possibility, any advice on what living with APS means?

1. I am curious if any of you have migraines with your Sjogren's?

2. Does anyone have antiphospholipid (APL) antibodies as well?

I was reading that APL antibodies can be found in both Sjogren's and in migraines. Also, migraines and intractable headaches are seen in Sjogren's.

Anyway, I have both and can't help but wonder about the frequency of these two findings in other redditors?

Hi there,

I am MtF and I was diagnosed with Antiphospholipid Syndrome. I actually wanted to start my hrt shortly. Is that an exclusion criterion for hrt? And even if it is not an exclusion criterion, what effects does it have on hormone treatment and follow-up. I'm extremely desperate right now!

Unfortunately, my doctor doesn't know much about transgender people. He just said that under no circumstances should I take estrogen tablets. Of course there is still gel and plaster, but he can't say anything about that. I finally want to live in my true gender, but that shouldn't kill me either!

Please if someone can help

Antiphospholipid syndrome can result in treatment resistant bipolar disorder, just curious if anyone has both.

I was having some weird neurological stuff and imbalanced after a time of anxiety and stress. Muscle twitching finger numbness all sorts of stuff. Then I got COVID and tested positive for APL a month after. No livedo, no clots. And since starting with a holistic medicine doctor my condition has improved. Rheumatologist believes that they are likely transient from COVID. I got pretty sick too idk if that matters. I’m 25 and literally no one in my family from great grandparents to cousins has any kind of autoimmune issues. Was just wondering if anyone else had this and had them clear up? I’m going to get retested tomorrow, many months later. I was dx with benign fasciculation syndrome before I got COVID. Twitches have improved and I don’t really feel dizzy that much anymore. But I don’t feel like myself still and COVID has complicated the shit out of things haha.

Have any of you with lupus and APS had an adverse reaction to the Johnson and Johnson vaccine? I had the first one and was fine and am scheduled to get the booster Wednesday but I’m so nervous. I take aspirin daily so I think I’ll be okay but I get so stressed after hearing about the blood clots from the j & j.

Like the title says, we had no idea why this had been happening or how to make any sort of difference.

Today at my appointment the OB looked over my record from when I was with Kaiser back in 2017 and she said that she thought she saw why we've had repeated loss. She mentioned something called Antiphospholipid syndrome (APS). She told me to start a regime and that the high risk doc would be in touch soon.

I was naturally anxious, as I am at every appointment. She offered to do an ultrasound so we could see baby, and baby was doing fine. Heart rate looked good, and she was even moving around showing off her little wiggles (which she hadn't been doing much at previous scans).

So all in all I am thankful for an OB who has paid attention to details and not made assumptions that I already knew this information. Since the tests she was reading from were from 2017 I was and am mystified as to why I hadn't heard of this before. Bit I'm glad it's come up. At that time of the tests we had only experienced two losses, and I was told that losses happen (especially early) but that I'd likely be pregnant soon. I was, quite a few times, but the little beans just weren't sticking. By now we have experienced seven losses.

This will be our last pregnancy, however it plays out. truth be told, we had decided just before this pregnancy that we will no longer go this route as we dream of growing our family. We will aim to have our forever home and stay the course of opening our lives to foster and adopt. We decided we were done with the route of trying for bio babies though it's just been so painful. We are thankful for our boy, and the experiences that have brought us together. (But, we were done) So, this pregnancy is a nice surprise. I do tend to hold it lightly. It all seems a little unreal.

That there is possibly some medical answer as to why it's happened and treatment to help protect us from another loss makes me hopeful. They said today I might start taking shots daily, and that things look as if they're going well.

I had believed that my losses just happened, and so many medical practitioners led me to and let me believe that there was just no answer as to why. I am thankful that there is a course of action to try, and that I can hold on a little tighter than I have these last few months.

Tldr; I had no idea Antiphospholipid syndrome (APS) was even a thing. Now that I do, I might have a course of action that might help minimize our chance of mc. We're pre

In my school biology project about diseases, I chose Antiphospholipid Syndrome (抗磷脂症候群). The project needs a treatment option outside of western medicine alongside the general information about the disease and treatment within western medicine.

Are there treatments for APS within Chinese medicine?

Hello! I have inflammatory arthritis and sjögrens syndrome confirmed, probably more but nobody really cares to investigate.

I am moderately controlled on Plaquenil (but have had issues getting it over the past 6 months which have sent me into flares....but I digress)

I am wondering about pregnancy risks! My fiance and I are looking into what we need to do to start getting ready to conceive, and ideally I would like to give birth in a birth center - but I have had rheums tell me that I will be high risk because of Lupus Anticoagulant Antibodies. I've never had a clot (in fact, I generally have problems not being able to stop bleeding!) and I haven't had any pregnancies so no actual APS diagnosis, just...copious amounts of antibodies.....

Just looking for experiences and wondering if I should continue forward and find a midwife and OBGYN that works with a birthing center or if I should give up the ghost and just go with a typical American hospital bed birth.

Hi all! I noticed some strange discoloration in my feet and toes, so my doctor did a lot of lab work and my results came back with higher than normal antiphospholipid antibodies.

I don’t have any other symptoms other than fatigue, which may be unrelated. I’m not sure. My doctor was at first concerned with how my feet looked, but they have cleared up a little bit recently but not completely and still have some dark red and purple marks on some of the toes. They are also quite susceptible to cold.

I have started the daily aspirin regimen, but I’m wondering if there’s anything else I need to watch out for. I’m not completely sure what the cause of this is. I am a 24-year-old male and I’m just seeking some advice.

Thanks!

I also just started seeing a rheumatologist. Two of my blood tests tests were high and she wants to repeat them in a couple of weeks...the IgM and one of the antiphospholipid tests (the other was normal). We didn’t talk about what to do if I got another clot but I’m pretty nervous. I went to an urgent care last time and they sent me to the ER. The ER dr was pretty chill about it bc the clot was still hanging out in my arm. So I’m not sure what to do. I’d definitely like to wait, with Covid and everything going on. I feel like there’s probably a lot of really sick people needing it more? Thanks for the advice! (It also could totally not be one, just kind of feels the same).

Have you ever taken serrapeptase, nattokinase, lumbrokinase, or streptokinase to keep the blood thin? (I might have spelled these wrong)

If so, do you take these in conjunction with your baby asprin, or just one or the other?

What are your opinions/experiences with these?

I don't know much about them yet, but it's my understanding they are natural enzymes that assist in blood thinning and have a good safety profile. I see a rheumatologist for my aPL, and a functional med doc for some other things and she mentioned these enzymes as potentially being helpful. TIA for your responses.

23 year old female, 130lbs, 5’6”, Canadian/Persian, non-drinker, non-smoker, no recreational drugs, currently taking 15mg of Mirtazapine for insomnia/appetite increase.

I would really appreciate it if someone can explain this to me. Can mono/EBV virus cause false-positive Antiphospholipid antibodies?

I was diagnosed with mono back in February, but I was having extreme symptoms after months, so I was referred to a rheumatologist in case, so I had some testing done. I ended up testing positive for some antibodies.

Cardiolipin Ab- igm 31.4 (should be under 20) Beta-2 glycoprotein 1 ab igm - 42.5 (should be under 20) aPTT actual/normal 1.21 (negative) Mono spot test positive

My doctor wasn’t too concerned as these tests have to be redone. So I redid it 12 weeks later and my results were:

Cardiolipin Ab- Igm 27.1 (should be under 20) Beta-2 glycoprotein 1 ab igm- 36.2 (should be under 20) aPTT actual/Normal 1.47 (weakly positive) Mono spot test negative

Might be a stupid question but what I’m asking is can mononucleosis/EBV create a false positive in these antibodies and does the fact that these antibodies went down mean anything, or the fact that my aPTT went up slightly? I’m getting different responses from my family physician, rheumatologist and hematologist.

Ive done a d-dimer test twice and was negative both times. I’m only asking because I have been having ongoing chest pain in my sternum and upper collarbones along side some shortness of breath for months now. However my 02 is always at 99-100 and I’ve done chest X-rays, pulmonary function tests and blood tests that have all came back clear/normal.

I was told to re-test again which I am planning to do within the next couple of weeks. Any help in understanding what these factors mean would be appreciated.

So my wife has had APS since she was 16 she is now 23. Now she is going through prob the worse week ever, she's been hospitalized for over 2 weeks now and we lost our 18 week baby do to HELLP syndrome but now it's only gotten worse. My wife's body can't keep her platelets level stable nor get them back to normal. Averaging around the 10's and 20's for two weeks now. But yesterday was the worse. She slowly starting getting confusion to the point she didn't know who i was or where she was at. At the end of the day she couldn't speak, she had a mri today and found out she has tiny blood cloths in her brain. The hematologist said its CAPS (catastrophic Antiphospholipid antibody syndrome). I really don't know what to do right now, we are at a great hospital but just want some answer to know when my wife can talk and be normal again.

Have you ever taken serrapeptase, nattokinase, lumbrokinase, or streptokinase to keep the blood thin? (I might have spelled these wrong)

If so, do you take these in conjunction with your baby asprin, or just one or the other?

What are your opinions/experiences with these?

I don't know much about them yet, but it's my understanding they are natural enzymes that assist in blood thinning and have a good safety profile. I see a rheumatologist for my aPL, and a functional med doc for some other things and she mentioned these enzymes as potentially being helpful. TIA for your responses.

Posted this also in Lupus, didn't get any responses?