Researchers have identified a drug that works against depression by a completely different mechanism than existing treatments. Ezogabine, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression. mountsinai.org/about/newsโ€ฆ
๐Ÿ‘︎ 8k
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๐Ÿ‘ค︎ u/Wagamaga
๐Ÿ“…︎ Mar 06 2021
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TIL if you don't enjoy music you may have a condition called specific musical anhedonia, which affects three-to-five per cent of the population. mcgill.ca/neuro/channels/โ€ฆ
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๐Ÿ‘ค︎ u/GladCricket
๐Ÿ“…︎ Apr 10 2021
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Any working musicians out there with musical anhedonia? (Hate music)

I do 3 hours a day busking and derive absolutely no pleasure from the music I play anymore, to the point of actively hating it and hating playing.

Doesn't matter what I play... its all the same to me now. Its all just shit. Just noise I don't want to listen to and don't want to hear.

I keep going because people enjoy it enough to give me a decent living off of it but it's made me not only hate my own music but hate music on a whole.

It gets worse the more I think about it. It's like my mind is actively against me on this.

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๐Ÿ‘ค︎ u/_mattgrantmusic_
๐Ÿ“…︎ May 12 2021
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Anhedonia, Me, Digital, 2021
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๐Ÿ‘ค︎ u/OmoNoHomo
๐Ÿ“…︎ May 10 2021
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Does anhedonia feel like this for anyone else?

I canโ€™t feel vibes or โ€˜feelingsโ€™ about things anymore. Like before Iโ€™d play a game and thereโ€™d be a vibe or something to it. Same with just going different places I feel nothing now everything feels exactly the same no matter what

๐Ÿ‘︎ 44
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๐Ÿ‘ค︎ u/Wooden-Building
๐Ÿ“…︎ May 06 2021
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anhedonia + binge eating

Does anyone else deal with this? I feel so incredibly deeply bored and disappointed by every single task in my life. All the things people normally go to for dopamine (music, movies, games, hobbies, even other people) has lost the appeal to me and I bounce between activities restlessly but never feel satisfied emotionally by anything except binge eating. I donโ€™t know how to get un-bored. I have lots of options for entertainment but I just donโ€™t really enjoy any of them, so Iโ€™m left feeling unsatisfied and empty and food fills that perfectly.

๐Ÿ‘︎ 87
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๐Ÿ‘ค︎ u/foxescanflyvu
๐Ÿ“…︎ Apr 30 2021
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Anhedonia

Just got clean again after relapsing and going back into active addiction for about a year. My first day clean was 4/30/21. Like a lot of people in early clean time, I feel pretty miserable. Nothing seems to be enjoyable or entertaining at the moment, and I'm perpetually bored. Furthermore some of the underlying issues that using was helping me avoid, namely chronic pain and mental health issues, are coming back with a vegeance. I've gotten clean before and know that this is a temporary phase that won't last forever, and that the temporary discomfort is more than worth it. But that doesn't change the fact that in the moment, it's hard to cope with. I know I can do this, but it's definitely not easy.

Edit: if anybody's got any advice for keeping yourself occupied or entertained during this phase, I would very much appreciate it

Edit: fair amount of responses with similar themes so I will just respond here: Things have gotten much easier in the past 2 days. I feel like I'm starting to get over the hump. I still have the experiences I was describing, but to a much lesser extent. I'm starting to get my energy back as well. I have gone to meetings in the past but have not gone to one since getting clean again. I was exercising for the first time in forever before I relapsed, but again I haven't really done any exercise since I've gotten clean. Now that my energy is returning I plan to start attending meetings and start exercising as well. Definitely getting my sense of hope and serenity back. Thanks for all the encouragement y'all, I really appreciate it.

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๐Ÿ‘ค︎ u/snailtitties
๐Ÿ“…︎ May 09 2021
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How are there no anhedonia specialists?

I am shocked by how much of a blind spot there is to this condition by virtue of it being lumped in with depression. My psychiatrist is useless and Iโ€™m paying every week for pointless CBT.

I love therapy, always have. But therapy doesnโ€™t work when you donโ€™t have emotions. The concepts canโ€™t be reinforced or effective without some sort of felt experience. Challenging my thoughts has zero effect on my experience of the emptiness. It feels like my sessions are just spent explaining the symptoms over and over, and getting responses that I know would be helpful if I was experiencing a normal depression, but do nothing right now.

I think a huge part of the hopelessness and suicidal ideation associated with this condition is that itโ€™s being misdiagnosed as โ€œtreatment resistantโ€ depression rather than directly treated itself. Has NO ONE here found a doctor up to date on anhedonia research and truly committed to achieving remission in their patients? Iโ€™ve found one website by a psychiatrist who had anhedonia himself but itโ€™s a blog with no contact info.

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๐Ÿ‘ค︎ u/DeliciousMail4675
๐Ÿ“…︎ Apr 26 2021
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Anhedonia is hell on earth

This fucking condition is mental torture. I just waste my whole fucking mindlessly scrolling through social media and thinking about how much of a mess my life is. I'm seriously so sick of this shit

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๐Ÿ‘ค︎ u/Colin-IRL
๐Ÿ“…︎ May 12 2021
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Is some degree of anhedonia natural aging / maturing?

And everyone experiences it a little bit

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๐Ÿ‘ค︎ u/Lolerino7
๐Ÿ“…︎ Apr 26 2021
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Anhedonia

Do you struggle to feel pleasure from everyday activities? Normal things that people do, like, watching Netflix, hanging out with friends, none of it feels satisfying. You feel empty.

With that, do you use substances to feel pleasure?

๐Ÿ‘︎ 42
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๐Ÿ‘ค︎ u/Purpleberri
๐Ÿ“…︎ Apr 24 2021
๐Ÿšจ︎ report
compiling potential anhedonia treatments (will continue adding more)

Nardil

Pramipexole

Parnate

Selegiline

Wellbutrin

Amitryptaline

TMS

ECT

DBS

rTMS

Agomelatine

9-Me-BC

NSI-189

Ketamine

Ibogaine

Rasagiline

Amantadine

Memantine

Lions Mane

Amisulpride 12.5 (low doses)

Modafinil

MIF-1

KB220Z

Vraylar

Sarcosine

n-acetylcysteine (nac)

Semax

DXM

Zinc

Pirebidil

Memantine

Moclobemide

Tianeptine

Yohimbine

Sulbutiamine

Cordyceps

"๐—œ๐˜ ๐—ถ๐˜€ ๐—ฒ๐˜€๐˜๐—ถ๐—บ๐—ฎ๐˜๐—ฒ๐—ฑ ๐˜๐—ต๐—ฎ๐˜ ๐—ฎ๐˜ ๐—น๐—ฒ๐—ฎ๐˜€๐˜ ๐Ÿฑ๐Ÿฌ ๐—ฝ๐—ฒ๐—ฟ๐—ฐ๐—ฒ๐—ป๐˜ ๐—ผ๐—ณ ๐˜๐—ต๐—ผ๐˜€๐—ฒ ๐˜„๐—ต๐—ผ ๐—ฎ๐—ฟ๐—ฒ ๐˜ƒ๐—ฒ๐—ฟ๐˜† ๐˜๐—ฟ๐—ฒ๐—ฎ๐˜๐—บ๐—ฒ๐—ป๐˜ ๐—ฟ๐—ฒ๐˜€๐—ถ๐˜€๐˜๐—ฎ๐—ป๐˜ ๐—ต๐—ฎ๐˜ƒ๐—ฒ ๐—น๐—ผ๐˜„ ๐—ณ๐—ผ๐—น๐—ฎ๐˜๐—ฒ & ๐—•๐—›๐Ÿฐ ๐—ถ๐—ป ๐˜๐—ต๐—ฒ ๐—–๐—ฆ๐—™. ๐—” ๐—ด๐—ฟ๐—ผ๐˜‚๐—ฝ ๐—ผ๐—ณ ๐˜๐—ต๐—ฒ๐˜€๐—ฒ ๐—ฝ๐—ฒ๐—ผ๐—ฝ๐—น๐—ฒ ๐—ฐ๐—ฎ๐—ป๐—ป๐—ผ๐˜ ๐˜‚๐˜๐—ถ๐—น๐—ถ๐˜‡๐—ฒ ๐—บ๐—ฒ๐˜๐—ต๐˜†๐—น ๐—ณ๐—ผ๐—น๐—ฎ๐˜๐—ฒ ๐——๐˜‚๐—ฒ ๐˜๐—ผ ๐—ฏ๐—ถ๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น ๐—บ๐—ฎ๐—ธ๐—ฒ๐˜‚๐—ฝ, ๐˜€๐—ผ ๐—™๐—ผ๐—น๐—ผ๐—ป๐—ถ๐—ฐ ๐—ฎ๐—ฐ๐—ถ๐—ฑ ๐—ถ๐˜€ ๐˜๐—ต๐—ฒ ๐—ข๐—ก๐—Ÿ๐—ฌ ๐˜€๐—ผ๐—น๐˜‚๐˜๐—ถ๐—ผn - https://www.bbrfoundation.org/blog/relieving-treatment-resistant-depression-treating-metabolic-deficiencies"

CERC-501

Buprenorphine + Samidorphan

Vagus Nerve TENS unit

Gabapentin

Low dose lithium

Magnesium absorption issues

NAD+ infusions

Ferritin Infusions

J147

Growth Hormone

DTMS

BH4

Amphetamine

Esketamine

5a-DHP

Bromantane

Psilocybin

Low dose Abilify

Cymbalta

BH4

Pregnenolone

Resveratrol

methylphenidate

๐Ÿ‘︎ 12
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๐Ÿ“…︎ May 09 2021
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How prevalent is anhedonia side effect with BPC 157?

Do we know how many in the greater pool anhedonia appears in as a side of BPC 157?

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๐Ÿ‘ค︎ u/AdSignificant6160
๐Ÿ“…︎ May 03 2021
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What Anhedonia feel like.

Anhedonia is browsing Netflix for 45 minutes trying to find something to watch but giving up because you find nothing interesting. Anhedonia is skipping song after song trying to find one that's good only to skip through your entire playlist and finding nothing. Anhedonia is constantly opening and closing apps because they can't hold your attention or interest. Anhedonia is finding social interaction a chore instead of something fun. Anhedonia is laying in your bed staring up at the ceiling because you can't bring yourself to do anything. Food doesn't taste good. Music doesn't sound good. Normal means of entertainment are not entertaining. Socializing is a chore. Walking and working out and yoga and being outside and going for long drives are a pain in the ass. Nothing spurs an emotional reaction in you anymore. You live your life as an empty shell devoid of all that makes us human. This isn't a life I would wish for anyone.

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๐Ÿ‘ค︎ u/Damiana7675
๐Ÿ“…︎ Apr 13 2021
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Succces stories on MAOI for anhedonia/depression?

Do you people on Maois feel euphoric or even slightly euphoric? Does ur depression get lifted? I sleep 16 hours a day because i cant find the motivation to wake up when my alarm clock goes off. I feel like i have no motivation for anything so my question is has your motivation for doing things improved by being on MAOIs? I feel like anhedonia and depression rule my life and i cant achieve much while im having issues with them. Please any succes stories with anhedonia and or depression?

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๐Ÿ‘ค︎ u/Smartsaucee
๐Ÿ“…︎ May 07 2021
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Has anyone got better from anhedonia?

Two years ago while on at summer camp I was betrayed by those around me. Last year I messily lost my best friend of four years that I heavily depended on as she essentially did the same. My problems seem trivial, but Iโ€™m still young and they caused me to go though trauma and long depressive periods. I used to get strong emotional chest pains, not physically painful but for me it was so much worse. I still see my ex best friend at school everyday because we have the same friend group and itโ€™s so exhausting. Iโ€™ve been exhausted for almost half a year now and I no longer find pleasure in socialising. I donโ€™t get emotional pains anymore, and I donโ€™t feel any emotions. Iโ€™m struggling to find friends that are close, because I simply find no humour from their words or any reaction so I always have to fake it, and itโ€™s been like that for half a year now. I have friends but Iโ€™m becoming more alone and itโ€™s a slap in the face since my ex best friend is a very emotive extrovert. Any advice about how to help this would be amazing as I just want to live my younger years happy-do antidepressants help? I canโ€™t see myself going to therapy. Thanks.

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๐Ÿ‘ค︎ u/aapplebottomjeans
๐Ÿ“…︎ May 08 2021
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Anhedonia and brain fog

I'm looking for some help maybe someone could recommend something that would help me out because I'm at a loss.

So I started having depression at around 19 and let it go on till I was about 23. Without realising I developed anhedonia and then just got more depressed to the point where I just shut down and slept for around 6 months.

After that something just broke and I didn't feel like a person anymore no feeling no thoughts just emptiness. I'm 25 now and for the past 3 years I've just been a husk of a person. I met someone and developed ED then tried to go on antidepressants but the stories about post SSRI sexual disfunction stop me from jumping fully in even though I did kinda feel good when I was on sertraline. I tried mirtazapine but it did absolutely nothing besides give me some energy for a week.

I'm looking for something that would help with the anhedonia and brain fog. Right now I just forget things I thought of after minutes and it's hard to learn and do new things when nothing goes in. So any recommendations would be appreciated

Edit: Also probably worth mentioning that sometimes I seem to have these "smart moments" where I feel like I can properly think and remember past events. They seem to happen randomly and usually when I'm at work, I'm kinda thinking that it may be linked to my sleep since I get up at 5am for work and it usually doesn't happen when I'm at home and sleep till like 10am.

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๐Ÿ‘ค︎ u/Ttsmoist
๐Ÿ“…︎ May 12 2021
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Therapy for Anhedonia

Iโ€™m experiencing lack of emotion and just no soul or empathy, and severe decline in cognition after one psychedelic induced mania at 29. No history of mania before, only depressive episodes that were very differentโ€”past depressions I felt deeply and my brain still worked perfectly I was just lethargic.

What therapy has worked for you for these symptoms? Iโ€™m doing everything Iโ€™m supposed to do and itโ€™s not getting better after 7 months. I am wishing for death over this emptiness. Iโ€™m doing weekly CBT, I did DBT at a treatment center, Iโ€™ve tried ACT. None of it helps itโ€™s basically โ€œaccept where you are and do things even if you donโ€™t want toโ€ but like..after 7 months or feeling zero reward or emotion that does not make life any more worth living.

Iโ€™m trying different meds and treatments but my symptoms donโ€™t vary. How can one move forward or make anything of their life given this predicament? What am I doing wrong? What can help? How have you coped? My therapist seems baffled and just keeps encouraging me to create a routine and believe Iโ€™ll get betterโ€”surely by 2021 we have a more effective approach Iโ€™m just not aware of??

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๐Ÿ‘ค︎ u/DeliciousMail4675
๐Ÿ“…︎ May 05 2021
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Difficulties with empathy with anhedonia and general emotional numbness

Does anyone else find it harder to truly empathize with other people? I can still simulate a kind of empathy because itโ€™s just in my nature to treat others with respect, but I just canโ€™t bring myself to truly feel the pain of others anymore or truly care for their misfortune.

๐Ÿ‘︎ 30
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๐Ÿ‘ค︎ u/Quick-Top-1531
๐Ÿ“…︎ Apr 25 2021
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Phenibut inducing anhedonia

Anybody else having the experience that Phenibut sometimes makes really anhedonic like nothing is enough, nothing can stimulate you anymore. Iโ€˜m going to try describing it the best I can. Maybe someone understands and has similar experiences or tips for me.

You hurry from one stimulus to the next one, not able to enjoy the moment. On Phenibut everythingโ€™s so amazing, you just want to do so much that you canโ€˜t really enjoy the moment and lose value in things. You suddenly donโ€™t focus on the moment anymore, on the here and now.

While starting one thing you already plan the next things to do instead of enjoying. I would describe this condition anhedonic mania. The usual โ€ževerything is amazingโ€œ type of feeling of Phenibut starts turning to โ€ževerything is impalable and transitoryโ€œ type of feeling.

I lose the track of all those things Iโ€˜m planning to do and nothing can stimulate me anymore. Everything seems worthless, too much and too few at the same time. Then I get sad about all the things I planned but canโ€˜t handle to do or to grasp them because I donโ€™t have enough time or cognitive capacity needed for this. I lost the track. I sold my here and now.

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๐Ÿ‘ค︎ u/Gottchen
๐Ÿ“…︎ Apr 20 2021
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Uridine for apathy/anhedonia

Iโ€™ve read mixed reviews for anhedonia from uridine, some say it helps others say it makes it worse. Does anyone have any experience with uridine?

๐Ÿ‘︎ 9
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๐Ÿ‘ค︎ u/depressedthotty
๐Ÿ“…︎ May 11 2021
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Did something major happen right before you got anhedonia?

I dropped out of med school which destroyed me. I think that contributed to my anhedonia. What about you?

๐Ÿ‘︎ 6
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๐Ÿ“…︎ Apr 20 2021
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How can I help someone with anhedonia

Hi people. I've been wandering around this community for a while until I finally decided to ask for your wisdom. I've read many stories from you here and I'm truly sorry and heartbroken for what you're going through. I really wish you will all recover and be well, I know you can.

My partner has been diagnosed with anhedonia for some months. I've tried to understand and looked everywhere and everything to get what was going on inside his mind. The cause for my partner was trauma and depression because of the pandemic and I couldn't do anything for him to help. I know I can't help him. I can't do anything. My partner also doesn't want to go to therapy or anything similar, but I know that the only thing that is helping now is my partner's passion, which seems doing it without feeling like a "chore", but I'm not really sure. I'd be happy if it was the case and I believe that.

So I finally ask you: what do you think friends and partners of a person with anhedonia should do?

Thank you for reading, have a great day

๐Ÿ‘︎ 5
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๐Ÿ‘ค︎ u/Round_End_9820
๐Ÿ“…︎ May 09 2021
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Anyone else get dumber as their anhedonia gets worse?

For instance, I will try playing chess and I just end up making the worst blunders. I just canโ€™t think clearly at all and find it difficult to come up with the right words.

๐Ÿ‘︎ 39
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๐Ÿ‘ค︎ u/hanfook
๐Ÿ“…︎ Apr 21 2021
๐Ÿšจ︎ report
Compiling potential Anhedonia treatments, feel free to add.

So far, I have:

Nardil

Pramipexole

Parnate

Selegiline

Wellbutrin

Amitryptaline

TMS

ECT

Exercise (I'm going to add this even though I'm fully aware not all people benefit from the feel-good emotions of exercise, for me personally, running/walking has been tremendously beneficial in helping my overall mood, but not my anhedonia per say.)

Has anyone had experience with Pramipexole? I've seen studies about it, I would love to know your experience on pramipexole and if it has helped you.

https://www.medscape.com/viewarticle/861659

https://pubmed.ncbi.nlm.nih.gov/16814808/

https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2015.15060788

Please read if you haven't tried Pramipexole for Anhedonia. Also, Iโ€™m not going to include compounds like 9-Me-BC, NSI-189, or other chemical compounds (specifically ones that donโ€™t require prescriptions).

Do not give up hope.

Update: Going to provide as many updates as I can while I simultaneously research solutions.

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๐Ÿ‘ค︎ u/Safe_Ad_9658
๐Ÿ“…︎ Apr 27 2021
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How long does Anhedonia last?

Hello everyone,

On April 13th I did a rapid detox off 12mgs of Buprenorphine/Naloxone (Suboxone). For those that donโ€™t know what rapid detox is its where they put you to sleep and give you Narcan and then a Vivitrol shot. I slept through the most acute withdrawals but as most of you know this is just the beginning. Especially with Suboxone. Even though Suboxone is a partial agonist its a very strong drug. Iโ€™ve been on Medication Assisted Treatment for 6 or 7 years. The first 4 was methadone and then switched to Suboxone.

The primary symptoms Iโ€™m experiencing is lack of energy, weakness, insomnia, dysphoria and anhedonia.

Dysphoria - is a profound state of unease or dissatisfaction. It is the opposite of euphoria. In a psychiatric context, dysphoria may accompany depression, anxiety or agitation.

Anhedonia - is the inability to experience pleasure.

Now I know that this has a lot to do with my brain healing and the lack of dopamine.

My question is when can I expect to feel somewhat normal again?

Ive been trying to eat right, going in the sauna, and exercise. Also been taking SynaptaGenX which is supposed to help rebalance the neurotransmitters. Will also be getting a supplement called Sam-e today from Amazon. So Im trying to check all the boxes.

Anything else I could be doing to help expedite the process?

Thanks everyone.

๐Ÿ‘︎ 2
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๐Ÿ‘ค︎ u/EuDAiMoNiA83
๐Ÿ“…︎ May 02 2021
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Is anhedonia always a symptom rather than an isolated disease? Also, are people really recovering from this (I need some good stories that can give me hope)?

Hi everybody. It has been almost a year for me of this and I have been diagnosed firstly with depression and anxiety, later with dysthymia and anhedonia. I think that my first symptoms were mostly related to anhedonia than something else (I could not feel sleepy or tiredness, couldn't feel hunger and I definetely isolated myself because of this)and my mood is not that low is everything more mental and about ''gone feelings'', like I became socially stupid all of a sudden. So, i am thinking is this might be just anhedonia instead of anhedonia linked to something else, is this possible? I feel like I won't ever recover so is there any story of success?

I must also add that all happened after the umpteeth drunk night, the day after I woke up and this was the new me

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๐Ÿ‘ค︎ u/weirdsomethingyey
๐Ÿ“…︎ Apr 25 2021
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Anhedonia, friendship, socializing and alcohol

As you can tell from the title, I want to talk about a bunch of separate things that are all interconnected in my life in a negative way. Iโ€™ll try my best to make it a cohesive story.

What inspired this post specifically is that for the first time today, I declined plans to meet up for drinks tomorrow with my best friend because I donโ€™t feel like it. I also told her about my resolution to stop drinking. She was understanding, but I got the impression that she took it a little personal, which I understand, but thatโ€™s also why I struggle with saying no to plans when I donโ€™t have a socially acceptable reason like sickness or deadlines or what have you. I donโ€™t want other people to feel rejected.

My decision to stop drinking has been a long time coming. I was a late bloomer, so I was in my early twenties when I started exploring going out to bars and binge drinking and it was amazing at first. It felt like something โ€˜clickedโ€™ and I was completely in sync with my surroundings and after years of isolation, social anxiety and depression, discovering this lively part of myself nurtured something inside of me that had been neglected for years. I was able to talk to strangers, to flirt and be intimate with people, to have vulnerable and effortless conversations with my friends. I wouldnโ€™t say I was happy, but I did feel like I could genuinely enjoy myself and that was worth something! But obviously that is a completely unsustainable way to live. Before I knew it, I was fixated on when I could get drunk again and I was hungover three days out of the week. Returning to my old self, when all the chemical magic had run out, also became more and more painful as I now knew what I was missing, which brings me to the subject of anhedonia (the inability to experience joy)...

As I started to feel uneasy with my drinking habits, I started paying attention to how I felt in social settings when I was sober. Hanging out at the park on a nice day, just going over to someoneโ€™s house to catch up, that kind of stuff. What I noticed is that it all felt forced and draining. Not because of something other people did, but because I somehow canโ€™t get into it. I feel restless, like Iโ€™m drawing a blank and am trying to keep up appearances until itโ€™s over and I can go home and fade into nothingness. Nothing about it energizes me, itโ€™s actually quite the opposite. And then I would find a reason to drink and I could just feel all of that tension leave my body.

I now have arrived at the po

... keep reading on reddit โžก

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๐Ÿ‘ค︎ u/vainplainness
๐Ÿ“…︎ May 09 2021
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My psychiatrist's cure for anhedonia

After trying various meds and ECT to no effect he said since nothing is helping my only hope is to work on developing a daily routine. Have a job that forces me to to get up daily in morning and work daily at it.

He said anhedonia/depression that I have is partly due to my brain makeup but it has worsened over the years because I have developed a habit, meaning I have given up and the brain has wired up in such a way to worsen the situation.

He mentioned brain plasticity and how forcing the brain into activity, even a tiny bit each day, will improve the brain.

๐Ÿ‘︎ 40
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๐Ÿ“…︎ Apr 04 2021
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Relentless Anhedonia!

How long does the anhedonia and deep depression last? I've used for 3.5 years reaching a max of 85gpd. So far I'm 24 days CT, and the depression and anhedonia are RELENTLESS! I mean it just DOESN'T STOP! I swear to god if you added up all the times I felt even normal in these last 576 hours, it might not even be minutes. And I'm not exaggerating. I haven't felt good once. I didn't even think that is possible right now. Just to be unable to feel anything good. It's not getting better. It just goes from horrible, to horrifying, to bad, back to horrible. I don't even get the brief moments of normalcy that people talk about. I just go to work, come home sleep. Go to work come home and sleep. Depressed depressed depressed. Nothing changes every day feels the same, even when I change it up. It's honestly getting so repetitive I feel like I'm going to get panic attack! I do have some hope though. As I'm pretty sure depression and anhedonia take the longest to go away. But jeez I didn't think it would be this bad. This feeling even follows me into my in my sleep. My dreams are literally as grey as real life. Does anyone have any Idea how long this lasts. Is it supposed to last 24 days! I've heard so many people say they felt better in like 7 days. Why is this taking so long?

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๐Ÿ‘ค︎ u/JimCarreyTheTruth
๐Ÿ“…︎ Apr 03 2021
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A few questions for those of you with SSRI-induced apathy, anhedonia, or emotional blunting (or similar drugs)
  1. Which condition do you have? (apathy and emotional blunting are essentially interchangable)
  2. Which drug caused this condition?
  3. When did the condition start (for example, during the initial desensitization phase, during normal treatment, or upon withdrawal.)
  4. How long did this condition last? (did it stop after the initial desensitization phase, at discontinuation, after the withdrawal period, or not yet?)

SSRI-induced apathy is the main term used in scientific literature. For context: I'm considering which antidepressant to try next after bupropion (which I've been on for about a year) hasn't seemed to work. Vortioxetine and vilazodone seem especially interesting, however I'm not willing to risk long-term side effects (after discontinuation) starting after a short time of being on one. There does not seem to be information on these symptoms being caused by these two, but other plain SSRIs and SNRIs have numerous reports. The two scientific articles linked below suggest that they do not cause it to the same extent as other SSRIs, or may even enhance emotion.
Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment
https://www.sciencedirect.com/science/article/pii/S0165032720330391
Adverse effects and treatment satisfaction among online users of four antidepressants
> Users of newer drugs (vilazodone and vortioxetine) more often reported emotional instability, while users of older drugs (escitalopram and duloxetine) reported more emotional blunting. Emotional and behavioral AEs demonstrated moderate to substantial relationships with users' satisfaction, whereas gastrointestinal, metabolic, or sexual AEs were minimally related.

https://pubmed.ncbi.nlm.nih.gov/28531820/

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๐Ÿ‘ค︎ u/jasonofspoons
๐Ÿ“…︎ Apr 20 2021
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Is anhedonia a permanent thing you always feel, or does it leave and come back randomly later on

Or do you not experience anhedonia at all?

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๐Ÿ‘ค︎ u/teenvirginblood
๐Ÿ“…︎ May 01 2021
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Planning a painless suicide because of total irreversible anhedonia

I've been depressed for about 10 years by now. Then I got totally fucked up by psych meds 2 years ago. They gave me PSSD. It took me a while to figure out what was going on. I am now unable to experience any positive emotions, unable to feel pleasure from an orgasm (genital anesthesia), a video game, a social interaction or a beer. I literally can no longer get a buzz from drinking alcohol, so no "escape" there ... Unlike depression, my condition is now irreversible, so kms is the only logical solution. Will be using the helium bag method and gathering supplies. Please no "don't do it" bs, there will be no more joy in my life because I have been chemically lobotomized and castrated by SSRIs, and there are MANY like me out there. This is just a heads up for anyone considering medication for their depression, you risk making your 1000x worse because of total emotional and sexual disability. Please try ANYTHING else before popping even a single pill. Ask me how I know. No doctor in the world will acknowledge or cure your condition, that they caused. There is no way back from this kind of neurological damage. You will be praying for death every day of your remaining "life", if you weren't already. Ironically enough, my suicide will be blamed on my depression, even though I litteraly shouted "I have numb genitals and no more pleasure because of your meds" in the face of a handful of doctors and psychiatrists. I'm done fighting the system that crippled me. I'll be at peace soon.

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๐Ÿ‘ค︎ u/sajagaroo
๐Ÿ“…︎ May 01 2021
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Anhedonia and ssri

Did anybody improve their anhedonia with

  1. Wellbutrin
  2. Ssri (mostly interested in Paxil) I find that small doses of Paxil help me feel but they also make me Light headed and more distracted, does anybody feel this way?
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๐Ÿ‘ค︎ u/weirdsomethingyey
๐Ÿ“…︎ May 05 2021
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lost my humanity, blank mind, anhedonia, after Lexapro. Is this curable and has one experienced something similar??

So.. I'm stuck in a particular state of mind that is haunting me for a few months now, before I'll try to explain it, yes I do have history of anxiety/depression, bloods are all fine, i eat healthy, exercise regular and overall physically healthy, no thyroid issues etc.

My issue is after stopping lexapro about a month after stopping i've been experiencing something extremely odd which i've never had in my life which still continues almost 4 months off lexapro, i dont even know what its called but a blank mind describes it best - I lack almost any kind "inner experience" or "self relationship", as if my consciousness experience is very dull now, It doesnโ€™t feel like life is a conscious experience that I am having anymore, as there is no inner construct within me to absorb an experience on any level. I see, hear, touch, and smell, yet each of these is so dulled and devoid of emotional content that they donโ€™t coalesce into anything meaningful I can call a human consciousness.

I don't experience time the same way, there is memory issues, inability to visualise or very weak, I don't have spontaneous thoughts like I used to, I feel like every insight I had has been disappeared, i cant think anymore, no introspection, specific emotions that defined my personal sense of being are no longer there, nothing clicks into place in my head, my mind feels blank ALL the time, there is no inner monologue activity, I cannot drift off in thought, when I talk to people there is no conscious planning ahead, I get no random associations\references from reading text, I can't say I'm depressed at the moment really, I know how depression feels like, this is something else completely where i just feel brain dead to a degree, although maybe the lexapro has put me in an extremely depressed state im not sure. Almost as if I'm just on autopilot all day. No emotions, nothing. I'm also experiencing total loss of libido and sexual dysfunction as well but id say that relates to this issues as well.

I read about the default mode network and its like mind has just completely shut itself down and im in some kind of very very very basic survival mode. https://en.wikipedia.org/wiki/Default_mode_network#:~:text=In%20neuroscience%2C%20the%20default%20mode,cortex%2Fprecuneus%20and%20angular%20gyrus.

Although i cant feel "distress" or any an

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๐Ÿ‘ค︎ u/Wooden-Building
๐Ÿ“…︎ Mar 29 2021
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Ssri anhedonia is brutal

Was on lexapro 3 months I have went off the medicine but feel completely anhedonic 4 months later like I have never before in my life experienced, no matter depression I ever had in the past. I was always able to connect to the world around me and enjoy and be glad that I was alive, find pleasure in small things. Since the medication, I have lost all feelings of pleasure and I don't do much anymore, don't enjoy anything, have nothing to say. I never experienced this before the medicines, I no longer laugh or smile.... my heart is broken and empty like a void inside. I don't know how to live this way.... I am numb, lost, empty, if only I knew it was going to go one day.

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๐Ÿ‘ค︎ u/Wooden-Building
๐Ÿ“…︎ Apr 22 2021
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Anhedonia but not with the abuser, some questions.

I had anhedonia before the abuse but now it is stronger. The thing is, i felt/feel flat towards my loved ones but not for my narcissistic x. The only time I felt strongly was either when she hurt me or made me feel loved. Is it my addiction that makes her an exception? Did I use her unpredictability to feel?

She used to claim it was just her depression whenever she hurt me, if it is true, am I traumatizing people too? I donโ€™t act the way she does or say stuff that could hurt but idk... since I am numb too i feel confused about this today! I mean i donโ€™t go straight up tell people that โ€œit is hard to love youโ€ stuff like that or lash out, give silent treatment...

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๐Ÿ“…︎ May 08 2021
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MDMA Induced Anhedonia?

So abouf 3/4 years ago I had a large dose of mdma in 1 night and this resulted in me having a severe comedown. Couldnโ€™t move out of bed for 5 days depressed etc. Iโ€™m convinced itโ€™s done permanent damage to my dopamine receptors as ever since Iโ€™ve felt mainly numb and just going through the motions, where as before Iโ€™d feel happy excited etc and I just donโ€™t get that feeling anymore, lost my libido & every bit of pleasure I used to get from life. Ive had blood works done and everything is in order hormonal wise and Iโ€™ve read on here a couple of times people mentioning 9meBc helped if it was stimulant abuse. Would people recommend this as There is not much info on it out there but Iโ€™m seriously struggling at the min and just want this nightmare to end

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๐Ÿ‘ค︎ u/pw1998-
๐Ÿ“…︎ May 07 2021
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Has Wellbutrin helped anyone's Anhedonia?

As above, thanks in advance for any info ๐Ÿ‘

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๐Ÿ‘ค︎ u/Suttisan
๐Ÿ“…︎ Apr 22 2021
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Anyone here get anhedonia from a hormonal fluctuation? Anabolic steroids or otherwise

Seems like most people got it from SSRIs or other drugs. I'm certain mine came from steroid use which ended up screwing up my psychology. Curious if the treatment process would be the same

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๐Ÿ‘ค︎ u/ChamedUp
๐Ÿ“…︎ Apr 26 2021
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Anhedonia and Addiction

I was digging through old posts on this sub and saw a remark by someone that (paraphrasing) "even alcohol and weed aren't fun anymore, they don't get me drunk/high".

This is something I've noticed in myself - I begin encountering unpleasant bodily side effects from these drugs long before (if at all) the desired effects on mental state take place. Likewise, other drugs seem to be diminished - Xanax just makes me sleepy. Adderall is a mixed bag - more drive and motivation but never any of the euphoria that stimulants can cause. Phenibut was a total dud for me. Pregabalin was one of the rare substances that seemed to have a significant effect on my mental state. I've never felt dependent or the beginnings of addiction with any of these drugs.

However, what I do seem to be hopelessly addicted to is the internet. Or perhaps not addicted, but dependent. I scroll and scroll and scroll and refresh and scroll but get almost no pleasure out of it, more that it's slightly preferable to doing productive things or literally nothing.

I'm curious about the experiences of other people in this sub - do you find what are normally addictive substances to be a solid meh/10? What do you feel you're addicted to/dependent on?

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๐Ÿ‘ค︎ u/thoroughlythrown
๐Ÿ“…︎ Apr 13 2021
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Parnate + NSI-189 for resistant social anxiety anhedonia

I'll outline everything I've tried below, but surficed to say it's a lot. And my anxiety in specific is genuinely crippling.

As a last resort, I have ordered some Tranylypromine out of India and am going to buy some NSI-189 to combine with it. I'm looking for advice on if there is an alternative to the NSI-189 I could take and if is worth the risk given my circumstance because it is a research chemical.

Given my history of Trauma, CPTSD (Childhood emotional neglect, abuse, bullying) I feel I need something to actually rewire my brain rather than just adjust neurotransmitter levels (e.i psychedelic action VS SSRI action) although I hope the MAOIs will at least quell some of my anxiety.

If it's also relevant in all I have the following: Unipolar depressive disorder (specifically persistent depressive), Social Anxiety disorder, GAD, Body dysmorphic disorder, Binge eating disorder, "Trauma",

Symptomatically: Anhedonia and Depersonalisation-derealisation disorder

Not diagnosed: ADHD-PI, C-PTSD

What I've tried:

  • Pharmaceuticals - venlafaxine, duloxetine, reboxetine, nortryptyline, amitryptiline, pregabalin, antipsychotics, benzos, AEDs/mood stabilisers, sertraline, citalopram, fluoxetine, mirtazapine, buspirone.
  • Automedding - Tried selegiline (MAOI) + Modafinil (DRI) and bupropion + duloxetine for triple reuptake SNDRI combo.
  • Non-pharma/nootropics wise I've tried CBD, NAC, Lionsmane, Noopept, Racetams, Sulbutiamine, Phenibut, Ashwagandha, Rhodiola Rosea, Bacopa Moneri, Fish oil high EPA, DHA. Methyl-B complex, Magnesium. Might be forgetting some.
  • Also had all possible lab work done, prolonged 7-day water fasting.

Can you just give me some advice or opinions or just a sanity check? Thanks!

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๐Ÿ‘ค︎ u/amenteco
๐Ÿ“…︎ Apr 27 2021
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Does alcohol misuse cause anhedonia? (loss of motivation, pleasure etc)

I've noticed that I have ZERO motivation to work on my business that I used to obsess over. Its physically painful for me to interact with any elements of my work, its like theres invisible barriers everywhere thats too mentally challenging to overcome.

I also get little enjoyment out of watching tv, playing games etc etc. Everything is really boring and uninspiring. Im starting to assume this is due to my alcohol misuse over years. Does anyone have experiences with regaining motivation and life vigour after extended alcohol sobriety?

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๐Ÿ‘ค︎ u/precariousdays
๐Ÿ“…︎ Apr 29 2021
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MDMA abuse can lead to anhedonia?

Since the drug works with the "pleasure system" of the body, when abused, it could lead to severe anhedonia?

If so, it is possible to reverse it?

I'm 5 months since my last roll (after 2 years of regular use) and I can't find anything that makes me feel something, I've lost interest on everything. Most of things I loved now seem stupid or a waste of time.

I'm seeing a therapist but the only things we talk are about my daily stuff, no medicine (which is good I think), and also no progress on my lack of feelings.

What can I do to recover them?

Many thanks,

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๐Ÿ‘ค︎ u/MadnezzRaver
๐Ÿ“…︎ Apr 21 2021
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Anhedonia

Everything is dull. I need mental and physical stimulation but I get none no matter what I do. People are a disgusting letdown. Food tastes like teeth. Traveling is more of a burden than a worthwhile experience. Ditched my hobbies because they were tediously repetitive. I workout to get rid of my excess energy but it gets boring after a while.

I have extra time to waste and think about random trash or the hardships of this pointless life.

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๐Ÿ‘ค︎ u/bluntcuntstunt
๐Ÿ“…︎ May 03 2021
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I'm scared that no matter what I do, my severe anhedonia/lack of interest in things will never get any better. RANT

It's been months now since I've been clean. I've had a previous year off of opiates before this (and before that I had quite a bit of clean time here and there) but relapsed on oxy. Even then with a year clean, I wasn't able to get over the severe depression and lack of interest/anhedonia that followed me no matter what I did. I tried exercising. I tried medications. I tried eating better. I tried therapy/CBT. I tried giving myself more clean time. Creating a schedule to distract myself. Nothing helped.

Nothing I did made me happy or gave me a feeling of pleasure. I was uninterested. I cried every day.

I'm doing all of this again and so far NOTHING has worked. I'm just as miserable as I've always been, and I'm fucking terrified that this is going to be the rest of my life. I struggle with chronic pain and I always hurt. Getting motivated is torture. I take it a day at a time, but I'm so TIRED of being tired.

I'm scared that my chronic pain is causing depression that will never go away. But I can't go back on opiates for my pain. I always ended up relapsing because of my pain and I refuse to go back to them. I feel so goddamn stuck.

TL;DR: How the fuck do you get over the severe anhedonia and severe depression when even medications, exercise, and therapy don't help you? Am I going to be miserable forever?

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๐Ÿ‘ค︎ u/DirtyAngelToes
๐Ÿ“…︎ May 03 2021
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Redditors with extreme anhedonia/depression what do you do for work?
๐Ÿ‘︎ 2
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๐Ÿ‘ค︎ u/SomeWh1teDood
๐Ÿ“…︎ May 11 2021
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Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder (2021) ncbi.nlm.nih.gov/pmc/artiโ€ฆ
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๐Ÿ‘ค︎ u/Kiraxes
๐Ÿ“…︎ Apr 13 2021
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Anhedonia in year 2

Hey, all!

Long time lurker here. I just passed the 20 month mark. Year two is proving far more difficult than year one. That first year was basically a constant celebration. I was picking up tokens every month, making wonderful memories, enjoying life, and just celebrating being alive and being able to perform basic human functions without drinking. Also, I spent my first year on probation getting tested randomly. That is gone now so Iโ€™ve lost a safeguard. I feel so incredibly flat. Nothing interests me anymore. I still get up, do my work out, go to work, go hiking on the weekends, etc., etc. Iโ€™m just finding it so hard to find joy in anything anymore. Come to think of it, iโ€™m finding it hard to find any emotion. I feel like I am just going through the motions and there is no way out. I donโ€™t miss drinking necessarily, but I do miss that temporary escape from reality. Reality just seems so mundane. I have heard this is a pretty common thing in recovery. Has anyone else with long-term sobriety gone through this? What did you do to get through it?

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๐Ÿ‘ค︎ u/AtG8605
๐Ÿ“…︎ May 05 2021
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Uridine for anhedonia?

Iโ€™ve read some great reviews some people say it makes it worse. Please help

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๐Ÿ‘ค︎ u/depressedthotty
๐Ÿ“…︎ May 11 2021
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