28 y/o trans man, bipolar II, complications from hypothyroidism and Stevens Johnson Syndrome / Toxic Epidermal Necrolysis - cessation of lithium treatment

Hi Docs, as stated in title I’m 161 cm, 88 kg, 28, ftm trans with no HRT, white, currently in Germany, and suffer primarily from bipolar 2 as well as some traits of PTSD and BPD. Haven’t used drugs or alcohol in 7 years, sterilized, smoke about 5 cigarettes a day, eat moderately healthy, exercise sometimes.

Current medications are: mornings - 450 mg of lithium carbonate, 175 mg of sertraline, 100 micrograms of Levothyroxine evenings - 675 mg of lithium carbonate, last measured concentration of lithium was 0.6mmol/l

I’ve been mentally ill and specifically depressed for most of my life and tried everything under the sun. Citalopram, Quetiapin, Doxepine, Venlafaxine, Promethazine, Lamotrigine, supplemental high dose 5-HTP, as well as a course of experimental rTMS.

The Lamotrigine triggered a bout of Stevens Johnson / TEN, put me in hospital for two months in incredible pain - couldn’t get pain killers due to background of addiction. The whole experience was extremely traumatic and makes me very apprehensive whenever I have to switch medication.

For about 6 months now all was well on a combination of Sertraline and Lithium, but my thyroid levels are abysmal, my last TSH was 37. My doctor has suggested switching the lithium to Topiramat, Aripiprazol or Valproate.

What should I do? Why can’t I just increase Levothyroxine and stay on the Lithium? Any input is welcome. Thanks in advance.

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πŸ‘€︎ u/ogredandy
πŸ“…︎ Jun 15 2021
🚨︎ report
First Case of Toxic Epidermal Necrolysis Following the COVID-19 Vaccination thetruedefender.com/the-f…
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πŸ“…︎ Aug 22 2021
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Toxic Epidermal Necrolysis Post COVID-19 Vaccination - Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) - Case presentation - [As commonly reported another "rare" case, because every case is unique] archive.ph/bnGZ6
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πŸ‘€︎ u/whosthetard
πŸ“…︎ Aug 20 2021
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As a doctor I know that toxic epidermal necrolysis is a disease in which one’s skin first develops a painless deep purple blush and then liquefies and sloughs off, and also that its mortality rate closely matches the percentage of a patient’s skin that is affected.

When my little boy turned purple over his entire body and asked if he would be ok, I couldn’t even stammer out a lie.

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πŸ‘€︎ u/K-no-B
πŸ“…︎ Apr 17 2021
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Toxic Epidermal Necrolysis - A condition where the top layer your skin literally falls off, caused by an allergic reaction to drugs, it can be fatal. This guy lived, picture of recovered state and more info in comments. imgur.com/hzshI2D
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πŸ‘€︎ u/OntShitter
πŸ“…︎ Mar 17 2013
🚨︎ report
Steven Johnson VS Toxic Epidermal Necrolysis

Can someone tell me if both of these have necrosis and Nikolsky sign? As far as I know both have necrosis and Nikolsky. The difference is that TEN has >30% involvement of the skin. Am I right? Thanks in advance for your help

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πŸ‘€︎ u/Dahenlicious
πŸ“…︎ May 05 2019
🚨︎ report
Stevens Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN)
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πŸ“…︎ Aug 05 2019
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[ETC] Toxic Epidermal Necrolysis en.wikipedia.org/wiki/Tox…
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πŸ‘€︎ u/thebrrrzing
πŸ“…︎ Dec 31 2018
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A Year Ago Today I was Hospitalized for what turned out to be a disorder called Toxic Epidermal Necrolysis. This is my (kind of long) story. (Mildly? Graphic Images) imgur.com/gallery/1MQdj
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πŸ‘€︎ u/Bsgriff687
πŸ“…︎ Dec 22 2017
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(x-post from r/wtf) TOXIC EPIDERMAL NECROLYSIS imgur.com/a/nE657#m7iUDfd
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πŸ‘€︎ u/threetogetready
πŸ“…︎ Aug 05 2016
🚨︎ report
Toxic Epidermal Necrolysis imgur.com/1Jjqo
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πŸ‘€︎ u/kmgolfer
πŸ“…︎ Oct 21 2012
🚨︎ report
Poor reporting and documentation in drug-associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis – Lessons for medication safety [Br J Clin Pharmacol., Feb 2017 β€” free full-text] doi.org/10.1111/bcp.13103
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Aug 29 2018
🚨︎ report
TIL of Toxic epidermal necrolysis, a rare skin condition by which the top layer of the skin (the epidermis) detaches itself from the lower layer (the dermis); in other words, the person's skin literally falls off. en.wikipedia.org/wiki/Tox…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Mar 13 2016
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Stevens–Johnson Syndrome & Toxic Epidermal Necrolysis youtube.com/watch?v=5Jhgk…
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πŸ‘€︎ u/Yoshimo123
πŸ“…︎ May 13 2019
🚨︎ report
Poor reporting and documentation in drug-associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis – Lessons for medication safety [Br J Clin Pharmacol., Feb 2017 β€” free full-text] doi.org/10.1111/bcp.13103
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Aug 29 2018
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Toxic Epidermal Necrolysis, it's as bad as it sounds en.wikipedia.org/wiki/Tox…
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πŸ‘€︎ u/Khris777
πŸ“…︎ Nov 24 2019
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[Article] Request: Generalized eruption with histopathologic toxic epidermal necrolysis caused by occupational exposure to thiourea dioxide

doi:10.1684/ejd.2009.0723

[URL](http://www.john-libbey-eurotext.fr/medline.md… )

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πŸ‘€︎ u/sefotaksim
πŸ“…︎ Jul 30 2018
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Severe cutaneous adverse reactions {e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis} related to systemic antibiotics [Clin Infect Dis., Mar 2014 β€” free full-text] cid.oxfordjournals.org/co…
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Aug 11 2015
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Skin sloughing: Toxic epidermal necrolysis syndrome
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πŸ‘€︎ u/RIPmod
πŸ“…︎ Aug 15 2016
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r/WTF: A reaction to medication, toxic epidermal necrolysis. TEN disease by /u/igivefreetickles (45 mins. old) reddit.com/r/WTF/comments…
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πŸ“…︎ Sep 30 2013
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Plasma Lipid Profiling of Patients with Chronic Ocular Complications Caused by Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis journals.plos.org/plosone…
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πŸ‘€︎ u/officialcitral
πŸ“…︎ Nov 29 2016
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I am a survivor of Steven Johnson's Syndrome/Toxic Epidermal Nacrolysis, ask me anything if you want to

Hello, I was searching about SJS and saw some posts from this sub. Thought you guys might be interested in it.

I am a 19 year old male who was diagnosed with SJS when I was about 9 months old. It was caused by Measles vaccine. The doctors couldn't figure out what it was in the beginning and gave me wrong treatment.

Almost all my body and skin was affected. I didn't die but had some severe damage to both of my eyes.

My eyes are dry, they are photophobic (high sensitivity to light) and I have low vision. My right eye has 65% and my left eye has 5% vision. I grew up in a blind hostel from age 6 to 12. I can read and write but need to keep it very close to my face. I always wear a cap when outside.

I also had extreme trouble gaining weight. I was 44lbs at 4th grade, about 54lbs in 5th and 97lbs at the age of 17. Since then I started working out and have gained some weight. I am at 130lbs at 5'8" right now. Gaining weight is hard.

I am not vaccinated other than what I was given at birth.

If you had any questions about someone who had it pretty bad, feel free to ask me!

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πŸ‘€︎ u/Username_4477
πŸ“…︎ Sep 05 2021
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M/17/5'7" [97 lbs to 121 lbs] (7 months) I am survivor of Toxic Epidermal Nacrolysis and severe Anorexia
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πŸ‘€︎ u/Oppressed_Ostrich
πŸ“…︎ Jan 10 2020
🚨︎ report
Trying to do a little self teaching as an EMT to further my medical knowledge and am very confused between these three: Stevens-johnson syndrom, toxic shock syndrome and toxicepidermal necrolysis. What are the differences/how can you tell the difference?

Edit: I really appreciate the advice guys but sadly I still can't figure it all out /: some of these answers seem somewhat different than others.

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πŸ‘€︎ u/bsiformybuddyandi
πŸ“…︎ Feb 20 2015
🚨︎ report
People can grow horns. It doesn’t happen very often, but people do grow horns. They’re called cutaneous horns and they are the result of a wide range of epidermal lesions. According to the World Journal of Surgical Oncology, cutaneous horns appear in men over 55 and women over 65.
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πŸ‘€︎ u/OkFriend9891
πŸ“…︎ Jan 06 2022
🚨︎ report
Sandra Bullock laughs about having a "penis facial" - Privileged and wealthy, beauty obsessed people can pay $650 to have "Epidermal Growth Factor" injected into their faces. This is harvested from foreskins taken from non-consenting babies, usually without the full informed consent of the parents. youtube.com/watch?v=G-kdX…
πŸ‘︎ 106
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πŸ“…︎ Nov 22 2021
🚨︎ report
Sandra Bullock laughs about having a "penis facial" - Privileged and wealthy, beauty obsessed people can pay $650 to have "Epidermal Growth Factor" injected into their faces. This is harvested from foreskins taken from non-consenting babies, usually without the full informed consent of the parents. youtube.com/watch?v=G-kdX…
πŸ‘︎ 62
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πŸ“…︎ Nov 22 2021
🚨︎ report
Sandra Bullock laughs about having a "penis facial" - Privileged and wealthy, beauty obsessed people can pay $650 to have "Epidermal Growth Factor" injected into their faces. This is harvested from foreskins taken from non-consenting babies, usually without the full informed consent of the parents. youtube.com/watch?v=G-kdX…
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πŸ“…︎ Nov 22 2021
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Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro [2021] karger.com/Article/Abstra…
πŸ‘︎ 34
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πŸ“…︎ Dec 10 2021
🚨︎ report
Sandra Bullock laughs about having a "penis facial" - Privileged and wealthy, beauty obsessed people can pay $650 to have "Epidermal Growth Factor" injected into their faces. This is harvested from foreskins taken from non-consenting babies, usually without the full informed consent of the parents. youtube.com/watch?v=G-kdX…
πŸ‘︎ 93
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πŸ“…︎ Nov 22 2021
🚨︎ report
Platelet-rich Fibrin; exosome therapy; topical human epidermal growth factor

Has anyone tried any of these options? PRF is a new generation PRP, said to be vastly more effective. Exosome treatment is also fairly new but hard to find.

As for topical EGF, cosmetic brands like Bioeffect and Easydew claim to have effective topical formulations, but I'm mostly interested in this gel for indicated for burns, necrosis and diabetic foot ulcers. It's not known to be used cosmetically (contrary to what this website is advising), but what if it could help?

https://okdermo.com/product/regen-d-60-recombinant-human-epidermal-growth-factor-gel-bharat-biotec-15g/

πŸ‘︎ 12
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πŸ‘€︎ u/nijigencomplex
πŸ“…︎ Dec 04 2021
🚨︎ report
Sandra Bullock laughs about having a "penis facial" - Privileged and wealthy, beauty obsessed people can pay $650 to have "Epidermal Growth Factor" injected into their faces. This is harvested from foreskins taken from non-consenting babies, usually without the full informed consent of the parents. youtube.com/watch?v=G-kdX…
πŸ‘︎ 75
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πŸ“…︎ Nov 22 2021
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How long do epidermal injections take?

How long does it take to get injections done in interventional radiology? Not looking forward to laying down on metal table. Going to get it done into my back. When it was done in my hip it was quick - very quick. Back this time, wondering if it's going to be lengthier? Sorta scared about getting up after laying flat on a hard surface.

πŸ‘︎ 2
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πŸ‘€︎ u/BraxtonRodex
πŸ“…︎ Jan 12 2022
🚨︎ report
Sandra Bullock laughs about having a "penis facial" - Privileged and wealthy, beauty obsessed people can pay $650 to have "Epidermal Growth Factor" injected into their faces. This is harvested from foreskins taken from non-consenting babies, usually without the full informed consent of the parents. youtube.com/watch?v=G-kdX…
πŸ‘︎ 56
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πŸ“…︎ Nov 22 2021
🚨︎ report
28 y/o trans man, bipolar II, complications from hypothyroidism and Stevens Johnson Syndrome / Toxic Epidermal Necrolysis - cessation of lithium treatment

as stated in title I’m 161 cm, 88 kg, 28, ftm trans with no HRT, white, currently in Germany, and suffer primarily from bipolar 2 as well as some traits of PTSD and BPD. Haven’t used drugs or alcohol in 7 years, sterilized, smoke about 5 cigarettes a day, eat moderately healthy, exercise sometimes. Current medications are: mornings - 450 mg of lithium carbonate, 175 mg of sertraline, 100 micrograms of Levothyroxine evenings - 675 mg of lithium carbonate, last measured concentration of lithium was 0.6mmol/l I’ve been mentally ill and specifically depressed for most of my life and tried everything under the sun. Citalopram, Quetiapin, Doxepine, Venlafaxine, Promethazine, Lamotrigine, supplemental high dose 5-HTP, as well as a course of experimental rTMS. The Lamotrigine triggered a bout of Stevens Johnson / TEN, put me in hospital for two months in incredible pain - couldn’t get pain killers due to background of addiction. The whole experience was extremely traumatic and makes me very apprehensive whenever I have to switch medication. For about 6 months now all was well on a combination of Sertraline and Lithium, but (edit: due to the lithium) my thyroid levels are abysmal, my last TSH was 37. My doctor has suggested switching the lithium to Topiramat, Aripiprazol or Valproate. What should I do? Why can’t I just increase Levothyroxine and stay on the Lithium? Any input is welcome. Thanks in advance.

πŸ‘︎ 2
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πŸ‘€︎ u/ogredandy
πŸ“…︎ Jun 15 2021
🚨︎ report
Toxic epidermal necrosis

Why is there anemia in ten? Because of the deshydratation shouldn t it be hemoconcentration? Thanks

πŸ‘︎ 6
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πŸ“…︎ Jan 16 2021
🚨︎ report

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