How do you differentiate between Buerger disease (thromboangiitis obliterans) and critical limb ischemia from peripheral artery disease (PAD)?

Hello smart and kind people!

I believe that smoking is a risk factor for both conditions and angiography will show segmental involvement for both. And toe necrosis can be seen in both too?? So how do you differentiate them?

Thanks!

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๐Ÿ‘ค︎ u/yournameinlights25
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Difference between thromboangiitis obliterans and Peripheral Arterial Disease

Not sure if this is the right subreddit, but I thought I might as well try here before asking my professor. They literally seem like the same disease. What the hell is the difference?

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Caladrius Biosciences Granted Orphan Drug Designation for CLBS12 for the Treatment of Buerger's Disease 3/8/21, 5:04 AM March 8, 2021 08:04 AM ET (BZ Newswire) -- News

March 8, 2021 08:04 AM ET (BZ Newswire) -- News

Caladrius Biosciences, Inc. (NASDAQ:CLBS) ("Caladrius" or the "Company"), a clinical-stage biopharmaceutical company dedicated to the development of cellular therapies designed to reverse disease, today announced that the U.S. Food and Drug Administration ("FDA") has granted orphan drug designation to the Company's CD34+ cell therapy product, CLBS12, for the treatment of Buerger's disease โ€“ also known as thromboangiitis obliterans โ€“ a condition related to critical limb ischemia ("CLI") with no approved treatments to date in the U.S. .

"We are very pleased that the FDA has granted orphan drug designation to CLBS12 in Buerger's disease. Without a currently approved or effective treatment for this condition in the U.S., a significant unmet need remains for therapies that slow, stop or, ideally, reverse this debilitating disease," stated David J. Mazzo, Ph.D., President and Chief Executive Officer of Caladrius. "The Company's ongoing open-label, registration-eligible study of HONEDRAยฎ (CLBS12) as a treatment for CLI and Buerger's Disease in Japan has shown strong results to date with approximately 60% of subjects in the completed Buerger's Disease cohort reaching a positive โ€˜CLI-free' endpoint despite the natural history of continuous disease progression leading to amputation. With this designation we can now engage FDA in discussions to define the most efficient and rapid development pathway to registration in the U.S. Achieving orphan designation for CLBS12 takes us one step closer to realizing our goal of fulfilling the unmet medical need for Buerger's Disease patients around the world."

Orphan drug designation is granted by the FDA's Office of Orphan Products Development, which provides orphan status to drugs or biologics that are intended to treat rare diseases or disorders that affect fewer than 200,000 people in the United States. This designation provides the sponsor of the drug certain incentives, including tax credits, for qualified clinical trials and fee waivers. Orphan Drug designation confers eligibility for seven years of market exclusivity to an orphan drug post-approval, subject to a receipt by the FDA of marketing approval.

Copyright ยฉ 2021 Benzinga (BZ Newswire, http://www.benzinga.com/licensing). Benzinga does not provide investmentadvice. All rights reserved. Write to editorial@benzinga.com with any questions about this content. Subscribe to Benzinga Pro (http://pro.benzinga.com).

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SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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A priest, a pastor, and a rabbit walk into a blood donation clinic.

The nurse asked the rabbit, โ€œwhat is your blood type?โ€

โ€œI am probably a type Oโ€ said the rabbit.

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What's the opposite of lady fingers?

Mentos

(I will see myself out)

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Iโ€™ve got this disease where I canโ€™t stop making airport puns.

The doctor says it terminal.

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Just because it's a joke, doesn't mean it's a dad joke

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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I heard that by law you have to turn on your headlights when itโ€™s raining in Sweden.

How the hell am I suppose to know when itโ€™s raining in Sweden?

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Puns make me numb

Mathematical puns makes me number

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So my mom is getting her foot cut off today.. (really)

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

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Petition to ban rants from this sub

Ants donโ€™t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

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.
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French fries werenโ€™t cooked in France.

They were cooked in Greece.

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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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Why does Spider-Man's calendar only have 11 months?

He lost May

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When I was a single man, I had loads of free time.

Now that I listen to albums, I hardly ever leave the house.

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You've been hit by
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Girlfriend got me good. Never been more proud of her.

Said if she ever hosts a gender reveal party, when it comes time to pop the balloon she'll spray everyone with water.

Gender is fluid.

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My 4 year oldest favourit joke, which he very proudly memorized and told all his teachers.

Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"

Then the other muffin says "AHH, TALKING MUFFIN!!!"

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I'm sick of you guys posting dumb wordplay in here for awards and upvotes.

Don't you know a good pun is its own reword?

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Chemist n Plumber
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As a doctor, I have never made a joke about unvaccinated babies before.

But let me give it a shot.

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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies ๐Ÿ˜‚

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What starts with a W and ends with a T

It really does, I swear!

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A coworker named Celcius recently retired from my company, so they hired a guy called Kelvin to replace him.

Heโ€™s the new temp.

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My wife left me because I couldnโ€™t stop doing impressions of pasta

And now Iโ€™m cannelloni

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Why did Karen press Ctrl+Shift+Delete?

Because she wanted to see the task manager.

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Argument at family dinner...
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Steve JOBS would have made a better President than Donald Trump

But thatโ€™s comparing apples to oranges

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I just flew in from Chernobyl

And boy are my arms legs.

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What do you call a woman whoโ€™s really good at darts?

Amy

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My 7 year old daughter just told me this one. I'm so proud. What did the duck say when he bought chapstick?

Put it on my bill

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So 2 trees got arrested in the town I live...

Heard they've been doing some shady business.

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No gains
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I was almost upset that my coffee tasted like dirt today

but then I remembered it was ground this morning.

Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale

Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments

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How eggs-traordinary
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What is the scariest tree?

BamBOO!

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Theyโ€™re on standbi

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My ten-year-old daughter came up with this at dinner tonight: What do you get if put a copy of Macbeth on top of a dictionary?

A play on words.

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A queen size statement.
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Did you know all dogs are made up of only 3 elements?

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