Hello smart and kind people!
I believe that smoking is a risk factor for both conditions and angiography will show segmental involvement for both. And toe necrosis can be seen in both too?? So how do you differentiate them?
Thanks!
Not sure if this is the right subreddit, but I thought I might as well try here before asking my professor. They literally seem like the same disease. What the hell is the difference?
March 8, 2021 08:04 AM ET (BZ Newswire) -- News
Caladrius Biosciences, Inc. (NASDAQ:CLBS) ("Caladrius" or the "Company"), a clinical-stage biopharmaceutical company dedicated to the development of cellular therapies designed to reverse disease, today announced that the U.S. Food and Drug Administration ("FDA") has granted orphan drug designation to the Company's CD34+ cell therapy product, CLBS12, for the treatment of Buerger's disease โ also known as thromboangiitis obliterans โ a condition related to critical limb ischemia ("CLI") with no approved treatments to date in the U.S. .
"We are very pleased that the FDA has granted orphan drug designation to CLBS12 in Buerger's disease. Without a currently approved or effective treatment for this condition in the U.S., a significant unmet need remains for therapies that slow, stop or, ideally, reverse this debilitating disease," stated David J. Mazzo, Ph.D., President and Chief Executive Officer of Caladrius. "The Company's ongoing open-label, registration-eligible study of HONEDRAยฎ (CLBS12) as a treatment for CLI and Buerger's Disease in Japan has shown strong results to date with approximately 60% of subjects in the completed Buerger's Disease cohort reaching a positive โCLI-free' endpoint despite the natural history of continuous disease progression leading to amputation. With this designation we can now engage FDA in discussions to define the most efficient and rapid development pathway to registration in the U.S. Achieving orphan designation for CLBS12 takes us one step closer to realizing our goal of fulfilling the unmet medical need for Buerger's Disease patients around the world."
Orphan drug designation is granted by the FDA's Office of Orphan Products Development, which provides orphan status to drugs or biologics that are intended to treat rare diseases or disorders that affect fewer than 200,000 people in the United States. This designation provides the sponsor of the drug certain incentives, including tax credits, for qualified clinical trials and fee waivers. Orphan Drug designation confers eligibility for seven years of market exclusivity to an orphan drug post-approval, subject to a receipt by the FDA of marketing approval.
Copyright ยฉ 2021 Benzinga (BZ Newswire, http://www.benzinga.com/licensing). Benzinga does not provide investmentadvice. All rights reserved. Write to editorial@benzinga.com with any questions about this content. Subscribe to Benzinga Pro (http://pro.benzinga.com).
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
The nurse asked the rabbit, โwhat is your blood type?โ
โI am probably a type Oโ said the rabbit.
Mentos
(I will see myself out)
The doctor says it terminal.
Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.
THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB
Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"
I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual
So check out r/jokes for all types of jokes
r/unclejokes for dirty jokes
r/3amjokes for real weird and alot of OC
r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes
Punchline !
Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub
Edit 2: don't touch the thermostat
Do your worst!
How the hell am I suppose to know when itโs raining in Sweden?
Mathematical puns makes me number
We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.
Ants donโt even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.
But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.
They were cooked in Greece.
I'm surprised it hasn't decade.
He lost May
Now that I listen to albums, I hardly ever leave the house.
Said if she ever hosts a gender reveal party, when it comes time to pop the balloon she'll spray everyone with water.
Gender is fluid.
Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"
Then the other muffin says "AHH, TALKING MUFFIN!!!"
Don't you know a good pun is its own reword?
But let me give it a shot.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies ๐
It really does, I swear!
Heโs the new temp.
And now Iโm cannelloni
Because she wanted to see the task manager.
But thatโs comparing apples to oranges
And boy are my arms legs.
Amy
Put it on my bill
Heard they've been doing some shady business.
but then I remembered it was ground this morning.
Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale
Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments
BamBOO!
Theyโre on standbi
A play on words.
Calcium, nickel, neon
