Hi everyone,
My question is about synonymous mutations in SARS-CoV-2 variants. As you all know, the big news with omicron is that it contains many nonsynonymous mutations in the spike protein. What we don't talk about very much are the synonymous mutations or conservative amino acid substitutions in old and new variants.
Apparently coronaviruses are generally deficient in G/C content (~40%), particularly at the third position of codons [1]. That reference found that SARS-CoV-2 is no different, and they proposed that high viral replication in host cells causes an imbalance in the t-RNA pool, reducing the amount of A- and U- ended t-RNAs available for native protein synthesis. They analyzed proteomic data from SARS-CoV-2 infected cells and observed that a subset of proteins with similar codon usage as SARS-CoV-2 were downregulated relative to controls. Therefore, SARS-CoV-2 may have an epistatic effect on native genes.
This may be common knowledge to people who study viruses, but I don't study viruses, and it's new to me. Has anyone heard of any work suggesting that silent mutations in variants like delta, omicron, or others could have an effect on disease severity or transmissibility?
(I have to leave for a while but I will get back to this post later if people respond)
Do your worst!
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
Pilot on me!!
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
I won't be doing that today!
You take away their little brooms
This morning, my 4 year old daughter.
Daughter: I'm hungry
Me: nerves building, smile widening
Me: Hi hungry, I'm dad.
She had no idea what was going on but I finally did it.
Thank you all for listening.
There hasn't been a post all year!
It’s pronounced “Noel.”
After all his first name is No-vac
What, then, is Chinese rap?
Edit:
Notable mentions from the comments:
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Spanish/Swedish/Swiss/Serbian hits
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French/Finnish art
-
Country/Canadian rap
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Chinese/Country/Canadian rock
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Turkish/Tunisian/Taiwanese rap
There hasn't been a single post this year!
(Happy 2022 from New Zealand)
Bob
So that I could frequently say, "I am going to walk 5 miles now."
Edit: My most popular post on Reddit! 😀 Thank you for the awards.
Just to clarify, 12345678
Me grabbing a soda from my (what I thought was) half full 12pk...
Notices there's only 2;
Me: "Awe man... This is a damn bird box!" Her: "What the hell does that mean?!" Me: (Pulls both cans out & shows them to her) "It's only got Toucans."
I'm not ashamed to admit the look on her face was glorious.
I was just sitting there doing nothing.
“BOOM”?!
"That's what they're fighting about."
Because his Visa didn’t work.
A happy Uncle.....
"Beauty, because beauty is in the eye of the bee-holder!"
I’d never seen him be 4.
Ice-olation.
She's only eleven and says she came up with that by herself. I'm so proud 😭😭😭
"No, it doesn't."
We couldn't afford a dog...
Actually different
You know. Roll reversal.
