Best Z-drug (aka nonbenzodiazepines)

The ones on the market are zopiclone (Imovane) and its isolated (S) enantiomer, eszopiclone (Lunesta), along with zolpidem (Ambien), and zaleplon (Sonata).

Zolpidem and zaleplon have quite a kick to them if you use alternate routes of administration. Most noticably IV zolpidem is a intense rush and very different from other ROA's. They have super short half lives though so you better get into bed right after taking it. Another issue I have with zolpidem and zaleplon is they are only selective for the sedative a1 benzodiazepine receptors in the brain leaving out a2 muscle relaxation in the spine and anxiety relief like true benzodiazepines.

That's where zopiclone/eszopiclone shines. It's non-selective like benzodiazepines making it feel like Valium or Xanax. Its half live is much more reasonable at 6 hours too. Downsides being it makes water have a metallic taste and some other foods too, and it lacks the rush that zolpidem and zaleplon can have if you abuse them by snorting, plugging, or shooting.

Eszopiclone is the winner being closest to traditional benzodiazepines. I want some muscle relaxation and anxiety relief along with the sedation when I try to sleep, and I have a couple hours to chill and enjoy it before I have to go to bed.

Having had experience with all three, zolpidem and zaleplon can cause one to be quite fiendish due to their kick and ultra short durations. As far as pleasure goes IV zolpidem was the best but it only lasted like 15-20 min.

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πŸ‘€︎ u/PurpleHaze147
πŸ“…︎ Sep 19 2021
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Is there any recreational value to Nonbenzodiazepine ( Z- Class) substances?

Originally tried to sumbit this to r/DrugNerds but realised "no asking about personal use" was rule (which is funny considering how I see it being broken all the time there) Anyway, as the title says, I'm kinda curious if anyone here uses any z class drugs or knows of some who uses them recreationally. They obviously have great medicinal value, especially in treating debilitating orders and helping with short term insomnia.

However I'm kind of confused as to why someone want to repeatedly use them to get "high". To me they are kind of interesting as a 1 time thing, however with them acting sort of like deliriants and the euphoria being minimal. Is there really a point to repeated use? Like I'm sure some of you've read the hundreds of stories of ppl abusing ambien which to me, just seems a bit weird.

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πŸ‘€︎ u/Gargonell
πŸ“…︎ Apr 23 2021
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Z-Drugs/Nonbenzodiazepines?

I'm curious to find out more about what nonbenzo/z-drugs might be available as research chemicals. Specifically, those which are subtype selective (like zolpidem) and function primarily as hypnotics, with low anxiolysis/muscle relaxation/anticonvulsant/tolerance producing properties.

Essentially, I'm interested in finding a hypnotic similar to zolpidem, although ideally with a longer duration of action.

Names of specific chemicals known to be available, and any safety information/personal experience with them would be much appreciated.

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πŸ‘€︎ u/mnrambler11
πŸ“…︎ Apr 07 2019
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Obscure Z-drugs/Nonbenzodiazepines?

I'm interested in finding a hypnotic with favorable pharmacology (selectivity for a1 subunit of GABAA, like zolpidem), but with a longer duration of action and perhaps increased potency.

Eszopiclone was a dud. Zaleplon is much too short acting. Benzos such as triazolam or temazepam come with too many complications. So essentially, procurement through the medical establishment is not viable.

I know there are many other similar chemicals in existence, but am trying to learn more about their efficacy/safety/availability.

Here's a partial list copied from Wikipedia:

Alpidem Necopidem Saripidem Zolpidem (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, etc.)

Divaplon Fasiplon Indiplon Lorediplon Ocinaplon Panadiplon Taniplon Zaleplon (Sonata, Starnoc, Andante)

Eszopiclone (Lunesta, Valnoc, etc.) Pagoclone Pazinaclone Suproclone Suriclone Zopiclone (Imovane, Zimovane, Somnol, etc.)

Abecarnil Gedocarnil SL-651,498 ZK-93423

CGS-20625 CGS-9896 CL-218,872 ELB-139 GBLD-345 HIE-124 L-838,417 NS-2664 NS-2710 Pipequaline RWJ-51204 SB-205,384 SL-651,498 SX-3228 TP-003 TP-13 TPA-023 Y-23684

Any experiences, recommendations or relevant advice would be appreciated.

Tl;dr: Need something similar to zolpidem, but with longer half-life/duration of action.

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πŸ‘€︎ u/mnrambler11
πŸ“…︎ Apr 07 2019
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Nonbenzodiazepines

What’s the high of nonbenzodiazepines such Lunesta like, how does it compare to Xanax? Has anyone ever combined the two? Anything you can tell me is greatly appreciated. Thank you!

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πŸ‘€︎ u/scxtty42
πŸ“…︎ Dec 13 2018
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What would happen if I took double the highest dose of nonbenzodiazepine after a long period of being clean?

I took 7.5 mg and in 30 minutes I started dreaming while I was awake and walked like I was drunk. 15 mg (the highest dose) the room literally started swaying. I felt like nothing bothered me. It felt like that phase just before sleep where your thoughts become really abstract. That was with tolerance rising as well. When I got to sleep, I slept for 12 hours and had no memory of that day or the day before.

What would happen if I took 4 (double the highest dose) at once? I'm not sure if nonbenzodiazepines have this effect with others. I'm small (like, really small) so any drugs hit me harder than most.

I wouldn't say I'm addicted, per se, but I find it very hard to meditate (which is more important to me than actual sleep) recently due to anxiety and stress and I'm wondering how 30 mg would effect me. With 15 mg I noticed it felt slightly different when I was breathing.

Sometimes it's hit and miss for example I once took 10 mg and just felt slightly relaxed, but other times it hits me hard.

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πŸ‘€︎ u/supernerdboyyyyy
πŸ“…︎ May 30 2017
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Nonbenzodiazepines?

Anyone have any experience with any of these so-called 'Z drugs'? I've taken Ambien in the past, but I'm looking for something less hypnotic and more anxiolytic (ie good for social settings without knocking you out). I get drug tested for probation so traditional benzos are a no-go. Stuff like pagoclone and alpidem have piqued my interest. The lack of information on them is a bit discouraging, though. Anyone have any input?

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πŸ‘€︎ u/Noodles1790
πŸ“…︎ Sep 03 2014
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Your views on 'Z-Drugs' (I.E. nonbenzodiazepines )as recreational drugs?

Pros, Cons, likes ,dislikes?

Edit : I use them in conjecture with other drugs, alone their rather bland.

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πŸ‘€︎ u/MiddAlien
πŸ“…︎ Nov 26 2011
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SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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πŸ‘€︎ u/anywhereiroa
πŸ“…︎ Jan 15 2022
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A priest, a pastor, and a rabbit walk into a blood donation clinic.

The nurse asked the rabbit, β€œwhat is your blood type?”

β€œI am probably a type O” said the rabbit.

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πŸ‘€︎ u/snc8698
πŸ“…︎ Jan 29 2022
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I’ve got this disease where I can’t stop making airport puns.

The doctor says it terminal.

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πŸ‘€︎ u/xIR0NPULSE
πŸ“…︎ Jan 28 2022
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Just because it's a joke, doesn't mean it's a dad joke

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

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πŸ‘€︎ u/CzarcasmRules
πŸ“…︎ Jan 23 2022
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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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I heard that by law you have to turn on your headlights when it’s raining in Sweden.

How the hell am I suppose to know when it’s raining in Sweden?

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πŸ‘€︎ u/justshtmypnts
πŸ“…︎ Jan 25 2022
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So my mom is getting her foot cut off today.. (really)

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

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πŸ‘€︎ u/Slimybirch
πŸ“…︎ Jan 27 2022
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Puns make me numb

Mathematical puns makes me number

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πŸ‘€︎ u/tadashi4
πŸ“…︎ Jan 26 2022
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Petition to ban rants from this sub

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

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πŸ‘€︎ u/drak0ni
πŸ“…︎ Jan 24 2022
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.
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πŸ‘€︎ u/SupremePalash
πŸ“…︎ Jan 29 2022
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French fries weren’t cooked in France.

They were cooked in Greece.

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πŸ“…︎ Jan 20 2022
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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
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Why does Spider-Man's calendar only have 11 months?

He lost May

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πŸ‘€︎ u/Toku-Nation
πŸ“…︎ Jan 26 2022
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When I was a single man, I had loads of free time.

Now that I listen to albums, I hardly ever leave the house.

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πŸ‘€︎ u/porichoygupto
πŸ“…︎ Jan 25 2022
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You've been hit by
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πŸ‘€︎ u/mordrathe
πŸ“…︎ Jan 20 2022
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Girlfriend got me good. Never been more proud of her.

Said if she ever hosts a gender reveal party, when it comes time to pop the balloon she'll spray everyone with water.

Gender is fluid.

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πŸ‘€︎ u/Mannheimd
πŸ“…︎ Jan 29 2022
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My 4 year oldest favourit joke, which he very proudly memorized and told all his teachers.

Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"

Then the other muffin says "AHH, TALKING MUFFIN!!!"

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πŸ‘€︎ u/smoffatt34920
πŸ“…︎ Jan 22 2022
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I'm sick of you guys posting dumb wordplay in here for awards and upvotes.

Don't you know a good pun is its own reword?

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πŸ‘€︎ u/diggitygiggitycee
πŸ“…︎ Jan 21 2022
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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What starts with a W and ends with a T

It really does, I swear!

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πŸ‘€︎ u/PsychedeIic_Sheep
πŸ“…︎ Jan 13 2022
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As a doctor, I have never made a joke about unvaccinated babies before.

But let me give it a shot.

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πŸ‘€︎ u/porichoygupto
πŸ“…︎ Jan 30 2022
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My wife left me because I couldn’t stop doing impressions of pasta

And now I’m cannelloni

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πŸ‘€︎ u/bluestratmatt
πŸ“…︎ Jan 23 2022
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Why did Karen press Ctrl+Shift+Delete?

Because she wanted to see the task manager.

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πŸ‘€︎ u/Eoussama
πŸ“…︎ Jan 17 2022
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A coworker named Celcius recently retired from my company, so they hired a guy called Kelvin to replace him.

He’s the new temp.

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πŸ‘€︎ u/SolicitedTitPics
πŸ“…︎ Jan 30 2022
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Steve JOBS would have made a better President than Donald Trump

But that’s comparing apples to oranges

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πŸ‘€︎ u/Ok-Ingenuity4838
πŸ“…︎ Jan 22 2022
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I just flew in from Chernobyl

And boy are my arms legs.

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πŸ‘€︎ u/JhopkinsWA
πŸ“…︎ Jan 23 2022
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What do you call a woman who’s really good at darts?

Amy

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πŸ‘€︎ u/Cinema_King
πŸ“…︎ Jan 29 2022
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My 7 year old daughter just told me this one. I'm so proud. What did the duck say when he bought chapstick?

Put it on my bill

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πŸ‘€︎ u/BigRedHusker_X
πŸ“…︎ Jan 26 2022
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So 2 trees got arrested in the town I live...

Heard they've been doing some shady business.

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πŸ‘€︎ u/K1ll47h3K1n9
πŸ“…︎ Jan 18 2022
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No gains
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πŸ‘€︎ u/ridi86
πŸ“…︎ Jan 22 2022
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I was almost upset that my coffee tasted like dirt today

but then I remembered it was ground this morning.

Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale

Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments

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πŸ‘€︎ u/scarf_spheal
πŸ“…︎ Jan 19 2022
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How eggs-traordinary
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πŸ‘€︎ u/Rix27_
πŸ“…︎ Jan 21 2022
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Duckduckgo
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πŸ‘€︎ u/findmebatman
πŸ“…︎ Jan 28 2022
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Geometry sucks
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πŸ‘€︎ u/Kash30
πŸ“…︎ Jan 25 2022
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What is a a bisexual person doing when they’re not dating anybody?

They’re on standbi

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πŸ‘€︎ u/Toby-the-Cactus
πŸ“…︎ Jan 12 2022
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What is the scariest tree?

BamBOO!

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πŸ‘€︎ u/K1ll47h3K1n9
πŸ“…︎ Jan 18 2022
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My ten-year-old daughter came up with this at dinner tonight: What do you get if put a copy of Macbeth on top of a dictionary?

A play on words.

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πŸ‘€︎ u/ah1887
πŸ“…︎ Jan 20 2022
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A queen size statement.
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πŸ‘€︎ u/Flight-less
πŸ“…︎ Jan 22 2022
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Orion's belt
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πŸ‘€︎ u/mordrathe
πŸ“…︎ Jan 25 2022
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Did you know all dogs are made up of only 3 elements?

Calcium, nickel, neon

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πŸ‘€︎ u/redneckvet
πŸ“…︎ Jan 25 2022
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