I have been observing my own family, families of friends and acquaintances for many years. It seems many people have similar set of issues growing up - Abusive, manipulative environments, dysfunctional families.
This might be anecdotal, but I noticed that once some of the people started therapy they realised they had underlying mental disorders (like ADHD, Bipolar). I have seen some of my family members have similar behavioral traits too that have been passed to their kids. Has there ever been a study on this? I have looked up any related studied but most of them point to non-Indian data.
I am a female UK born teenager who was grown up to be quite nationalist when it came to the Tamil Tigers. My paternal uncles fought in the Tamil Tigers and I was grown up to be proud of this, and to believe that the South of Sri Lanka was an awful place and that the Sinhalese were bad. I remember bringing the Tamil Tigers flag to school, not knowing the truth about it and telling people how great and brave these soldiers were. Only recently after reading this BBC article https://www.bbc.co.uk/news/world-south-asia-45347956 and seeing a post on this subreddit of how some guy put a up a Tamil Tigers flag on his window and seeing all the negative comments the post got, got me realising how awful this organisation actually is. I am so embarrassed about how much I supported it, not knowing about what they actually had done. Does anyone have any good articles on the actual history?
Edit: I would like to thank you all so much for the amazing unbiased replies I have received.
Hello there! I am doing a little genetics study and I want people with schizophrenia, schizoaffective disorder, bipolar disorder, or autism to help me out a bit! Those of you who dont have these conditions are free to contribute your genome as well!
Please list your proteins for the following snps:
rs1801028 (Me == GG)
rs6277 (Me == GG)
rs11868035 (Me == AG)
rs2494732 (Me == TT)
rs165599 (Me == AA)
rs4633 (Me == CT)
rs769224 (Me == GG)
send me the aforementioned snps from your raw file, as well as list what mental health condition if any you were diagnosed with, thank you in advance !
Introduced: Sponsor: Rep. Larry Bucshon [R-IN8]
This bill was referred to the House Committee on Energy and Commerce which will consider it before sending it to the House floor for consideration.
Rep. Larry Bucshon [R-IN8] is a member of the committee.
https://doi.org/10.1016/j.eplepsyres.2021.106826
https://pubmed.ncbi.nlm.nih.gov/34839144
Abstract
PURPOSE
The gut-brain axis has been discussed as a possible factor contributing to ictogenesis and epilepsy. While recent preclinical studies have proposed a link between the antiseizure effect of a ketogenic diet (KD) and alterations to the gut microbiota, there is a knowledge gap about microbial composition as a result of Scn1a genetic deficiency and how this is affected by KD in Dravet syndrome.
METHODS
A large-scale microbiome analysis using 16S rRNA gene sequencing was performed in fecal samples collected from wildtype and Dravet mice fed either control diet (CD) or KD. Microbial alterations associated with the Dravet phenotype or triggered by KD exposure were identified.
RESULTS
The comprehensive microbial analysis revealed pronounced alterations in gut microbiota between wildtype and Dravet mice. The regulation of Chao index indicated a reduced species richness in Dravet mice when compared to wildtype controls. The ratio between Firmicutes and Bacteroidetes phyla was increased in mice with the Dravet genotype, therefore implying a microbial dysbiosis in these animals. Following the switch to CD or KD, several bacteria phyla and genera were regulated in Dravet mice. Interestingly, an increased abundance of the Clostridium genus and a decreased abundance of the Romboutsia genus showed a significant correlation with the severity of the phenotype in Dravet mice. KD increased the abundance of Firmicutes and reduced the abundance of Bacteroidetes phyla in Dravet mice. The degree of these microbial alterations correlated with the reduction in the frequency and duration of motor seizures in these animals.
CONCLUSION
In conclusion, the comprehensive microbial analysis demonstrated pronounced alterations in the gut microbiota with evidence of a gut dysbiosis as a consequence of the Scn1a genetic deficiency. Exposure to KD affected the gut microbiome in Dravet mice. Interestingly, abundance of selected genera correlated with the seizure phenotype of Dravet mice. Future studies investigating the functional relevance of disease-associated and KD-triggered changes would be essential to confirm the relevance of these findings.
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... keep reading on reddit ➡
Twin studies (identical twins vs fraternal twins) are used to compare traits and determine what is due to genetics, family environment, or unique environment.
But where does epigenetics fit in these categories? My own thinking was that if the DNA methylation was passed down from parents it would count as genetics. However, the environment may also cause DNA methylation from scratch also.
So to reiterate the post title question. Is epigenetic variance in a population counted as genetics or environment based on twin studies?
Rev Environ Health. 2021 Sep 16.
https://pubmed.ncbi.nlm.nih.gov/34529912/
doi: 10.1515/reveh-2021-0043. Online ahead of print.
Neurological susceptibility to environmental exposures: pathophysiological mechanisms in neurodegeneration and multiple chemical sensitivity
John Molot 1 , Margaret Sears 2 , Lynn Margaret Marshall 3 , Riina I Bray 3
Affiliations
1 Family Medicine, University of Ottawa Faculty of Medicine, North York, ON, Canada.
2 Ottawa Hospital Research Institute, Ottawa, ON, Canada.
3 Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
PMID: 34529912 DOI: 10.1515/reveh-2021-0043
Abstract
The World Health Organization lists air pollution as one of the top five risks for developing chronic non-communicable disease, joining tobacco use, harmful use of alcohol, unhealthy diets and physical inactivity. This review focuses on how host defense mechanisms against adverse airborne exposures relate to the probable interacting and overlapping pathophysiological features of neurodegeneration and multiple chemical sensitivity.
Significant long-term airborne exposures can contribute to oxidative stress, systemic inflammation, transient receptor subfamily vanilloid 1 (TRPV1) and subfamily ankyrin 1 (TRPA1) upregulation and sensitization, with impacts on olfactory and trigeminal nerve function, and eventual loss of brain mass.
The potential for neurologic dysfunction, including decreased cognition, chronic pain and central sensitization related to airborne contaminants, can be magnified by genetic polymorphisms that result in less effective detoxification.
Onset of MCS may be gradual following long-term low dose airborne exposures, or acute following a recognizable exposure. Upregulation of chemosensitive TRPV1 and TRPA1 polymodal receptors has been observed in patients with neurodegeneration, and chemically sensitive individuals with asthma, migraine and MCS.
In people with chemical sensitivity, these receptors are also sensitized, which is defined as a reduction in the threshold and an increase in the magnitude of a response to noxious stimulation. There is likely damage to the olfactory system in neurodegeneration and trigeminal nerve hypersensitivity in MCS, with different effects on olfactory processing.
Table 2 presents a summary of neurodegeneration and MCS, comparing 16 distinctive genetic, pathophysiological and clinical fea
... keep reading on reddit ➡Hello Debate a Catholic,
Yesterday, u/luvintheride made a post in this sub, linked here:
In this post, LuvinTheRide argues that Catholics should reject Evolution Darwinism & Evolution. My post here is not a rebuttal to LuvinTheRide’s post, since I already engaged with Luvin in the comments. However, in other comments to other repliers, Luvin left a source from a Catholic organization called the “Kolbe Center”:
https://www.kolbecenter.org/wp-content/uploads/2014/07/Genetic-Entropy-Recorded-in-the-Bible.pdf
Link to the website for the Kolbe Center for the Study of Creation, which calls itself "A catholic apostolate dedicated to proclaimng the truth about the origins of man and the universe": https://www.kolbecenter.org/
This source argues that the ages listed in the Old Testament are literal, and the Kolbe Center argues for a Young Earth Creationist view. Funnily enough, I attended “Kolbe Immaculata Preparatory School” as a kid for first through eighth grades, an FSSP school. Although Kolbe Prep doesn’t appear to be affiliated with the Kolbe Center, I was curious and so I read this source in its entirety. This source is so unscientific that I decided to dedicate an entire post to objections to the claims made within. I would love to hear the opinions of the folks in this sub. Obviously Catholics are allowed to accept or reject evolution, so I suspect that many (most?) of the Catholics in this sub might actually agree with me, but obviously Luvin does not, and I wonder if some of you might want to raise objections to my objections. So, without further ado:
The Kolbe Center’s Claim:
The Kolbe Center argues that Noah truly lived until the age of 950, and that his descendants experienced “rapid degenerative process[es]” which resulted in the massive decline in life expectancy. They supply the following data:
https://preview.redd.it/0gnq53y25r581.png?width=800&format=png&auto=webp&s=afb0d6c354032827575de65546be4f9c8b24efd2
https://preview.redd.it/5l9ivb875r581.png?width=925&format=png&auto=webp&s=98841e987a5719250f5c4098ecf9f2817183852d
https://preview.redd.it/68q2yrf85r58
... keep reading on reddit ➡Hey all,
Came across this fascinating study ( https://www.nature.com/articles/ncomms10326 ) about the ancestry and genetics of Britain’s peoples—the study largely supports the traditional Welsh narrative that Wales is a remnant of the indigenous pre-Roman and Roman era Briton society.
While intuitively it may make sense to assume that all of the UK’s people are genetically mixed and that there is no longer such thing as being directly descended from one group, gene/ancestry studies have largely shown that this is not true. Barring instances of mass genocide, ethnic cleansing/expulsions, or mass migrations/evacuations, a population’s base gene pool is usually not significantly altered by the arrival of immigrants, foreigners, or conquering armies.
In the case of Wales, this shows that today’s Welsh are in fact primarily descended from the Celtic Britons while the English are primarily descended from the Anglo-Saxon invaders. Emphasis on the word primarily, as of course the UK has a large immigrant population today and has had people come in for a thousand years.
Hello there! I am doing a little genetics study and I want people with schizophrenia, schizoaffective disorder, bipolar disorder, or autism to help me out a bit! Those of you who dont have these conditions are free to contribute your genome as well!
Please list your proteins for the following snps:
rs1801028 (Me == GG)
rs6277 (Me == GG)
rs11868035 (Me == AG)
rs2494732 (Me == TT)
rs165599 (Me == AA)
rs4633 (Me == CT)
rs769224 (Me == GG)
send me the aforementioned snps from your raw file, as well as list what mental health condition if any you were diagnosed with, thank you in advance !
