Up til now, I’ve only been on lamictal and lithium which really have gotten me quite far from where I was, but I’m still a visible mess in public and really am all over the place.

My doctor suggested trying antipsychotics which I was originally adverse to. But after seeing how well my dad was doing on ability and seroquel I figured I’d give it a shot.

He started me on zyprexa and in regards to cognition and treating my symptoms. I’ve never had such a perfect fix. I had low expectations after hearing how many people turned into zombies after trying these meds. But honestly, I just felt normal, I felt regular human emotions, more social desire, just plain good. Where I was once someone who was always on edge I was able to laugh and smile and just kick back.

However, physically I feel like a wretch. The drowsiness was unfavorable but was manageable. But the muscle symptoms are unbearable. Walking up or down the stairs is suffering. Even holding a pencil is painful. Ever basic movement is exhausting. And I suppose as breathing and digestion involve muscles too, I’ve been horribly nauseous and out of breath.

He’s since switched me to seroquel which seems maybe a little better but still the same stuff.

Should I try to tough it out? Is there anything I can do?

EPS is associated with antipsychotic D2 blocking agents and apparently the mechanism is dopamine-blocking agents somehow causing D2 receptor upregulated and supersensitivity. I need help...

1. How does blocking dopamine causing regulation of dopamine receptors?
2. If there's a D2 blocking agent, wouldn't it always be binding dopamine neurotransmitters thus preventing DOPA from binding to D2 receptors? So, does that mean dopamine production is upregulated? ...in addition to the upregulation of dopamine receptors?
3. Is there some sudden "flip of the switch" where there's suddenly enough dopamine around and enough D2 receptors around to cause EPS?

The cards I'm referring to are below. For instance, I don't understand why reserpine can be used for tardive dyskinesia but not acute dystonia, or why benztropine can be used for dystonia and akathisia but not tardive dyskinesia. Clearly I don't understand the underlying pathologies and/or pharm as I should be, if someone could help me out I would greatly appreciate it.

What features of extrapyramidal symptoms may be treated with benztropine and diphenhydramine? Acute dystonia

What features of extrapyramidal symptoms may be treated with reserpine, tetrabenazine, or a switch to an atypical antipsychotic? Tardive Dyskinesia

What features of extrapyramidal symptoms may be treated with Beta-blockers, benzodiazepines, and benztropine? Akathisia

What features of extrapyramidal symptoms may be treated with benztropine and amantadine? Parkinsonism

dystonia, akathisia, and parkinsonism are due to D2 block in the nigrostriatal pathway... but why are they called extrapyramidal symptoms? i know its related to anatomy & phys but i need some help putting it all together so i could make sense of it

On and off for awhile I've had an uncontrolled muscle twitch. It's like what happens when you put an electronic muscle stimulator on. Always in my right arm. Always the same muscle.

Could this be something like tardive dyskinesia? The last time I had it it was a face twitch and I was stoned out of my mind on geodon and ECT-brain.

Should I be calling my psychiatrist to ask to lower my antipsychotic? (Latuda, idk its rate for EPS, but I thought it's on the higher end)

Edit: I texted my psychiatrist to schedule a call and she said she'll call later. Hopefully I can get this addressed without coming off my so-far favorite antipsychotic.

Edit 2: another day later and she hasn't called.

I've been on prozac for like, two weeks maybe? I take it around noon because that's about when I wake up at this point thanks to the new fucked sleep schedule. Whenever I try to sleep, it feels like my muscles are vibrating and my body goes full fight or flight, to where I absolutely have to move or else I get extremely physically uncomfortable. It's a cycle of: I get comfortable, I suddenly have to sit up or jerk my legs around, I get comfortable again, repeat. I don't get to sleep until I just pass out from exhaustion. I know the side effects should only last a couple of weeks but goddamn this is miserable.

Just started Wellbutrin 100mg SR 3 days ago and I’m already getting jaw pain/tightness. Does this go away or should I get off the stuff while it’s still early?

I was prescribed Duloxetine for mixed depression and anxiety disorder. I understand how AD’s work however what i don’t quite understand is what will happen after i discontinue the use. Will my serotonin just start to naturally be properly balanced and i will be happy and non anxious without AD’s ?

Does anyone else get the shakey shakies from Abilify? How do you mitigate?

I am starting to take an antidepressant called Duloxetine, an SNRS , and just with the first two pills I feel like I have taken mdma. Dry mouth, trembling hands, pupil dilation, increased heartbeat, closed stomach, not hungry , with some nausea like when you're getting high, headache....

Is it normal to feel it so strong? Has it happened to anyone? What do you think?

There is not much info out there about this that is neither overly cautious nor completely reckless. I think it could be useful to try to clarify this a bit.

Note that I'm talking about people who take MAOIs daily here, both selective or not, reversible or not, and not one time pretreatment or coadministration of reversible ones, like in the huascas preparations.

It's pretty rudimentary, but I hope people will come up with elements that will help expend the list, or make it more accurate and documented. I will edit as it goes. Personnal anecdotes are welcome too, but they won't be considered as proof of safety, as you can understand.

Do not base any decision on this list without further research, and consulting with an health professionnal ! This list aims at reducing harm, but it's not done by professionnals and is pretty speculative as actual data on those combinations is very scarce. Stay safe.

Serotonin tocicity/syndrom (ST) and hypertensive crisis (HC), as well as pharmacokinetic interactions through MAO are the focus here. Note that depending on which MAOI you are taking, other interactions can exist too (interactions through other enzymes, lower seizure threshold, hypotension...).

Cannabinoids

• Cannabis : Safe. Combination is widespread and not known to lead to any problem. No case report that I know of.
• RCs : ?

GABAergics

• Alcohol : /!\ Some are unsafe /!\. Alcohol itself is not an issue, but many fermented beverage have a high level of tyramine that can lead to HC. In particular, non-pasteurized beers, wines (especially chianti) cherry and ciders. Liquors and pasteurized beers have usually much lower tyramine levels and carry less risk. Selective MAO-A inhibitors like moclobemide are not concerned.
• Benzo and z-drugs (xanax, diazepam, etizolam, clonazolam, ambien, zopiclone...) : Safe. Commonly prescribed together without any issues.
• Phenibut : Probably safe. Maybe Russian speakers can confirm, but even though there is some indirect influence on dopamine, this is nowhere near concerning. Plenty of anecdotes for this combination and no case reports of any issue that I know of.
• Pregabalin, gabapentine : Probably safe. Commonly prescribed together without any issues, although there is some indirect influence on monoamines, and there is one case report of ST supposdly precipited by pregabalin in a patient taking antidepressants (not of the MAOI cl

Been dealing with taking 30 x 30mg adderall over the course of one week in a month for the past several years. I’ve noticed some health issues arise from it that freak me out all the time. I know no one is a doctor/allowed to diagnose. Im just Too scared and ashamed to speak to a doctor. And need reassurance or something?

I’ll get bad extrapyramidal symptoms that have resulted in me uncontrollably knocking things over. Tongue movements, slack jawed, twitches, muscle constructions. Goes away after I sleep thank god. But makes my nervous system itch and burn and writhe while I experience it. It’s the worst sensation I’ve ever felt

Muscles Have gotten weaker and weaker over the months

Skin turns orange almost instantly now

Anger issues Increased

Have a desire to stop but have shown no signs of being able to.

On top of that, I’m bipolar, have anxiety disorder, and drink too much. I’m kind of a mess right now.

Any kind words or insight or help would be great. Please no, “you’re dying!!!” Type responses. I’m already always freakin out about my health.

I have been on vraylar for a month. I am currently on 4.5 mg. I love it. My thinking is clear. I am able to feel my emotions and think clearly. My focus is better. My hypomania has decreased. The only side effect I am really dealing with is hair loss. I ordered a hair supplement to hopefully combat this side effect. It’s called nutrafol. Wondering if anyone else has had this side effect or any other side effects? Thanks!

My review of my experience at a "leading" mental health facility that was almost immediately deleted from Google.

"Not a healing place. Polypharmacy is the rule, not the exception here. They load you up with various toxic drug cocktails (antipsyschotics, antiseizure meds) and inform you that you will need to stay on these drugs for life or otherwise, suffer severe consequences. They don't listen to patients either. When I raised concerns about side effects based on the black box labels for meds like Haldol, Risperdal, Vraylar, and Depakote, e.g. high risk of renal/ liver damage, obesity, extrapyramidal symptoms like tardive dyskinesia, and decreased brain matter, the doctor huffily informed me that I **“**lacked insight into my condition”. Then, the social worker I was assigned went behind my back and called my wife and parents and told them that I was “insufficiently committed to my own treatment and recovery.” I almost lost my job as a result of brain fog/lack of motivation from the drugs, and bills are enormous. It did motivate me to work on self-mastery and mood- regulation knowing I never want to end up in a place like this again.

I am starting AbiliFy. Tomorrow's morning. As I told my physchiatrisct I wanted back on Benzodiazpine's and he said: NOPE!!!. Well fux meh. I told him that the 50mg Zoloft was not working. The Trazodone is not working. I can rarely get the affects of my Gabapentin's 800mg 3x daily anymore. I am still currently having to take Kepra 500mg due to the Seizures I am still suffering from my benzo withdrawal. I just want to know if I have anything to look forward to. Tomorrow.tomorrowwww

I’ve had trouble sleeping for the past 2 weeks. I have a history of depression and anxiety so having trouble sleeping wasn’t relatively new to me, but this time I couldn’t figure out the trigger. I was feeling okay before I started developing this short insomnia stint. It started off with me waking up randomly to pee. This happened more often and then it finally came to a point where once I woke up I couldn’t go back to sleep. I would wake up after 2 hours of falling asleep. So I was basically averaging around 2-4 hours of sleep a night. This started to piss me off because I would be physically tired during the day when I had work + other things to do.

Here comes the tricky part. After a few days, I was basically able to power through the lack of sleep mentally. Like my mind was awake event though my body was not. I would get waves of extreme exhaustion throughout the day, but I would snap through it and find the willpower to finish my work and exercise. I never made irrational decisions or thought I was fucking amazing or think I was on top of the word. But I did feel “wired in” and I had racing thoughts due to the lack of sleep. I eventually resorted to OTC sleeping aids, but they didn’t really work for the most part. I would still wake up after 2 hours and manage to fall asleep again for another 2 after staying up for half the night. No delusions or hallucinations, but I was so frustrated and desperate to sleep that I started hearing myself in my head. I would tell myself how fucking stupid and horrible this whole situation is etc.

I went to see a psychiatrist and she told me I have bipolar tendencies and set me up right away on Olanzapine. Tbh, its been working really well in terms of knocking me out, but I HATE all the side effects it gives me and I do not want to be on an anti-psychotic long term. Especially since I’m not 100% if what I experienced was hypomania.

I just wanted to know other people’s thoughts. Did that sound like a hypomanic episode? Like I was going through hypomania and did that cause my insomnia? Or was I just sleep deprived and I started experiencing hypomania

What is the first-line treatment for drug-induced akathisia/extrapyramidal symptoms? I had recently made a consultation for Lexapro-induced akathisia and the psych reduced Lexapro to 20mg along with adding 1mg Risperidone to the mix. Is Risperidone somehow going to help the motor tics?

I’m definitely manic right now. Haven’t slept in days, other than last night induced by two benadryl and two tylonel pms. I spent all of my check today - 470$ of unemployment. Been doing that every week for many weeks. I have 14$ left.

I couldn’t sleep because I was excited to get my nipples pierced? Maybe? I got them done and still don’t feel like sleeping.

I posted nudes of myself and sent many to some guy in another country I don’t know. Blocked him. Blocked many people on reddit too, but didn’t delete my obviously sexual posts. No, I don’t really care that they’re out there, but it still isn’t something I normally do unless I’m feeling ungodly confident.

I watched Black Mirror for the first time (just Arcangel and Bandersnatch) and now I feel like flying off the handle. That’s unrelated but inflated my sense of paranoia.

I feel abnormally creative and took up many hobbies in the past several days (knitting, took up writing again, art, cleaned and redecorated my room).

At the same time I had a crying fit on Sunday in the early AM about something that hurt my feelings and thought about killing/cutting myself.

Then today and yesterday I was back to feeling tip-top! Even got some sleep! (Benadryl sleep!)

Anyways should I go to the hospital and also do you think they’ll make me take out my nipple piercings cause I would rather just suffer at home?

I am now standing naked in my shower with nothing running but loud music cause I wasted all the water trying to figure out if I need the psych ward for the umpteenth time.

Extra Notes (Important): I have been hospitalized multiple times before, leading to a diagnosis of bipolar disorder. Usually for suicide but then I cycled right back to mania when placed in the new environment.

MOST IMPORTANT: My geodon is causing extrapyramidal symptoms in my head, especially jaw and neck. So I went from taking 120 mg to 60 mg a day to compensate. I did talk to my psych and therapist about the EP symptoms and my geodon was lowered a little but it took me awhile to pick up the scrips so I just took 60 mg for several days. Causation?

EDIT: 03/10/21 I went to the emergency room shortly after and was admitted to the mood disorder unit. I stayed for six days and went home. I’m definitely more depressed now, but it’s manageable. Thank you all for your advice and concern.

The funeral director was asking us what we think Mum should wear in her casket.

Mum always loved to wear sarongs (fabric wraps that go around the torso and drape downward a bit like a long skirt would), so my uncle suggested that she wear a sarong in there.

The funeral director looked a bit confused, as did some of our family members, to which my uncle added:

"What's sarong with that?"

I started laughing like an idiot. He was proud of it too. The funeral director was rather shocked. We assured her, and our more proper relatives, that Mum would've absolutely loved the joke (which is very true).

His delivery was perfect. I'll never forget the risk he took. We sometimes recall the moment as a way help cushion the blows of the grieving process.

--Edit-- I appreciate the condolences. I'm doing well and the worst is behind me and my family. But thanks :)

--Edit-- Massive thanks for all the awards and kind words. And the puns! Love 'em.

Hi.
So, I'm psychotic but I have no diagnosis. I was suffering from auditory hallucinations, paranoia and Truman show delusions since the end of 2019 and now I'm partially stabilized with chlorpromazine but I'm suffering from strong avolition that are destroying my life.
I've read about amantadine and memantine being used along with antipsychotics to deal with negative symptoms, as well as extrapyramidal symptoms. Anyone here have experience with this meds? I will ask my doctor.
Sorry, thank you.

Because 10+10 is twenty and 11+11 is twenty too..

Edit: thank you for awards, I have never gotten one before. I apologize that this is a repost, I did see it on TikTok and thought that it was cute and wanted to share. In the future I will check the sub for similar content before I post anything.

I would have a daughter

I’ve tried overdosing on sertraline three times and each time I just felt dizzy.

Capital of Ireland

It's Dublin everyday

http://m.imgur.com/ImM3RWz

But Bill kept the Windows

True story; it even happened last night. My 5-year-old son walks up behind me and out of the blue says, "hey."

I turn to him and say, "yeah, kiddo? What's up?"

He responds, "it's dead grass."

I'm really confused and trying to figure out what's wrong and what he wants from me. "What? There's dead grass? What's wrong with that?"

.

.

.

He says, totally straight-faced, "hay is dead grass," and runs off.

K9P

You officially hit rock bottom

And then you will all be sorry.

No it doesn't.