According to Sketchy, extramammary Paget disease differs from Paget disease of the breast in that there is no malignancy. But aren't both carcinoma in situ? So why would malignancy be an issue for Paget disease of the breast? Thank you so much!
I wondered if a mammogram is the appropriate test for Paget’s or if it requires a biopsy to show it
Has anyone out there been treated for Paget's disease of the Breast? Have any of you that have been treated NOT had an underlying breast cancer? I'd love to hear from anyone with experience with Paget's. Thanks!
Hello all!I can understand in osteopetrosis the osteoclast is not working so you get overgrowth of cortical bone into BM and pancytopenia.But why it does not happen in sclerotic phase of paget disease?I assume in this phase,osteoblast cell is hyperfunctional,However I can't find any BM problems in paget disease on UTD...
Thanks in advance!
In Paget disease, there is hypervascular marrow in early-stage osteoclastic dominant or mixed due to endothelial and fibroblast stimulation by cytokine released from osteoclast but in the osteosclerotic stage the marrow is hypovascular. source is uworld. but in one question uworld saying cortical thickening with local warmth. cortical thickening occurs in osteosclerotic and warmth is due to increase blood flow. so should I considered it a mixed stage?
Thanks
Shouldn't AV shunts decrease afterload, per FA? If so, how does heart failure happen? (It can't be systolic because there's no increased preload leading to eccentric hypertrophy, nor diastolic because afterload isn't increased.) A huge thank you!!
UWorld states that the Osteosclerotic phase is characterized by a "dense, hypovascular, mosaic pattern of lamellar bone with irregular, haphazardly oriented sections separated by prominent cement lines"
I am a little confused because I originally thought the replaced bone is hypervascular - resulting in high output cardiac heart failure and "vascular steal" phenomenon.
https://www.ncbi.nlm.nih.gov/pubmed/23406029?dopt=Abstract
Would be very grateful if someone could clarify this!
I have had crispy, scaly skin on one side of my right nipple for a few weeks now. Am worried about Pagets although there is no history of breast cancer in my family. I have a pic but not sure how to post it...help appreciated.
Hey. Thought I’d ask this here after googling and perhaps scaring myself with more info?! I suffer from eczema anyways - always have from a young age and regularly (daily usually) have outbreaks in random places all across my body. Recently, I’ve had an irritating problem with my nipple area in particular itching in an incredibly irritating way. My right nipple seems particularly ‘fatter’ in the tip than my left, yet there is a small white mark above my left one which you should be able to see. Believe that’s been there for several months and I’ve thought nothing of it.
Last time I had these itching was during puberty stages. I’m now coming up on 19 so that’s not so much a thing, but back then I believe it was aggravated by hair growth.
If someone would be able to assure me this is just my eczema continuing to cause trouble, or if it’s much more serious please let me know.
Pictures of both nipple areas at the following link (potentially NSFW, depending on where you are?!) - I should say I’m a male too.
http://imgur.com/a/L5xM4
My dad's dream has always been to win the lottery jackpot, whose odds are 1 in 14 million. Yesterday, he was diagnosed with the extremely rare Extramammary Paget's disease of the scrotum (EMPD). I do not know all the details yet, but CK tests resulted to positive staining, which means an underlying malignancy in the pelvic region. Looks like he got the odds, but not the jackpot.
EMPD is a funny thing. It started out a rash in the jock/groin area. My dad thought he was just allergic to his underwear material. When it didn't get any better, he consulted the local dermatologist, who gave him antifungal topical cream. When it seemed to get worse, we consulted another dermatologist, who perfomed a biopsy on the rash. Turned out it was squamous cell carcinoma in situ or Bowen's disease, the second most common type of type of skin cancer. We got referred to another derma who specializes in MOHS surgery for its removal. Topical medications are applied for a few weeks as treatment, and further tests were conducted to make sure it is an isolated case. Turned out that it wasn't skin cancer after all. It was EMPD. And to make it worse, it looks like an invasive one.
I have tried to read up on it from Google searches and because it is such a rare type of disease, all I got are scientific papers. I still have to catch up on those things because I cannot seem to read on because my hearts starts beating fast, hands are turning clammy, and the tears on my eyes keep on interrupting me.
My dad is a fit, 76 year old man who cannot seem to catch a break in life. He lost his mother to complications of diabetes at 25 (he took care of her medicines and all). He started a public transportation fleet business but one of the drivers ran and killed somebody. To pay damages, the inherited ancestral house from his mom was seized by the bank because his business went bankrupt. Had me and my sister when he was 38-40's. Because he was old and almost a retiree by that time, he had to use his pension to pay for our school tuition. All of that was ok now. I am 26 years old, and my sister and I are now young engineering professionals. My family and I never ever went to a vacation in our life because all the money went to our education. My childhood dream was to afford a car (btw I'm from Philippines hence, different family dynamics) and to take my aging parents for a ride around the city. And then this happenned.
Guess th
... keep reading on reddit ➡I have the weirdest bone right now.
Dr. James Paget described this disease in 1877, nearly 20 years before the invention on x-rays. It is a tumor-like process that causes osteolysis followed by extensive attempts to repair resulting in an increased thickness of the bone's cortex.
i think that’s really cool and such a small world lmao
