A list of puns related to "Epistasis"
I need someone who's very good at Genetics and other Science subjects. I need someone to lighten up my load, possible long time work if magaling talaga.
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I've been looking for something directly addressing the creationist claim that certain studies which observe negative Epistasis and its effects are confirmation of genetic entropy theory. As the YouTube comment I originally found them through put it, "For mutations under epistasis to produce innovations, there must be a way for them to work together (synergistic epistasis), and the reference research on bacteria indicates that they don't."
A primary example is this one: https://pubmed.ncbi.nlm.nih.gov/21636772/
Which I also found cited in a quite enthusiastic creationist article here: https://crev.info/2011/06/110605-genetic_entropy_confirmed/
ABSTRACT: Epistatic interactions between mutations play a prominent role in evolutionary theories. Many studies have found that epistasis is widespread, but they have rarely considered beneficial mutations. We analyzed the effects of epistasis on fitness for the first five mutations to fix in an experimental population of Escherichia coli. Epistasis depended on the effects of the combined mutations--the larger the expected benefit, the more negative the epistatic effect. Epistasis thus tended to produce diminishing returns with genotype fitness, although interactions involving one particular mutation had the opposite effect. These data support models in which negative epistasis contributes to declining rates of adaptation over time. Sign epistasis was rare in this genome-wide study, in contrast to its prevalence in an earlier study of mutations in a single gene.
Others: https://pubmed.ncbi.nlm.nih.gov/21636772/
https://pubmed.ncbi.nlm.nih.gov/21636771/
Anyway point is I'm aware this topic is extremely technical, and while even if Genetic Entropy is true the presence of all the other evidence means it simply creates a problem for the mechanics of a phenomenon we've basically established has happened, rather than prove YEC. But if anyone can assist me in figuring out whether that's actually the case is I'd appreciate it.
I've got a few hundred genomes, with binary phenotype data. I'd like to infer epistatic couplings that are associated with the phenotype, and have found several algorithms to do this but not for bacteria. E.g. plink command --epistasis, which is not designed for bacteria.
Are there any good alternatives for bacterial genomes?
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